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Applications of Targeted Nano Drugs and Delivery Systems: Nanoscience and Nanotechnology in Drug Delivery [Pehme köide]

Edited by (Distinguished USF Health Professor, Director of the Division of Translational Medicine, University of South Florida, USA), Edited by , Edited by (School of Nano Science and Technology (SNST), Indian Institute of Technology, Kharagpur), Edited by , Edited by (LV Prasad Eye Inst)
  • Formaat: Paperback / softback, 682 pages, kõrgus x laius: 235x191 mm, kaal: 1560 g
  • Sari: Micro & Nano Technologies
  • Ilmumisaeg: 10-Oct-2018
  • Kirjastus: Elsevier Science Publishing Co Inc
  • ISBN-10: 0128140291
  • ISBN-13: 9780128140291
Teised raamatud teemal:
  • Formaat: Paperback / softback, 682 pages, kõrgus x laius: 235x191 mm, kaal: 1560 g
  • Sari: Micro & Nano Technologies
  • Ilmumisaeg: 10-Oct-2018
  • Kirjastus: Elsevier Science Publishing Co Inc
  • ISBN-10: 0128140291
  • ISBN-13: 9780128140291
Teised raamatud teemal:

Applications of Targeted Nano-Drugs and Delivery Systems: Nanoscience and Nanotechnology in Drug Delivery explores the applications of Nano-drugs and their delivery systems, investigating the role they can play in key body systems and major diseases. The book explores how nanotechnology can be deployed in developing new drug delivery systems and how they enable pharmaceutical companies to reformulate existing drugs on the market, thereby extending the lifetime of products and enhancing performance by increasing effectiveness, safety and patient adherence, and ultimately reducing healthcare cost. Reflecting the interdisciplinary nature of the subject matter, this book includes contributions by experts from different fields.

Readers will find a reference and practical source of guidance for researchers, students and scientists working in the fields of nanotechnology, materials science, and technology and biomedical science.

  • Enables readers from different fields to access recent research and protocols across traditional boundaries
  • Focuses on protocols and techniques, as well as the knowledge base of the field, thus enabling those in R&D to learn about, and successfully deploy, cutting-edge techniques
  • Explores the applications of Nano-drugs and their delivery systems, investigating the role they can play in key body systems and major disease types
List of Contributors
xix
Foreword xxiii
Chapter 1 Nanotherapeutics and Nanobiotechnology
1(14)
Vivek P. Chavda
1 Introduction
1(1)
2 Advantages
1(2)
3 Fabrication Challenges
3(1)
4 Applications of Nanobiotechnology
4(1)
5 Toxicity of the Nanocarrier Systems
5(1)
6 Recent Patents
5(1)
7 Challenges for Nanobiotechnology
5(1)
8 Ethical Perspective of Nanobiotechnology
6(3)
9 Regulatory Perspective of Nanobiotechnology
9(1)
10 Future Prospects
9(1)
11 Conclusion
10(5)
References
10(5)
Chapter 2 Application and Perspective of pH-Responsive Nano Drug Delivery Systems
15(20)
Amit K. Goyal
Gautam Rath
Chetna Faujdar
Basant Malik
1 Introduction
15(6)
2 Polymer-Drug Conjugates
21(1)
3 Nanoparticles
21(3)
4 Nanogels
24(1)
5 Dendrimers
25(2)
6 Niosomes
27(1)
7 Liposomes
27(2)
