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Biological Science 7th ed. [köitmata]

(Utah State University), (University of Washington), (Salisbury University), (College of William and Mary), (California Polytechnic State University San Luis Obispo), (California Polytechnic State University in San Luis Obispo), (Uni)
  • Formaat: Loose-leaf, 1408 pages, kõrgus x laius x paksus: 277x224x51 mm, kaal: 2654 g, Illustrations
  • Ilmumisaeg: 18-Jan-2019
  • Kirjastus: Pearson
  • ISBN-10: 0135272807
  • ISBN-13: 9780135272800
Teised raamatud teemal:
  • Formaat: Loose-leaf, 1408 pages, kõrgus x laius x paksus: 277x224x51 mm, kaal: 2654 g, Illustrations
  • Ilmumisaeg: 18-Jan-2019
  • Kirjastus: Pearson
  • ISBN-10: 0135272807
  • ISBN-13: 9780135272800
Teised raamatud teemal:

NOTE: This loose-leaf, three-hole punched version of the textbook gives you the flexibility to take only what you need to class and add your own notes — all at an affordable price. For loose-leaf editions that include MyLab™ or Mastering™, several versions may exist for each title and registrations are not transferable. You may need a Course ID, provided by your instructor, to register for and use MyLab or Mastering products.

 

For introductory courses for biology majors.

 

Discover biology, develop skills, and make connections

Known for its discovery-based, student-centered approach, Scott Freeman’s Biological Science emphasizes higher-order thinking, enhances skill development, and promotes active learning. Biological Science equips students with strategies that go beyond memorization and guides them in making connections between core concepts and content, underscoring principles from the Vision and Change in Undergraduate Biology Education report. Students learn to apply their knowledge throughout the course, assess their level of understanding, and identify the types of cognitive skills that need improvement.


The 7th Edition enables students to see that biology concepts are connected by weaving one case study throughout the entire text, helping students make connections across biology. New content includes updated coverage of advances in genomic editing, global climate change, and recent insights into the evolution of land plants. New embedded Pearson eText assets support content in the text with whiteboard Making Models videos, Figure Walkthrough videos, and BioFlix animations that engage students, help them learn, and guide them in completing assignments.

 

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1 Biology: The Study of Life 1(19)
1.1 What Does It Mean to Say that Something Is Alive?
2(1)
1.2 Life Is Cellular and Replicates through Cell Division
2(2)
All Organisms Are Made of Cells
2(1)
Where Do Cells Come From?
3(1)
Life Replicates through Cell Division
4(1)
1.3 Life Processes Information and Requires Energy
4(2)
The Central Dogma
5(1)
Life Requires Energy
5(1)
1.4 Life Evolves
6(1)
What Is Evolution?
6(1)
What Is Natural Selection?
6(1)
1.5 The "Tree of Life" Depicts Evolutionary History
7(3)
Using Genetic Sequences to Understand the Tree of Life
7(2)
How Should We Name Branches on the Tree of Life?
9(1)
1.6 Doing Biology
10(5)
The Nature of Science
10(1)
An Introduction to Hypothesis Testing: Why Do Giraffes Have Long Necks?
10(2)
An Introduction to Experimental Design: How Do Ants Navigate?
12(3)
Review
15(2)
End Of Unit Case Study: Mystery of the Newt
17(1)
Big Picture: Doing Biology
18(2)
BioSkills 20(38)
B.1 Using the Metric System and Significant Figures
21(2)
Metric System Units and Conversions
21(1)
Significant Figures
22(1)
B.2 Reading and Making Graphs
23(3)
Getting Started
24(1)
Types of Graphs
25(1)
Getting Practice
26(1)
B.3 Interpreting Standard Error Bars and Using Statistical Tests
26(3)
Standard Error Bars
26(1)
Using Statistical Tests
27(1)
Interpreting Differences: P Values and Statistical Significance
28(1)
Evaluating Causation versus Correlation
28(1)
B.4 Working with Probabilities
29(1)
The "Both-And" Rule
29(1)
The "Either-Or" Rule
29(1)
B.5 Using Logarithms
29(1)
B.6 Separating and Visualizing Molecules
30(4)
Using Electrophoresis to Separate Molecules
30(2)
Using Thin Layer Chromatography to Separate Molecules
32(1)
Visualizing Molecules
32(2)
B.7 Separating Cell Components by Centrifugation
34(1)
B.8 Using Spectrophotometry
35(1)
B.9 Using Microscopy
36(3)
Light and Fluorescence Microscopy
36(1)
Electron Microscopy
36(2)
Studying Live Cells and Real-Time Processes
38(1)
B.10 Using Molecular Biology Tools and Techniques
39(5)
Making and Using cDNA Libraries
39(1)
Amplifying DNA Using the Polymerase Chain Reaction (PCR)
40(1)
Dideoxy Sequencing
41(1)
Shotgun Sequencing
42(1)
DNA Microarrays
43(1)
B.11 Using Cell Culture and Model Organisms as Tools
44(4)
Cell and Tissue Culture Methods
44(1)
Model Organisms
45(3)
B.12 Reading and Making Visual Models
48(2)
Tips for Interpreting Models
48(1)
Tips for Making Your Own Models
49(1)
Concept Maps
49(1)
B.13 Reading and Making Phylogenetic Trees
50(2)
Anatomy of a Phylogenetic Tree
50(1)
How to Read a Phylogenetic Tree
51(1)
How to Draw a Phylogenetic Tree
51(1)
B.14 Reading Chemical Structures
52(1)
B.15 Translating Greek and Latin Roots in Biology
53(1)
B.16 Reading and Citing the Primary Literature
53(2)
What Is the Primary Literature?
53(1)
Getting Started
53(2)
Citing Sources
55(1)
Getting Practice
55(1)
B.17 Recognizing and Correcting Misconceptions
55(1)
B.18 Using Bloom's Taxonomy for Study Success
56(2)
Categories of Human Cognition
56(1)
Six Study Steps to Success
56(2)
Unit 1 The Molecular Origin And Evolution Of Life 58(88)
2 Water and Carbon: The Chemical Basis of Life
58(22)
2.1 Atoms, Ions, and Molecules: The Building Blocks of Chemical Evolution
59(5)
Basic Atomic Structure
59(2)
How Does Covalent Bonding Hold Molecules Together?
61(1)
Ionic Bonding, Ions, and the Electron-Sharing Continuum
62(1)
Some Simple Molecules Formed from C, H, N, and O
63(1)
The Geometry of Simple Molecules
63(1)
Representing Molecules
64(1)
2.2 Properties of Water and the Early Oceans
64(7)
What Properties Are Correlated with Water's Structure?
65(3)
The Role of Water in Acid-Base Chemical Reactions
68(3)
2.3 Chemical Reactions, Energy, and Chemical Evolution
71(2)
How Do Chemical Reactions Happen?
71(1)
What Is Energy?
71(1)
What Makes a Chemical Reaction Spontaneous?
72(1)
2.4 Investigating Chemical Evolution
73(1)
2.5 Life Is Carbon Based
74(4)
Carbon Provides a Molecular Skeleton
75(1)
Functional Groups Define the Chemical Behavior of Organic Molecules
75(1)
Small Organic Molecules Can Assemble into Large Molecules
75(3)
Review
78(2)
3 Protein Structure and Function
80(15)
3.1 Amino Acids and Their Polymerization
81(3)
The Structure of Amino Acids
81(1)
The Nature of Side Chains
81(2)
How Do Amino Acids Link to Form Proteins?
83(1)
3.2 What Do Proteins Look Like?
84(5)
Primary Structure
85(1)
Secondary Structure
86(1)
Tertiary Structure
87(1)
Quaternary Structure
88(1)
3.3 Folding and Function
89(3)
Normal Folding Is Crucial to Function
90(1)
Protein Shape Is Flexible
90(2)
3.4 Protein Functions Are as Diverse as Protein Structures
92(1)
Why Are Enzymes Good Catalysts?
92(1)
Did Life Arise from a Self-Replicating Enzyme?
93(1)
Review
93(2)
4 Nucleic Acids and an RNA World
95(14)
4.1 What Is a Nucleic Acid?
96(2)
Could Chemical Evolution Result in the Production of Nucleotides?
97(1)
How Do Nucleotides Polymerize to Form Nucleic Acids?
