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Basic Veterinary Immunology [Pehme köide]

3.33/5 (6 hinnangut Goodreads-ist)
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  • Formaat: Paperback / softback, 337 pages, kõrgus x laius x paksus: 254x178x23 mm, kaal: 874 g, 250 colour illus
  • Ilmumisaeg: 15-May-2014
  • Kirjastus: University Press of Colorado
  • ISBN-10: 1607322188
  • ISBN-13: 9781607322184
Teised raamatud teemal:
Basic Veterinary ImmunologySuurem pilt
  • Formaat: Paperback / softback, 337 pages, kõrgus x laius x paksus: 254x178x23 mm, kaal: 874 g, 250 colour illus
  • Ilmumisaeg: 15-May-2014
  • Kirjastus: University Press of Colorado
  • ISBN-10: 1607322188
  • ISBN-13: 9781607322184
Teised raamatud teemal:
Püsilink: https://www.kriso.ee/db/9781607322184.html
Märksõnad:
"Designed to fill the current gap in resources for teaching veterinary immunology, Basic Veterinary Immunology offers a solid background in the essentials of immunology within the context of veterinary medicine. The book combines a clinical framework complete with real-world examples to integrate the theory and practice of veterinary medicine. Each chapter begins with a clinically relevant veterinary issue and then presents one aspect of basic immunology in the context of that issue. All chapters includelearning objectives and a clinical correlation follow-up section that includes student considerations and a review of the possible explanations for the clinical presentation. Illustrated with 250 full-color images and figures that will also be available as PowerPoint teaching aids, Basic Veterinary Immunology and related materials will be made available online to students, faculty, and clinical veterinarians in partnership with the Veterinary Information Network. Basic Veterinary Immunology will provide students with a good working knowledge of veterinary immunology that will serve them both in the completion of their curricula and in professional practice"--Provided by publisher.

Designed to fill the current gap in resources for teaching veterinary immunology, Basic Veterinary Immunology offers a solid background in the essentials of immunology within the context of veterinary medicine.

The book combines a clinical framework complete with real-world examples to integrate the theory and practice of veterinary medicine. Each chapter begins with a clinically relevant veterinary issue and then presents one aspect of basic immunology in the context of that issue. All chapters include learning objectives and a clinical correlation follow-up section that includes student considerations and a review of the possible explanations for the clinical presentation.

Illustrated with 250 full-color images and figures that will also be available as PowerPoint teaching aids, Basic Veterinary Immunology and related materials will be made available online to students, faculty, and clinical veterinarians in partnership with the Veterinary Information Network.

Basic Veterinary Immunology will provide students with a good working knowledge of veterinary immunology that will serve them both in the completion of their curricula and in professional practice.

Arvustused