8 Miscellaneous Nanocarriers
29(1)
9 Conclusion
29(6)
References
29(6)
Chapter 3 Mechanism for Development of Nanobased Drug Delivery System
35(34)
Chandramani Pathak
Foram U. Vaidya
Shashibhal M. Pandey
1 Introduction
35(8)
1.1 Nanomaterials in Drug Delivery
36(7)
2 Mechanisms for Synthesis of Nanobased Drug Delivery System
43(7)
2.1 Thin Film Hydration Method
43(1)
2.2 Solvent Evaporation Method
43(1)
2.3 Emulsions- Diffusion Method
43(1)
2.4 Double Emulsion and Evaporation Method
44(1)
2.5 Solvent Displacement/Precipitation Method
44(1)
2.6 Salting Out Method
45(1)
2.7 Emulsion Polymerization Technique
45(1)
2.8 Mini-Emulsion Polymerization
46(1)
2.9 Microemulsion Polymerization
46(1)
2.10 Interfacial Polymerization
47(1)
2.11 Controlled/Living Radical Polymerization
47(1)
2.12 Dialysis
48(1)
2.13 Solvent Injection Method
48(1)
2.14 Supercritical Fluid Technology
49(1)
2.15 Methods for Synthesis of Dendrimers
50(1)
3 Mechanism of Drug Targeting
50(2)
3.1 Passive Targeting
50(1)
3.2 Active Targeting
51(1)
4 Conclusion
52(17)
References
52(17)
Chapter 4 Nanobased Nano Drug Delivery: A Comprehensive Review
69(24)
Vivek P. Chavda
1 Introduction
59(10)
2 How to Design Nanobased Drug Delivery
69(2)
3 Route of Administration for Nanobased Drug Delivery
71(1)
4 Types of Nano Drug Delivery Systems
71(11)
4.1 Dendrimers
72(2)
4.2 Nanosuspensions
74(1)
4.3 Nanoemulsion
75(3)
4.4 Nanocrystals
78(2)
4.5 Carbon Nanomaterials
80(1)
4.6 Magnetic Nanoparticles
81(1)
5 Characterization of Nano Drug Delivery System
82(1)
6 Advantages of Nano Drug Delivery System
82(2)
7 Disadvantages of Nano Drug Delivery System
84(1)
8 Recent Patents in Nano Drug Delivery
84(4)
9 Concluding Remarks and Future Prospects for Nano Drug Delivery
88(5)
References
88(5)
Chapter 5 Recent Advances in Development of Nano Drug Delivery
93(40)
Vikas Rana
Radhika Sharma
1 Introduction
93(6)
2 Recent Advances in Nano Drug Delivery
99(15)
2.1 Lipid-Based Nano Drug Delivery Systems
99(4)
2.2 Polymeric Nano Drug Delivery Systems
103(4)
2.3 Silica-Based Nano Drug Delivery Systems
107(3)
2.4 Carbon-Based Nano Drug Delivery Systems
110(1)
2.5 Metal-Based Nano Drug Delivery Systems
111(3)
3 Nanoformulations: FDA Approved and in Recent Clinical Trials
114(1)
4 Challenges of Nano Drug Delivery
114(9)
5 Safety Issues
123(1)
6 Commercially Available Nano Drug Delivery Systems
123(3)
7 Conclusions and Future Perspectives
126(7)
References
126(7)
Chapter 6 Thermoresponsive Drug Delivery Systems, Characterization and Application
133(24)
Debabrata Ghosh Dastidar
Gopal Chakrabarti
1 Introduction
133(1)
2 Characterization
134(2)
2.1 Phase Diagram
134(2)
2.2 Glass Transition Temperature
136(1)
3 Thermoresponsive Polymers
136(4)
3.1 Poly(N-Isopropylacrylamide) and Derivatives
137(2)
3.2 Poly(N-Vinylisobutyramide) and Derivatives
139(1)
3.3 Poly(Oxyethylene Vinyl Ether)
139(1)
3.4 Cellulose Derivatives
140(1)
4 Delivery Systems and Applications
140(10)
4.1 Liposomes
141(1)
4.2 Hydrogels
142(2)
4.3 Polymeric Nanoparticles
144(1)
4.4 Nanofibers
145(1)
4.5 Polymeric Micelles
146(1)
4.6 Elastin-Like Peptide-Drug Conjugates
147(3)
5 Conclusions and Future Perspectives
150(7)
References
