Advancements in Modeling-Based Therapeutics and Technology for Chronic Diseases explores the fundamental role played by animal and cellular models in unravelling the complexities of chronic diseases and underlying treatments. These models serve as crucial tools for scrutinizing the complicated molecular and cellular mechanisms underlying such diseases, conducting preclinical evaluations of pharmaceutical compounds, and probing into the genetic components contributing to disease pathogenesis and are the foundation of innovative therapeutic approaches for optimizing patient care in the treatment of chronic diseases. The book explores critical chronic diseases, providing insights into their complexities, causes, and potential therapeutic approaches. Content is organized into three sections. The first section begins with an introductory exploration of the intricate interplay of factors contributing to chronic illness burden then goes on to compare animal models, precision medicine and personalized drug design approaches, and advancements in biomarker discovery and validation used in targeted therapies. Further, this section intricately examines cellular and immunotherapy modelling as well as the role of transnational models for the management of chronic diseases. Various technological innovations in chronic diseases management are reviewed in the second section, including gene editing techniques in chronic disease treatment, image technologies for modelling and monitoring, computational tools and methods, as well as integrated systems biology approaches in chronic disease research. The book’s final section is devoted to discussing ethical and regulatory considerations, dilemmas and obstacles, with special focus on addressing data privacy concerns. In summary, this valuable resource offers a combination of current advances, practical insights, and treatment strategies, enabling scientists and researchers working in the field of modeling-based therapeutics for chronic diseases to stay abreast of novel developments and drive future direction in healthcare.
Section 1: Chronic Diseases, Modeling, and Therapeutic Strategies
1. Unravelling the complexity of chronic diseases: an introductory
exploration
2. Comparative information of different animal models used in chronic
diseases
3. Precision medicine: tailoring therapeutics through advanced modeling
strategies
4. Personalized drug design: from models to therapeutics
5. Advancements in biomarker discovery and validation for targeted therapies
6. Advancement in the animal model-based therapeutics in neurodegenerative
diseases
7. Cellular models of chronic diseases: from bench to bedside
8. Toxin induced animal models in Parkinsons disease: recent updates
9. Immunotherapy modeling: harnessing the immune system in chronic disease
treatment
10. The Role of transnational models for the management of chronic diseases
Section 2: Technological Innovations in Chronic Disease Management
11. Gene editing technologies: transformative approaches in chronic disease
treatment
12. Innovations in imaging technologies for disease modeling and monitoring
13. Computational tools and techniques for disease modeling: bridging the
gap
14. Integrated systems biology approaches in chronic disease research
Section 3: Ethical and Regulatory Considerations
15. Ethical considerations in transnational chronic disease management
models
16. Exploring ethical dilemmas and regulatory obstacles in modeling-based
therapeutics: addressing data privacy concerns
Dr. Sachchida Nand Rai is a Research Associate (ICMR-RA) at Centre of Experimental Medicine and Surgery, Institute of Medical Sciences, Banaras Hindu University (BHU), Varanasi. Dr. Rai also completed his PhD from the Biochemistry Department (Institute of Science) of the same university in 2018. The BHU consistently ranks among the top universities in India in terms of research output and quality in the life sciences. Before joining the BHU as Research Associate, he was post-Doctoral fellow at Centre of Biotechnology, University of Allahabad, Prayagraj, India. Dr Rai has edited over 100 manuscripts, reviewed more than 900 manuscripts for high-impact journals, and has published 3 books. He is a member of the Indian Academy of Neurosciences and serves as editorial board member for multiple journals such as 3-Biotech, Oxidative Medicine and Cellular Longevity.
Santosh Kumar Singh is a Senior Scientist at the Centre of Experimental Medicine & Surgery, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.
Dr. Veer Singh is currently working as Young Scientist (Department of Health Research) at the Department of Biochemistry, ICMR-Rajendra Memorial Research Institute of Medical Sciences, Patna, India. He received his PhD from the Indian Institute of Technology (Banaras Hindu University), Varanasi. He has more than 45 publications with Internationally reputed publishers. He published two Indian patents. His area of work involves Environmental contamination and human health. He is also reviewer and guest editor of reputed publishers.
