This book is a detailed and comprehensive synthesis of the scientific study of aging. Dozens of contributions from leading scholars review various theories of aging, and molecular, cellular, biochemical and microbial aspects of aging, among just a few of the topics included. Authoritative, wide ranging and thorough, this book will act as a source for experimental design, a comprehensive description of age related diseases, and provide information of the latest molecular theories underlying their causes. Additionally, it will target industries involved in developing anti-aging drugs, post-graduate medical students, and university libraries.
What is aging. Biological theories of aging. Free radical theory.
Mitochondrial dysfunction theory. Error catastrophe theory. Evolutionary
theory of aging. Fading electricity theory. Quasi-program theory for aging.
Multiple hormone deficiency theory of aging. Oxidationinflammation theory of
aging. Reproductive-cell cycle theory of aging. Telomeres and telomerase
theory of aging. Markov Models of aging. Immunological theory of aging.
Social theory of aging. Genetic program theory of aging. Psychological theory
of aging. Healthy living and its effects on aging. Longevity in aging. Impact
of climate on aging. Centenarians in Okinawa. Genetics of the population.
Caloric restriction, healthy diet. Staying young at heart. Genetics of aging
and longevity. Metabolic programming, exercise, caloric restriction and
aging. Premature aging. Progeria and Werners syndrome. Stem cell aging in
progeria. Oxidative and nitrosative stress and accelerative aging. Progeria:
Genetics, and lamin disorder. Molecular aspect of aging. Hematopoietic stem
cells aging. Immune system and aging. Sirtuins in aging and age related
diseases. AMPK function in aging. Aging mechanisms and lipid changes.
Biochemical aspects of aging. GABA(A) receptors in aging. The
ubiquitin-proteasome system and aging. Autophagy and aging. Oxidation of
potassium channels and aging. Proteins and lipids in aging. Spatial protein
quality control and aging. Klotho protein and aging. Glutathione as
antioxidant. Neuropeptide Y as an anti-aging agent. Adipokines and aging.
Lamins and aging. Sestrins and aging. HDL metabolism and aging. Growth
hormone and aging. DNA damage, repair and aging. DNA damage, repair and
neurodegenerative diseases. yH2AX molecular marker for DNA damage and aging.
DNA repair in organelles and aging. Transcriptional blocking and DNA damage
in aging. Microbiota and aging. Neuroscience of aging. Thermal stress in
human and aging. Age related diseases. Ischemic heart disease and aging.
Endothelial and vascular aging. The aging heart. Age related eye disease. Age
related inflammation and osteoarthritis. Aging and musculoskeletal health.
Cancer and aging. Sexual health in aging. Sleep disturbance in aging. Anxiety
in aging. Female sexuality and aging. Aging and circadian rhythm. Metabolic
syndrome and aging. Environmental toxicants and aging. Stem cell and aging.
Non-human models for aging studies. Aging modulation in multiple species.
Mouse models. Murine genetic models. C. elegans model. S. cerevisiae model.
Drosophila model. Pig model. Mammalian hibernation and aging. Neobiosis as a
predecessor of mammalian hibernation. Chemosensory and chemosensory systems
and aging. Molecular biology of freezing tolerance. Freezing susceptibility
in arthropods. Proteomic approach to study mechanisms of aging. Therapeutic
approach for facial aging. Integrative medicine research on aging population.
Meditation and aging. Life after death: Fact or fiction.
Shamim I. Ahmad received his PhD from Leicester University and has been Lecturer at Nottingham Trent University where he the British Asian Award for "Excellence in Education." He has authored or edited eleven books and dozens of peer reviewed research papers. His research interests are in the field of DNA damage and repair and associated diseases, molecular mechanisms of Fanconi anemia, role of reactive oxygen species (ROS) in health and diseases, skin cancer by sunlight, Anti-AIDS drug development, development of new procedures for treatment of cancer, viral and bacterial infections.
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