Antimicrobial Dressings: The Wound Care Applications explores the literature surrounding the catalytic behavior of proteolytic enzymes immobilized together with nanoparticles. As numerous applications using proteolytic enzymes for debridement, silver as antibiotic and nanoparticles for enzyme immobilization were developed in the last years, this book explores interdisciplinary information combining nanotechnology, biotechnology and medicine and how it's still in early stages. The book adopts a holistic approach in a lifecycle context to evaluate their final feasibility, including industrial exploitability without disregard of the potential risks of enzymes and nanomaterials to human health and the environment.
- Describes the drawback of using unstable enzymes in wound debridement such as infections, irritations, low availability, rapid elimination from the body, and impossibility of creating a high local concentration of the preparation without increasing its systemic concentration
- Provides information on higher efficient antimicrobial property and enzyme stability using nanoparticles as carriers for enzyme immobilization due to minimum diffusional limitation, maximum surface area per unit mass, and high enzyme loading
- Discusses the physical characteristics of the nanoparticles through multilayer polyelectrolytes encasing, such as diffusion and particle mobility that will influence the catalytic activity, pH and thermal stability of attached enzymes
1. Overview and Summary of Antimicrobial Activity in Wound Dressings and its Biomedical Applications
2. Traditional and Modern Wound Dressings- Characteristics of Ideal Wound Dressings
3. Nanoparticles as Potential Antimicrobial Agents for Enzyme Immobilization in Antimicrobial Wound Dressing
4. Polyelectrolyte (PEM) Assembly With NP-Immobilized Enzymes
5. Role of Debridement and its Biocompatibility in Antimicrobials Wound Dressing
6. Different Immobilized-Enzyme Nanoparticles Multilayered Preparations
7. Kinetic, Stability and Activity of the NP-Immobilized Enzymes
8. The Antibacterial Hydrogel Dressings and their Applications in the Treatment of Wound
9. Medicated Wound Dressings
10. Clinical Effectiveness of Antimicrobial Dressing
11. Future Research Directions of Antimicrobial Wound Dressing
Raju Khan is a Senior Principal Scientist and Professor, at CSIR-Advanced Materials and Processes Research Institute, Bhopal. He did his PhD in Chemistry in 2005 from Jamia Millia Islamia, Central University, New Delhi, and Postdoctoral researcher at the Sensor Research Laboratory” University of the Western Cape, Cape Town. His current research involved synthesizing novel materials to fabricate electrochemical and fluorescence-based biosensors integrated with microfluidics to detect target disease risk biomarkers for health care monitoring. He has published over 150 papers in SCI journal, which attracted over 5500 citations as per Google Scholar, published 45 book chapters in the reputed book Elsevier and Taylor Francis, editing of 28 books from Elsevier and Taylor Francis, and his research has been highlighted in Nature India. He has supervised 5 PhD and 30 undergraduate/postgraduate theses and has supervised 4 numbers of postdoctoral fellows under the scheme of N-PDF, CSIR-Nehru Fellowship, and DST-Women Scientist Projects.
V Sorna Gowri PhD is currently working as a Principal Technical officer, in CSIR-Advanced Materials and Processes Research Institute (AMPRI. Her recent research is on development of multifunctional nanocoatings on textiles. She has more than 21 years of R&D experience in CSIR-AMPRI, Bhopal Govt. of India. She worked as a Postdoctoral Fellow at Institute Curie, Paris France, and also worked as a Postdoctoral Fellow at University of Minho. Dr. S. Gowri was involved in synthesizing polymer nanocomposites for multifunctional surface coatings. She has published more than 21 SCI journals, Granted and Filed 2 patents. She is also team member of two technology transfers to industries
