This book aims to provide an up-to-date overview of the many signaling pathways regulating autophagy in response to different cellular needs. Discussion will include the current status and future directions of autophagy signaling research in different topics of health and disease. These include the roles of autophagy in regulating cell fate, immune response and host defense, nutrient sensing and metabolism, neural functions and homeostasis. The mechanisms and significance of cross-talk between autophagy and other cellular processes will also be explored. Lastly, alterations in autophagy observed in aging and age-related pathologies will also be described.
| Series Preface |
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vii | |
| Preface |
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ix | |
| Contributors |
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xi | |
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SECTION I Signaling Pathways Regulating Autophagy |
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Chapter 1 Regulation of Autophagy by AMPK |
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3 | (22) |
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Chapter 2 Signal Regulation of WIPI Protein Function in Macroautophagy |
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25 | (18) |
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SECTION II Autophagy and Cell Fate |
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Chapter 3 Cross Talk between Autophagy and Cell Death Pathways: Toward Understanding a System |
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43 | (24) |
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Chapter 4 Autophagy, Cellular Senescence, and Cancer |
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67 | (26) |
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SECTION III Autophagy in Immunity and Metabolism |
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Chapter 5 Autophagy and Regulation of Immune Response |
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93 | (26) |
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Chapter 6 Cilia-Related Autophagy in Nutrient Sensing |
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119 | (28) |
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Chapter 7 Regulation of Lipophagy |
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147 | (28) |
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SECTION IV Autophagy in Neural Homeostasis and Neurodegeneration |
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Chapter 8 Mitophagy and Neurodegeneration |
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175 | (18) |
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193 | (24) |
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Chapter 10 Chaperone-Mediated Autophagy and Neurodegeneration |
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217 | (24) |
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Chapter 11 Autophagy in Synaptic Structure and Function |
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241 | (22) |
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| Index |
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263 | |
Esther Wong graduated from the National University of Singapore with her PhD in 2004. She is an Assistant Professor with the School of Biological Sciences at Nanyang Technological University in Singapore. Her research focuses on autophagy, a cellular quality control pathway involved in protein degradation by lysosomes. The overall goal is to elucidate yet unknown mechanisms in the degradation of proteins by autophagy and how the related defects result in accumulation of damaged components, proteotoxicity and loss of cognitive functions associated with neurodegeneration and aging.
