| Preface |
|
xix | |
| Author's Comment |
|
xxix | |
| Disclaimer |
|
xxxiii | |
| What is this Book? |
|
xxxv | |
| Foreword I |
|
xxxvii | |
| Foreword II |
|
xxxix | |
|
Chapter 1 The Cannabis Revolution |
|
|
1 | (30) |
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The Evolving Use of Cannabis |
|
|
1 | (3) |
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4 | (1) |
|
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|
4 | (1) |
|
The DEA's Position on Cannabis |
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5 | (1) |
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Defensive Positions on Cannabis |
|
|
6 | (1) |
|
The Department of Justice Speaks (Verbatim Quotes) |
|
|
6 | (1) |
|
Guidance Regarding the Ogden Memo in Jurisdictions Seeking to Authorize Marijuana for Medical Use (Verbatim) |
|
|
6 | (3) |
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Guidance Regarding Marijuana Enforcement: The Ogden Memorandum (Verbatim) |
|
|
9 | (4) |
|
Is the Federal Government in a Legal Bind? |
|
|
13 | (1) |
|
|
|
14 | (2) |
|
Toward the Responsible Use of Cannabis |
|
|
16 | (1) |
|
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17 | (1) |
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Education about Cannabis: A Key Initiative |
|
|
17 | (1) |
|
Continuing Vigilance for Safety |
|
|
18 | (1) |
|
|
|
19 | (1) |
|
A Note on Taxation and Cannabis Use |
|
|
20 | (1) |
|
|
|
21 | (1) |
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Awareness of Cannabis Risks |
|
|
21 | (1) |
|
Important: Definition of Terms |
|
|
22 | (3) |
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Differences between Hemp and Marijuana (Cannabis) |
|
|
25 | (1) |
|
More on Distinguishing Hemp from Cannabis |
|
|
26 | (1) |
|
Classifying Cannabinoids by Origin |
|
|
27 | (2) |
|
|
|
29 | (2) |
|
Chapter 2 Different Modes of Cannabis Intake |
|
|
31 | (20) |
|
Beware of "Synthetic Cannabis": Synthetic Pot |
|
|
31 | (2) |
|
Aspects of the Law in the United States |
|
|
33 | (3) |
|
Reducing Harm with Cannabis Use |
|
|
36 | (1) |
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Perspectives on the Harm Caused by Substance Abuse |
|
|
37 | (1) |
|
Cannabis: Intake and Modes of Delivery |
|
|
37 | (1) |
|
Vaporizing Cannabis: An Increasingly Preferred Method |
|
|
38 | (2) |
|
Vaping on the Rise: Edibles Present Problems |
|
|
40 | (1) |
|
An Overview of Consuming Cannabis |
|
|
41 | (3) |
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Different Cannabinoid Drugs |
|
|
44 | (1) |
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Ajumelic Acid (CT3): An Example of Required Research |
|
|
45 | (1) |
|
A Note on Different Effects of Cannabinoids |
|
|
46 | (1) |
|
Marijuana Availability and Negative Health Outcomes |
|
|
47 | (1) |
|
Cannabis and Positive Health Outcomes |
|
|
48 | (1) |
|
Cannabis: Key Characteristics at a Glance---A Revision |
|
|
48 | (2) |
|
|
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50 | (1) |
|
Chapter 3 The Expanding use of Cannabis |
|
|
51 | (38) |
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Milestones in Cannabis Knowledge |
|
|
51 | (3) |
|
Mechoulam Wakes the Sleeping Giant |
|
|
54 | (2) |
|
|
|
56 | (1) |
|
|
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57 | (1) |
|
Cannabis and Coffee and Alcohol |
|
|
57 | (1) |
|
The Dopamine Reward System |
|
|
58 | (1) |
|
The Responsible Use of Cannabis |
|
|
59 | (7) |
|
Medical School Teaching about Cannabis |
|
|
66 | (1) |
|
Should Cannabis Be Sold or Prescribed with Warnings? |
|
|
67 | (4) |
|
|
|
71 | (1) |
|
Assessments for Cannabis Use Disorders |
|
|
72 | (2) |
|
Medicinal and Street Cannabis |
|
|
74 | (3) |
|
Cannabis and Opioid Use and Abuse |
|
|
77 | (1) |
|
The Cannabis (THC) Sequence of Effects |
|
|
77 | (1) |
|
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|
78 | (1) |
|
Cannabinoid-like Substances in Other Plants? |
|
|
79 | (1) |
|
Today's Cannabis Is Different from Yesterday's |