151(6)
Chapter 7 Graphene and Graphene-Based Nanomaterials Are Suitable Vehicles for Drug Delivery
157(34)
Yogendrakumar Lahir
1 Overview of Graphene
157(1)
2 Structural Aspects of Graphene and Graphene-Based Materials and Their Functionality
158(2)
3 Physicochemical Aspects of Graphene and Graphene-Based Materials and Their Functionality
160(1)
4 Broad Classification and Its Functionality
161(3)
5 Biocompatibility of Graphene and Graphene-Based Materials in Biosystem
164(5)
6 Factors Affecting Dispersibility of Graphene and Graphene-Based Materials
169(2)
7 Interactions Between Graphene, Graphene-Based Materials, and Cell/Cell Membrane
171(5)
8 Modifications to be Brought in Graphene and Graphene Based Materials to Enable Them to be Used as Drug Carriers
176(5)
9 Conclusions
181(10)
Acknowledgments
182(1)
References
182(9)
Chapter 8 Combination Strategies for Targeted Delivery of Nanoparticles for Cancer Therapy
191(30)
Zhonglei He
Kangze Liu
Hugh J. Byrne
Patrick J. Cullen
Furong Tian
James F. Curtin
1 Introduction
191(1)
2 Drug Delivery and Therapeutic Nanovectors
192(9)
2.1 Liposomes
193(3)
2.2 Nanogels and Polymeric Nanoparticles
196(1)
2.3 Metal-Based Nanovectors
197(2)
2.4 Silicon and Silica Nanoparticles
199(1)
2.5 Dendrimers
200(1)
3 Nanosensitizers
201(4)
3.1 Photosensitizers
201(2)
3.2 Sonosensitizers
203(1)
3.3 Radiosensitizers
204(1)
4 Conclusion
205(16)
References
206(15)
Chapter 9 Nanotechnology Toward Treating Cancer: A Comprehensive Review
221(36)
Gopalakrishna Pillai
1 Introduction
221(1)
2 Nanocarriers for Drug Delivery
222(2)
3 Does the Size Matter?
224(1)
4 Passive and Active Targeting Strategies
225(1)
4.1 Passive Targeting
225(1)
4.2 Aiming at a Target: Active Drug Targeting
225(1)
5 Multiple Drug Resistance
226(1)
6 Examples of Nanomedicines for Cancer Approved by FDA and Those Undergoing Clinical Trials
227(7)
6.1 Doxil (Liposomal Doxorubicin)
227(4)
6.2 ThermoDox
231(1)
6.3 DaunoXome (Liposomal Daunorubicin)
232(2)
7 Liposomal Daunorubicin and Cytarabine Combination (VYXEOS)
234(1)
8 Abraxane (Albumin-Bound Paclitaxel, Paclitaxel Protein Bound)
234(3)
9 EndoTAG-1
237(1)
9.1 Lipoplatin (Liposomal Cisplatin)
237(1)
10 Liposomal Vincristine (Marqibo, OncoTCS)
238(1)
11 Vinorelbine
239(2)
11.1 Liposomal Cytarabine (DepoCyt)
240(1)
12 Liposomal Annamycin
241(4)
12.1 Oncaspar (Asparaginase)
242(1)
12.2 Camptothecines
243(2)
13 Gold Nanoparticles
245(1)
14 SiRNA Delivery
246(1)
15 Mepact (Liposomal Mifamurtide)
247(1)
16 Ceramide Delivery via Nanoliposomes
248(1)
17 Conclusion
248(9)
References
249(7)
Further Reading
256(1)
Chapter 10 Nanoparticles as Delivery Systems in Cancer Therapy: Focus on Gold Nanoparticles and Drugs
257(40)
Andreia Carvalho
Alexandra R. Fernandes
Pedro V. Baptista
1 Introduction
257(1)
2 Types of Nanoparticles
258(9)
2.1 Polymer-Based Nanoparticles
258(4)
2.2 Dendrimers
262(1)
2.3 Lipid-Based Nanoparticles
262(2)
2.4 Protein Nanoparticles
264(1)
2.5 Inorganic Nanoparticles
264(3)
3 AuNPs in Biology and Medicine
267(12)
3.1 Biocompatibility and Biodistribution
267(1)
3.2 Applications of AuNPs (Single Systems)
268(6)
3.3 Applications of AuNPs (Combined Systems)
274(5)
