|
|
xiii | |
Preface |
|
xix | |
|
Part I Biomaterials for Oral and Dental Tissue Engineering |
|
|
1 | (154) |
|
1 Introduction to oral and dental tissue engineering |
|
|
3 | (4) |
|
|
|
|
5 | (2) |
|
2 Bioactive glasses and calcium phosphates |
|
|
7 | (18) |
|
|
|
|
|
|
Morteza Rasoulianboroujeni |
|
|
|
|
7 | (1) |
|
|
8 | (5) |
|
|
13 | (4) |
|
|
17 | (8) |
|
|
17 | (8) |
|
3 Polymers for oral and dental tissue engineering |
|
|
25 | (22) |
|
|
|
|
|
|
25 | (1) |
|
3.2 Different types of polymeric scaffolds |
|
|
25 | (9) |
|
3.3 Methods for scaffold fabrication |
|
|
34 | (5) |
|
|
39 | (8) |
|
|
39 | (8) |
|
4 Hydrogels in craniofacial tissue engineering |
|
|
47 | (18) |
|
|
|
|
|
|
|
47 | (1) |
|
4.2 Hydrogel biomaterials |
|
|
48 | (10) |
|
4.3 Summary: current status and future prospects |
|
|
58 | (7) |
|
|
58 | (7) |
|
|
65 | (20) |
|
|
|
|
|
|
|
|
|
|
65 | (1) |
|
5.2 Classification of biocomposites |
|
|
65 | (2) |
|
5.3 Natural biocomposites |
|
|
67 | (1) |
|
5.4 Synthetic biocomposites |
|
|
68 | (1) |
|
5.5 Unique properties and adaptability of biocomposites |
|
|
69 | (3) |
|
5.6 Applications of biocomposites materials in dentistry |
|
|
72 | (1) |
|
5.7 Restorative applications |
|
|
73 | (1) |
|
|
73 | (3) |
|
5.9 Allogeneic bone grafts |
|
|
76 | (1) |
|
|
76 | (1) |
|
|
77 | (1) |
|
5.12 Shortcomings of existing biocomposites and recent developments |
|
|
77 | (3) |
|
|
80 | (5) |
|
|
80 | (4) |
|
|
84 | (1) |
|
6 Surface modification of dental implants |
|
|
85 | (12) |
|
|
|
|
Morteza Rasoulianboroujeni |
|
|
|
|
|
85 | (1) |
|
6.2 Surface treatment methods |
|
|
86 | (4) |
|
6.3 Prospective surface modification methods |
|
|
90 | (4) |
|
|
94 | (3) |
|
|
94 | (3) |
|
7 Characterization of biomaterials |
|
|
97 | (20) |
|
|
|
|
|
|
|
|
|
|
|
|
97 | (1) |
|
7.2 Chemical characterization techniques |
|
|
97 | (5) |
|
7.3 Physical characterizations techniques |
|
|
102 | (6) |
|
7.4 Biological characterization technique |
|
|
108 | (9) |
|
|
112 | (1) |
|
|
112 | (5) |
|
8 Biocompatibility of dental biomaterials |
|
|
117 | (24) |
|
|
|
|
|
117 | (1) |
|
8.2 Concepts of biocompatibility testing |
|
|
117 | (1) |
|
|
118 | (3) |
|
|
121 | (2) |
|
|
123 | (1) |
|
8.6 Combining in vitro, animal, and usage tests together |
|
|
124 | (2) |
|
8.7 Biomaterials for tissue engineering |
|
|
126 | (9) |
|
|
135 | (6) |
|
|
135 | (6) |
|
9 Processing and preservation of biomaterials and regulatory issues |
|
|
141 | (14) |
|
|
|
141 | (1) |
|
9.2 Processing of biomaterials |
|
|
142 | (3) |
|
9.3 Sterilization of biomaterials |
|
|
145 | (1) |
|
9.4 Preservation and storage |
|
|
146 | (1) |
|
|
147 | (2) |
|
|
149 | (6) |
|
|
150 | (5) |
|
Part II Tissue Engineering Strategies |
|
|
155 | (66) |
|
10 Specific considerations in scaffold design for oral tissue engineering |
|
|
157 | (28) |
|
|
|
Morteza Rasoulianboroujeni |
|
|
|
|
|
|
|
|
157 | (1) |
|
10.2 Scaffold fabrication techniques |
|
|
158 | (11) |
|
10.3 Multi-tissue scaffolds for oral and dental regeneration |
|
|
169 | (4) |
|
10.4 Applications of scaffolds in oral tissue engineering |
|
|
173 | (4) |
|
|
177 | (8) |
|
|
178 | (7) |
|
11 Stem cells from oral and maxillofacial tissues |
|
|
185 | (8) |
|
|
|
|
Morteza Rasoulianboroujeni |
|
|
|
|
185 | (1) |
|
11.2 Types of stem cells extracted from oral and maxillofacial tissues dental pulp stem cells |
|
|
186 | (1) |
|
11.3 Application of clinically relevant stem cells in oral and maxillofacial surgery |
|
|