97(1)
4.2 DNA Structure and Function
98(5)
What Is the Nature of DNA's Secondary Structure?
99(2)
The Tertiary Structure of DNA
101(1)
DNA Functions as an Information-Containing Molecule
101(1)
The DNA Double Helix Is a Stable Structure
102(1)
4.3 RNA Structure and Function
103(2)
Structurally, RNA Differs from DNA
103(1)
RNA's Versatility
104(1)
RNA Can Function as a Catalytic Molecule
105(1)
4.4 In Search of the First Life-Form
105(2)
How Biologists Study the RNA World
106(1)
An RNA World May Have Sparked the Evolution of Life
106(1)
Review
107(2)
5 An Introduction to Carbohydrates
109(12)
5.1 Sugars as Monomers
110(2)
What Distinguishes One Monosaccharide from Another?
110(1)
Can the Same Monosaccharide Exist in More Than One Form?
110(2)
5.2 The Structure of Polysaccharides
112(3)
Starch: A Storage Polysaccharide in Plants
113(2)
Glycogen: A Highly Branched Storage Polysaccharide in Animals
115(1)
Cellulose: A Structural Polysaccharide in Plants
115(1)
Chitin: A Structural Polysaccharide in Fungi and Animals
115(1)
Peptidoglycan: A Structural Polysaccharide in Bacteria
115(1)
5.3 What Do Carbohydrates Do?
115(4)
Carbohydrates Can Provide Structural Support
116(1)
The Role of Carbohydrates in Cell Identity
116(1)
Carbohydrates and Energy Storage
117(2)
Review
119(2)
6 Lipids, Membranes, and the First Cells
121(21)
6.1 Lipid Structure and Function
122(3)
How Does Bond Saturation Affect Hydrocarbon Structure?
122(1)
A Look at Three Types of Lipids Found in Cells
123(1)
How Membrane Lipids Interact with Water
124(1)
6.2 Phospholipid Bilayers
125(4)
Artificial Membranes as an Experimental System
126(1)
Selective Permeability of Lipid Bilayers
127(1)
How Does Lipid Structure Affect Membrane Permeability?
127(2)
How Does Temperature Affect the Fluidity and Permeability of Membranes?
129(1)
6.3 How Substances Move across Lipid Bilayers: Diffusion and Osmosis
129(3)
Diffusion
129(1)
Osmosis
130(1)
Membranes and Chemical Evolution
131(1)
6.4 Proteins Alter Membrane Structure And Function
132(8)
Development Of The Fluid-Mosaic Model
132(2)
Systems For Studying Membrane Proteins
134(1)
Channel Proteins Facilitate Diffusion
134(2)
Carrier Proteins Facilitate Diffusion
136(1)
Pumps Perform Active Transport
137(2)
Plasma Membranes Define The Intracellular Environment
139(1)
Review
140(2)
End-Of-Unit Case Study: What's So Toxic About Tetrodotoxin?
142(2)
Big Picture: The Chemistry Of Life
144(2)
Unit 2 Cell Structure And Function 146(132)
7 Inside the Cell
146(29)
7.1 Bacterial and Archaeal Cell Structures and Their Functions
147(3)
A Revolutionary New View
147(1)
Prokaryotic Cell Structures: A Parts List
147(3)
7.2 Eukaryotic Cell Structures and Their Functions
150(8)
The Benefits of Organelles
150(1)
Eukaryotic Cell Structures: A Parts List
151(7)
7.3 Putting the Parts into a Whole
158(1)
Structure and Function at the Whole-Cell Level
158(1)
The Dynamic Cell
159(1)
7.4 Cell Systems I: Nuclear Transport
159(2)
Structure and Function of the Nuclear Envelope
159(1)
How Do Molecules Enter the Nucleus?
160(1)
7.5 Cell Systems II: The Endomembrane System Manufactures, Ships, and Recycles Cargo
161(6)
Studying the Pathway through the Endomembrane System
161(2)
How Do Proteins Enter the Endomembrane System?
163(1)
Moving from the ER to the Golgi Apparatus
164(1)
What Happens Inside the Golgi Apparatus?
164(1)
How Do Proteins Reach Their Proper Destinations?
164(1)
Recycling Material in the Lysosome
165(2)
7.6 Cell Systems III: The Dynamic Cytoskeleton
167(5)
Actin Filaments
168(1)
Intermediate Filaments
168(1)
Microtubules
169(2)
Flagella and Cilia: Moving the Entire Cell
171(1)
Review
172(3)
8 Energy and Enzymes: An Introduction to Metabolism
175(18)
8.1 What Happens to Energy in Chemical Reactions?
176(3)
Chemical Reactions Involve Energy Transformations
176(1)
Temperature and Concentration Affect Reaction Rates
177(2)
8.2 Nonspontaneous Reactions May Be Driven Using Chemical Energy
179(4)
Redox Reactions Transfer Energy via Electrons
179(2)
ATP Transfers Energy via Phosphate Groups
181(2)
8.3 How Enzymes Work
183(3)
Enzymes Help Reactions Clear Two Hurdles
183(2)
What Limits the Rate of Catalysis?
185(1)
Do Enzymes Work Alone?
186(1)
8.4 What Factors Affect Enzyme Function?
186(3)
Enzymes Are Optimized for Particular Environments
187(1)
Most Enzymes Are Regulated
187(2)
8.5 Enzymes Can Work Together in Metabolic Pathways
189(2)
Metabolic Pathways Are Regulated
189(1)
Metabolic Pathways Evolve
190(1)
Review
191(2)
9 Cellular Respiration and Fermentation
193(21)
9.1 An Overview of Cellular Respiration
194(3)
What Happens When Glucose Is Oxidized?
194(2)
Cellular Respiration Plays a Central Role in Metabolism
196(1)
9.2 Glycolysis: Oxidizing Glucose to Pyruvate
197(3)
Glycolysis Is a Sequence of 10 Reactions
197(1)
How Is Glycolysis Regulated?
198(2)
9.3 Processing Pyruvate to Acetyl CoA
200(1)
9.4 The Citric Acid Cycle: Oxidizing Acetyl CoA to CO2
201(4)
How Is the Citric Acid Cycle Regulated?
202(1)
What Happens to the NADH and FADH2?
203(2)
9.5 Electron Transport and Chemiosmosis: Building a Proton Gradient to Produce ATP
205(5)
The Electron Transport Chain
205(1)
The Discovery of ATP Synthase
206(1)
The Chemiosmosis Hypothesis
207(3)
Organisms Use a Diversity of Electron Acceptors
210(1)
9.6 Fermentation
210(2)
Many Different Fermentation Pathways Exist
210(1)
Fermentation as an Alternative to Cellular Respiration
211(1)
Review
212(2)
10 Photosynthesis
214(24)
10.1 Photosynthesis Harnesses Sunlight to Make Carbohydrate from CO2
215(2)
Photosynthesis: Two Linked Sets of Reactions
215(1)
Photosynthesis Occurs in Chloroplasts
216(1)
10.2 How Do Pigments Capture Light Energy?
217(5)
Photosynthetic Pigments Absorb Light
218(2)
When Light Is Absorbed, Electrons Enter an Excited State
220(1)
Photosystems
221(1)
10.3 The Discovery of Photosystems I and II
222(5)
How Does Photosystem II Work?
222(2)
How Does Photosystem I Work?
224(1)
The Z Scheme: Photosystems II and I Work Together
225(2)
10.4 How Do Cells Capture Carbon Dioxide?
227(5)
The Calvin Cycle Fixes Carbon
228(1)
The Discovery of Rubisco
229(1)
Mechanisms for Increasing CO2 Concentration
230(2)
10.5 Captured Carbon Dioxide Is Reduced to Make Sugar
232(1)
The Calvin Cycle Is a Three-Step Process
232(1)
How Is Photosynthesis Regulated?
233(1)
What Happens to the Sugar That Is Produced by Photosynthesis?