|
|
80 | (1) |
|
Cannabis Legalization and the Black Market |
|
|
81 | (1) |
|
Concerns about the Cannabis Industry |
|
|
82 | (1) |
|
Medicinal Benefits of Cannabis |
|
|
82 | (2) |
|
Medicinal Futures of Cannabis |
|
|
84 | (1) |
|
Cannabis: Research Problems |
|
|
85 | (2) |
|
Summary of Problems with Cannabis Research |
|
|
87 | (2) |
|
Chapter 4 Medical Cannabis |
|
|
89 | (48) |
|
Cannabis for Disease Treatment |
|
|
89 | (3) |
|
Whole versus Reductionist Cannabis |
|
|
92 | (1) |
|
Evidence Supporting Medical Cannabis Use |
|
|
92 | (1) |
|
Acts of Decriminalization and Legalization of Marijuana |
|
|
93 | (2) |
|
Toward the Clinical Use of Cannabis |
|
|
95 | (1) |
|
Introducing Preparations of Cannabis: The Cannabinoids |
|
|
96 | (3) |
|
Summary of the Expanding Medical Use of Cannabis |
|
|
99 | (1) |
|
Cannabis: General Observations |
|
|
99 | (3) |
|
Reducing Problems with Cannabis Use |
|
|
102 | (2) |
|
Effects of Cannabis on the Nervous System |
|
|
104 | (1) |
|
Effects on Motor Tasks: Motor Vehicle and Machinery Use |
|
|
105 | (1) |
|
Effects on Cardiac and Lung Function |
|
|
106 | (2) |
|
Effects on Appetite, Learning, and Memory |
|
|
108 | (1) |
|
Effects on Other Drug Use: Gateway and Closed-Gate Phenomena |
|
|
109 | (2) |
|
Marijuana: Focus on Health Benefits in Certain Diseases |
|
|
111 | (1) |
|
|
|
111 | (1) |
|
|
|
112 | (11) |
|
Synthetic Cannabis Mimics or Synthetic Pot |
|
|
123 | (4) |
|
European Experiences with Synthetic Cannabinoid Mimics (Pot) |
|
|
127 | (1) |
|
|
|
128 | (1) |
|
Opioid Deaths: Cannabis to the Rescue? |
|
|
129 | (1) |
|
Cannabis Drug Interactions |
|
|
130 | (1) |
|
Characteristics of Cannabis Disposition in the Body |
|
|
131 | (1) |
|
Drug Treatment of Cannabis Addiction |
|
|
131 | (3) |
|
Cannabis and Work Performance |
|
|
134 | (1) |
|
Self-Identification of Problems with Cannabis Use |
|
|
135 | (1) |
|
|
|
135 | (2) |
|
|
|
137 | (14) |
|
Hemp: General Information |
|
|
137 | (2) |
|
Hemp and Nutrition: Brief Overview |
|
|
139 | (1) |
|
Cannabis in the Food Chain |
|
|
139 | (4) |
|
|
|
143 | (1) |
|
EFA and PUFA in Hemp Seed |
|
|
143 | (1) |
|
|
|
144 | (1) |
|
Health Benefits of Hemp Seed |
|
|
144 | (2) |
|
Diet and Nutritional Status in Adult Marijuana Users |
|
|
146 | (1) |
|
The Cannabis Plant Genome |
|
|
147 | (1) |
|
|
|
148 | (1) |
|
|
|
149 | (1) |
|
Driving the Quest for Cannabis/Legalization |
|
|
150 | (1) |
|
|
|
150 | (1) |
|
Chapter 6 Cannabinoids and the Endocannabinoid System |
|
|
151 | (76) |
|
|
|
151 | (1) |
|
An Overview of Cannabinoid Actions |
|
|
152 | (1) |
|
Endocannabinoids and Cannabinoids |
|
|
153 | (2) |
|
|
|
155 | (1) |
|
Further Insight into Endocannabinoids |
|
|
156 | (1) |
|
Endocannabinoid: Overview |
|
|
156 | (2) |
|
Cannabinoid Receptors: Detail |
|
|
158 | (1) |
|
Cannabinoid Receptor: Activities |
|
|
159 | (2) |
|
|
|
161 | (1) |
|
|
|
161 | (1) |
|
A Further Review of the Functions of Endocannabinoids: Revision |
|
|
162 | (1) |
|
Revealing Terms: Tonic and Entourage Effects |
|
|
163 | (1) |
|
The Entourage of Cannabinoids and Other Compounds |
|
|
164 | (3) |
|
Tetrahydrocannabinol (THC) |
|
|
167 | (2) |
|
Different Modes of Delivery |
|
|
169 | (1) |
|
Absorption, Distribution, and Metabolism of Cannabis |
|
|
169 | (1) |
|
Unpredictable Effects of THC |
|
|
170 | (1) |
|
Reviewing Effects of Cannabis on the Psyche and Body |
|
|
171 | (2) |
|
Professor Wayne Hall Speaks |
|
|
173 | (1) |
|
Is There a Need for Secondary Prevention of Cannabis Use? |
|
|
174 | (2) |
|
|
|
176 | (1) |
|
|
|
177 | (1) |
|
|
|
177 | (1) |
|
|
|
177 | (1) |
|
Tetrahydrocannabivarin (THCV) and (CBDV) Cannabidivarin |
|
|
178 | (1) |
|
Cannabidiolic Acid (CBD-A) |
|
|
178 | (1) |
|
|
|
178 | (2) |
|
Is Cannabidiol (CBD) Legal? |
|
|
180 | (3) |
|
Clinical Endocannabinoid Deficiency (CECD) |
|
|
183 | (1) |
|
Cannabinoids: Effects at a Glance |
|
|
184 | (1) |
|
|
|
185 | (3) |
|
Terpenes Analysis Arjan's Haze #1---(Hydroponic) |
|
|