4 How Far From Clinical Translation?
279(1)
5 Conclusions
280(17)
Acknowledgments
281(1)
References
281(14)
Further Reading
295(2)
Chapter 11 Trends in Nanotechnology for Practical Applications
297(30)
Mohammad Rashid
Qazilaid Ahmad
Tajuddin
1 Introduction
297(1)
2 Nanoparticulate Drug Delivery System
298(1)
3 Advantages of Nanoparticulate Drug-Delivery Systems
299(1)
4 Manufacturing Techniques for Nanoparticulate Drug-Delivery Systems
300(1)
4.1 Interfacial Polymerization of Alkylcyanoacrylate Monomers
300(1)
4.2 Interfacial Deposition of Performed Polymers
301(1)
5 Nanoparticulate Drug Delivery System Applications
301(8)
5.1 Nanoparticulate System for Cancer
301(1)
5.2 Ocular Applications of Nanoparticulate Drug Delivery System
302(1)
5.3 Nanoparticulate System for Central Nervous System
303(1)
5.4 Nanomaterials as Gene Therapy
304(4)
5.5 Nanomaterials for Treatment of Vascular Thrombosis
308(1)
6 Nanomaterials as Targeted Delivery
309(8)
6.1 Skin
309(2)
6.2 Nanomaterials as Proteins and Peptides
311(3)
6.3 Pulmonary System
314(1)
6.4 Nanomaterials as Enzymes for Drug Delivery
315(1)
6.5 Nanomaterials as Mucoadhesives
316(1)
7 Risks of Nanoparticles
317(1)
8 Conclusion
318(9)
References
318(9)
Chapter 12 Antiviral and Antimicrobial (Antibacterial) Potentiality of Nano Drugs
327(16)
Marcia E. de Souza
Camila M. Verdi
Eduardo N.C. de Andrade
Roberto C. V. Santos
1 Nanoparticles as Promising Research
328(1)
2 Metallic Nanoparticles
329(3)
2.1 Silver Nanoparticles
329(2)
2.2 Gold Nanoparticles
331(1)
3 Organic Nanoparticles
332(3)
3.1 Polymeric Nanoparticles
332(1)
3.2 Solid Lipid Nanoparticles
333(1)
3.3 Liposomes
334(1)
3.4 Nanoemulsions
335(1)
4 Micelles
335(1)
5 Dendrimers
336(1)
6 Other Nanocarriers
337(1)
7 Conclusion
337(6)
References
337(6)
Chapter 13 Antiviral and Antimicrobial Potentiality of Nano Drugs
343(14)
Kushagri Singh
Abha Mishra
Deepankar Sharma
Kavita Singh
1 Introduction
343(1)
2 Antimicrobial Activity of Carbon-Based Nanoparticles
344(1)
2.1 Carbon Nanotube Nanoparticles
344(1)
2.2 Fullerene Nanoparticles
344(1)
2.3 Graphene Oxide Nanoparticles
345(1)
3 Antimicrobial Activity of Metallic Nanoparticles
345(3)
3.1 Silver Nanoparticles
346(1)
3.2 Zinc Oxide Nanoparticles
346(1)
3.3 Aluminium Oxide Nanoparticles
347(1)
4 Polymeric Chitosan Nanoparticles
348(1)
5 Antiviral Property of Some Metallic Nanoparticles
349(1)
6 Conclusion
350(7)
References
350(6)
Further Reading
356(1)
Chapter 14 Nanotechnology in Targeted Drug Delivery and Therapeutics
357(54)
Diana Sousa
Debora Ferreira
Joana L. Rodrigues
Ligia R. Rodrigues
1 Introduction
357(1)
2 Nanocarriers
358(11)
2.1 Liposomes
358(4)
2.2 Polymeric Nanocarriers
362(1)
2.3 Micelles
362(1)
2.4 Dendrimers
363(1)
2.5 Hydrogels
363(1)
2.6 Metallic Nanocarriers
364(1)
2.7 Quantum Dots
365(1)
2.8 Ceramic-Based Nanocarriers
366(1)
2.9 Carbon-Based Nanocarriers
366(1)
2.10 Exosomes
367(1)
2.11 Virus-Based Nanocarriers
368(1)
3 Targeting
369(16)
3.1 Passive Targeting
370(2)
3.2 Active Targeting
372(8)
3.3 Moieties Conjugation Strategies
380(5)
4 Future Perspectives
