Atherosclerosis XIII: Proceedings of the 13th International Symposium, Kyoto, Japan 28 September-2 October 2004 [Kõva köide]

Preface. Young Investigator Award. International Atherosclerosis
Society. XIIIth International Symposium on Atherosclerosis. International
Advisory Board. Young Investigator Award Committee. Acknowledgements.
Plenary lectures. The origin of the statins (A. Endo). New frontiers in
atherosclerosis prevention and treatment: HDL as a novel therapeutic target
(C.R. Sirtori). Therapeutic angiogenesis (S. Yla-Herttuala). Genetics,
obesity, and the metabolic syndrome: The Professor Donald S. Fredrickson
Memorial Lecture (S.M. Grundy). PPAR- #945; and atherosclerosis from basic
research to clinical applications (J.-C. Fruchart, P. Duriez). Risk
assessment of myocardial infarction and stroke (G. Assmann, P. Cullen, H.
Schulte). Understanding atherothrombosis: from vulnerable plaque to
vulnerable patient (P.R. Moreno, R. Corti, V. Fuster). Symposium. Nuclear
receptors as a target for treatment. PPAR #947; fundamental role in
adipogenesis (T.-A. Cock, J. Auwerx). Peroxisome proliferator-activated
receptor gamma - insights from human genetics (V.K.K. Chatterjee). Fatty
acids, cholesterol, and sphingolipids: interactive regulators and targets for
SREBP processing (R.A. Juliano, R.J. Deckelbaum, T.S. Worgall). Immunity and
inflammation in atherosclerosis. Detrimental and protective roles of
adaptive immunity in atherosclerosis (G.K. Hansson, G.P. Berne, X. Zhou). The
long pentraxin PTX3: from innate immunity to ischemic heart disorders (B.
Bottazzi et al.). Plaque instability and acute coronary syndrome. Vascular
biology of collagenases in vulnerable atherosclerotic plaques (M. Aikawa).
Oxidative stress and inflammation in plaque instability - role of vascular
C-reactive protein (N. Inoue, S. Kobayashi, M. Yokoyama). Plaque instability
in human coronary atherosclerotic lesions: roles of oxidized LDL and
neutrophils (M. Ueda et al.). Development of vascular systems; from capillary
to the heart. Plasmin activates VEGF-C and VEGF-D (B.K. McColl et al.).
Oxidized lipoprotein and atherosclerosis. Oxidized lipoprotein regulation of
tissue factor in smooth muscle cells (S.-L. Liang et al.). Measurement of
oxidized LDL present in human plasma and atherosclerotic lesions (H. Itabeet
al.). Paraoxonase 1: biochemistry and contribution to atherosclerosis (B.
Mackness, M. Mackness). Image analysis of atherosclerotic lesions and
therapeutic application. High-resolution magnetic resonance imaging of
carotid atherosclerosis (T.S. Hatsukami et al.). Angioscopic assessment of
vulnerable plaque and therapeutic application-lessons from acute coronary
syndrome (A. Hirayama, Y. Yeda, K. Kodama). Proliferation and differentiation
of smooth muscle cells. Signal transduction regulating the vascular smooth
muscle phenotype and early molecular events of atherogenesis (K. Sobue, K.
Shibata, K. Hayashi). KLF5/BTEB2, a Kruppel-like zinc-finger type
transcription factor, mediates smooth muscle cell activation as well as
cardiovascular remodeling (R. Nagai et al.). Rho and smooth muscle cell
phenotype (N.F. Worth et al.). Vascular tissue engineering and clinical
applications. Induction of endothelialization of tissue-engineered
cardiovascular constructs via in vivo angiogenesis during post-implant
remodeling (H.P. Greisler). Body cavities as bioreactors to grow arteries
(J.H. Campbell et al.). Critical issues in vascular tissue engineering (R.M.
Nerem). Recent optimization of a tissue engineered blood vessel: the LOEX
experience (F.A. Auger et al.). Molecular basis of endothelial activation.
Atheroprotective mechanisms of flow: inhibition of apoptosis (X. Pi, C. Yan,
B.C. Berk). A molecular mechanism for mechanical activation of endothelial
cells (K. Fujiwara et al.). Role of TRP channels in endothelial
pathophysiology-evidence for vascular TRPs as a potential target for drug
therapy (A. Graziani et al.). Featured symposium. Diabetic angiopathy.
PPAR- #947; signalling and vascular cells in 2003 (D. Bruemmer et al.).
Exogenous and endogenous mechanisms of PPAR activation: implications for
inflammation and atherosclerosis (O. Ziouzenkova, J. Plutzky). The role of
protein kinase C activation in cardiovascular dysfunctions of diabetes and
insulin resistance (Y. Yasuda, G.L. King). Cellular crosstalk under
hyperglycemic stress-the diabetic retina as a paradigm (J. Lin et al.).