233(1)
Review
233(3)
Big Picture: Energy For Life
236(2)
11 Cell-Cell Interactions
238(19)
11.1 The Cell Surface
239(3)
The Structure and Function of an Extracellular Layer
239(1)
The Cell Wall in Plants
239(1)
The Extracellular Matrix in Animals
240(2)
11.2 How Do Adjacent Cells Connect and Communicate?
242(5)
Cell-Cell Attachments in Multicellular Organisms
242(4)
Cells Communicate via Cell-Cell Gaps
246(1)
11.3 How Do Distant Cells Communicate?
247(7)
Cell-Cell Signaling in Multicellular Organisms
247(1)
Signal Reception
248(1)
Signal Processing
248(4)
Signal Response
252(1)
Signal Deactivation
252(1)
Crosstalk: Synthesizing Input from Many Signals
253(1)
11.4 Signaling between Unicellular Organisms
254(1)
Review
255(2)
12 The Cell Cycle
257(19)
12.1 How Do Cells Replicate?
258(3)
What Is a Chromosome?
258(1)
Cells Alternate between M Phase and Interphase
259(1)
The Discovery of S Phase
259(1)
The Discovery of the Gap Phases
259(1)
The Cell Cycle
260(1)
12.2 What Happens during M Phase?
261(6)
Events in Mitosis
262(3)
How Do Chromosomes Move during Anaphase?
265(1)
Cytokinesis Results in Two Daughter Cells
266(1)
Bacterial Cell Replication
267(1)
12.3 Control of the Cell Cycle
267(4)
The Discovery of Cell-Cycle Regulatory Molecules
267(2)
Cell-Cycle Checkpoints Can Arrest the Cell Cycle
269(2)
12.4 Cancer: Out-of-Control Cell Division
271(3)
Properties of Cancer Cells
271(1)
Cancer Involves Loss of Cell-Cycle Control
272(2)
Review
274(2)
End-Of-Unit Case Study: How Did the Newt Become So Toxic?
276(2)
Unit 3 Gene Structure And Expression 278(170)
13 Meiosis
278(17)
13.1 How Does Meiosis Occur?
279(7)
Chromosomes Come in Distinct Sizes and Shapes
279(1)
The Concept of Ploidy
280(1)
An Overview of Meiosis
280(3)
The Phases of Meiosis I
283(1)
The Phases of Meiosis II
284(1)
Mitosis versus Meiosis
284(2)
13.2 Meiosis Promotes Genetic Variation
286(2)
Independent Assortment
287(1)
Crossing Over
288(1)
How Does Fertilization Affect Genetic Variation?
288(1)
13.3 What Happens When Things Go Wrong in Meiosis?
288(2)
How Do Mistakes Occur?
289(1)
Why Do Mistakes Occur?
290(1)
13.4 What Are the Benefits of Meiosis?
290(3)
The Paradox of Sex
290(1)
The Purifying Selection Hypothesis
291(1)
The Changing-Environment Hypothesis
291(2)
Review
293(2)
14 Mendel and the Gene
295(27)
14.1 Mendel's Experimental System
296(2)
What Questions Was Mendel Trying to Answer?
296(1)
The Garden Pea Served as the First Model Organism in Genetics
296(2)
14.2 Mendel's Experiments with a Single Trait
298(5)
The Monohybrid Cross
298(2)
Particulate Inheritance
300(3)
14.3 Mendel's Experiments with Two Traits
303(3)
The Dihybrid Cross
303(2)
Using a Testcross to Confirm Predictions
305(1)
14.4 The Chromosome Theory of Inheritance
306(2)
Meiosis Explains Mendel's Principles
306(1)
Testing the Chromosome Theory of Inheritance
306(2)
14.5 Extending Mendel's Rules
308(8)
Linkage: What Happens When Genes Are Located on the Same Chromosome?
309(2)
Quantitative Methods: Linkage and Genetic Mapping
311(1)
How Many Alleles Can a Gene Have?
312(1)
Are Alleles Always Dominant or Recessive?
312(1)
Does Each Gene Affect Just One Trait?
312(1)
Is a Particular Trait Determined by One Gene?
313(1)
Are Traits Determined Exclusively by Genes?
314(1)
Can Mendel's Principles Explain Traits That Don't Fall into Distinct Categories?
314(2)
14.6 Applying Mendel's Rules to Human Inheritance
316(3)
Identifying Alleles as Recessive or Dominant
317(1)
Identifying Traits as Autosomal or Sex-Linked
317(2)
Review
319(3)
15 DNA and the Gene: Synthesis and Repair
322(19)
15.1 What Are Genes Made Of?
323(3)
The Hershey-Chase Experiment
323(1)
The Structure of DNA
324(2)
15.2 Testing Early Hypotheses about DNA Synthesis
326(2)
Three Alternative Hypotheses
326(1)
The Meselson-Stahl Experiment
326(2)
15.3 A Model for DNA Synthesis
328(5)
Where Does Replication Start?
328(1)
How Is the Helix Opened and Stabilized?
329(1)
How Is the Leading Strand Synthesized?
330(1)
How Is the Lagging Strand Synthesized?
330(2)
New Discoveries in DNA Synthesis
332(1)
15.4 Replicating the Ends of Linear Chromosomes
333(2)
The End-Replication Problem
333(1)
Telomerase Solves the End-Replication Problem
333(1)
Effect of Telomere Length on Cell Division and Aging
333(2)
15.5 Repairing Mistakes and DNA Damage
335(3)
Correcting Mistakes in DNA Synthesis
335(2)
Repairing Damaged DNA
337(1)
A DNA Repair Defect in Humans
337(1)
Review
338(3)
16 How Genes Work
341(13)
16.1 What Do Genes Do?
342(1)
The One-Gene, One-Enzyme Hypothesis
342(1)
An Experimental Test of the Hypothesis
342(1)
16.2 The Central Dogma of Molecular Biology
343(3)
The Genetic Code Hypothesis
344(1)
RNA as the Intermediary between Genes and Proteins
344(1)
Dissecting the Central Dogma
344(2)
16.3 The Genetic Code
346(3)
How Long Is a "Word" in the Genetic Code?
346(1)
How Did Researchers Crack the Code?
347(2)
16.4 What Are the Types and Consequences of Mutation?
349(3)
Point Mutations
349(1)
Chromosome Mutations
350(2)
Review
352(2)
17 Transcription, RNA Processing, and Translation
354(19)
17.1 An Overview of Transcription
355(3)
Initiation: How Does Transcription Begin in Bacteria?
355(1)
Elongation and Termination in Bacteria
356(1)
Transcription in Eukaryotes
357(1)
17.2 RNA Processing in Eukaryotes
358(2)
The Startling Discovery of Split Eukaryotic Genes
358(1)
RNA Splicing
359(1)
Adding Caps and Tails to Transcripts
360(1)
17.3 An Introduction to Translation
360(2)
Ribosomes Are the Site of Protein Synthesis
360(1)
An Overview of Translation
361(1)
How Does mRNA Specify Amino Acids?
362(1)
17.4 The Structure and Function of Transfer RNA
362(3)
What Is the Structure of tRNAs?
363(1)
How Are Amino Acids Attached to tRNAs?
364(1)
How Many Types of tRNAs Are There?
364(1)
17.5 Ribosome Structure and Function in Translation
365(5)
Initiating Translation
366(1)
Elongation: Extending the Polypeptide
367(1)
Terminating Translation
368(1)
Polypeptides Are Modified after Translation
368(2)
Review
370(3)
18 Control of Gene Expression in Bacteria
373(12)
18.1 An Overview of Gene Regulation and Information Flow
374(2)
Mechanisms of Regulation
374(1)
Metabolizing Lactose-A Model System
375(1)
18.2 Negative and Positive Control of Transcription
376(6)
A Gene Needed to Regulate Lactose Metabolism
376(2)
Negative Control of Lactose Utilization Genes
378(1)
The Operon Model
378(1)
Positive Control of Lactose Utilization Genes
379(1)
Why Has the lac Operon Model Been So Important Scientifically?
380(1)
The trp Operon: A Twist on Negative Control
381(1)
18.3 Global Gene Regulation
382(1)
Review
383(2)
19 Control of Gene Expression in Eukaryotes
385(21)
19.1 Gene Regulation in Eukaryotes-An Overview
386(1)
19.2 Chromatin Remodeling
387(4)
Chromatin Structure
387(1)
Chromatin Structure Is Altered in Active Genes
388(1)
How Is Chromatin Altered?
389(1)
DNA and Chromatin Modifications Vary and Can be Inherited
389(2)
19.3 Initiating Transcription
391(4)
Promoter-Proximal Elements Are Regulatory Sequences Near the Core Promoter
391(1)
Enhancers Are Regulatory Sequences Far from the Core Promoter
392(1)
The Role of Transcription Factors in Differential Gene Expression
392(1)
How Do Transcription Factors Recognize Specific DNA Sequences?
