modalities. The single most important fact about breast cancer is the great variation in its natural history and its responsiveness to therapy from one patient to another. The clinician must integrate an assessment of the patient's likely course based on clinical and pathological staging and laboratory studies with objective evidence on the benefits of therapy. The primary aim of this book is to provide the clinician with the tools to do just that. Outcomes of clinical trials and details about commonly used drug regimens, drug dosage, and the expected side effects are summarized in generous tables and figures. Medical terminology has been defined and descriptions of the evolution in our thinking and understanding of the disease are often given to provide perspective in the interpretation of evidence from current studies for busy clinicians and trainees alike.
Arvustused
This is an excellent, manageable reference for a variety of practitioners who treat breast cancer patients. It is both informative and easy to navigate, with a streamlined approach to the history, progression, and treatment of breast cancer. * Susan Skaff Hagen, MD, MSPH, MME (Boulder Valley Surgery), Doody's Notes *
Preface
ix
Acknowledgments
xi
1 Epidemiology and Risk Factors for Breast Cancer
1
(23)
2 Primary and Secondary Prevention of Breast Cancer
24
(18)
3 Premalignant Changes and in Situ Carcinoma
42
(13)
4 Natural History of Invasive Breast Cancer
55
(15)
5 Histology of Breast Cancer
70
(10)
6 Clinical and Pathological Staging
80
(6)
7 Molecular Factors as Prognostic/Predictive Tools and Therapeutic Targets
86
(20)
8 Diagnosis, Workup, and Follow-up of Breast Cancer Patients
106
(15)
9 Treatment of the Breast and Regional Lymph Nodes: Surgery and Radiation Therapy
121
(22)
10 Adjuvant Systemic Therapy
143
(28)
11 Neoadjuvant Therapy and Locally Advanced or Inflammatory Breast Cancer
171
(17)
12 Management of Metastatic Disease
188
(47)
Index
235
I. Craig Henderson is a Professor of Medicine at the University of California San Francisico's Helen Diller Family Comprehensive Care Center in San Francisco, California.