Molecular mechanisms of retinal neovascularization in diabetic retinopathy
(H. Takagi et al.). Nurture vs. nature in diabetic vasculopathy: roles of
advanced glycation endproducts and the receptor for them (Y. Yamamoto et
al.). Life style and vascular disease - the West and the East meet together.
Geoethnic-sensitive and cross-culture differences of dietary patterns and
blood pressure among five ethnic populations in China (L. Liu et al.).
Homocysteine and folate: from genes to greens (L. Tokgozoglu). Diet, physical
activity, childhood obesity and risk of cardiovascular disease (Y. Wang). The
impact of westernization on the risk of atherosclerotic vascular disease
among Japanese-American men in Hawaii (K. Yano et al.). How can we propose
global guidelines for prevention of atherosclerosis? Global guidelines:
national issues (P. Barter). Japan Atherosclerosis Society (JAS) guidelines
for diagnosis and treatment of atherosclerotic cardiovascular diseases (H.
Mabuchi). Low HDL-C: lessons learned from the Turkish Heart Study (U.
Hodoglugil, D. Williamson, R.W. Mahley). Is hypertriglyceridemia an
independent risk factor for coronary heart disease? A debate over the
centuries.Nonfasting serum triglycerides and risk of ischemic heart disease
among Japanese men and women (H. Iso et al.). Hypercholesterolemia and
hypertriglyceridemia-greatest cardiac risk in subjects with high apoB/apoA-I
levels (G. Walldius, A. Aastveit, I. Jungner). Are plasma triglycerides a
good predictor of CHD risk? (P.J. Talmud et al.). Molecular basis of
metabolic syndrome. The role of atypical PKCs in insulin-resistant states
(R.V. Farese). PPAR #945; controlling HDL metabolism and atherosclerosis (R.
Paumelle et al.). Genetic and genomic studies of type 2 diabetes in mice
(A.D. Attie). Genetics of the metabolic syndrome and implications for therapy
(R.I. Hughes, T.J. Aitman). HDL and reverse cholesterol transport.
Unraveling the role of phospholipid transfer protein (PLTP) in lipoprotein
metabolism and atherogenesis (S. Siggins et al.). Effect of hormone
replacement therapy on the reverse cholesterol transport (C. Calvo). Bridging
the decades: A new era with preclinical and clinical trials has started.
Bridging the decades: new era is open for preclinical and clinical trials:
Introductory remarks - "looking back the past decades" (A. Yamamoto).
Ezetimibe: first in a new class of cholesterol absorption inhibitors (H.R.
Davis). Biological therapies for dyslipidemia (M.H. Davidson). State of the
art symposium. Atherosclerosis: A multifactorial disease. What happens
inside an atherosclerotic plaque? (P. Libby). Seeing is believing: imaging
techniques to measure atherosclerosis progression (S.E. Nissen). Past,
present, and future clinical trials of cardiovascular risk reduction-the
hypertension perspective (T. Fujita). Past, present, and future clinical
trials of cardiovascular risk reduction - the hyperlipidemia perspective
(N.R. Poulter). A targeted dual therapy approach to cardiovascular risk
reduction (R.P. Mason). The metabolic syndrome: A new reality above and
beyond conventional risk factors. Prevalence of low HDL-cholesterol and the
metabolic syndrome (S. Yamashita et al.). Workshop. Molecular basis of
blood vessel formation: From hypoxia to cell signaling. Positive and
negative regulation of endothelial cell function (L. Claesson-Welsh). VEGF
and its receptors (N. Ferrara). Oxygen regulates brain angiogenesis and tight
junction formation in blood-brain barrier (S.-W. Lee et al.). Regulation of
vascular remodeling and cardiovascular protection. Non-genomic activation of
protein kinase Akt by steroid hormones (J.K. Liao). Regulation of vascular
remodeling and cardiovascular protection: NFnB and vascular remodeling (B.R.
Binder, J.M. Breuss). Molecular basis of lipoprotein disorders.
Sitosterolemia; of mice and man (S.B. Patel et al.). Molecular defects in the
ABCA1 pathway affect HDL metabolism and function of macrophages (G. Schmitz).
Novel genetic markers for structural coronary artery disease, myocardial
infarction, and familial combined hyperlipidemia: candidate and genome scans
of functional SNPs (J.P. Kane et al.). Nutritional strategy for prevention of
atherosclerosis. Nutrition and inflammation: role of dietary cholesterol (A.
Chait et al.). Isoflavones: effects on cardiovascular risk and functions (P.