393(1)
A Model for Transcription Initiation
393(2)
19.4 Post-Transcriptional Control
395(3)
Many Primary Transcripts Are Alternatively Spliced
396(1)
mRNA Stability and Translation Are Important Mechanisms of Post-Transcriptional Control
396(2)
Post-Translational Control
398(1)
19.5 Linking Cancer to Defects in Gene Regulation
398(2)
The Genetic Basis of Uncontrolled Cell Growth
399(1)
The p53 Tumor Suppressor
399(1)
19.6 A Comparison of Gene Expression in Bacteria and Eukaryotes
400(1)
Review
401(3)
Big Picture: Genetic Information
404(2)
20 The Molecular Revolution: Biotechnology, Genomics, and New Frontiers
406(22)
20.1 Recombinant DNA Technology
407(3)
Using Plasmids in Cloning
407(1)
Using Restriction Endonucleases and DNA Ligase to Cut and Paste DNA
407(1)
Transformation: Introducing Recombinant Plasmids into Bacterial Cells
408(1)
Complementary DNA (cDNA)
409(1)
Biotechnology in Agriculture
409(1)
20.2 The Polymerase Chain Reaction
410(1)
Requirements of PCR
410(1)
PCR In Action: DNA Fingerprinting
410(1)
20.3 Analyzing Genomes
411(3)
Whole-Genome Sequencing
412(1)
Analyzing Genomes Through Bioinformatics
412(1)
Genome-Wide Association Studies-An Alternative Approach to Identifying Genes
413(1)
20.4 Insights into Genomes
414(5)
Prokaryotic Genomes
415(1)
Eukaryotic Genomes
416(2)
Insights from the Human Genome Project
418(1)
20.5 Genome Editing
419(3)
The Biology of the CRISPR-Cas System
419(1)
Using the CRISPR-Cas System for Genome Editing
420(1)
What's Been Achieved With CRISPR-Cas Genome Editing?
420(2)
20.6 Gene Therapy
422(1)
20.7 New Frontiers: Functional Genomics, Proteomics, Systems and Synthetic Biology
423(2)
Functional Genomics Seeks to Understand How Genes and Genomes Work
423(1)
Proteomics Seeks to Identify the Entire Set of Proteins Expressed in a Cell
424(1)
Systems and Synthetic Biology-New Approaches to Understanding Life
424(1)
Review
425(3)
21 Genes, Development, and Evolution
428(18)
21.1 Genetic Equivalence and Differential Gene Expression in Development
429(2)
Evidence that Differentiated Plant Cells Are Genetically Equivalent
429(1)
Evidence that Differentiated Animal Cells Are Genetically Equivalent
429(1)
How Does Differential Gene Expression Occur?
430(1)
21.2 Cells Are Determined Before They Differentiate
431(2)
Commitment and Determination
431(1)
Master Regulators of Differentiation and Development
431(1)
Stem Cells and Stem Cell Therapy
432(1)
21.3 Shared Developmental Processes
433(4)
Cell Division
433(1)
Cell-Cell Interactions
434(1)
Cell Differentiation
434(1)
Cell Movement and Changes in Shape
435(1)
Programmed Cell Death
436(1)
21.4 Establishing the Body Plan
437(5)
Morphogens Set Up the Body Axes in Drosophila
437(2)
Genetic Regulatory Cascades Provide Increasingly Specific Positional Information
439(1)
Regulatory Genes and Signaling Molecules Are Evolutionarily Conserved
440(2)
One Regulator Can Be Used in Different Ways
442(1)
21.5 Changes in Developmental Gene Expression Drive Evolutionary Change
442(1)
Review
443(3)
End-Of-Unit Case Study: How Can Mutations Save a Snake?
446(2)
Unit 4 Evolutionary Patterns And Processes 448(86)
22 Evolution by Natural Selection
448(21)
22.1 The Rise of Evolutionary Thought
449(1)
Plato and Typological Thinking
449(1)
Aristotle and the Scale of Nature
449(1)
Lamarck and the Idea of Evolution as Change through Time
450(1)
Darwin and Wallace and Evolution by Natural Selection
450(1)
22.2 The Pattern of Evolution: Have Species Changed, and Are They Related?
450(7)
Evidence for Change through Time
450(3)
Evidence of Descent from a Common Ancestor
453(3)
Evolution's "Internal Consistency"-The Importance of Independent Data Sets
456(1)
22.3 The Process of Evolution: How Does Natural Selection Work?
457(2)
Darwin's Inspiration
458(1)
Darwin's Four Postulates
458(1)
Biological Definitions of Fitness, Adaptation, and Selection
459(1)
22.4 Evolution in Action: Measuring Natural Selection in Populations Today
459(4)
Case Study 1: How Did Mycobacterium tuberculosis Become Resistant to Antibiotics?
459(2)
Case Study 2: Why Do Beak Sizes and Shapes Vary in Galapagos Finches?
461(2)
22.5 Debunking Common Misconceptions about Natural Selection and Evolution
463(4)
Natural Selection Does Not Change Individuals
463(2)
Natural Selection Is Not Goal Directed
465(1)
Natural Selection Does Not Lead to Perfection
465(2)
Review
467(2)
23 Evolutionary Processes
469(24)
23.1 Null Hypothesis: The Hardy-Weinberg Principle
470(4)
The Gene Pool Concept
470(1)
The Hardy-Weinberg Principle Makes Important Assumptions
471(1)
Quantitative Methods: Deriving the Hardy-Weinberg Principle
472(1)
Case Study: Are MN Blood-Type Alleles in Humans in Hardy-Weinberg Equilibrium?
473(1)
23.2 Nonrandom Mating
474(1)
How Does Inbreeding Affect Allele Frequencies and Genotype Frequencies?
474(1)
How Does Inbreeding Influence Evolution?
475(1)
Nonrandom Mating via Sexual Selection
475(1)
23.3 Natural Selection
475(7)
How Does Selection Affect Genetic Variation?
476(2)
Sexual Selection
478(4)
23.4 Genetic Drift
482(4)
Simulation Studies of Genetic Drift
482(2)
Experimental Studies of Genetic Drift
484(1)
What Causes Genetic Drift in Natural Populations?
484(1)
Take-Home Messages
485(1)
23.5 Gene Flow
486(1)
Measuring Gene Flow between Populations
486(1)
Gene Flow Is Random with Respect to Fitness
487(1)
23.6 Mutation
487(3)
Mutation as an Evolutionary Process
488(1)
Experimental Studies of Mutation
488(1)
Studies of Mutation in Natural Populations
489(1)
Take-Home Messages
489(1)
Review
490(3)
24 Speciation
493(17)
24.1 How Are Species Defined and Identified?
494(4)
The Biological Species Concept
495(1)
The Morphospecies Concept
495(1)
The Phylogenetic Species Concept
496(1)
Species Definitions in Action: How Many Species of Elephants Are There?
497(1)
24.2 Isolation and Divergence in Allopatry
498(2)
Allopatric Speciation by Dispersal
498(1)
Allopatric Speciation by Vicariance
499(1)
24.3 Isolation and Divergence in Sympatry
500(4)
Sympatric Speciation by Disruptive Selection
500(2)
Sympatric Speciation by Polyploidization
502(2)
24.4 What Happens When Isolated Populations Come into Contact?
504(4)
Fusion or Extinction
504(1)
Reinforcement of Divergence
505(1)
Hybrid Zone Formation
505(1)
New Species through Hybridization
506(1)
Take-Home Messages
507(1)
Review
508(2)
25 Phylogenies and the History of Life
510(20)
25.1 Tools for Studying Life's History: Phylogenetic Trees
511(6)
Fish Fraud Case Study: How Do Biologists Interpret Phylogenetic Trees?
511(1)
How Do Biologists Estimate Phylogenies?
512(2)
How Can Biologists Use Phylogenetic Trees to Study the History of Life?
514(1)
Case Study: Where Do Whales Belong on the Tree of Life?
515(2)
25.2 Tools for Studying Life's History: The Fossil Record
517(4)
Biologists Study Many Types of Fossils
517(1)
What Are the Opportunities and Limitations of the Fossil Record?
518(1)
How Are Fossils Used to Estimate Life's Time Line?
