The field of asthma has expanded in the last decade with specific drugs targeting the disease mechanisms. This book is an updated treatise covering diagnoses, phenotypes and endotypes of asthma along with its management. It includes diagnostic work-up which is required prior to medical assistance and basic immunology assessment, illustrating the types, severity, number of exacerbations due to disease activity, allergy or infections. As the treatment selection has changed from one size fits all to precision-based medicine, it aims to refine asthma management with right medication usage, neither overuse nor underuse, and initiation of the new hospital administered biologic drugs.
Key Features Covers both respiratory physiology and airway inflammation Highlights the use of biologic drugs Discusses precision-based medicine Explores the comorbidities through clinical cases
Arvustused
'This book is a short yet comprehensive guide describing various types of asthma and how the treatment of this condition has changed over the years. The subjects are presented in an organized fashion and are easy to follow. This book is a valuable resource for those who are interested in reviewing a short topic on asthma treatment.'
- Massoud Mahmoudi, DO, PhD, University of California San Francisco, Doody Enterprises
| Preface |
|
vii | |
| Acknowledgements |
|
ix | |
| Authors |
|
xi | |
| Abbreviations |
|
xiii | |
|
|
|
1 | (4) |
|
1.1 Asthma: A historical perspective |
|
|
1 | (1) |
|
1.2 A new era: Asthma phenotypes, endotypes, treatable traits and personalised management |
|
|
2 | (3) |
|
2 Pulmonary -- Treatable traits |
|
|
5 | (24) |
|
|
|
5 | (4) |
|
2.2 What clinical problems does it cause? |
|
|
9 | (1) |
|
2.3 How can it be detected? |
|
|
10 | (1) |
|
|
|
11 | (3) |
|
2.5 What is the result of treatment? |
|
|
14 | (1) |
|
2.6 Type-2 airway inflammation |
|
|
14 | (5) |
|
|
|
19 | (4) |
|
2.8 What is the result of treatment? |
|
|
23 | (1) |
|
2.9 Disordered airway mucosal immunity |
|
|
23 | (1) |
|
2.10 Altered cough reflex sensitivity |
|
|
24 | (1) |
|
2.11 Structural changes to the airway |
|
|
25 | (1) |
|
2.12 Common patterns of asthma |
|
|
25 | (4) |
|
3 Extrapulmonary -- Treatable traits |
|
|
29 | (18) |
|
|
|
29 | (6) |
|
3.2 UA -- Vocal cord dysfunction (VCD) and exercise-induced laryngeal obstruction mechanism |
|
|
35 | (2) |
|
3.3 Upper airway mechanisms in obstructive sleep apnoea |
|
|
37 | (3) |
|
|
|
40 | (3) |
|
3.5 Overlap between COPD and asthma |
|
|
43 | (1) |
|
3.6 Gastro-oesophageal reflux disease |
|
|
44 | (1) |
|
3.7 Depression and anxiety with asthma |
|
|
45 | (2) |
|
4 Risk factors -- Treatable traits |
|
|
47 | (22) |
|
4.1 Tobacco exposure and the asthmas |
|
|
47 | (6) |
|
4.2 The allergic history -- And allergic asthma |
|
|
53 | (4) |
|
4.3 Air pollution and the asthmas |
|
|
57 | (3) |
|
|
|
60 | (3) |
|
|
|
63 | (1) |
|
|
|
64 | (5) |
|
5 Diagnostic tests in respiratory medicine |
|
|
69 | (18) |
|
5.1 Diagnoses of respiratory allergies |
|
|
69 | (1) |
|
5.2 Fraction of exhaled nitric oxide |
|
|
70 | (3) |
|
5.3 Inflammatory cell counts: Eosinophilic and neutrophilic cells |
|
|
73 | (2) |
|
5.4 Blood, sputum or bronchial alveolar lavage fluid cytokines |
|
|
75 | (1) |
|
|
|
76 | (1) |
|
5.6 Airway hyperresponsiveness |
|
|
77 | (5) |
|
|
|
82 | (1) |
|
5.8 Cough reflex sensitivity |
|
|
83 | (4) |
|
6 Key cases -- Treatable traits |
|
|
87 | (8) |
|
|
|
87 | (2) |
|
|
|
89 | (2) |
|
|
|
91 | (4) |
|
7 Evaluation of the asthmas |
|
|
95 | (14) |
|
7.1 A pragmatic, assumption-free approach to asthma diagnosis and management |
|
|
95 | (3) |
|
7.2 Severity of respiratory symptoms |
|
|
98 | (11) |
|
8 Organising an asthma clinic |
|
|
109 | (4) |
|
|
|
109 | (1) |
|
8.2 Principles of treatable traits in organisation of care |
|
|
109 | (1) |
|
|
|
109 | (3) |
|
8.4 Other factors in organisation of care |
|
|
112 | (1) |
|
9 The future of the asthmas |
|
|
113 | (4) |
|
|
|
113 | (1) |
|
9.2 Future research needs |
|
|
113 | (1) |
|
9.3 Excellent asthma papers supporting treatable traits |
|
|
114 | (3) |
|
|
|
117 | (2) |
| Index |
|
119 | |
Vibeke Backer, MD DMSci, is Professor at the Copenhagen University, and pulmonologist responsible for Global Airways (CRSwNP, Asthma and Allergy) at the Department of ENT, as well a Senior Researcher at the Centre of Physical Activity Research (CFAS), Rigshopitalet, Copenhagen, Denmark. She has published 400 articles and has an H-index of 50.
Peter G. Gibson, MBBS, DMed, FRACP, FAAHMS F Thor Soc, FERS, FAPSR, is Professor at John Hunter Newcastle, the Sydney University, NSW, Australia. He works as a doctor who cares for people with respiratory diseases and as a clinical scientist investigating the mechanisms and treatment of asthma, COPD, cough, and other airway disorders. He has published more than 700 articles, and has an H-index of 96.
Ian D. Pavord, MA, DM, FRCP, FERS FMedSci, is Professor of Respiratory Medicine at the University of Oxford and Honorary Consultant Physician at the Oxford University Hospitals. He is a member of congregation at the University of Oxford and a Professorial Fellow of St Edmund Hall.
