Reviewing the most current literature, this text is a guide to medical decision-making regarding the diagnosis and treatment of patients with acromegaly. The scope of the book is comprehensive, covering all relevant facets of acromegaly, beginning with a history of the disorder and a review of the somatotrophic axis. Etiology is then discussed, including growth hormone secreting pituitary adenomas and other neuroendocrine tumors. Subsequent chapters present imaging modalities and diagnosis via radiology and clinical findings, as well as comorbid symptoms such as sleep apnea, musculoskeletal considerations, cardiovascular disorders, cancer and diabetes. Both medical and surgical management chapters describe each in detail, including radiotherapy, transsphenoidal surgery, somatostatin analogues and dopamine agonists. Concluding chapters present long-term follow-up as well as an extended selected patient story detailing life with the disease.
Bringing together the latest in endocrinologic and neurosurgical evidence and practice, Acromegaly will be the go-to resource for this challenging condition for years to come.
The Molecular Biology and Pathology of Acromegaly.- Growth
Hormone-releasing Hormone Secreting Neuroendocrine Tumors.- Diagnosis of
Acromegaly.- Imaging in Acromegaly.- The Clinical Presentation of
Acromegaly.- Sleep-Disordered Breathing in Acromegaly.- Cardiovascular
Pathology in Acromegaly.- Diabetes and Acromegaly.- Musculoskeletal Disorders
of Acromegaly.- Acromegaly and Cancer.- Mortality in Acromegaly.- An Overview
to the Approach to the Management of Acromegaly.- Transsphenoidal Surgery for
Acromegaly.- Stereotactic Radiosurgery and Radiation Therapy for
Acromegaly.- Challenging Questions in the Management of Acromegaly in the
Young.- Somatostatin Analogues in the Management of patients with
Acromegaly.- Use of Dopamine Agonists for Acromegaly.- Pegvisomant: Lessons
Learned After 20 Years and Practical Recommendations of its use for the
Treatment of Acromegaly.- Perspectives on Combination Medical Therapy in the
Treatment of Acromegaly.- Long-term Follow-up of Patients with Acromegaly.- A
Patients Perspective on Acromegaly.
Lewis S. Blevins Jr., MD, Department of Neurological Surgery, California Center for Pituitary Disorders and Brain Tumor Center, University of California - San Francisco, San Francisco, CA, USA Manish Aghi, MD, PhD, Department of Neurological Surgery, California Center for Pituitary Disorders and Brain Tumor Center, University of California - San Francisco, San Francisco, CA, USA
