| Preface |
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xi | |
| One World, One Humanity |
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xv | |
| Acknowledgments |
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xvii | |
| Editor |
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xix | |
| Contributors |
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xxi | |
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SECTION I Introduction to Aging |
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Chapter 1 A Synopsis on Aging |
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3 | (20) |
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Chapter 2 Understanding Aging after Darwin |
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23 | (20) |
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SECTION II Aging Hypothesis |
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Chapter 3 Evolutionary Theories of Aging: A Systemic and Mechanistic Perspective |
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43 | (30) |
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Chapter 4 The Indispensable Soma Hypothesis in Aging |
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73 | (18) |
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Chapter 5 Programmed Aging Paradigm and Aging of Perennial Neurons |
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91 | (26) |
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Chapter 6 The Genetic Program of Aging |
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117 | (18) |
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Chapter 7 The Origins of Aging: Multicellularity, Speciation, and Ecosystems |
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135 | (26) |
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Chapter 8 Human Culture: Urbanization and Human Aging |
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161 | (14) |
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Chapter 9 Aging Epigenetics: Accumulation of Errors and More |
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175 | (34) |
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SECTION III Diseases Associated with Aging and Treatment |
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Chapter 10 The Premature Aging Characteristics of RecQ Helicases |
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209 | (22) |
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Chapter 11 Cockayne Syndrome and the Aging Process |
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231 | (6) |
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Maria de la Luz Arenas-Sordo |
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Chapter 12 Cancer: The Price for Longevity |
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237 | (10) |
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Chapter 13 Nodular Thyroid Disease with Aging |
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247 | (12) |
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Chapter 14 HIV and Aging: A Multifaceted Relationship |
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259 | (12) |
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Chapter 15 Maturation, Barrier Function, Aging, and Breakdown of the Blood--Brain Barrier |
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271 | (34) |
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Chapter 16 Senescent Cells as Drivers of Age-Related Diseases |
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305 | (30) |
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Chapter 17 Osteoimmunology in Aging |
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335 | (16) |
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Chapter 18 Manipulating Aging to Treat Age-Related Disease |
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351 | (6) |
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Chapter 19 Therapeutic Options to Enhance Poststroke Recovery in Aged Humans |
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357 | (26) |
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SECTION IV Mechanisms of Aging |
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Chapter 20 Increase in Mitochondrial DNA Fragments inside Nuclear DNA during the Lifetime of an Individual as a Mechanism of Aging |
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383 | (12) |
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Chapter 21 Mitochondrial Oxidative Stress in Aging and Healthspan |
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395 | (28) |
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Chapter 22 Immunology of Aging and Cancer Development |
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423 | (14) |
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Chapter 23 Oxidation of Ion Channels in the Aging Process |
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437 | (18) |
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Chapter 24 Lipid Raft Alteration and Functional Impairment in Aged Neuronal Membranes |
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455 | (20) |
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Catherine Malaplate-Armand |
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Chapter 25 Autophagy: The Way to Death or Immortality? Activators and Inhibitors of Autophagy as Possible Modulators of the Aging Process |
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475 | (14) |
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SECTION V Treatments in Aging |
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Chapter 26 Aging: Grounds and Determents |
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489 | (10) |
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Chapter 27 Skin Aging Clock and Its Resetting by Light-Emitting Diode Low-Level Light Therapy |
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499 | (18) |
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SECTION VI Healthy and Successful Aging |
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Chapter 28 Social Structure and Healthy Aging: Case Studies |
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517 | (8) |
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Chapter 29 Successful Aging: Role of Cognition, Personality, and Whole-Person Wellness |
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525 | (18) |
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Chapter 30 Physical Activity in Prevention of Glucocorticoid Myopathy and Sarcopenia in Aging |
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543 | (16) |
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Chapter 31 Reductionism versus Systems Thinking in Aging Research |
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559 | (18) |
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SECTION VII Anti-Aging Drugs |
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Chapter 32 Anti-Aging Drug Discovery in Experimental Gerontological Studies: From Organism to Cell and Back |
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577 | (22) |
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SECTION VIII Aging in Caenorhabditis elegans |
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Chapter 33 Caenorhabditis elegans Aging Is Associated with a Decline in Proteostasis |
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599 | (18) |
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SECTION IX Hibernation and Aging |
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Chapter 34 Hibernation and Aging: Molecular Mechanisms of Mammalian Hypometabolism and Its Links to Longevity |
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617 | (20) |
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SECTION X Mathematical Modeling of Aging |
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Chapter 35 The Role of Mathematical Modeling in Understanding Aging |
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637 | (16) |
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| Index |
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653 | |
Lisainfo e-raamatute kohta