519(2)
25.3 Large-Scale Pattern in Life's History: Adaptive Radiation
521(4)
Why Do Adaptive Radiations Occur?
522(1)
The Cambrian Explosion
522(3)
25.4 Large-Scale Pattern in Life's History: Mass Extinction
525(2)
How Do Mass Extinctions Differ from Background Extinctions?
525(1)
The End-Permian Extinction
525(1)
The End-Cretaceous Extinction
526(1)
The Sixth Mass Extinction
527(1)
Review
527(3)
End-Of-Unit Case Study: Are Garter Snakes and Newts Engaged in an Arms Race?
530(2)
Big Picture: Evolution
532(2)
Unit 5 The Diversification Of Life 534(190)
26 Bacteria and Archaea
534(21)
26.1 Why Do Biologists Study Bacteria and Archaea?
535(4)
Biological Impact
535(1)
Some Prokaryotes Thrive in Extreme Environments
536(1)
Medical Importance
536(2)
Role in Bioremediation
538(1)
26.2 How Do Biologists Study Bacteria and Archaea?
539(2)
Using Enrichment Cultures
539(1)
Using Metagenomics
540(1)
Investigating the Human Microbiome
540(1)
Evaluating Molecular Phylogenies
541(1)
26.3 What Themes Occur in the Diversification of Bacteria and Archaea?
541(9)
Genetic Variation through Gene Transfer
541(2)
Morphological Diversity
543(1)
Metabolic Diversity
544(3)
Ecological Diversity and Global Impacts
547(3)
26.4 Key Lineages of Bacteria and Archaea
550(3)
Bacteria
550(1)
Archaea
550(3)
Review
553(2)
27 Diversification of Eukaryotes
555(22)
27.1 Why Do Biologists Study Protists?
556(3)
Impacts on Human Health and Welfare
556(2)
Ecological Importance of Protists
558(1)
27.2 How Do Biologists Study Protists?
559(3)
Microscopy: Studying Cell Structure
560(1)
Evaluating Molecular Phylogenies
560(1)
Discovering New Lineages via Direct Sequencing
561(1)
27.3 What Themes Occur in the Diversification of Protists?
562(9)
What Morphological Innovations Evolved in Protists?
562(4)
How Do Protists Obtain Food?
566(1)
How Do Protists Move?
567(1)
How Do Protists Reproduce?
568(3)
27.4 Key Lineages of Eukaryotes
571(4)
Amoebozoa
571(1)
Opisthokonta
571(1)
Excavata
571(1)
Plantae
572(1)
Rhizaria
573(1)
Alveolata
573(1)
Stramenopila (Heterokonta)
574(1)
Review
575(2)
28 Green Algae and Land Plants
577(29)
28.1 Why Do Biologists Study Green Algae and Land Plants?
578(2)
Plants Provide Ecosystem Services
578(1)
Plants Provide Humans with Food, Fuel, Fiber, Building Materials, and Medicines
579(1)
28.2 How Do Biologists Study Green Algae and Land Plants?
580(4)
Analyzing Morphological Traits
580(2)
Using the Fossil Record
582(1)
Evaluating Molecular Phylogenies
583(1)
28.3 What Themes Occur in the Diversification of Land Plants?
584(13)
The Transition to Land I: How Did Plants Adapt to Dry Conditions with Intense Sunlight?
584(3)
Mapping Evolutionary Changes on the Phylogenetic Tree
587(1)
The Transition to Land II: How Do Plants Reproduce in Dry Conditions?
587(9)
The Angiosperm Radiation
596(1)
28.4 Key Lineages of Green Algae and Land Plants
597(7)
Green Algae
598(1)
Nonvascular Plants
598(1)
Seedless Vascular Plants
598(1)
Seed Plants: Gymnosperms and Angiosperms
598(6)
Review
604(2)
29 Fungi
606(23)
29.1 Why Do Biologists Study Fungi?
607(2)
Fungi Have Important Economic and Ecological Impacts
607(1)
Mycorrhizal Fungi Provide Nutrients for Land Plants
608(1)
Saprophytic Fungi Accelerate the Carbon Cycle on Land
609(1)
29.2 How Do Biologists Study Fungi?
609(5)
Analyzing Morphological Traits
610(2)
Evaluating Molecular Phylogenies
612(2)
29.3 What Themes Occur in the Diversification of Fungi?
614(10)
Fungi Often Participate in Symbioses
615(3)
What Adaptations Make Fungi Such Effective Decomposers?
618(1)
Variation in Reproduction
619(2)
Four Major Types of Life Cycles
621(3)
29.4 Key Lineages of Fungi
624(2)
Microsporidia
624(1)
Chytrids
625(1)
Zygomycetes
625(1)
Glomeromycota
626(1)
Basidiomycota
626(1)
Ascomycota
626(1)
Review
626(3)
30 An Introduction to Animals
629(21)
30.1 What Is an Animal?
630(1)
30.2 What Key Innovations Occurred during the Origin of Animal Phyla?
631(8)
Origin of Multicellularity
632(2)
Origin of Embryonic Tissue Layers and Muscle
634(1)
Origin of Bilateral Symmetry, Cephalization, and the Nervous System
635(2)
Origin of the Gut and Coelom
637(1)
Origin of Protostomes and Deuterostomes
638(1)
Origin of Segmentation
639(1)
30.3 What Themes Occur in the Diversification within Animal Phyla?
639(7)
Sensory Organs
640(1)
Feeding
641(1)
Movement
642(2)
Reproduction
644(1)
Life Cycles
645(1)
30.4 Key Lineages of Animals: Non-Bilaterian Groups
646(2)
Porifera (Sponges)
646(1)
Ctenophora (Comb Jellies)
647(1)
Cnidaria (Jellyfish, Corals, Anemones, Hydroids)
647(1)
Review
648(2)
31 Protostome Animals
650(22)
31.1 What Is a Protostome?
651(3)
The Water-to-Land Transition
652(1)
Compartmentalized and Flexible Body Plans
653(1)
31.2 What Is a Lophotrochozoan?
654(7)
What Is a Flatworm?
655(2)
What Is a Segmented Worm?
657(1)
What Is a Mollusk?
658(3)
31.3 What Is an Ecdysozoan?
661(9)
What Is a Roundworm?
662(1)
What Are Water Bears and Velvet Worms?
663(1)
What Is an Arthropod?
663(2)
Arthropod Diversity
665(3)
Arthropod Metamorphosis
668(1)
Take-Home Messages
669(1)
Review
670(2)
32 Deuterostome Animals
672(27)
32.1 What Is a Deuterostome?
673(1)
32.2 What Is an Echinoderm?
674(2)
The Echinoderm Body Plan
674(1)
Echinoderms Are Important Consumers
674(2)
32.3 What Is a Chordate?
676(2)
The Cephalochordates
676(1)
The Urochordates
677(1)
The Vertebrates
678(1)
32.4 What Is a Vertebrate?
678(1)
32.5 What Key Innovations Occurred during the Evolution of Vertebrates?
679(11)
Urochordates: Sister Group to Vertebrates
679(1)
First Vertebrates: Origin of the Cranium and Vertebrae
679(2)
Gnathostomes: Origin of the Vertebrate Jaw
681(2)
Origin of the Bony Endoskeleton
683(1)
Origin of the Lungs
683(1)
Tetrapods: Origin of the Limb
684(1)
Amniotes: Origin of the Amniotic Egg
685(1)
Mammals: Origin of Lactation and Fur
686(1)
Reptiles: Origin of Scales and Feathers Made of Keratin
687(2)
Parental Care
689(1)
Take-Home Messages
690(1)
32.6 The Primates and Hominins
690(7)
The Primates
690(2)
Fossil Humans
692(3)
The Out-of-Africa Hypothesis
695(1)
Have Humans Stopped Evolving?
696(1)
Review
697(2)
33 Viruses
699(21)
33.1 Why Do Biologists Study Viruses?
700(3)
Viruses Shape the Evolution of Organisms
700(1)
Viruses Cause Disease
700(2)
Current Viral Pandemics in Humans: AIDS
702(1)
33.2 How Do Biologists Study Viruses?
703(9)
Analyzing Morphological Traits
703(1)
Analyzing the Genetic Material
704(1)
Analyzing the Phases of Replicative Growth
705(6)
Analyzing How Viruses Can Coexist with Host Cells
711(1)
33.3 What Themes Occur in the Diversification of Viruses?
712(2)
Where Did Viruses Come From?
