This book reviews recent advances in drug discovery for Alzheimers disease, focusing on major targets and approaches. Topics include approaches to targetingdirectly or indirectlythe two proteins that pathologically accumulate in the brain in Alzheimers disease, the amyloid -peptide and the microtubule-associated protein tau, which remain top targets for disease prevention and treatment. A chapter on the emerging area of AI approaches to drug repurposing and discovery will also be included, with examples of the use of big data to identify novel therapeutic modalities. An overview chapter will put these approaches into broader context; describe other important and emerging approaches, targets, and drug candidates; and provide a critical assessment of the potential of these approaches to lead to effective therapeutics. This book is particularly appealing to researchers, clinicians, and students in the fields of medicinal chemistry, neuroscience, pharmacology, and biomedical sciences, as well as anyone interested in the latest advancements in Alzheimers disease research and drug discovery.
