Muutke küpsiste eelistusi

Advances in Genetics, Volume 105 [Kõva köide]

Series edited by (Honorary Clinical Professor, William Harvey Research Institute, Queen Mary University of London, UK)
  • Formaat: Hardback, 392 pages, kõrgus x laius: 229x152 mm, kaal: 770 g
  • Sari: Advances in Genetics
  • Ilmumisaeg: 13-Jun-2020
  • Kirjastus: Academic Press Inc
  • ISBN-10: 0128216859
  • ISBN-13: 9780128216859
Teised raamatud teemal:
Advances in Genetics, Volume 105Suurem pilt
  • Formaat: Hardback, 392 pages, kõrgus x laius: 229x152 mm, kaal: 770 g
  • Sari: Advances in Genetics
  • Ilmumisaeg: 13-Jun-2020
  • Kirjastus: Academic Press Inc
  • ISBN-10: 0128216859
  • ISBN-13: 9780128216859
Teised raamatud teemal:
Püsilink: https://www.kriso.ee/db/9780128216859.html
Märksõnad:

Advances in Genetics, Volume 105, provides the latest information on the rapidly evolving field of genetics, presenting new medical breakthroughs that are occurring as a result of advances in our knowledge of the topic. The book continually publishes important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines, critically analyzing future directions.