712(1)
Emerging Viruses, Emerging Diseases
712(2)
33.4 Key Lineages of Viruses
714(4)
Review
718(2)
End-Of-Unit Case Study: Are Newts Adapted to Kill Humans?
720(2)
Big Picture: Diversity of Life
722(2)
Unit 6 How Plants Work 724(116)
34 Plant Form and Function
724(23)
34.1 Plant Form: Themes with Many Variations
725(8)
The Importance of Surface Area to Volume Relationships
726(1)
The Root System
726(2)
The Shoot System
728(2)
The Leaf
730(3)
34.2 Plant Cells and Tissue Systems
733(5)
The Dermal Tissue System
734(1)
The Ground Tissue System
734(2)
The Vascular Tissue System
736(2)
34.3 Primary Growth Extends the Plant Body
738(3)
How Do Apical Meristems Produce the Primary Plant Body?
738(2)
How Is the Primary Root System Organized?
740(1)
How Is the Primary Shoot System Organized?
741(1)
34.4 Secondary Growth Widens Shoots and Roots
741(4)
What Is a Cambium?
742(1)
How Does a Cambium Initiate Secondary Growth?
743(1)
What Do Vascular Cambia Produce?
743(1)
What Do Cork Cambia Produce?
744(1)
The Structure of Tree Trunks
744(1)
Review
745(2)
35 Water and Sugar Transport in Plants
747(20)
35.1 Water Potential and Water Movement
748(4)
What Is Water Potential?
748(1)
What Factors Affect Water Potential?
748(1)
Working with Water Potentials
749(1)
Water Potentials in Soils, Plants, and the Atmosphere
750(2)
35.2 How Does Water Move from Roots to Shoots?
752(6)
Movement of Water and Solutes into the Root
752(2)
Water Movement via Root Pressure
754(1)
Water Movement via Capillary Action
754(1)
The Cohesion-Tension Theory
755(2)
Plant Features That Reduce Water Loss through Transpiration
757(1)
35.3 Translocation of Sugars
758(7)
Tracing Connections between Sources and Sinks
759(1)
The Anatomy of Phloem
760(1)
The Pressure-Flow Hypothesis
760(2)
Phloem Loading
762(2)
Phloem Unloading
764(1)
Review
765(2)
36 Plant Nutrition
767(18)
36.1 Nutritional Requirements of Plants
768(3)
Which Nutrients Are Essential?
768(2)
What Happens When Key Nutrients Are in Short Supply?
770(1)
36.2 Soil: A Dynamic Mixture of Living and Nonliving Components
771(3)
The Importance of Soil Conservation
772(1)
What Factors Affect Nutrient Availability?
773(1)
36.3 Nutrient Uptake
774(4)
Mechanisms of Nutrient Uptake
774(2)
Mechanisms of Ion Exclusion
776(2)
36.4 Nitrogen Fixation
778(3)
The Role of Symbiotic Bacteria
779(1)
What Is the Relationship between Plants and Nitrogen-Fixing Bacteria?
779(2)
36.5 Nutritional Adaptations of Plants
781(2)
Parasitic Plants
781(1)
Epiphytic Plants
781(1)
Carnivorous Plants
781(2)
Review
783(2)
37 Plant Sensory Systems, Signals, and Responses
785(28)
37.1 Information Processing in Plants
786(2)
How Do Cells Receive and Process an External Signal?
786(1)
How Do Cells Respond to Cell-Cell Signals?
786(2)
37.2 Blue Light: The Phototropic Response
788(4)
Phototropins as Blue-Light Receptors
788(1)
Auxin as the Phototropic Hormone
789(3)
37.3 Red and Far-Red Light: Germination, Stem Elongation, and Flowering
792(3)
The Red/Far-Red "Switch"
792(1)
Phytochrome Is a Red/Far-Red Receptor
792(1)
Signals That Promote Flowering
793(2)
37.4 Gravity: The Gravitropic Response
795(2)
The Statolith Hypothesis
795(1)
Auxin as the Gravitropic Signal
796(1)
37.5 How Do Plants Respond to Wind and Touch?
797(1)
Changes in Growth Patterns
797(1)
Movement Responses
797(1)
37.6 Youth, Maturity, and Aging: The Growth Responses
798(8)
Auxin and Apical Dominance
798(1)
Cytokinins and Cell Division
799(1)
Gibberellins and ABA: Growth and Dormancy
799(3)
Brassinosteroids and Body Size
802(1)
Ethylene and Senescence
803(1)
An Overview of Plant Growth Regulators
804(2)
37.7 Pathogens and Herbivores: The Defense Responses
806(4)
How Do Plants Sense and Respond to Pathogens?
806(2)
How Do Plants Sense and Respond to Herbivore Attack?
808(2)
Review
810(3)
38 Flowering Plant Reproduction and Development
813(23)
38.1 An Introduction to Flowering Plant Reproduction
814(2)
Asexual Reproduction
814(1)
Sexual Reproduction and the Flowering Plant Life Cycle
815(1)
38.2 Reproductive Structures
816(4)
The General Structure of the Flower
816(2)
How Are Female Gametophytes Produced?
818(1)
How Are Male Gametophytes Produced?
819(1)
38.3 Pollination and Fertilization
820(3)
Pollination
820(2)
Fertilization
822(1)
38.4 Seeds and Fruits
823(4)
Seed Maturation
823(1)
Fruit Development and Seed Dispersal
824(2)
Seed Dormancy
826(1)
Seed Germination
826(1)
38.5 Embryogenesis and Vegetative Development
827(4)
Embryogenesis
828(1)
Meristem Formation
829(1)
Which Genes Determine Body Axes in the Plant Embryo?
829(1)
Which Genes Determine Leaf Structure and Shape?
830(1)
38.6 Reproductive Development
831(2)
The Floral Meristem and the Flower
831(1)
The Genetic Control of Flower Structures
832(1)
Review
833(3)
End-Of-Unit Case Study: Can Plant Compounds Perform a Role Similar to Tetrodotoxin?
836(2)
Big Picture: Plant and Animal Form and Function
838(2)
Unit 7 How Animals Work 840(214)
39 Animal Form and Function
840(18)
39.1 Form, Function, and Adaptation
841(2)
The Role of Fitness Trade-Offs
841(2)
Adaptation and Acclimatization
843(1)
39.2 Tissues, Organs, and Organ Systems: How Does Structure Correlate with Function?
843(5)
Structure-Function Relationships at the Molecular and Cellular Levels
844(1)
Tissues Are Groups of Cells That Function as a Unit
844(3)
Organs and Organ Systems
847(1)
39.3 How Does Body Size Affect Animal Physiology?
848(3)
Surface Area to Volume Relationships: Theory
848(1)
Surface Area to Volume Relationships: Data
849(1)
Adaptations That Increase Surface Area
850(1)
39.4 Homeostasis
851(2)
Homeostasis: General Principles
851(1)
The Role of Regulation and Feedback
851(2)
39.5 Thermoregulation: A Closer Look
853(3)
Mechanisms of Heat Exchange
853(1)
Thermoregulatory Strategies
853(1)
Comparing Endothermy and Ectothermy
854(1)
Countercurrent Heat Exchangers
855(1)
Review
856(2)
40 Water and Electrolyte Balance in Animals
858(19)
40.1 Osmoregulation and Excretion
859(3)
What Is Osmotic Stress?
859(1)
Osmotic Stress in Seawater, in Fresh Water, and on Land
859(1)
How Do Electrolytes and Water Move across Cell Membranes?
860(1)
How Do Different Forms of Nitrogenous Waste Impact Water Balance?
861(1)
40.2 Water and Electrolyte Balance in Marine and Freshwater Fishes
862(2)
Osmoconformation versus Osmoregulation in Marine Fishes
862(1)
How Do Sharks Excrete Salt?
862(2)
How Do Freshwater Fishes Osmoregulate?
864(1)
40.3 Water and Electrolyte Balance in Terrestrial Insects
864(2)
How Do Insects Minimize Water Loss from the Body Surface?
865(1)
How Do Insects Regulate the Amount of Water and Electrolytes They Excrete?
