The book presents the latest findings on C-type lectin receptors, focusing on individual receptors and their signaling. In recent years there have been great advances in the understanding of the function of these receptors as a newly emerging family of pattern-recognition receptors (PRRs) for pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs). Comprising four parts: ITAM-coupled Activating Receptors; HemITAM-bearing Receptors; ITIM-bearing Receptors; and Other Receptors and Related Topics, this comprehensive review covers a broad range of C-type lectin receptors. The updated information on C-type lectin receptors and their ligands provided will appeal to a wide readership, from basic immunologists to physicians and surgeons. In addition, sections on novel drug development make this a valuable resource for pharmaceutical scientists.
Part 1 ITAM-coupled Activating Receptors.- 1Dectin-2 in anti-microbial immunity and homeostasis.- 2 The function of Mincleas a danger sensor.- 3 The DAP12-Associated Myeloid C-type Lectin 5A (CLEC5A).-Part 2 HemITAM-bearing Receptors.- 4 Dectin-1 (CLEC7A, BGR, CLECSF12).- 5 DNGR-1,an F-actin-binding C-type lectin receptor involved in cross-presentation ofdead cell-associated antigens by dendritic cells.- 6 C-type lectin-like receptor2 (CLEC-2).- Part 3 ITIM-bearing Receptors.- 7 Dendritic cell immunoreceptor(DCIR): An ITIM-harboring C-type lectin receptor.- 8 Regulation and Function ofthe Inhibitory C-type Lectin Clec12A/MICL.- Part 4 Other receptors and relatedtopics.- 9 DC-SIGN in infection and immunity.- 10 LOX-1 and immunity.- 11 MGL/CD301as a unique C-type lectin expressed on dendritic cells and macrophages.- 12 Structuralaspects of C-type lectin receptors.- 13 The Ligands of C-Type Lectins.
Sho Yamasaki, PhD, Professor at Kyushu University