"A much needed, entry-level introduction to veterinary-specific immunology. Aimed at students, it fills a gap in the market and, in doing so, will be a welcome read for anyone requiring an understanding of immunology either for curriculum-based studies, or to build on basic existing knowledge. . . . this book is a welcome addition to any student library, but also as a go to book for the new graduate clinician with its easy to read format and extensive index." Melanie S. Lean, Veterinary Record "The superb illustrations in this book, as well as the clarity of the writing, mean that some of the more difficult concepts in immunology are presented in a way that will facilitate student learning. The clinical examples and review exercises will also assist with this. I highly recommend this book to those involved in teaching immunology to veterinary students" Dr. Joan Lloyd, Australian Veterinary Journal "...a welcome resource for veterinary and graduate students who are studying the fascinating and increasingly complex subject of immunology."  Margaret C. Barr, Vet Med Today

Chapter 1 Overview of Mechanisms of Defense
1(16)
Clinical Correlation: Simian Acquired Immune Deficiencies
1(1)
Learning Objectives
1(1)
Essential Involvement of Animal Immune Systems in All Aspects of Animal Health
1(1)
Immune System
2(14)
Cells of Defense
3(1)
Communication between Cells of the Immune System
3(1)
Communication through cytokines
3(1)
Other cytokines
4(1)
Communication through other signaling molecules
4(1)
Communication through cell--cell contact
4(1)
Innate and Adaptive Immune Systems
5(1)
Innate immune system
5(4)
Adaptive immune system
9(7)
Clinical Correlation Follow-Up
16(1)
Student Considerations
16(1)
Possible Explanations
16(1)
Chapter 2 Overview of the Innate Immune System
17(20)
Clinical Correlation: Cyclic Neutropenia in Gray Collies
17(1)
Learning Objectives
17(1)
Anatomical and Physiological Barriers to Microbial Invasion
18(3)
Epithelial Barrier
18(1)
Secretions
18(2)
Mucus and Mucociliary Clearance
20(1)
Commensal Organisms
21(1)
Cells of the Innate Immune System
21(4)
Hematopoiesis
21(2)
Coordinating Hematopoiesis
23(1)
Monitoring Hematopoesis
23(2)
Overview of the Cells of the Innate Immune System
25(8)
Myeloid Innate Immune Cells
25(1)
Neutrophils
25(1)
Eosinophils
26(1)
Basophils
27(1)
Monocytes
28(1)
Macrophages
29(1)
Myeloid dendritic cells
30(1)
Mast cells
31(1)
Lymphoid Innate Immune Cells
31(1)
Natural killer cells
31(2)
Other Innate Immune Cells
33(1)
Clinical Correlation: Follow-Up
33(4)
Student Considerations
33(1)
Possible Explanations
34(3)
Chapter 3 Innate Immune Recognition
37(16)
Clinical Correlation: Sepsis in Neonatal Foals
37(1)
Learning Objectives
38(1)
Introduction
38(2)
Evolutionarily Conserved Molecular Patterns
40(1)
Pathogen-Associated Molecular Patterns
40(1)
Pattern-Recognition Receptors
40(6)
Signaling Pattern-Recognition
Receptors
41(1)
Toll-like receptors
42(2)
NOD-like receptors and RIG-like receptors
44(1)
Phagocytic Pattern-Recognition Receptors
44(2)
Other Pattern-Recognition Receptors
46(1)
Innate Recognition of Damage-Associated Molecular Patterns
46(4)
Inflammasome
48(2)
Consequences of Danger Signal Recognition by Sentinel Cells
50(1)
Activation of Macrophages
50(1)
Proinflammatory Mediators
50(1)
Clinical Correlation: Follow-Up
50(3)
Student Considerations
50(1)
Possible Explanations
51(2)
Chapter 4 The Complement System
53(14)
Clinical Correlation: C3 Deficiency in Brittany Dogs
53(1)
Learning Objectives
53(1)
Complement Activation
54(6)
Classical Pathway
55(2)
Lectin Pathway
57(1)
Alternative Pathway
58(2)
Terminal Membrane Attack Pathway
60(1)
Regulation of Complement Activation
60(2)