188 | (1) |
|
Synthetic, Pharmaceutical-Grade Cannabinoids (Analogues) |
|
|
189 | (2) |
|
Strains of Cannabis and Cannabinoid Content |
|
|
191 | (2) |
|
Cannabis Strains: What's in a Name? |
|
|
193 | (1) |
|
Cannabis Use May Be Part of an Antiaging Strategy |
|
|
194 | (1) |
|
Medical Conditions That May Respond to Cannabis Use |
|
|
195 | (4) |
|
The Widespread Use of Cannabis Therapy |
|
|
199 | (2) |
|
Further Defining Medical Uses of Cannabis |
|
|
201 | (1) |
|
A Note on Cannabis Tea, Soda, and Edibles |
|
|
202 | (1) |
|
The Range of Cannabis-Derived Products |
|
|
203 | (1) |
|
Drugs Related to Cannabis |
|
|
204 | (2) |
|
Denbinobin: Another Cannabis Gem |
|
|
206 | (1) |
|
|
|
207 | (1) |
|
|
|
207 | (1) |
|
Two Decades of Cannabis Use |
|
|
208 | (1) |
|
A Brief Review of the Medical Use of Cannabis |
|
|
209 | (3) |
|
Long-Term Consequences of Cannabis Use |
|
|
212 | (4) |
|
Cannabis and Motor Vehicle Accidents |
|
|
216 | (2) |
|
|
|
218 | (1) |
|
Teen Cannabis Use Is Clearly Associated with Adult Disorders |
|
|
218 | (2) |
|
|
|
220 | (3) |
|
Cannabis Treatment of Developmental and Behavioral Disorders |
|
|
223 | (1) |
|
|
|
223 | (1) |
|
Revising Cannabinoids: Simple Perspectives |
|
|
224 | (1) |
|
|
|
224 | (1) |
|
|
|
225 | (2) |
|
|
|
227 | (18) |
|
Major Effects of Cannabis in Cancer |
|
|
227 | (1) |
|
Applying Medical Cannabis |
|
|
228 | (4) |
|
Carcinogenicity of Cannabis Smoke |
|
|
232 | (1) |
|
Laboratory and Clinical Research in Cancer |
|
|
233 | (1) |
|
Guzman's Classic Cancer Studies |
|
|
234 | (1) |
|
A Brief Overview of Cancer and Its Responses to Cannabinoids |
|
|
234 | (3) |
|
Cannabinoids and Malignancy of Immune Origin |
|
|
237 | (1) |
|
Cancer Pain and Cannabinoids |
|
|
237 | (2) |
|
Advocacy for Cannabis Use in Cancer? |
|
|
239 | (1) |
|
Does Marijuana Cause Cancer? |
|
|
239 | (1) |
|
More Anticancer Observations |
|
|
240 | (2) |
|
Anticancer Effects of Cannabinoids: Revision |
|
|
242 | (2) |
|
|
|
244 | (1) |
|
Chapter 8 Mental Disorders |
|
|
245 | (28) |
|
Links between Mental Illness and Cannabis |
|
|
245 | (2) |
|
The Association of Substance Abuse with Mental Disease |
|
|
247 | (2) |
|
Cannabis Benefits in Psychiatric Disorders |
|
|
249 | (2) |
|
More on the Association of Cannabis with Mental Illness: Genetics |
|
|
251 | (1) |
|
More on Cannabis Use in Schizophrenia |
|
|
252 | (3) |
|
Treating Schizophrenia with CBD |
|
|
255 | (1) |
|
Cannabis and Bipolar Disorder |
|
|
256 | (1) |
|
Attention-Deficit Hyperactivity Disorder |
|
|
256 | (3) |
|
|
|
259 | (1) |
|
The Clinical Spectrum of Cannabis Abuse |
|
|
259 | (1) |
|
Marijuana Dependence and Addiction |
|
|
260 | (1) |
|
|
|
261 | (2) |
|
|
|
263 | (1) |
|
Regional Brain Shrinkage and Expansion? |
|
|
264 | (1) |
|
Cannabis Altering Brain Structure and Function |
|
|
265 | (1) |
|
|
|
266 | (1) |
|
|
|
267 | (1) |
|
Value of Cannabis in Alcohol and Opioid Withdrawal |
|
|
268 | (1) |
|
Antimotivational Syndrome |
|
|
268 | (1) |
|
|
|
269 | (1) |
|
Cannabis and Brain Injury |
|
|
270 | (1) |
|
Chronic Traumatic Encephalopathy |
|
|
270 | (1) |
|
|
|
271 | (2) |
|
Chapter 9 The Gastrointestinal Tract |
|
|
273 | (18) |
|
|
|
273 | (1) |
|
The Brain-Adipose-Gut Axis and Its Regulation |
|
|
274 | (1) |
|
Cannabinoid Receptor Effects and the Gut |
|
|
275 | (2) |
|
Cannabis: Gastrointestinal Controls |
|
|
277 | (1) |
|
|
|
278 | (1) |
|
Cannabis and Cotton Mouth |
|
|
278 | (1) |
|
Cannabis and Bowel Function |
|
|
278 | (1) |
|
Anti-inflammatory and Hormonal Effect of Cannabinoids in the Gut |
|
|
279 | (3) |
|
Cannabis and Cystic Fibrosis |
|
|
282 | (1) |
|
Some Therapeutic Comments |
|
|
282 | (4) |
|
Inflammatory Bowel Disease and Cannabis (Summary) |
|
|
286 | (1) |
|
|
|
287 | (1) |
|
Pancreatic Disease and Cannabinoids |
|
|
287 | (1) |
|
Liver Disease and Cannabinoids |
|
|
288 | (1) |
|
Cannabis and Hepatitis C: Paradox |
|
|
289 | (1) |
|
Cannabis Hyperemesis Syndrome |
|
|
289 | (1) |
|
|
|
290 | (1) |
|