385(26)
List of Abbreviations
385(2)
Acknowledgments
387(1)
References
387(24)
Chapter 15 Engineering Nanomaterials for Smart Drug Release: Recent Advances and Challenges
411(40)
Akhilesh K. Singh
Thakur P. Yadav
Brijesh Pandey
Vinay Gupta
Satarudra P. Singh
1 Introduction
411(4)
2 Engineering Nano Drug Systems
415(1)
3 Engineered Nanomaterials for Smart Drug Delivery
415(3)
4 Reports on Nanomaterials for Smart Drug Delivery
418(15)
4.1 Polymeric Materials
418(1)
4.2 Polyketals
419(1)
4.3 Nanogels
420(1)
4.4 Dendrimers and Hyperbranched Polymers
420(2)
4.5 Chitosan and Lecithin
422(1)
4.6 Liposomes and Niosomes
423(2)
4.7 Micelles
425(1)
4.8 Solid Lipid Nanoparticles
426(1)
4.9 Nanostructured Lipid Carriers
426(1)
4.10 Nanoemulsions
426(1)
4.11 Lipid Nanocapsules
427(1)
4.12 Protein Albumin Nanoparticles
428(1)
4.13 Gold Nanoparticles
428(1)
4.14 Magnetic Nanoparticles
429(1)
4.15 Ceramic Nanoparticles
429(1)
4.16 Nanoshells
429(1)
4.17 Aptamer-Nanoparticle Conjugates
430(1)
4.18 Nanosuspensions and Nanocrystals
431(1)
4.19 Carbon Nanostructures
432(1)
5 Toxicity of Engineered Nanoparticles
433(1)
6 In Authors Laboratory: A Case Study of Nano Drug Formulation of Amphotericin B Against Leishmaniasis
433(4)
6.1 Synthesis and Characterization of Nano-Amphotericin B
434(1)
6.2 Anti-Ieishmanial Activity of Conventional- and Nano-AB
435(2)
7 Conclusions and Future Prospects
437(14)
References
438(13)
Chapter 16 Nano Drugs for Curing Malaria: The Plausibility
451(18)
Murugesan Gnanadesigan
Veeraiyan Nanadagopalan
Gnanajothi Kapildev
Mallikarjun Gundappa
1 Introduction
451(1)
2 Life Cycle of the Malaria Parasite
452(1)
3 Conventional Malaria Chemotherapy
452(3)
4 Drug Targeting and Delivery
455(1)
4.1 Nano Drug Targeting in Malaria Treatment
455(1)
5 Liposomes
456(5)
5.1 Nanoemulsion
457(1)
5.2 Solid Lipid Nanoparticles
458(1)
5.3 Polymeric Nanoparticles
459(1)
5.4 Nanosuspension
459(1)
5.5 Metallic Nanoparticles
460(1)
5.6 Dendrimers
460(1)
5.7 Self-Assembling Protein Nanoparticles
461(1)
6 Conclusions
461(8)
Acknowledgment
461(1)
References
462(7)
Chapter 17 Nanoparticles Mediated Gene Knockout Through miRNA Replacement: Recent Progress and Challenges
469(30)
Brijesh Pandey
Akhilesh K. Singh
Satarudra P. Singh
1 Introduction
469(2)
2 Central Dogma of Molecular Biology and Regulation of Gene Expression
471(4)
2.1 Gene Knockout Strategies
472(1)
2.2 miRNA as a Tool for Regulation of Gene Expression
473(1)
2.3 miRNA Replacement Therapy
474(1)
3 Types of Nanoparticles Used in miRNA Replacement Therapy
475(12)
3.1 Polymer-Based Nanocarriers
475(4)
3.2 Lipid-Based Nanocarriers
479(3)
3.3 Metal/Meta-oxide Nanocarriers
482(3)
3.4 Other Nucleic Acid/Protein Based Nanocarriers
485(2)
4 Immunological Response Against Nanocarriers and miRNA
487(1)
5 Challenges of Nanocarriers-Based Delivery of miRNA
488(1)
6 Conclusions and Future Prospects
489(10)
References
489(8)
Further Reading
497(2)
Chapter 18 Transdermal and Intravenous Nano Drug Delivery Systems: Present and Future
499(52)
Monica Sharma
1 Introduction
499(1)
2 Rationale of TDDS
500(1)