Outcomes of Complement Activation
62(2)
Inflammation and Chemotaxis
62(1)
Enhancement of Phagocytosis (Opsonization)
63(1)
Promoting Humoral Immunity
63(1)
Clearance of Immune Complexes
64(1)
Clinical Correlation: Follow-Up
64(3)
Student Considerations
64(1)
Possible Explanations
64(3)
Chapter 5 Acute Inflammation
67(22)
Clinical Correlation: Acute Bovine Mastitis
67(1)
Learning Objectives
67(1)
Purposes of Acute Inflammation
68(1)
Signs of Acute Inflammation
69(1)
Initiators and Mediators of Acute Inflammation
70(2)
Vascular Changes in Acute Inflammation
72(3)
Leukocyte Recruitment
75(5)
Leukocyte Extravasation
75(4)
Diversity and Timeline of Leukocyte Recruitment
79(1)
Systemic Effects of Acute Inflammation
80(5)
Clinical Correlation Follow-Up
85(4)
Student Considerations
86(1)
Possible Explanations
86(3)
Chapter 6 Innate Cellular Effector Mechanisms
89(20)
Clinical Correlation: Rattles in Foals
89(1)
Learning Objectives
90(1)
Classification of Innate Cellular Effector Mechanisms
90(1)
Phagocytes and Phagocytosis
91(8)
Phagocytosis Part I Recognition and Adhesion of Particles on the Plasma Membrane of the Phagocyte
91(3)
Phagocytosis Part II Membrane and Cytoskeletal Reorganization to Mediate Particle Engulfment and the Creation of a Phagosome
94(1)
Phagocytosis Part III Maturation of the Phagosome into a Microbicidal and Degradative Phagolysosome
94(5)
Extracellular Innate Effector Mechanisms
99(2)
Degranulation by Neutrophils and Eosinophils
99(1)
Release of Neutrophil Extracellular Traps
100(1)
Natural Killer Cell---Mediated Cytotoxicity
101(4)
Recognition of Target Cells
101(1)
Activating stimulus
101(1)
Inhibitory stimulus
102(1)
Targeted Degranulation by Natural Killer Cells
102(3)
Antibody-Dependent Cell-Mediated Cytotoxicity
105(1)
Clinical Correlation: Follow-Up
105(4)
Student Considerations
105(1)
Possible Explanation
106(3)
Chapter 7 Cells and Organs of the Adaptive Immune System
109(12)
Clinical Correlation: Feline Lymphadenopathy
109(1)
Learning Objectives
109(1)
Organs and Cells of the Adaptive Immune System
109(10)
Primary Lymphoid Organs and Hematopoiesis
110(1)
Bone marrow
110(2)
Thymus
112(2)
Secondary Lymphoid Organs
114(1)
Lymph nodes
115(2)
Spleen
117(1)
Mucosa-associated lymphoid tissue
118(1)
Clinical Correlation: Follow-Up
119(2)
Student Considerations
120(1)
Possible Explanations
120(1)
Chapter 8 Antigens and Antigen Processing
121(22)
Clinical Correlation: Caprine Arthritis Encephalitis
121(1)
Learning Objectives
122(1)
Stimulators of Adaptive Immunity: Pathogens, Antigens, and Epitopes
122(2)
Major Histocompatibility Complex
124(8)
History of the Major Histocompatibility Complex
124(1)
Major Histocompatibility Complex Genetics
125(4)
Structure and Distribution of Major Histocompatibility Complex Class I and Class II Molecules
129(2)
Antigen---Major Histocompatibility Complex Interactions
131(1)
Antigen Acquisition, Processing, and Presentation
132(7)
Antigen-Presenting Cells
132(3)
Major Histocompatibility Complex Class I Antigen Processing and Presentation
135(1)
Major Histocompatibility Complex Class II Antigen Processing and Presentation
136(1)
Cross-Presentation
137(2)
Clinical Correlation: Follow-Up
139(4)
Student Considerations
140(1)
Possible Explanations
140(3)
Chapter 9 T-Lymphocyte Development
143(18)
Clinical Correlation: Severe Combined Immunodeficiency Disease in Arabian Foals
143(1)
Learning Objectives
143(1)
T-Cell Receptor Genes
144(6)