Chapter 10 Bones and Joints |
|
|
291 | (8) |
|
|
|
291 | (2) |
|
|
|
293 | (1) |
|
|
|
294 | (1) |
|
Cannabis and Osteoporosis |
|
|
295 | (1) |
|
|
|
295 | (1) |
|
Failure of Classic Treatment of Fibromyalgia |
|
|
296 | (1) |
|
|
|
297 | (2) |
|
Chapter 11 Cannabis and Cardiorespiratory Disorders |
|
|
299 | (14) |
|
Association between Cannabis and Cardiorespiratory Disease |
|
|
299 | (1) |
|
Cannabis and Vascular Disease |
|
|
300 | (1) |
|
How Does Cannabis Damage Cardiovascular Function? |
|
|
301 | (2) |
|
Signals of Risk for Cannabis Induced Cardiovascular Disorders |
|
|
303 | (3) |
|
Cannabis, Hypertension, and Arrhythmias |
|
|
306 | (1) |
|
Respiratory Disorders and Cannabis |
|
|
307 | (4) |
|
|
|
311 | (2) |
|
Chapter 12 Neurological Disorders |
|
|
313 | (28) |
|
Endocannabinoids Modulate CNS Function: A Recap |
|
|
313 | (1) |
|
Function of Cannabinoid Receptors: A Review |
|
|
314 | (1) |
|
|
|
315 | (1) |
|
|
|
316 | (1) |
|
The Double-Edged Sword of Cannabis in Epilepsy |
|
|
317 | (2) |
|
|
|
319 | (1) |
|
The Endocannabinoids Control Motor Function |
|
|
320 | (1) |
|
|
|
321 | (1) |
|
|
|
322 | (1) |
|
|
|
322 | (2) |
|
|
|
324 | (1) |
|
Amyotrophic Lateral Sclerosis |
|
|
325 | (1) |
|
Spinal Cord Injury or Disease |
|
|
326 | (1) |
|
|
|
327 | (2) |
|
Multiple Sclerosis Is an Autoimmune Disorder |
|
|
329 | (1) |
|
Multiple Sclerosis: NMSS Review of Trials |
|
|
330 | (2) |
|
Alzheimer's Disease and Dementia |
|
|
332 | (2) |
|
|
|
334 | (2) |
|
Headache, Migraine, and Cannabis |
|
|
336 | (1) |
|
The Chatter between Cannabinoid and Opioid Systems |
|
|
337 | (1) |
|
|
|
338 | (1) |
|
Benefits of Correcting Sleep Disorders |
|
|
338 | (1) |
|
|
|
339 | (1) |
|
|
|
339 | (2) |
|
Chapter 13 Diabetes Mellitus |
|
|
341 | (12) |
|
Cannabis and Energy Controls in the Body |
|
|
342 | (4) |
|
Endocannabinoids and Obesity |
|
|
346 | (2) |
|
Negative and Positive Effects of Cannabinoids in Diabetes Mellitus |
|
|
348 | (1) |
|
Endocannabinoids, Inflammasomes, and Diabetes |
|
|
349 | (1) |
|
Treating Complications of Diabetes |
|
|
350 | (1) |
|
Cannabis and Diabetes (Summary) |
|
|
351 | (1) |
|
|
|
352 | (1) |
|
Chapter 14 Infections, Hiv Disease, and Inflammation |
|
|
353 | (14) |
|
The Association of Illicit Drug Use and Infection |
|
|
353 | (1) |
|
Cannabis and Immune Phenomena |
|
|
354 | (2) |
|
A Note on Bacterial Infection |
|
|
356 | (1) |
|
|
|
356 | (1) |
|
|
|
357 | (1) |
|
|
|
357 | (1) |
|
|
|
358 | (1) |
|
Cannabinoids and the Immune System: Focus on HIV/AIDS |
|
|
358 | (3) |
|
Reviewing Effects of Cannabis in HIV and AIDS |
|
|
361 | (2) |
|
|
|
363 | (1) |
|
|
|
364 | (1) |
|
|
|
365 | (2) |
|
Chapter 15 Skin Disease and Reproductive Health |
|
|
367 | (18) |
|
Cannabis and Skin Disease |
|
|
367 | (3) |
|
|
|
370 | (1) |
|
Transdermal Delivery of Cannabis Compounds |
|
|
370 | (1) |
|
|
|
371 | (2) |
|
Skin Esthetics with Cannabis |
|
|
373 | (1) |
|
|
|
373 | (1) |
|
|
|
373 | (1) |
|
Sexual Health and Function |
|
|
374 | (2) |
|
Endocannabinoids and the Fetus or Newborn |
|
|
376 | (3) |
|
|
|
379 | (1) |
|
A Summary of Cannabis Use in Pregnancy |
|
|
380 | (1) |
|
Cannabis, Menstrual Problems, and Menopause |
|
|
381 | (1) |
|
|
|
382 | (1) |
|
|
|
383 | (2) |
|
Chapter 16 Miscellaneous Issues |
|
|
385 | (24) |
|
|
|
385 | (1) |
|
|
|
386 | (1) |
|
|
|
386 | (1) |
|
|
|
387 | (1) |
|
|
|
387 | (1) |
|
|
|
387 | (1) |
|
|
|
387 | (1) |
|
|
|
388 | (1) |
|
Cannabis and Urinary Problems |
|
|
389 | (1) |
|
|
|
390 | (1) |
|
Cannabis and Endocrine Function |
|
|
391 | (1) |
|
Cannabis and Biological Rhythms |
|
|
392 | (2) |
|
Cannabis in Palliative Care |
|
|
394 | (1) |
|
|
|
395 | (1) |
|
|
|
395 | (1) |
|
|
|
396 | (1) |
|
|
|
397 | (1) |
|
|
|
398 | (1) |
|
|
|
398 | (1) |
|
|
|
399 | (1) |
|
Cannabis and Organ Transplantation |
|
|
400 | (1) |
|
|
|
401 | (1) |
|
Genetics and Cannabis Comorbidity with Cannabis |
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402 | (1) |
