Cann's Principles of Molecular Virology, Seventh Edition provides an easily accessible introduction to modern virology, presenting principles in a clear and concise manner. The new edition provides the history of virology and the fundamentals of the molecular basis of how viruses work. It discusses the interactions which control the structure of virus particles, the ways viruses infect cells, how viruses replicate themselves, and the consequences and pathogenesis of virus infection for host organisms. This fully updated edition also reflects advances made in the field and includes new content on phage therapy, CRISPR as a phage defense / offense system, new ideas about evolution, and giant viruses. With the addition of ancillary resources, Cann's Principles of Molecular Virology, Seventh Edition is an essential foundational reference for academics, graduate students, and advance undergraduates in virology, molecular biology, and microbiology as well as researchers entering virology, infectious disease, and immunology research.
- Provides a conceptual approach to the principles of molecular virology, with important examples of new advances in virology
- Includes new concepts in this edition include coverage of emerging topics and new technologies in viral research like phage therapy, CRISPR as a phage defense / offense system, new ideas about evolution, and giant viruses
- Contains updated learning outcomes and further reading for each chapter
- Supported by online resources for students and instructors
| Preface |
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vii | |
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1 What are viruses, and how were they discovered? |
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1 | (6) |
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The history of the discovery of viruses |
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7 | (45) |
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52 | (1) |
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53 | (2) |
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2 Viruses and their particles |
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Viruses and their particles |
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55 | (3) |
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58 | (23) |
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81 | (1) |
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81 | (2) |
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3 Virus origins and genetics |
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The structure and complexity of virus genomes |
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83 | (1) |
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84 | (1) |
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From what did viruses evolve? |
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85 | (5) |
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The origins of modern eukaryote viruses |
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90 | (15) |
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105 | (5) |
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The complexity of virus genomes |
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110 | (2) |
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112 | (1) |
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113 | (8) |
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121 | (1) |
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122 | (1) |
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123 | (1) |
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123 | (1) |
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124 | (1) |
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4 Virus genomes and their replication |
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Overview of virus replication |
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125 | (1) |
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Entrance into cells and viral genome replication |
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126 | (17) |
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Genome replication and gene expression |
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143 | (11) |
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154 | (11) |
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165 | (1) |
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165 | (1) |
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166 | (1) |
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5 Expression of virus genomes |
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Expression of genetic information |
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167 | (10) |
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Virus genome coding strategies |
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177 | (25) |
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Transcriptional control of expression |
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202 | (4) |
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Posttranscriptional control of expression |
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206 | (8) |
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214 | (1) |
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215 | (1) |
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215 | (2) |
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Virus infection of prokaryotes |
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217 | (6) |
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Virus infections of plants |
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223 | (6) |
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Immune responses to virus infections in animals |
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229 | (1) |
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230 | (9) |
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Adaptive immune responses in vertebrates |
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239 | (7) |
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246 | (3) |
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249 | (9) |
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The course of virus infections |
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258 | (4) |
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Prevention and therapy of virus infection |
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262 | (5) |
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267 | (1) |
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Chemotherapy of virus infections |
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268 | (9) |
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277 | (1) |
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277 | (1) |
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278 | (2) |
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Mechanisms of cellular injury |
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280 | (2) |
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Viruses and immunodeficiency |
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282 | (1) |
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Acquired immunodeficiency syndrome (AIDS) |
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283 | (3) |
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286 | (3) |
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Bacteriophages and human disease |
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289 | (1) |
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Cell transformation by viruses |
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290 | (4) |
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Cell transformation by retroviruses |
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294 | (2) |
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Cell transformation by DNA viruses |
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296 | (4) |
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300 | (5) |
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305 | (1) |
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306 | (1) |
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306 | (1) |
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New, emerging, and re-emerging viruses |
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307 | (2) |
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309 | (16) |
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325 | (2) |
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327 | (2) |
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329 | (22) |
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Biowarfare and bioterrorism |
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351 | (2) |
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353 | (1) |
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353 | (2) |
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355 | (2) |
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9 Subviral agents: Deltaviruses and prions |
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357 | (3) |
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360 | (7) |
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Molecular biology of prions |
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367 | (5) |
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372 | (1) |
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372 | (1) |
| Appendix 1 |
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373 | (6) |
| Index |
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379 | |
Dr. Edward Rybicki is a Professor in the Department of Molecular and Cell Biology and Biopharming Research Unit of the University of Cape Town, South Africa. His research interests focus around vaccinology, protein expression, marine viromics, and virus diversity. He has authored two books, co-authored over 120 articles and 19 reviews in peer-reviewed journals, about 20 book chapters, and a number of popular or opinion articles and conference reports. Dr. Rybicki is listed as an inventor on 17 patent families, with around 44 country patents published. He writes educational and study material for the Web like the Electronic Introduction to Molecular Virology as well as via the UCT Open Educational Resources page like the Manual of Online Molecular Biology Techniques, which is extensively used by researchers outside of UCT. He maintains a university-level Virology teaching resource called ViroBlogy, as well as a general public information site called Virology News, runs the International Society for Plant Molecular Farming site, co-curates an information page on aquatic viruses and another on virology and bioinformatics, and tweets on virology topics (and other things) under @edrybicki.