Structure of the T-Cell Receptor
144(1)
T-Cell Receptor Gene Families
145(1)
Gene Rearrangement in the Thymus
145(5)
T-Cell Selection in the Thymus
150(8)
Products of T-Cell Gene Rearrangement
150(3)
Positive Selection of Functional T Cells
153(2)
CD4, CD8, and Major Histocompatibility Complex Recognition
155(1)
Negative Selection of Self-Reactive T Cells
155(1)
T-Helper, Cytotoxic T, and T-Regulatory Cells
156(1)
γ/δ T Cells
156(2)
Clinical Correlation: Follow-Up
158(3)
Student Considerations
158(1)
Possible Explanations
158(3)
Chapter 10 T-Cell Activation
161(20)
Clinical Correlation: Canine X-Linked Severe Combined Immunodeficiency
161(1)
Learning Objectives
162(1)
Antigen Recognition by T Cells
162(7)
First Signal: T-Cell Receptors and Major Histocompatibility Complex-Antigen Interactions
162(2)
Second Signal and Major Histocompatibility Complex-CD4/8 Interactions
164(2)
Signal Transduction and T-Cell Activation
166(2)
Third Signal and T-Helper Cell Differentiation
168(1)
Effector T Cells
169(12)
Effector T-Helper Cells: Th1, Th2, Tfh, and Th17 Cells
169(2)
Effector Regulatory T Cells: Treg, Th3, and Tr1 Cells
171(2)
Effector Cytotoxic T Cells
173(4)
Clinical Correlation Follow-Up
177(1)
Student Considerations
177(1)
Possible Explanations
177(4)
Chapter 11 B-Cell Development
181(16)
Clinical Correlation: Equine Agammaglobulinemia
181(1)
Learning Objectives
181(1)
B Cells and the Structure of the B-Cell Receptor
182(1)
B-Cell Genetics, Development, and Circulation
183(8)
B-Cell Receptor Gene Families, Genetic Rearrangement, and Junctional Diversity
183(3)
Order and Regulation of B-Cell Development
186(3)
Immunoglobulin Isotypes
189(2)
Other Populations of B Cells
191(4)
B-1 B Cells
191(3)
Marginal-Zone B Cells
194(1)
Clinical Correlation Follow-Up
195(2)
Student Considerations
195(1)
Possible Explanations
195(2)
Chapter 12 B-Cell Activation and Differentiation
197(22)
Clinical Correlation: Selective Immunoglobulin A Deficiencies in Dogs
197(1)
Learning Objectives
197(2)
T-Dependent B (B-2) Cells
199(14)
Interaction of B Cells with Antigens
199(4)
B Cells as Antigen-Presenting Cells
203(1)
Activation of B Cells by T-Helper Cells
204(2)
Isotype Switching, Somatic Hypermutation, and Terminal Differentiation of B Cells into Plasma Cells
206(7)
Antibody Effector Functions
213(2)
Pathogen and Toxin Neutralization
213(1)
Opsonization and Activation of Complement
213(1)
Distribution and Function of Fc Receptors
214(1)
Clinical Correlation Follow-Up
215(4)
Student Considerations
215(2)
Possible Explanations
217(2)
Chapter 13 Adaptive Immune Responses to Infections and Immunological Memory
219(22)
Clinical Correlation: Canine Parvovirus and the Wolves of Isle Royale
219(1)
Learning Objectives
220(1)
Adaptive Immunity: The Big Picture---From Insult to Recovery
221(16)
Routes of Infection
223(1)
Mechanisms of Pathogenesis
223(2)
Innate Response Cells and Cytokines of Innate Responses Direct T-Cell Differentiation
225(1)
Effector T Cells Home to Sites of Infection and Inflammation
226(3)
Antibody Responses Develop in Secondary Lymphoid Tissues
229(4)
Importance of Different Adaptive Responses to Clearance of Different Pathogens
233(1)
Immune Responses in the Gut
233(4)
Immunological Memory
237(2)
Primary and Subsequent Immune Reponses
237(1)
Memory B Cells
238(1)
Memory T Cells
238(1)
Clinical Correlation Follow-Up
239(2)
Student Considerations
239(1)
Possible Explanations
239(2)
Chapter 14 Fetal and Neonatal Immunity
