Analytical Chemistry of Cannabis: Chemistry, Pharmacology, Manufacturing, Use, and Control of Medicinal Cannabis and Cannabinoid Dosage Formulations 2nd edition [Pehme köide]

1. Introduction to Cannabis, Cannabinoids, and Cannabimimetics
2. The Endogenous Cannabinoid Signaling System
3. Botany of Cannabis Sativa
4. Synthesis of Cannabinoids
5. Isolation of Cannabinoids and Manufacture of Cannabinoid-Containing Dosage
Formulations
6. Quality Control/Quality Assurance of Cannabis and Cannabinoid-Containing
Products
7. Bioanalytical Methods and Pharmacokinetic Assessment
8. Post-Marketing Surveillance and Pharmacovigilance
9. Identification and Quantitation of Synthetic Cannabimimetics
10. Research and Regulation of Cannabinoid Receptor Ligands
11. The Future of Cannabis, Cannabinoids, and Cannabimimetics

Brian F. Thomas earned his doctoral degree in 1992 from the Medical College of Virginia/Virginia Commonwealth University, USA. He then joined Research Triangle Institute and assumed the role of Principal Investigator on National Institute on Drug Abuse (NIDA) research contracts titled Purity Specifications, Storage and Distribution for Medications Development,” Preparation and Distribution of Research Drug Products,” and Production, Analysis and Distribution of Cannabis, Marijuana Cigarettes and Related Materials.” Serving in these roles, he coordinated the preparation and analysis of research drugs and substance abuse treatment medications at RTI for over 28 years. In addition to contract research, Dr. Thomas served as Principal Investigator on several NIDA R01 grant-funded research awards involving the characterization of cannabinoid ligand-receptor interactions and their relationship to in vivo pharmacological effects.

In 2019, he joined Canopy Growth Corporation as Senior Director, Analytical Chemistry, Discovery Sciences, and Pharmaceutics, where he had management oversight of drug substance and product testing to support preclinical and clinical studies of cannabinoids in accordance with regulatory guidance. He also directed the integration of medicinal chemistry and in vitro pharmacological screening approaches to support development of consumer products and drive clinical drug discovery and therapeutic product development and commercialization efforts. He was subsequently recruited by The Cronos Group to serve as the Director of Analytical Sciences, with management oversight of scientists at production and research and development facilities in the United States, Canada, and Israel. He also engaged with the US Hemp Roundtable and other trade and scientific organizations to provide critical input to regulations and regulatory oversight by state, federal, and international regulatory authorities. He is currently providing pharmaceutical consulting services as the Principal Scientist at Empirical Pharmaceutical Services, LLC. He also serves on the Scientific Advisory Boards of Bright Green Corporation and Biopharmaceutical Research Company, two of the cannabis companies selected by the US government to grow, manufacture, and sell, legally under federal and state laws, cannabis and cannabis-related products for research, pharmaceutical applications, and export. He has authored or co-authored over 120 peer-reviewed manuscripts and numerous book chapters, coauthored a book, and served as the Series Editor of Elseviers Emerging Issues in Analytical Chemistry. Mahmoud A. ElSohly is a Research Professor at the National Center for Natural Products Research and Professor of Pharmaceutics in the Department of Pharmaceutics and Drug Delivery, School of Pharmacy, University of Mississippi, USA. He is the Project Director, National Institute on Drug Abuse Marijuana Project at the University of Mississippi (1981 to present). He is President and Director of ElSohly Laboratories Incorporated, Oxford, MS, a small company providing precision analytical testing and manufacturing services for the drug testing industry since 1985. He obtained a Ph.D. degree in Pharmacy (Pharmacognosy) from the University of Pittsburgh in 1975. Dr. ElSohly holds more than 30 patents dealing with the processing, testing, and detection of drugs of abuse along with other patents dealing with biologically active natural products. He has authored over 300 peer-reviewed scholarly articles published in top-tier international journals. He is a member of 14 scholarly scientific societies and was recognized by The Scientist (April 17, 1995) and ScienceWatch (January 1995) as the second most cited author in forensic sciences in the world for the period 19811993. Suman Chandra received his M.Phil. degree in Environmental Plant Physiology and Ph.D. in Plant Physiology from High Altitude Plant Physiology Research Center, HNB Garhwal University, India. He worked at the High-Altitude Plant Physiology Research Center and the G.B. Pant National Institute of Himalayan Environment, India from 1992 to 2000. He joined the University of Mississippi, USA in 2001 and is currently working as Principal Scientist at the National Center for Natural Product Research and the Research Institute of Pharmaceutical Sciences in the School of Pharmacy. His research interests include conservation, cultivation and improvement of medicinal plants, and effects of climatic changes on physiology and secondary metabolites of medicinally important plants. Dr. Chandra has more than 22 years of experience in the field of cannabis and cannabinoid research. He has authored or co-authored more than 100 peer-reviewed publications and two edited books.