187 | (1) |
|
|
188 | (5) |
|
|
189 | (4) |
|
12 Bioreactor design for oral and dental tissue engineering |
|
|
193 | (12) |
|
|
|
|
|
193 | (1) |
|
12.2 Fundamentals of bioreactors and bioreactor design |
|
|
194 | (2) |
|
12.3 Different types of bioreactors |
|
|
196 | (1) |
|
12.4 Application of bioreactors for tissue engineering of oral tissue |
|
|
197 | (4) |
|
|
201 | (4) |
|
|
201 | (4) |
|
13 Growth factors for oral and maxillofacial regeneration applications |
|
|
205 | (16) |
|
|
Morteza Rasoulianboroujeni |
|
|
|
|
|
|
205 | (1) |
|
13.2 Platelet-derived growth factor |
|
|
206 | (1) |
|
13.3 Insulin-like growth factors |
|
|
207 | (1) |
|
13.4 Transforming growth factor beta |
|
|
208 | (1) |
|
13.5 Bone morphogenic proteins |
|
|
209 | (2) |
|
13.6 Platelet rich plasma |
|
|
211 | (1) |
|
13.7 Vascular endothelial growth factor |
|
|
212 | (1) |
|
|
213 | (8) |
|
|
213 | (8) |
|
Part III Oral and Dental Soft Tissue Engineering |
|
|
221 | (164) |
|
14 Oral mucosa tissue engineering |
|
|
223 | (22) |
|
|
|
223 | (1) |
|
14.2 Normal human oral mucosa |
|
|
223 | (1) |
|
14.3 Split-thickness oral mucosa engineering |
|
|
224 | (1) |
|
14.4 Full-thickness oral mucosa engineering |
|
|
225 | (7) |
|
14.5 Applications of tissue-engineered oral mucosa |
|
|
232 | (5) |
|
|
237 | (8) |
|
|
237 | (8) |
|
15 Tissue-engineered models of oral soft tissue diseases |
|
|
245 | (12) |
|
|
|
|
|
|
245 | (1) |
|
15.2 In vitro models of dysplasia and oral cancer |
|
|
245 | (2) |
|
15.3 Tissue-engineered models of radiotherapy-induced oral mucositis |
|
|
247 | (1) |
|
15.4 In vitro three-dimensional models of bisphosphonate and medication-related osteonecrosis |
|
|
247 | (1) |
|
15.5 Imaging and spectroscopic diagnostic techniques |
|
|
248 | (1) |
|
15.6 Oral candidiasis disease modeling |
|
|
249 | (1) |
|
15.7 Oral mucosal models of bacterial infection |
|
|
250 | (1) |
|
15.8 Immune response studies |
|
|
251 | (1) |
|
15.9 Drug delivery systems |
|
|
251 | (1) |
|
|
252 | (5) |
|
|
252 | (5) |
|
16 Periodontal soft tissue reconstruction |
|
|
257 | (22) |
|
|
|
|
|
257 | (1) |
|
|
257 | (2) |
|
16.3 General considerations for biomaterials in periodontal soft tissue reconstruction |
|
|
259 | (1) |
|
|
260 | (2) |
|
16.5 Xenogeneic materials |
|
|
262 | (5) |
|
16.6 Autogenous materials |
|
|
267 | (1) |
|
|
268 | (3) |
|
16.8 Alloplastic materials |
|
|
271 | (1) |
|
|
272 | (7) |
|
|
272 | (7) |
|
17 Layered scaffolds for periodontal regeneration |
|
|
279 | (18) |
|
|
|
|
|
279 | (1) |
|
17.2 Structure of periodontium |
|
|
280 | (3) |
|
17.3 Requirements of a layered scaffold for periodontal regeneration |
|
|
283 | (1) |
|
17.4 Current solutions available |
|
|
284 | (6) |
|
17.5 Conclusions, limitations, and recommendations to readers |
|
|
290 | (7) |
|
|
290 | (7) |
|
18 Dental pulp tissue engineering and regenerative endodontic therapy |
|
|
297 | (22) |
|
|
|
|
|
|
|
|
297 | (1) |
|
|
298 | (1) |
|
18.3 Regenerative endodontic procedures |
|
|
299 | (13) |
|
|
312 | (7) |
|
|
313 | (1) |
|
|
313 | (6) |
|
19 Oral nerve tissue repair and regeneration |
|
|
319 | (18) |
|
|
|
|
|
|
|
319 | (1) |
|
19.2 Peripheral neuroanatomy applicable to dentistry |
|
|
320 | (1) |
|
19.3 Nerve tissue engineering principles |
|
|
321 | (6) |
|
19.4 Applicable stem cells in oral and maxillofacial nerve repair |
|
|
327 | (2) |
|
19.5 Growth factors in oral and maxillofacial nerve repair |
|
|
329 | (1) |
|
19.6 Clinical applications and future trends |