241(12)
Clinical Correlation: Failure of Passive Transfer
241(1)
Learning Objectives
241(1)
Fetal Development of the Immune System
241(2)
Maternal Transfer of Immunity
243(5)
Prenatal Transfer of Immunity
243(2)
Postnatal Transfer of Immunity
245(3)
Neonatal Acquisition of Memory and Immune Capacity
248(1)
Vaccination of Neonates
249(2)
Clinical Correlation Follow-Up
251(2)
Student Considerations
251(1)
Possible Explanations
252(1)
Chapter 15 Vaccination
253(18)
Clinical Correlation: Animal Vaccines
253(1)
Learning Objectives
253(1)
Vaccines
253(14)
Vaccine Characteristics
253(2)
Live-Attenuated Vaccines
255(4)
Killed Vaccines
259(1)
Component, Toxoid, Conjugate, Recombinant, and Naked DNA Vaccines
259(4)
Adjuvants
263(3)
Administration
266(1)
Frequency
266(1)
Passive Immunotherapy
267(1)
Clinical Correlation Follow-Up
268(3)
Student Considerations
268(1)
Possible Explanations
268(3)
Chapter 16 Immune Deficiencies and Immune-Mediated Diseases
271(16)
Clinical Correlation: Feline Immunodeficiency Virus
271(1)
Learning Objectives
271(1)
Immune Deficiencies
272(2)
Congenital Immune Deficiencies
272(1)
Acquired Immune Deficiencies
273(1)
Immune-Mediated Diseases
274(10)
Hypersensitivities Type I, III, and IV
274(1)
Type I hypersensitivities
274(5)
Type III hypersensitivities
279(3)
Type IV hypersensitivities
282(1)
Type II Hypersensitivities and Autoimmune Diseases
283(1)
Clinical Correlation Follow-Up
284(3)
Student Considerations
284(1)
Possible Explanations
284(3)
Chapter 17 The Immune System and Cancer
287(8)
Clinical Correlation: Canine Cancer
287(1)
Learning Objectives
287(1)
Background
287(2)
Evidence That Mammalian Immune Systems Affect Tumors
289(1)
Tumor---Host Interactions
290(2)
Outcomes
292(1)
Clinical Correlation: Follow-Up
293(2)
Student Considerations
293(1)
Possible Explanations
294(1)
Chapter 18 Veterinary Clinical Laboratory Immunology
295(24)
Clinical Correlation: Transfusion Reactions
295(2)
Learning Objectives
297(1)
Principles of Antibody-Based Techniques
298(9)
Generating Antibodies: Polyclonal and Monoclonal Antibodies
298(1)
Production of polyclonal antibodies
298(1)
Production of monoclonal antibodies
299(1)
Detecting Antibody--Antigen Reactions
300(1)
Specific Techniques
300(1)
Enzyme-linked immunosorbent assays
300(2)
Immunoblotting
302(1)
Immunofluorescent microscopy
303(1)
Precipitation assays
304(1)
Flow cytometry
305(1)
Immunohistochemistry
306(1)
Diagnosis of Blood Type Incompatibilities
307(5)
Blood Typing
307(1)
Blood typing cards
308(1)
Typing gel
308(1)
Membrane dipstick
309(1)
Crossmatching
309(3)
Diagnosis of Immunodeficiencies
312(1)
Serum Immunoglobulin Quantification
312(1)
Phenotypic Analysis of Lymphocytes
312(1)
Other Immunodeficiency Tests
313(1)
Diagnosis of Autoimmunity
313(6)
Antinuclear Antibody Test
313(1)
Coombs Test
314(1)
Antiplatelet Antibody Test
314(1)
Antithyroglobulin Autoantibody Test
315(1)
Clinical Correlation: Follow-Up
316(1)
Student Considerations
316(1)
Possible Explanations
316(3)
Glossary 319(8)
Index 327
Gerald N. Callahan is a professor of immunology and public understanding of science at Colorado State University with joint appointments in the Department of Microbiology, Immunology, and Pathology and the Department of English. Robin M. Yates is associate professor in the Departments of Comparative Biology and Experimental Medicine, Veterinary Medicine, and Biochemistry and Molecular Biology at the University of Calgary.