Nestel). Flavonoids-rich nutrients with potent antioxidant activity prevent
atherosclerosis development: the licorice example (M. Aviram). Recent
lifestyle trials in the prevention of type 2 diabetes (J. Tuomilehto, J.
Lindstrom). Therapeutic angiogenesis for vascular diseases. Therapeutic
angiogenesis: cellular approach from bone marrow, cord blood and peripheral
blood (T. Murohara). Cardiomyocyte regeneration following
angioblast-dependent neovascularization of ischemic myocardium (M.D. Schuster
et al.). Asian sessions: Cerebrovascular diseases and their treatment in
Asian countries. Changes in incidence and mortality of stroke and risk
factors in a Japanese general population: the Hisayama study (M. Fujishima,
Y. Kiyohara). Stroke in Korea (J.S. Kim). Stroke therapies in Asian
populations (G.A. Donnan, M. Koga, B.B. Pedreira). Interventional cardiology
forum. Administration of control-released basic fibroblast growth factor -
Is it a more effective angiogenic therapy than bone marrow cell
transplantation for severely ischemic hearts? (K. Tambara et al.). Will all
postinfarction patients receive defibrillators? Recent trials and expanding
indications (P.A. Friedman). First human randomized trial of G-CSF stem cell
mobilization to treat large acute myocardial infarction-preliminary results
of a pilot study (S.G. Ellis et al.). Obesity, insulin resistance and
atherosclerosis. Adiponectin as a potential key player in metabolic
syndrome: Insights into atherosclerosis, diabetes and cancer (T. Funahashi,
Y. Matsuzawa, S. Kihara). Obesity and other risk factors for cardiovascular
diseases among Africans: results from CARDIAC study in Tanzania (M. Njelekela
et al.). On behalf of the WHO cardiovascular diseases and alimentary
comparison (CARDIAC) study group. Thrombosis in vascular disease.
Homocysteine as a risk factor of cardiovascular disease (M. Merkel). Omega-3
fatty acids, thrombosis and vascular disease (W.S. Harris). Gene targeting
and animal models of atherosclerosis. Genetic manipulation of macrophage -
and vascular genes in mouse models of atherosclerosis (Th.J.C. van Berkel et
al.). ApoE4 trapping by the low density lipoprotein receptor (M.K. Altenburg
et al.). Intracellular lipid transport system and metabolism. Signal
transduction pathways in free cholesterol-loaded macrophages: cell biological
insight into the progression of atherosclerosis (I. Tabas). Caveolin and
cholesterol in lipid transport and signaling (C.J. Fielding). MTP/apoB
mediated lipoprotein assembly: an emerging pathway for lipid secretion and
transport (J.R. Wetterau). Extracellular matrix and proteases in vascular
medicine. The pro-inflammatory nature of the vascular extracellular matrix
(T.N. Wight et al.). Regulation of extracellular matrix production and
degradation of endothelial cells by shear stress (T. Yamane et al.). The
elastin-laminin receptor-mediated matrix degradation. Effect of glucose
concentration. Role in atherosclerosis (G. Faury et al.). The role of
extracellular matrix in restenosis after percutaneous coronary intervention
(I.-M. Chung). Novel anti-inflammatory properties of the Na+/H+ exchange
inhibitor ethylisopropylamiloride result in attenuation of atherogenesis in
apolipoprotein Edeficient mice (Y.-X. Chen, S. Whitman, E. O'Brien).
Infection and atherosclerosis: Where do we currently stand? Infections and
atherosclerosis - is serology useful? (P. Saikku). Infection and
atherosclerosis: mechanisms involving Chlamydia pneumoniae in cardiovascular
disease (G.I. Byrne, S.P. Ouellette, R.J. Belland). Interaction of host and
microbes in the atherosclerotic plaques (J. Rupp, M. Maass). Detection of
infective agents in atherosclerotic tissues (K. Ouchi). Asian sessions:
Trends in cardiovascular diseases in Asian countries. Trends of
cardiovascular diseases among Koreans (H.K. Lee). Prevalence of metabolic
syndrome among adult Filipinos (F.E.R. Punzalan, R.G. Sy, T. Ty-Willing).
Trends in cardiovascular diseases and risk factors in Malaysia (R.
Zambahari). Fibrinolysis and proteolysis in vascular disease. The von
Hippel-Lindau protein: a key player in oxygen homeostasis and matrix assembly
(M.A. Esteban, S.J. Mandriota, P.H. Maxwell). Recent topics in research on
hypertension and atherosclerosis. Mechanical stress-related atherosclerosis
and functional genomics (H. Rakugi et al.). Hypolipidemic drugs, blood
pressure, heart rate, heart rate variability and sympathetic activity (R.
