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Biological Membranes: A Molecular Perspective from Computation and Experiment [Kõva köide]

  • Formaat: Hardback, 500 pages, 197 b&w illustrations
  • Ilmumisaeg: 30-Jul-1996
  • Kirjastus: Birkhauser Boston Inc
  • ISBN-10: 081763827X
  • ISBN-13: 9780817638276
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  • Formaat: Hardback, 500 pages, 197 b&w illustrations
  • Ilmumisaeg: 30-Jul-1996
  • Kirjastus: Birkhauser Boston Inc
  • ISBN-10: 081763827X
  • ISBN-13: 9780817638276
Provides an overview of theoretical and experimental advances in the understanding of lipid bilayers and protein/lipid interactions at the microscopic level, with sections on computational issues regarding biomembrane simulation; experimental probes of biomembrane structure and dynamics; small molecules and peptides in biomembranes; and membrane protein. Topics include lipid force field development, Monte Carlo methods, NMR and IR techniques in biomembrane studies, and thermodynamics and structural aspects of protein/peptide interactions. Of interest to molecular biologists, pharmaceutical chemists, and protein chemists. Annotation c. by Book News, Inc., Portland, Or.
Preface vii(4) List of Contributors xi PART I: COMPUTATIONAL ISSUES REGARDING BIOMEMBRANE SIMULATION 3(124)
1. Time Scales of Lipid Dynamics and Molecular Dynamics 3(28) Richard W. Pastor Scott E. Feller
2. An Empirical Potential Energy Function for Phospholipids: Criteria for Parameter Optimization and Applications 31(52) Michael Schlenkrich Jurgen Brickmann Alexander D. MacKerell, Jr. Martin Karplus
3. Statistical Mechanics and Monte Carlo Studies of Lipid Membranes 83(22) H. Larry Scott
4. Strategic Issues in Molecular Dynamics Simulations of Membranes 105(22) Eric Jakobsson Shankar Subramaniam H. Larry Scott PART II: EXPERIMENTAL PROBES OF BIOMEMBRANE STRUCTURE AND DYNAMICS 127(128)
5. The Liquid-Crystallographic Structure of Fluid Lipid Bilayer Membranes 127(18) Stephen H. White Michael C. Wiener
6. Infrared Spectroscopic Determination of Conformational Disorder and Microphase Separation in Phospholipid Acyl Chains 145(30) Richard Mendelsohn Robert G. Snyder
7. Membrane Structure and Dynamics Studied with NMR Spectroscopy 175(80) Michael F. Brown PART III: SMALL MOLECULES AND PEPTIDES IN BIOMEMBRANES 255(100)
8. Movement of Small Molecules in Lipid Bilayers: Molecular Dynamics Simulation Studies 255(26) Terry R. Stouch Donna Bassolino
9. Structural Basis and Energetics of Peptide Membrane Interactions 281(18) Huey W. Huang
10. Computational Refinement Through Solid State NMR and Energy Constraints of a Membrane Bound Polypeptide 299(24) Randal R. Ketchem Benoit Roux Timothy A. Cross
11. Bilayer-Peptide Interactions 323(32) K. V. Damodaran Kenneth M. Merz, Jr. PART IV: MEMBRANE PROTEINS 355(234)
12. Peripheral Membrane Proteins 355(50) Barbara A. Seaton Mary F. Roberts
13. Thermodynamics of the Interaction of Proteins with Lipid Membranes 405(58) Thomas Heimburg Derek Marsh
14. Role of Lipid Organization and Dynamics for Membrane Functionality 463(40) Ole G. Mouritsen Paavo K. J. Kinnunen
15. Prediction of the Structure of an Integral Membrane Protein: The Light-Harvesting Complex II of Rhodospirillum molischianum 503(32) Xiche Hu Dong Xu Kenneth Hamer Klaus Schulten Juergen Koepke Hartmut Michel
16. Monte Carlo Models of Spontaneous Insertion of Peptides into Lipid Membranes 535(20) Jeffrey Skolnick Mariusz Milik
17. Molecular Dynamics of Pf1 Coat Protein in a Phospholipid Bilayer 555(34) Benoit Roux Thomas B. Woolf Index 589