The second edition of Blood Substitutes delivers a comprehensive and authoritative update on the rapidly evolving field of artificial oxygen therapeutics and nextgeneration blood products. Building on the foundation of the first edition, this volume expands its scope to include the latest scientific advances and innovative approaches that are reshaping transfusion medicine. From hemoglobinbased and perfluorocarbonbased oxygen carriers to engineered proteins, vesicles, and nanotechnologies, the book offers an indepth exploration of the most promising solutions to global blood supply challenges.
A significantly expanded set of chapters on plasma, platelets, and hemostasis reflects the fast-growing importance of novel blood product development. Readers will find expert coverage of lyophilized plasma, freezedried platelet hemostatic technologies, cryopreserved platelets, and the regenerative and immunologic properties of plasma-based therapies. These insights highlight both the scientific innovation and clinical potential driving the next generation of trauma, perioperative, and critical care interventions.
With contributions from leading investigators and clinicianscientists, this edition integrates foundational biochemistry with translational research, regulatory considerations, and real-world applications. Detailed analyses of cutting-edge agents equip readers with a clear understanding of current evidence, safety profiles, and therapeutic opportunities.
Designed for a wide clinical and scientific audience, Blood Substitutes, 2nd Edition serves as an essential reference for professionals in surgery, anesthesiology, obstetrics and gynecology, trauma care, hematology/oncology, cardiology, pediatrics, critical care, and military medicine. Whether used for research, education, or clinical decision-making, this volume offers a definitive and forwardlooking guide to the future of blood replacement and oxygen biotherapeutics.
Biochemistry of Hemoglobin and Hemoglobin-Based Oxygen Carrier.-
Platelet Mimicry for Biomechanical Function.- HBOC Impact Upon Vasoactive
Effectors, Rheology and Blood Flow.- Recombinant Hemoglobins with Enhanced
Oxydative Stability.- Nitric Oxide Protectants as a Potential Adjunct of
HBOCs.- Non-hemoglobin Engineered Protein Oxygen Carriers: Omniox.-
Metal-Organic Framework-Based Oxygen Carriers.- Coupled Cross-Linked Human
Hemoglobins (Bis-Tetramers) Overcome HBOC Problems.- Hemoglobin-based Oxygen
Carriers, Oxidative Stress and Myocardial Infarction Issues and
Implications for HBOC Development.- Fractionated Polymerized Hemoglobin-A
Modernized Erythrocytic Substitute and Oxygen Biotherapeutic.-
Hemoglobin-Based Oxygen Carriers: Toxicity Mechanisms and Molecular
Mitigation Strategies.- Nitric Oxide and Hemoglobin: physiological
implications.- Ideal P50: The Ability to Design Artificial Oxygen Carriers
and to Create a Product that Self Regulates.- Hemoglobin-Based Oxygen
Carriers: Evolving Concepts and Clinical Implications.- HBOC Design Using
Protein Engineering.- Pegylated Bovine Hemoglobin: Manufacturing and
Characterization.- Benefits and risks of encapsulated Hb as an artificial
oxygen carrier.- Cardiovascular Effects of Hemoglobin-Based Oxygen Carriers.-
Perfluorocarbon-based Oxygen Carriers: A Comprehensive Overview.- Expanded
Access when Blood Not an Option: Use of Hemopure and Sanguinate.-
Perfluorocarbon-based artificial oxygen carriers for kidney and heart
perfusion.- Perfluorocarbon-based Artificial Oxygen Carriers for Ex Vivo
Organ Perfusion.- The Erythrocruorins as Synthetic Blood Products: What Is
New?.- Whole Blood vs Blood Component Therapy.- Biosynthetic Blood
Components: Use Case for Hemorrhagic Shock and Clinical Trial Design.- Phase
I clinical trial of hemoglobin vesicles (HbV).- Blinded, Randomized,
Controlled Trials of HBOC-201 (Hemopure).- Clinical Development and
Therapeutic Applications of Clinical Development and Therapeutic Applications
of SANGUINATE (PP-007).- Real-Time Circulating Blood Volume Measurements
Using Hemoglobin-based Oxygen Carriers: A Novel Alternative to Traditional
Methods.- YQ23: A New Hemoglobin Based Oxygen Carrier in Critical Limb
Ischemia Phase I/II Trials.- The Therapeutic Potential of Plasma
Extracellular Vesicles.- Pathogen Reduction for Novel Blood Product
Development.- Prothrombin Complex Concentrate as a Therapeutic in Trauma.-
The Regenerative Properties of Plasma in Burns.- The Role of Cryoprecipitate
in Trauma-Induced Hemorrhagic Shock and Endotheliopathy.- Plasma versus
Factor Concentrates Therapy.- The Endotheliopathy of Trauma Patients with
Plasma Product Transfusion: Emerging Clinical Developments.-
Solvent/Detergent-Treated Pooled Plasma Products and Factor Concentrates.-
Freeze Dried Plasma.- Platelets-Fibrin-RBC Interactions in Hemostatic Clots.-
Apheresis Platelet Product Functional Variability.- SynthoPlate and Related
Platelet-Inspired Synthetic Nanotechnologies for Hemorrhage Control.- Blood
Substitutes Related Regulatory Updates (FDA/CBER).- Innovative Pre-Clinical
Models to Prepare Products for FDA Review.- The Regulatory Challenges of
Producing Dried Plasma or Whats a Regulator to Do?.- The addition of a
simple aqueous solution of synthetic neocatalase, neosuperoxide dismutase and
neocarbonic anhydrase improve the effectiveness of oxygen carriers for the
preservation of warm ischemic cell/tissue.- A Military-Civilian Partnership
Model to Advance Commercialization of Blood Products.- Acute Safety Study of
the Intravenous Injection of a Lyophilized Form of an Extracellular
Hemoglobin, M101, in the Rat.
Henry Liu, MD University of Pennsylvania Perelman School of Medicine Anesthesiology & Critical Care Medicine Philadelphia, PA 19104 USA
Dr. Alan David Kaye, MD, PhD, DABA, DABPM, DABIPP, FASA
Former Vice-Chancellor of Academic Affairs, Chief Academic Officer, and Provost,
Vice Chairman, Research on Interventional Pain
Fellowship Director, Department of Anesthesiology
Professor, Department of Pharmacology, Toxicology and Neurosciences
Tenured Professor of Anesthesiology and Pharmacology, Toxicology, and Neurosciences,
Pain Fellowship Program Director,
LSU School of Medicine, 1501 Kings Hwy, Shreveport, LA 71103
Jonathan S. Jahr, MD, PhD, DABA, FASA
Professor Emeritus of Anesthesiology and Perioperative Medicine
Emeritus Chair of the Faculty, Faculty Executive Committee, David Geffen School of Medicine at UCLA
Ronald Reagan UCLA Medical Center
757 Westwood Plaza, Suite 3325
Los Angeles, California 90095