|
|
330 | (1) |
|
|
330 | (7) |
|
|
331 | (6) |
|
20 Tissue engineering of salivary glands |
|
|
337 | (16) |
|
|
|
|
337 | (1) |
|
20.2 Salivary gland function, anatomy, and histology |
|
|
338 | (1) |
|
20.3 Salivary gland diseases and pathology |
|
|
339 | (2) |
|
20.4 Prevention and preservation of salivary glands |
|
|
341 | (1) |
|
20.5 Tissue-engineering approaches |
|
|
342 | (3) |
|
20.6 Regeneration challenges |
|
|
345 | (1) |
|
|
346 | (7) |
|
|
346 | (7) |
|
21 Facial muscle tissue engineering |
|
|
353 | (14) |
|
|
|
|
|
|
|
353 | (1) |
|
21.2 Anatomy and structure of facial muscles |
|
|
353 | (1) |
|
21.3 Tissue engineering approaches |
|
|
354 | (1) |
|
|
354 | (1) |
|
|
355 | (1) |
|
21.6 Laboratory and clinical challenges |
|
|
355 | (5) |
|
21.7 Conclusion/future trends |
|
|
360 | (7) |
|
|
360 | (7) |
|
|
367 | (18) |
|
|
|
|
|
367 | (1) |
|
22.2 Craniofacial and dental tissue-engineering approaches |
|
|
368 | (1) |
|
22.3 Clinical transplantation of engineered blood vessels |
|
|
369 | (1) |
|
22.4 Current strategies to increment vascularization |
|
|
369 | (6) |
|
22.5 Key challenges and future trend |
|
|
375 | (10) |
|
|
376 | (9) |
|
Part IV Oral and Dental Hard Tissue Engineering |
|
|
385 | (140) |
|
23 Bone tissue engineering in maxillofacial region |
|
|
387 | (18) |
|
|
|
|
|
387 | (1) |
|
23.2 Natural alveolar bone structure |
|
|
388 | (2) |
|
23.3 Strategies for bone tissue engineering |
|
|
390 | (1) |
|
23.4 Tissue-engineered bone |
|
|
391 | (7) |
|
23.5 Challenges in bone tissue engineering |
|
|
398 | (1) |
|
|
399 | (6) |
|
|
399 | (6) |
|
24 Periodontal and peri-implant hard tissue regeneration |
|
|
405 | (24) |
|
|
|
|
|
|
|
405 | (1) |
|
24.2 Conventional approaches |
|
|
406 | (6) |
|
|
412 | (6) |
|
24.4 Conclusion and future direction |
|
|
418 | (11) |
|
|
419 | (10) |
|
25 Regeneration concerns in craniofacial cartilage and bone defects |
|
|
429 | (16) |
|
|
|
|
429 | (2) |
|
25.2 Tissue engineering bone grafts |
|
|
431 | (4) |
|
25.3 Craniofacial tissue engineering approaches |
|
|
435 | (3) |
|
25.4 Conclusions/future trends |
|
|
438 | (7) |
|
|
439 | (6) |
|
26 Craniofacial surgery, orthodontics, and tissue engineering |
|
|
445 | (22) |
|
|
|
|
|
|
|
|
445 | (1) |
|
|
446 | (1) |
|
|
446 | (2) |
|
26.4 Alveolar bone defects, current, and future repairing techniques |
|
|
448 | (3) |
|
26.5 Periodontal ligament tissue engineering |
|
|
451 | (4) |
|
26.6 Low-intensity pulsed ultrasound |
|
|
455 | (2) |
|
|
457 | (10) |
|
|
460 | (7) |
|
27 Tooth tissue engineering |
|
|
467 | (36) |
|
|
|
Mohamadreza Baghaban Eslaminejad |
|
|
|
467 | (1) |
|
27.2 Biological structure of teeth |
|
|
468 | (1) |
|
27.3 Developmental process of tooth formation |
|
|
469 | (2) |
|
27.4 Triad of tooth tissue engineering |
|
|
471 | (14) |
|
27.5 Whole teeth regeneration: Recent strategies and techniques |
|
|
485 | (4) |
|
27.6 Future trends and concluding remarks |
|
|
489 | (14) |
|
|
490 | (13) |
|
28 Pharmacological agents for bone remodeling: An experimental approach |
|
|
503 | (22) |
|
|
|
|
|
503 | (1) |
|
|
504 | (2) |
|
|
506 | (4) |
|
|
510 | (3) |
|
|
513 | (1) |
|
|
514 | (2) |
|
28.7 Fibroblast growth factor |
|
|
516 | (1) |
|
28.8 Nonsteroidal antiinflammatory drugs (ibuprofen, aspirin) and acetaminophen |
|
|
517 | (1) |
|
28.9 Bisphosphonates (pamidronic acid, zoledronic acid) |
|
|
518 | (2) |
|
|
520 | (5) |
|
|
520 | (1) |
|
|
520 | (3) |
|
|
523 | (2) |
Index |
|
525 | |