  • Critically analyzes future directions for the study of clinical genetics
  • Written and edited by recognized leaders in the field
  • Presents new medical breakthroughs that are occurring as a result of advances in our knowledge of genetics
Contributors ix
Preface xi
1 Pathogen and host genetics underpinning cryptococcal disease
1(66)
Carolina Coelho
Rhys A. Farrer
1 Introduction
2(1)
2 Cryptococcus spp. genetics and genomics
3(27)
3 Cryptococcosis
30(16)
Acknowledgments
46(1)
References
46(21)
2 Role of RNA-interacting proteins in modulating plant-microbe interactions
67(28)
Saurabh Pandey
Namisha Sharma
Manoj Prasad
1 Introduction
68(8)
2 Crossing barriers: HIGS into action
76(1)
3 RNA-interacting proteins at the verge of plant-pathogen interaction
77(1)
4 RNA chaperone-sRNA interplay in host-microbe interaction
78(7)
5 Pathogenic sRNAs to impede host defense
85(1)
6 sRNAs on the move: Mechanistic insights into cross-kingdom sRNA movement
86(1)
7 Concluding remarks
87(1)
Acknowledgments
88(1)
References
88(7)
3 FMRP ribonucleoprotein complexes and RNA homeostasis
95(42)
Gabriela Aparecida Marcondes Suardi
Luciana Amaral Haddad
1 Introduction
96(3)
2 FMR1-associated clinical conditions
99(5)
3 FMRP is a synaptic regulator
104(2)
4 FMRP in ribonucleoprotein (RNP) complexes
106(14)
5 Concluding remarks
120(1)
Acknowledgments
121(1)
References
121(16)
4 "Electrifying dysmorphology": Potassium channelopathies causing dysmorphic syndromes
137(38)
Mark James Hamilton
Mohnish Suri
1 Introduction
138(1)
2 Potassium channel structure and function
139(2)
3 Andersen-Tawil syndrome
141(4)
4 Bauer-Tartaglia (FHEIG) syndrome
145(3)
5 Birk-Barel syndrome (BBS)
148(2)
6 Cantu syndrome
150(4)
7 Keppen-Lubinsky syndrome (KLS)
154(4)
8 Temple-Baraitser syndrome (TBS)
158(4)
9 Zimmermann-Laband syndrome (ZLS)
162(4)
10 Conclusions
166(1)
Acknowledgments
167(1)
References
167(8)
5 Recent advances in oomycete genomics
175(54)
Jamie Mcgowan
David A. Fitzpatrick
1 The oomycetes
176(4)
2 Oomycete genomes
180(10)
3 Oomycete phylogenomics
190(4)
4 Oomycete mitochondrial genomes
194(2)
5 The impact of horizontal gene transfer on oomycete evolution
196(3)
6 Genome mining for oomycete effectors
199(7)
7 Oomycete OMICS studies
206(6)
8 Tools for oomycete genomics
212(2)
9 Oomycetes in the post-genomic era
214(3)
10 Conclusions and future outlook
217(1)
Acknowledgments
218(1)
References
218(11)
6 Antibiotic drug discovery: Challenges and perspectives in the light of emerging antibiotic resistance
229(64)
Keshab Bhattarai
Rina Bastola
Bikash Baral
1 Introduction
231(1)
2 History of novel antibiotic discovery
232(2)
3 Metabolite biosynthesizing microbes
234(1)
4 Antibiotics classification and their mode of actions
235(1)
5 Antibiotic resistance and evolution of superbugs
235(2)
6 Problem of antimicrobial resistance
237(1)
7 Foundation of antibiotic era
238(1)
8 Qualities to qualify as an antibiotic
238(1)
9 Antibiotics developmental pipeline and causes of discovery void
239(1)
10 Maintenance of antibiotics pipeline
240(1)
11 Metabolites detection
241(3)
12 Metabolites profiling
244(1)
13 Characteristics of versatile surrogate chassis hosts
245(1)
14 Silent/cryptic gene clusters, their roles and significance
246(1)
15 Secondary metabolic cluster (presence of biosynthetic, resistance and transporters)
247(1)
16 Complex cascade regulation of antibiotic biosynthesis in actinomycetes (Nikkomycin biosynthetic cluster as an example)
247(3)
17 Classical approaches for detection of novel antibiotics
250(8)
18 Bioactivity analysis of novel antimicrobial compounds
258(1)
19 Strategies for prediction, analysis and activation of BGC
259(11)
20 Alternative approaches to conventional antibiotics
270(4)
21 Perspectives, challenges and conclusions
274(1)
References
275(18)
7 Application of yeast to studying amyloid and prion diseases
293
Yury O. Chernoff
Anastasia V. Grizel
Aleksandr A. Rubel
Andrew A. Zelinsky
Pavithra Chandramowlishwaran
Tatiana A. Chernova
1 Introduction
296(4)
2 Overview of yeast prions
300(8)
3 Yeast models for polyglutamine aggregation
308(9)
4 Yeast models for aggregation of α-synuclein, associated with Parkinson's disease (PD)
317(3)
5 Yeast models for amyloid proteins associated with Alzheimer's disease (AD) and tauopathies
320(9)
6 Yeast models for aggregation of mammalian prion protein (PrP)
329(6)
7 Yeast models for proteins associated with amyotrophic lateral sclerosis (ALS)
335(11)
8 Aggregation of transthyretin in yeast
346(1)
9 Yeast assay for amyloid nucleation by mammalian proteins
347(5)
10 Conclusions and future directions
352(2)
Acknowledgments
354(1)
References
354
Professor Kumar has considerable previous experience in writing and editing books and journals related to genetics and genomics. His books include Genomics and Clinical Medicine and Genomics and Health in the Developing World. He founded and leads the new open access journal Applied and Translational Genomics, published by Elsevier. He has published 40 articles in the journals literature. Professor Dhavendra Kumar is a Visiting Professor, Genomic Policy Unit, Faculty of Life Sciences and Education, The University of South Wales and Consultant in Clinical Genetics at the University Hospital of Wales, Institute of Medical Genetics, Cardiff University, Cardiff, United Kingdom. He is one of the Consultants for the All Wales Medical Genetics Service and the lead Clinician for Clinical Cardiovascular Genetics. After qualifying in Medicine from the King Georges Medical College, University of Lucknow, India, he completed postgraduate training in Pediatrics with an MD. Since 1980 he has pursued a career in Medical Genetics in the UK. In 1990 he became a Diplomate of the American Board of Medical Genetics. He is a Fellow of the American College of Medical Genetics (FACMG) and as well as Royal Colleges of Physicians (FRCP-London and FRCP-Ireland) and Pediatrics and Child Health (FRCPCH-UK).

In 2015, he was conferred with the higher degree of DSc by his Alma Mater, King Georges Medical University, Lucknow (UP, India) based on his life-time contributions and achievements to genetic and genomic applications in medicine and health.