2.1 Why and When Is TDDS Important?
500(1)
3 Route of Drug Absorption: Skin
500(5)
3.1 Factors Influencing Nano Drug Transdermal Delivery
503(2)
4 Skin Permeation Enhancement
505(12)
4.1 Physical Penetration Enhancement
505(1)
4.2 Structure-Based Permeation Enhancement
506(2)
4.3 Electrical-Based Permeation Enhancement
508(9)
4.4 Velocity-Based Permeation Enhancement
517(1)
5 IrUravenous Route of Drug Administration
517(2)
5.1 Nanoparticles Toxicity: Intravenous Route of Drug Administration
518(1)
6 Nanocarriers for Transdermal and Intravenous Application
519(14)
6.1 Metallic Nanoparticles
520(2)
6.2 Vesicular Systems
522(5)
6.3 Lipid Nanoparticles
527(3)
6.4 Polymeric Nanoparticles
530(1)
6.5 Microemulsions
531(1)
6.6 Dendrimers
531(2)
7 Conclusions
533(18)
References
535(15)
Further Reading
550(1)
Chapter 19 Nanobased Intravenous and Transdermal Drug Delivery Systems
551(44)
Rathna VN Gundloori
Amarnath Singam
Naresh Killi
1 Introduction
551(2)
2 Different Kinds of Constituents of Nano Drug Delivery Systems
553(2)
2.1 Inorganic Constituents
553(1)
2.2 Organic Constituents
554(1)
2.3 Hybrid Constituents
554(1)
3 Intravenous Nano DDS
555(1)
4 Nanoforms in DDS
555(9)
4.1 Nanoparticles
555(2)
4.2 Nanogels
557(1)
4.3 Nanofibers
558(1)
4.4 Micelles
559(2)
4.5 Liposomes
561(2)
4.6 Dendrimers
563(1)
5 Nano Transdermal Drug Delivery Systems
564(10)
5.1 Nanoparticles
565(1)
5.2 Nanogels
566(2)
5.3 Nanofibers
568(3)
5.4 Dendrimers
571(1)
5.5 Liposomes
572(1)
5.6 Micelles
573(1)
6 Methods of Preparation of Nano DDS
574(9)
6.1 Nanoparticles
574(8)
6.2 Dendrimers
582(1)
6.3 Nanofibers
582(1)
6.4 Nanogels
583(1)
7 Characterizations
583(1)
8 Conclusions
584(11)
Acknowledgments
585(1)
References
585(10)
Chapter 20 Electrospun Nanofibers for Drug Delivery in Regenerative Medicine
595(32)
Sakthivel Nagarajan
Mikhael Bechelany
Narayana S. Kalkura
Philippe Miele
Celine P. Bohatier
Sebastien Balme
1 Introduction
595(2)
2 Methods for Loading Drugs/Biomolecules Through Electrospinning
597(2)
3 Mechanism of Delivery
599(1)
4 Polymer Properties
600(1)
5 Stimuli-Responsive Polymers in Drug Delivery
601(1)
6 Drug Release Using Electrospun Fibers
602(8)
6.1 Delivery of Antibiotics
603(3)
6.2 Delivery of Antiinflammatory Drugs
606(1)
6.3 Delivery of Antiretroviral Drugs
606(1)
6.4 Delivery of Anticancer Drags
607(2)
6.5 Delivery of Other Drugs
609(1)
7 Biomolecules and Drug Delivery for Regenerative Tissue Engineering
610(7)
7.1 Wound Tissue Engineering
610(1)
7.2 Bone Regenerative Tissue Engineering
611(2)
7.3 Neural Regenerative Tissue Engineering
613(2)
7.4 Heart and Vascular Tissue Engineering
615(1)
7.5 Other Tissue Engineering Applications of Drug/Biomolecule-Loaded ESM
616(1)
8 Conclusion and Future Perspective
617(10)
Acknowledgments
617(1)
References
618(9)
Index 627
Shyam Mohapatra is Distinguished USF Health Professor, Director of the Division of Translational Medicine at the University of South Florida. He also directs the USF Center for Research and Education in Nanobioengineering and is a Research Career Scientist at the James A. Haley VA Hospital in Tampa. He also serves as Associate Dean of Graduate Programs at the USF College of Pharmacy, and established a highly innovative Master of Science program in Pharmaceutical Nanotechnology. He has published over 170 papers and holds over 30 U.S. and international patents. He is a Fellow of the AAAAI, NAI, and AIMBE, and a 2014 inductee of the Florida Inventors Hall of Fame. Dr. Shivendu Ranjan has extensive expertise in Micro/Nanotechnology and is currently working as Head R&D and Technology Development at E-Spin Nanotech Pvt. Ltd. He has founded and drafted the concept for the first edition of the VIT Bio Summit” in 2012, and the same has been continued till date by the university. He has worked in CSIR-CFTRI, Mysuru, India as well as UP Drugs and Pharmaceutical Co. Ltd., India and IIFPT, Thanjavur, MoFPI, Govt of India. At IIFPT, Thanjavur, he was involved in a project funded by a leading pharmaceutical company, Dr. Reddys Laboratories and have successfully engineered micro-vehicles for model drug molecules. His research interests are