Associated with both acute kidney injury (AKI) and cardio-renal syndromes (CRS), new biomarkers represent both a popular area of investigation and a new opportunity for advancement of therapy. This book contains the resolutions of the most recent ADQI conferences on biomarkers in AKI (Dublin) and on cardio-renal syndromes (Venice). The first part answers specific questions about new biomarkers and their use and utility in AKI: What are the most suitable candidate molecules and physiologic measures, how solid and evidence based is the discovery phase? How can we incorporate the new biomarkers in the AKI conceptual model describing the evolution from susceptibility to insult, decreased GFR and organ death? Even if we have a positive biomarker pattern and we can identify patients at risk or patients with early or even subclinical AKI, how is this information affecting our clinical behavior and practice? The second part is dedicated to the appraisal of the current knowledge about the pathophysiological mechanisms involved in different forms of CRS: it contains contributions on the state-of-the-art knowledge and practice of CRS, particularly focusing on the pathophysiology of the five subtypes. Acute and chronic mechanisms of damage are explored in depth, with particular attention to the primacy of organ involvement and the subsequent pathways of organ crosstalk. Presenting the most recent research in the field of biomarkers, AKI and CRS, this publication is an important educational tool for advanced investigators and clinical experts, but also for students and fellows.
Preface: McCullough, P.A. et al.; Acute Dialysis Quality Initiative
(ADQ): Ronco, C. et al.; Implementation of Novel Biomarkers in the Diagnosis,
Prognosis, and Management of Acute Kidney Injury: Executive Summary from the
Tenth Consensus Conference of the Acute Dialysis Quality Initiative (ADQI):
McCullough, P.A. et al, for the Acute Dialysis Quality Initiative (ADQI)
Consensus Group; Diagnosis of Acute Kidney Injury Using Functional and Injury
Biomarkers: Workgroup Statements from the Tenth Acute Dialysis Quality
Initiative Consensus Conference: McCullough, P.A. et al., for the ADQI 10
Workgroup; Differential Diagnosis of AKI in Clinical Practice by Functional
and Damage Biomarkers: Workgroup Statements from the Tenth Acute Dialysis
Quality Initiative Consensus Conference: Endre, Z.H. et al., for the ADQI 10
Workgroup; Use of Biomarkers to Assess Prognosis and Guide Management of
Patients with Acute Kidney Injury: Cruz, D.N. et al., for the ADQI 10
Workgroup; Physiological Biomarkers of Acute Kidney Injury: A Conceptual
Approach to Improving Outcomes: Okusa, M.D. et al., for the ADQI 10
Workgroup; Pathophysiology of the Cardiorenal Syndromes: Executive Summary
from the Eleventh Consensus Conference of the Acute Dialysis Quality
Initiative (ADQI): McCullough, P.A. et al., for the Acute Dialysis Quality
Initiative (ADQI) Consensus Group; Pathogenesis of Cardiorenal Syndrome Type
1 in Acute Decompensated Heart Failure: Workgroup Statements from the
Eleventh Consensus Conference of the Acute Dialysis Quality Initiative
(ADQI): Haase, M. et al., for the Acute Dialysis Quality Initiative (ADQI)
Consensus Group; Pathophysiology of Cardiorenal Syndrome Type 2 in Stable
Chronic Heart Failure: Workgroup Statements from the Eleventh Consensus
Conference of the Acute Dialysis Quality Initiative (ADQI): Cruz, D.N. et
al., for the Acute Dialysis Quality Initiative (ADQI) Consensus Group;
Cardiorenal Syndrome Type 3: Pathophysiologic and Epidemiologic
Considerations: Bagshaw, S.M. et al., for the Acute Dialysis Quality
Initiative 11 Working Group; Cardiorenal Syndrome Type 4: Insights on
Clinical Presentation and Pathophysiology from the Eleventh Consensus
Conference of the Acute Dialysis Quality Initiative (ADQI): Tumlin, J.A. et
al., for the Acute Dialysis Quality Initiative (ADQI) 11 Consensus Group;
Cardiorenal Syndrome Type 5: Clinical Presentation, Pathophysiology and
Management Strategies from the Eleventh Consensus Conference of the Acute
Dialysis Quality Initiative (ADQI): Mehta, R.I. et al., for the Acute
Dialysis Quality Initiative (ADQI) 11 Working Group; Appendix 1: 10th Acute
Dialysis Quality Initiative (ADQI) Consensus Group; Appendix 2: 11th Acute
Dialysis Quality Initiative (ADQI) Consensus Group.