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More on Cannabis and Antiaging |
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402 | (2) |
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404 | (1) |
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Cannabis and Retinal Degeneration |
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404 | (1) |
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405 | (1) |
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405 | (1) |
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405 | (3) |
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408 | (1) |
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Chapter 17 Some Social Perspectives |
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409 | (16) |
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409 | (1) |
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410 | (1) |
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American Indian Tribes and Marijuana |
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411 | (2) |
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Cannabis, African Americans, and Latinos |
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413 | (1) |
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414 | (1) |
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415 | (1) |
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416 | (1) |
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Cannabis, Violence, and Crime |
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417 | (1) |
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418 | (1) |
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419 | (1) |
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420 | (2) |
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Cannabis and Public Opinion |
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422 | (1) |
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WHO Estimates of Cannabis Use |
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423 | (1) |
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423 | (2) |
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Chapter 18 The Hidden Potaholic |
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425 | (30) |
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The Hidden Pot User---The Hidden Potaholic |
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425 | (1) |
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A Substance-Abuse Vignette: Alice |
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426 | (1) |
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Approaching the Edge of Addiction |
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427 | (1) |
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428 | (2) |
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Marijuana Use and Short-Term Acute Brain Syndrome |
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430 | (1) |
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431 | (1) |
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Holistic Approaches to Substance Abuse and Addiction |
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432 | (3) |
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Notes on Addiction Treatments |
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435 | (5) |
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Social Aspects of Cannabis Use |
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440 | (2) |
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442 | (1) |
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Prevention and Treatment of Cannabis Abuse |
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443 | (1) |
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444 | (1) |
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The Emergence of D.A.R.E. |
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445 | (2) |