multidisciplinary and include: Micro/Nanobiotechnology, Nano-toxicology, Environmental Nanotechnology, Nanomedicine, and Nanoemulsions. . He is the associate editor of Environmental Chemistry Letters a Springer journal of 3.59 impact factor and an editorial board member in Biotechnology and Biotechnological Equipment(Taylor and Francis). He is serving as executive editor of a journal in iMed Press, USA, and also serving as editorial board member and referee for reputed international peer-reviewed journals. He is the author of many books and edited six books. Dr. Nandita Dasgupta has vast working experience in Micro/Nanoscience and is currently working at LV Prasad Eye Institute, Bhubaneswar, India. She has exposure of working at university, research institutes and industries including VIT University, Vellore, Tamil Nadu, India; CSIR-Central Food Technological Research Institute, Mysore, India; and Uttar Pradesh Drugs and Pharmaceutical Co. Ltd., Lucknow, India and Indian Institute of Food Processing Technology (IIFPT), Thanjavur, Ministry of Food Processing Industries, Government of India. At IIFPT, Thanjavur, she was involved in a project funded by a leading pharmaceutical company, Dr. Reddys Laboratories and have successfully engineered micro-vehicles for model drug molecules. Her areas of interest include Micro/Nanomaterial fabrication and its applications in various fields medicine, food, environment, agriculture biomedical. She is the author os many books and edited more than 6 books. She has authored many chapters and also published many scientific articles in international peer-reviewed journals. She has received the Certificate for Outstanding Contribution” in Reviewing from Elsevier, Netherlands. She has also been nominated for advisory panel for Elsevier Inc., Netherlands. She is the associate editor of Environmental Chemistry Letters a Springer journal of 3.59 impact factor and also serving as editorial board member and referee for reputed international peer-reviewed journals. She has received several awards and recognitions from different national and international organizations. Dr. Sabu Thomas (Ph.D.) is the Director of the School of Energy Materials, School of Nanoscience and Nanotechnology of Mahatma Gandhi University, India. He received his Ph. D. in 1987 in Polymer Engineering from the Indian Institute of Technology (IIT), Kharagpur, India. He is a fellow of the Royal Society of Chemistry, London, and a member of the American Chemical Society. He has been ranked no.1 in India about the number of publications (most productive scientists). Prof. Thomass research group specialized areas of polymers which includes Polymer blends, Fiber filled polymer composites, Particulate-filled polymer composites and their morphological characterization, Ageing and degradation, Pervaporation phenomena, sorption and diffusion, Interpenetrating polymer systems, Recyclability and reuse of waste plastics and rubbers, Elastomer cross-linking, Dual porous nanocomposite scaffolds for tissue engineering, etc. Prof. Thomass research group has extensive exchange programs with different industries, research, and academic institutions all over the world and is performing world-class collaborative research in various fields. Professors Centre is equipped with various sophisticated instruments and has established state-of-the-art experimental facilities which cater to the needs of researchers within the country and abroad. His H Index- 133, Google Citations- 86424, Number of Publications- 1300, and Books-160.

Raghvendra Kumar Mishra is a Materials Scientist in the Chemical Engineering Department at IIT Delhi, India, and he has previously held research positions at Cranfield University (United Kingdom), Madrid Institute of Advanced Studies (Spain), and Mahatma Gandhi University (India). His research interests focus on nanomaterials and polymer composites, including new applications of nanomaterials, developing nanomaterials-based systems for diverse functionalities, creating biopolymer-based composites, and utilizing advanced fabrication techniques such as electrospinning and 3D printing.