865(1)
40.4 Water and Electrolyte Balance in Terrestrial Vertebrates
866(9)
Structure of the Mammalian Kidney
866(1)
Function of the Mammalian Kidney: An Overview
867(1)
Filtration: The Renal Corpuscle
868(1)
Reabsorption: The Proximal Tubule
868(2)
Creating an Osmotic Gradient: The Loop of Henle
870(2)
Regulating Water and Electrolyte Balance: The Distal Tubule and Collecting Duct
872(1)
Urine Formation in Nonmammalian Vertebrates
873(2)
Review
875(2)
41 Animal Nutrition
877(19)
41.1 Nutritional Requirements
878(2)
41.2 Capturing Food: The Structure and Function of Mouthparts
880(1)
Mouthparts as Adaptations
880(1)
A Case Study: The Cichlid Throat Jaw
880(1)
41.3 The Structure and Function of Animal Digestive Tracts
881(10)
An Introduction to the Digestive Tract
881(1)
An Overview of Digestive Processes
882(1)
The Mouth and Esophagus: Digestion and Ingestion
883(1)
The Stomach: Digestion
884(2)
The Small Intestine: Digestion and Absorption
886(5)
The Large Intestine: Absorption and Elimination
891(1)
41.4 Nutritional Homeostasis-Glucose as a Case Study
891(2)
Insulin's Role in Glucose Homeostasis
891(1)
Diabetes Mellitus Has Two Forms
892(1)
The Type 2 Diabetes Mellitus Epidemic
892(1)
Review
893(3)
42 Gas Exchange and Circulation
896(25)
42.1 The Respiratory and Circulatory Systems
897(1)
42.2 Air and Water as Respiratory Media
897(2)
How Do Oxygen and Carbon Dioxide Behave in Air?
898(1)
How Do Oxygen and Carbon Dioxide Behave in Water?
898(1)
42.3 Organs of Gas Exchange
899(6)
Physical Parameters: The Law of Diffusion
899(1)
How Do Gills Work?
900(1)
How Do Insect Tracheae Work?
901(2)
How Do Vertebrate Lungs Work?
903(1)
Homeostatic Control of Ventilation
904(1)
42.4 How Are Oxygen and Carbon Dioxide Transported in Blood?
905(3)
Structure and Function of Hemoglobin
905(3)
CO2 Transport and the Buffering of Blood pH
908(1)
42.5 Circulation
908(10)
What Is an Open Circulatory System?
909(1)
What Is a Closed Circulatory System?
909(3)
How Does the Heart Work?
912(4)
Patterns in Blood Pressure and Blood Flow
916(2)
Review
918(3)
43 Animal Nervous Systems
921(23)
43.1 Principles of Electrical Signaling
922(4)
Types of Neurons
922(1)
The Anatomy of a Neuron
923(1)
An Introduction to Membrane Potentials
923(1)
How Is the Resting Potential Maintained?
924(1)
Using Electrodes to Measure Membrane Potentials
925(1)
What Is an Action Potential?
925(1)
43.2 Dissecting the Action Potential
926(4)
Distinct Ion Currents Are Responsible for Depolarization and Repolarization
926(1)
How Do Voltage-Gated Channels Work?
926(2)
How Is the Action Potential Propagated?
928(2)
43.3 The Synapse
930(4)
Synapse Structure and Neurotransmitter Release
930(1)
What Do Neurotransmitters Do?
931(1)
Postsynaptic Potentials
932(2)
43.4 The Vertebrate Nervous System
934(7)
What Does the Peripheral Nervous System Do?
934(1)
Functional Anatomy of the CNS
934(4)
How Do Learning and Memory Work?
938(3)
Review
941(3)
44 Animal Sensory Systems
944(20)
44.1 How Do Sensory Organs Convey Information to the Brain?
945(1)
Sensory Transduction
945(1)
Transmitting Information to the Brain
946(1)
44.2 Mechanoreception: Sensing Pressure Changes
946(6)
How Do Sensory Cells Respond to Sound Waves and Other Forms of Pressure?
947(1)
The Mammalian Ear: Hearing
948(2)
The Mammalian Ear: Equilibrium
950(1)
Sensing Pressure Changes in Water
950(2)
44.3 Photoreception: Sensing Light
952(4)
The Insect Eye
952(1)
The Vertebrate Eye
952(4)
44.4 Chemoreception: Sensing Chemicals
956(3)
Taste: Detecting Molecules in the Mouth
956(1)
Olfaction: Detecting Molecules in the Air
957(2)
44.5 Other Sensory Systems
959(2)
Thermoreception: Sensing Temperature
959(1)
Electroreception: Sensing Electric Fields
960(1)
Magnetoreception: Sensing Magnetic Fields
960(1)
Review
961(3)
45 Animal Movement
964(19)
45.1 How Do Muscles Contract?
965(4)
Early Muscle Experiments
965(1)
The Sliding-Filament Model
965(1)
How Do Actin and Myosin Interact?
966(2)
How Do Neurons Initiate Contraction?
968(1)
45.2 Classes of Muscle Tissue
969(3)
Smooth Muscle
969(1)
Cardiac Muscle
969(1)
Skeletal Muscle
970(2)
45.3 Skeletal Systems
972(4)
Hydrostatic Skeletons (Hydrostats)
973(1)
Endoskeletons
974(1)
Exoskeletons
975(1)
45.4 Locomotion
976(5)
How Do Biologists Study Locomotion?
976(3)
Size Matters
979(2)
Review
981(2)
46 Chemical Signals in Animals
983(20)
46.1 Cell-to-Cell Signaling: An Overview
984(4)
Major Categories of Chemical Signals
984(1)
Hormone Signaling Pathways
985(2)
What Structures Make Up the Endocrine System?
987(1)
How Do Researchers Identify a Hormone?
987(1)
A Breakthrough in Measuring Hormone Levels
988(1)
46.2 How Do Hormones Act on Target Cells?
988(4)
Hormone Concentrations Are Small, but Their Effects Are Large
988(1)
The Three Chemical Classes of Hormones
988(1)
Steroid Hormones Bind to Intracellular Receptors
989(1)
Polypeptide Hormones Bind to Receptors on the Plasma Membrane
990(2)
Why Do Different Target Cells Respond in Different Ways?
992(1)
46.3 What Do Hormones Do?
992(5)
How Do Hormones Direct Developmental Processes?
992(3)
How Do Hormones Coordinate Responses to Stressors?
995(1)
How Are Hormones Involved in Homeostasis?
996(1)
46.4 How Is the Production of Hormones Regulated?
997(3)
The Hypothalamus and Pituitary Gland
998(2)
Control of Epinephrine by Sympathetic Nerves
1000(1)
Review
1000(3)
47 Animal Reproduction and Development
1003(27)
47.1 Asexual and Sexual Reproduction
1004(4)
How Does Asexual Reproduction Occur?
1004(1)
Switching Reproductive Modes in Daphnia: A Case History
1004(1)
Mechanisms of Sexual Reproduction: Gametogenesis
1005(3)
47.2 Reproductive Structures and Their Functions
1008(3)
The Male Reproductive System
1009(1)
The Female Reproductive System
1009(2)
47.3 Fertilization and Egg Development
1011(5)
External Fertilization
1011(1)
Internal Fertilization
1012(1)
The Cell Biology of Fertilization
1013(1)
Why Do Some Females Lay Eggs, while Others Give Birth to Live Offspring?
1014(2)
47.4 Embryonic Development
1016(5)
Cleavage
1016(1)
Gastrulation
1017(1)
Organogenesis
1018(3)
47.5 The Role of Sex Hormones in Mammalian Reproduction
1021(4)
Which Hormones Control Puberty?
1021(1)
Which Hormones Control the Menstrual Cycle in Humans?
1022(3)
47.6 Pregnancy and Birth in Mammals
1025(3)
Gestation and Development in Marsupials
1025(1)
Major Events during Human Pregnancy
1025(1)
How Does the Mother Exchange Materials with the Fetus?
1026(1)
Birth
1027(1)
Review
1028(2)
48 The Immune System in Animals
1030(22)
48.1 Innate Immunity: First Response
1031(4)
Barriers to Entry
1031(1)
The Innate Immune Response
1032(3)
48.2 Adaptive Immunity: Recognition
1035(5)
An Introduction to Lymphocytes
1035(1)
Lymphocytes Recognize a Diverse Array of Antigens
1036(3)
How Does the Immune System Distinguish Self from Nonself?