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Identifying the Hidden Potaholic |
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447 | (2) |
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Outcomes of Heavy Cannabis Use |
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449 | (1) |
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A Step-by-Step Approach to Cannabis Use in Young People |
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449 | (1) |
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Reasons Why Young People Do Drugs---A Review |
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450 | (1) |
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451 | (1) |
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More on How to Spot Cannabis Use---A Review |
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452 | (1) |
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453 | (2) |
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455 | (48) |
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459 | (44) |
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459 | (44) |
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503 | (34) |
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Chapter 1 Medical Cannabis |
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503 | (2) |
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Chapter 2 Different Modes of Delivery of Cannabis |
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505 | (1) |
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Chapter 3 The Expanding Use of Cannabis |
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506 | (3) |
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Chapter 4 Medical Cannabis |
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509 | (5) |
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514 | (2) |
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Chapter 6 Cannabinoids and the Endocannabinoid System |
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516 | (4) |
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520 | (2) |
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Chapter 8 Mental Disorders |
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|
522 | (2) |
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Chapter 9 The Gastrointestinal Tract |
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524 | (2) |
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Chapter 10 Bones and Joints |
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526 | (1) |
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Chapter 11 Cardiorespiratory Disorders |
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527 | (1) |
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Chapter 12 Neurological Disorders |
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528 | (3) |
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Chapter 13 Diabetes Mellitus |
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531 | (1) |
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Chapter 14 Infections, HIV Disease, and Inflammation |
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532 | (1) |
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Chapter 15 Skin Disease and Reproductive Health |
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|
533 | (1) |
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Chapter 16 Miscellaneous Topics |
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534 | (1) |
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Chapter 17 Social Perspectives |
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|
535 | (1) |
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Chapter 18 The Hidden Potaholic |
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536 | (1) |
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|
536 | (1) |
| Answer Sheet |
|
537 | (4) |
| Other Books by the Author |
|
541 | (2) |
| About the Author |
|
543 | (2) |
| Index |
|
545 | |