Ceska et al.). Renin-angiotensin system and vasculature-focusing on insulin's
action (K. Kamide, M.L. Tuck). Risk factors of stroke: Recent evidence and
new aspects. Stroke risk factors: recent evidence and new aspects (M.
Cubrilo-Turek). Stroke-blood pressure and blood pressure-lowering (A.
Tonkin). Carotid artery disease and risk of ischaemic stroke and coronary
events (P.M. Rothwell). Remnant lipoprotein and lipoprotein (a) as risk
factors for stroke and carotid disease (S. Uchiyama, M. Yamazaki, M. Iwata).
Genetic risk factors for stroke: insights into pathophysiology from candidate
gene approaches (S.E. Humphries, L. Morgan). Proteases in atherosclerotic
plaque rupture. Matrix, matrix metalloproteinases and smooth muscle cell
function in atherosclerosis (M.P. Bendeck et al.). Role of oxidant stress in
vascular proteolysis (Z.S. Galis). The mast cell, a rich source of neutral
proteases in atherosclerotic plaques (P.T. Kovanen et al.). Role of
elastolytic cathepsins in vascular remodeling (G.K. Sukhova, G.-P. Shi, P.
Libby). Health economics and policy. Economic burden of
atherosclerosis-related diseases in Korea (C.-y. Kim). Diabetic dyslipidemia.
CETP, a key player in atherogenic dyslipidemia of Type II diabetes (J.M.
Chapman, M. Guerin). Triglycerides rich lipoproteins and atherosclerosis: in
vitro and in vivo studies (G.D. Norata et al.). Dyslipidaemia, inflammation
and endothelial dysfunction in diabetes mellitus (K. Tan). Postmenopausal
woman and HRT: To be or not to be? What are certified scientific findings in
HRT? Shall we proceed? (T. Hayashi). Hormone replacement therapy and
atherosclerosis-postmenopausal women and HRT: the fallen myth of the
cardiovascular protective effects of hormone replacement therapy (E.H.
Moriguchi, J.L.C. Vieira). Hormone replacement therapy and cardiovascular
disease (E. Windler, B. Eidenmuller, B.-Chr. Zyriax). Scavenger receptors.
Function and regulation of hepatic scavenger receptor class B type I (SR-BI)
(A. Rigotti). LOX-1, a lectin-like oxidized LDL receptor identified form
endothelial cells, in endothelial dysfunction (T. Sawamura). Asian sessions:
Metabolic syndrome in Asian countries. Metabolic syndrome and its relevance
to Asia (E.D. Janus). Dietary habits, obesity status and cardiovascular risk
factors in Koreans (J.H. Lee, Y. Jang, J.Y. Kim). Obesity as the key player
in the metabolic syndrome (K.S.L. Lam et al.). The metabolic syndrome: an
Asian perspective (C.-E. Tan, S.-K. Chew, E.-S. Tai). Lp(a) - Still a
mystery. Lipoprotein (a) and atherosclerosis: a study from transgenic
rabbits (J. Fan, T. Watanabe). The catabolism of lipoprotein(a) (G.M. Kostner
et al.). The effect of methodological differences in the measurement of Lp(a)
on the interpretation of clinical data (S.M. Marcovina). Aging and blood
vessels. Molecular mechanisms of age-related regulation of genes (K. Kurachi
et al.). Vascular cell senescence in human atherosclerosis (T. Minamino, I.
Komuro). Role of inflammation in atherosclerotic calcification, metaplasia
and osteoporosis (L.L. Demer, Y. Tintut, M. Abedin). ABC transporters and
related disorders. Modulation of the ABCA1 transporter activity by protein
kinase CK2 (S. Roosbeek et al.). Cloning, tissue distribution and function of
ABCA transporters (N. Inagaki et al.). Geographic epidemiology of
atherosclerotic diseases in different populations. Trends in morbidity,
mortality, and risk factor levels of coronary heart disease in Japan - Are
Japanese living in Japan still protected against coronary heart disease? (K.
Kodama, F. Kasagi). Coronary heart disease in Japanese and Japanese
Americans: does it provide clues for prevention? (J.D. Curb et al.). The
pandemic of atherosclerosis in the Mediterranean area (O.A. Aziz). Meet the
Professor session. What is the most important in treating hypertension?
(K. Arakawa). Possible molecular mechanisms regulating endothelial repair in
unstable fibroinflammatory atheroma (J.S.Y. Lee, B. Dickson, A.I. Gotlieb).
Use of plasma markers as indices of sterol metabolism (G.R. Thompson). In
Memoriam. Donald S. Fredrickson (August 8, 1924-June 7, 2002). Yuichiro
Goto (October 6, 1922-May 28, 2003) (A.M. Gotto Jr.). Author index. Keyword
index.