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ix | |
| Acknowledgements |
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xi | |
| Introduction |
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xiii | |
| About the companion website |
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xvi | |
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1 Epidermal growth factor receptor family |
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1 | (24) |
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1.1 ErbB receptors and their structure |
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1 | (1) |
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2 | (3) |
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1.3 Downstream signalling molecules and events |
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5 | (3) |
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1.4 Signalling regulation |
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8 | (2) |
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1.5 Dysregulation of signalling in cancer |
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10 | (3) |
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1.6 Therapeutic opportunities |
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13 | (12) |
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17 | (8) |
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2 Insulin and the insulin-like growth factor (IGF) family |
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25 | (20) |
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25 | (3) |
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28 | (2) |
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2.3 Downstream signalling molecules and events |
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30 | (2) |
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2.4 Dysregulation of signalling in cancer |
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32 | (2) |
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2.5 Therapeutic opportunities |
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34 | (11) |
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37 | (8) |
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3 Transforming growth factor- β receptor signalling |
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45 | (22) |
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45 | (3) |
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48 | (1) |
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3.3 Downstream signalling molecules and events |
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49 | (4) |
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3.4 Signalling regulation |
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53 | (3) |
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3.5 Dysregulation of signalling in cancer |
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56 | (2) |
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3.6 Therapeutic opportunities |
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58 | (9) |
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60 | (7) |
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67 | (26) |
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4.1 Introduction and overview |
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67 | (2) |
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4.2 The ligands: Wnt proteins, their modification and secretion |
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69 | (1) |
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4.3 The receptors: Frizzleds and LRPs, multiple receptors and combinations |
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70 | (1) |
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4.4 Regulation of signalling |
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71 | (8) |
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4.5 When good signalling goes bad: Wnt signalling in diseases |
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79 | (1) |
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4.6 Taming the beast: drugs and small molecule inhibitors targeting Wnt signalling |
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80 | (1) |
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4.7 Conclusion and perspectives |
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81 | (12) |
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82 | (11) |
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5 Mammalian target of rapamycin (mTOR) signalling |
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93 | (22) |
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93 | (1) |
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94 | (5) |
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5.3 mTOR dysregulation in disease |
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99 | (5) |
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5.4 Therapeutic opportunities |
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104 | (11) |
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107 | (8) |
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6 c-Met receptor signalling |
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115 | (24) |
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6.1 Historical context --- identification of the MET gene |
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115 | (4) |
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6.2 c-Met expression, activation and signal transduction |
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119 | (2) |
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6.3 Physiological roles of c-Met |
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121 | (2) |
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123 | (5) |
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6.5 c-Met as a potential therapeutic target in malignancy |
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128 | (2) |
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130 | (9) |
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130 | (9) |
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7 Vascular endothelial growth factor and its receptor family |
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139 | (32) |
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139 | (1) |
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140 | (3) |
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7.3 Downstream signalling molecules and events |
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143 | (7) |
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7.4 Signalling regulation |
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150 | (2) |
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7.5 Dysregulation of signalling in cancer |
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152 | (1) |
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7.6 Therapeutic opportunities |
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153 | (18) |
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158 | (13) |
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8 Progesterone receptor signalling in breast cancer models |
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171 | (22) |
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8.1 Progesterone receptor function |
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172 | (2) |
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8.2 Model systems: context for studying PR biochemistry |
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174 | (1) |
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8.3 Progesterone receptor signalling |
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175 | (1) |
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8.4 Regulation of signalling |
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176 | (5) |
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8.5 Tissue specific PR actions (breast versus reproductive tract) |
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181 | (2) |
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8.6 Progesterone receptor and cancer |
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183 | (1) |
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183 | (10) |
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184 | (9) |
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193 | (14) |
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193 | (2) |
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9.2 Examples of cross-talk |
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195 | (2) |
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9.3 Convergence of signalling at downstream foci |
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197 | (1) |
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9.4 Common signalling components |
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198 | (4) |
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9.5 Compensatory signalling |
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202 | (1) |
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203 | (4) |
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203 | (4) |
| Index |
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207 | |