1039(1)
48.3 Adaptive Immunity: Activation
1040(4)
The Clonal Selection Theory
1040(1)
T-Cell Activation
1040(2)
B-Cell Activation and Antibody Secretion
1042(2)
48.4 Adaptive Immunity: Response and Memory
1044(4)
How Are Extracellular Pathogens Eliminated? The Humoral Response
1044(1)
How Are Intracellular Pathogens Eliminated? The Cell-Mediated Response
1044(2)
Why Does the Immune System Reject Foreign Tissues and Organs?
1046(1)
Responding to Future Infections: Immunological Memory
1046(2)
48.5 What Happens When the Immune System Doesn't Work Correctly?
1048(1)
Allergies
1048(1)
Autoimmune Diseases
1048(1)
Immunodeficiency Diseases
1049(1)
Review
1049(3)
End-Of-Unit Case Study: Do Garter Snakes Resistant to TTX Experience Trade-Offs?
1052(2)
Unit 8 Ecology 1054
49 An Introduction to Ecology
1054(22)
49.1 Levels of Ecological Study
1055(2)
Organismal Ecology
1055(1)
Population Ecology
1056(1)
Community Ecology
1056(1)
Ecosystem Ecology
1056(1)
Global Ecology
1056(1)
Conservation Biology Applies All Levels of Ecological Study
1056(1)
49.2 What Determines the Distribution and Abundance of Organisms?
1057(4)
Present Abiotic Factors
1057(1)
Present Biotic Factors
1058(1)
Past Abiotic Factors
1059(1)
Past Biotic Factors
1059(1)
Looking to the Future
1060(1)
49.3 Climate Patterns
1061(3)
Why Are the Tropics Warm and the Poles Cold?
1061(1)
Why Are the Tropics Wet?
1061(1)
What Causes Seasonality in Weather?
1062(1)
What Regional Effects Do Mountains and Oceans Have on Climate?
1063(1)
Do Biotic Factors Affect Climate?
1064(1)
49.4 Types of Terrestrial Biomes
1064(5)
What Are the Major Natural Terrestrial Biomes?
1064(3)
Human Land Use Is Displacing Natural Biomes
1067(1)
How Is Global Climate Change Affecting Terrestrial Biomes?
1067(2)
49.5 Types of Aquatic Biomes
1069(5)
Salinity
1069(1)
Water Depth and Sunlight Availability
1069(1)
Water Flow
1070(1)
Nutrient Availability
1071(1)
How Are Aquatic Biomes Affected by Humans?
1072(2)
Review
1074(2)
50 Behavioral Ecology
1076(19)
50.1 An Introduction to Behavioral Ecology
1077(2)
Proximate and Ultimate Causation
1077(1)
Types of Behavior: An Overview
1078(1)
Choices Involve Trade-Offs
1079(1)
50.2 Choosing What, How, and When to Eat
1079(3)
Proximate Causes: Foraging Alleles in Drosophila melanogaster
1079(1)
Ultimate Causes: Optimal Foraging
1080(2)
50.3 Choosing a Mate
1082(2)
Proximate Causes: How is Sexual Activity Triggered in Anolis Lizards?
1083(1)
Ultimate Causes: Sexual Selection
1083(1)
50.4 Choosing Where to Go
1084(2)
Proximate Causes: How Do Animals Navigate?
1084(2)
Ultimate Causes: Why Do Animals Migrate?
1086(1)
50.5 Communicating with Others
1086(3)
Proximate Causes: How Do Honeybees Communicate?
1087(1)
Ultimate Causes: Why Do Honeybees Communicate the Way They Do?
1088(1)
When is Communication Honest or Deceitful?
1088(1)
50.6 Cooperating with Others
1089(4)
Kin Selection
1089(1)
Quantitative Methods: Calculating the Coefficient of Relatedness
1089(2)
Manipulation
1091(1)
Reciprocal Altruism
1091(1)
Cooperation and Mutualism
1092(1)
Individuals Do Not Act for the Good of the Species
1092(1)
Take-Home Messages
1092(1)
Review
1093(2)
51 Population Ecology
1095(22)
51.1 Distribution and Abundance
1096(2)
Geographic Distribution
1096(1)
Sampling Methods
1097(1)
Quantitative Methods: Mark-Recapture Studies
1098(1)
51.2 Demography and Life History
1098(5)
Life Tables
1099(2)
The Role of Life History
1101(1)
Quantitative Methods: Using Life Tables to Calculate Population Growth Rates
1101(2)
51.3 Population Growth
1103(5)
Exponential Growth
1103(2)
Quantitative Methods: Using Growth Models to Predict Population Growth
1105(1)
Logistic Growth
1106(1)
What Factors Limit Population Size?
1107(1)
51.4 Population Dynamics
1108(4)
Why Do Some Populations Crash?
1108(1)
Why Do Some Populations Cycle?
1108(2)
How Do Metapopulations Change through Time?
1110(2)
51.5 Case Study: Human Population Growth
1112(2)
Age Structure in Human Populations
1112(1)
Analyzing Change in the Growth Rate of Human Populations
1113(1)
Take-Home Messages
1114(1)
Review
1114(3)
52 Community Ecology
1117(24)
52.1 Species Interactions
1118(10)
Species Interaction: Commensalism
1118(1)
Species Interaction: Competition
1118(4)
Species Interaction: Consumption
1122(3)
Species Interactions: Mutualism
1125(2)
Take-Home Messages
1127(1)
52.2 Community Structure
1128(5)
How Many Species Occur in Communities?
1128(1)
How Do Species Interactions Form Networks?
1128(1)
Quantitative Methods: Measuring Species Diversity
1129(1)
Why Are Some Species More Important than Others in Structuring Communities?
1130(1)
How Predictable Are Communities?
1131(2)
52.3 Community Dynamics
1133(3)
Disturbance and Change in Ecological Communities
1133(1)
Succession: The Development of Communities after Disturbance
1134(2)
52.4 Geographic Patterns in Species Richness
1136(3)
Predicting Species Richness: The Theory of Island Biogeography
1137(1)
Global Patterns in Species Richness
1138(1)
Review
1139(2)
53 Ecosystems and Global Ecology
1141(24)
53.1 How Does Energy Flow through Ecosystems?
1142(7)
How Efficient Are Autotrophs at Capturing Solar Energy?
1142(1)
What Happens to the Biomass of Autotrophs?
1143(2)
Energy Transfer between Trophic Levels
1145(2)
Global Patterns in Productivity
1147(2)
53.2 How Do Nutrients Cycle through Ecosystems?
1149(6)
Nutrient Cycling within Ecosystems
1149(2)
Global Biogeochemical Cycles
1151(4)
53.3 Global Climate Change
1155(8)
What Is the Cause of Global Climate Change?
1155(2)
How Much Is the Climate Changing?
1157(2)
Biological Effects of Climate Change
1159(2)
Consequences to Net Primary Productivity
1161(2)
Review
1163(2)
54 Biodiversity and Conservation Biology
1165(23)
54.1 What Is Biodiversity?
1166(4)
Biodiversity Can Be Measured and Analyzed at Several Levels
1166(2)
How Many Species Are Living Today?
1168(1)
Where Is Biodiversity Highest?
1168(2)
54.2 Threats to Biodiversity and Ecosystem Function
1170(7)
Multiple Interacting Threats
1171(4)
How Will These Threats Affect Future Extinction Rates?
1175(1)
Quantitative Methods: Species-Area Plots
1176(1)
54.3 Why Are Biodiversity and Ecosystem Function Important?
1177(4)
Biological Benefits of Biodiversity and Ecosystem Function
1177(2)
Ecosystem Services: Economic and Social Benefits of Biodiversity and Ecosystems
1179(2)
An Ethical Dimension
1181(1)
54.4 Preserving Biodiversity and Ecosystem Function
1181(5)
Addressing the Ultimate Causes of Loss
1182(1)
Conservation Strategies to Preserve Genetic Diversity, Species, and Ecosystem Function
1182(3)
Take-Home Message
1185(1)
Review
1186(2)
End-Of-Unit Case Study: What Is the Larger Ecological Context of Toxic Newts?
1188(2)
Big Picture: Ecology
1190
Appendix A Answers A-1
Appendix B Periodic Table of Elements B-1
Glossary G-1
Credits CR-1
Index I-1