Volumes in the Proven Synthetic Methods Series address the concerns many chemists have regarding irreproducibility of synthetic protocols, lack of identification and characterization data for new compounds, and inflated yields reported in chemical communicationstrends that have recently become a serious problem.
Featuring contributions from world-renowned experts and overseen by a highly respected series editor, Carbohydrate Chemistry: Proven Synthetic Methods, Volume 4 compiles reliable synthetic methods and protocols for the preparation of intermediates for carbohydrate synthesis or other uses in the glycosciences.
Exploring carbohydrate chemistry from both the academic and industrial points of view, this unique resource brings together useful information into one convenient reference. The series is unique among other synthetic literature in the carbohydrate field in that, to ensure reproducibility, an independent checker has verified the experimental parts involved by repeating the protocols or using the methods.
The book includes new or more detailed versions of previously published protocols as well as those published in not readily available journals. The essential characteristics of the protocols presented are reliability, updated characterization data for newly synthesized substances and the expectation of wide utility in the carbohydrate field. The protocols presented will be of wide use to a broad range of readers in the carbohydrate field and the life sciences, including undergraduates taking carbohydrate workshops.
Arvustused
'The contributors are the best scientists in the field and the series editor is highly respected. The volumes will ... be of use to undergraduates involved in carbohydrate workshops.' Alexei Demchenko, Associate Professor of Chemistry and Biochemistry, Director of Graduate Studies, University of Missouri St. Louis.
This essential book series, focused on carbohydrate synthesis, starts with a dedication to Nobel Laureate Sir John W. Cornforth, who is credited with the first public criticism of what he pictured as pouring a large volume of unpurified sewage into the chemical literature.1 Unfortunately, this issue is not limited to the field of chemistry as many high profile cases of irreproducible experiments have led to alarms being set off even in the popular press.2 This series then serves as the much-needed water treatment plants places where the reader can be guaranteed a good clean reproducible experiment. at least now chemists with or without expertise in carbohydrates can count on finding reliable procedures to make sugar-based compounds at one scale a major achievement. Not only should current practitioners gain back time lost in attempts to properly reconstruct experimental procedures, but these procedures should also allow more creative scientists to contribute to this growing area.
Cornforth JW. Austr. J. Chem. 1993;46:157e70.
For example, see Unreliable research: trouble at the lab. Econ. October 19, 2013.
Nicola L.B. Pohl, Indiana University, Department of Chemistry, Bloomington, IN, USA, for Carbohydrate Research, http://dx.doi.org/10.1016/j.carres.2015.04.007.
ForewordIntroductionEditorsSeries EditorContributorsSection I Synthetic
MethodsChapter 1 Picoloyl-Protecting Group in Oligosaccharide Synthesis:
Installation, H-Bond-Mediated Aglycone Delivery (HAD), and Selective
RemovalMichael P. Mannino, Jagodige P. Yasomanee, Alexei V. Demchenko, and
Venukumar PattetiChapter 2 Monomethoxytrityl (MMTr) as an Efficient
S-Protecting Group in the Manipulation of Glycosyl ThiolsRaymond Smith,
Xiangming Zhu, and Elena Calatrava-PérezChapter 3 One-Step Inversion of
Configuration of a Hydroxy Group in CarbohydratesShino Manabe and Markus
BlaukopfChapter 4 Formation and Cleavage of Benzylidene Acetals Catalyzed by
NaHSO4?SiO2Lifeng Sun, Xin-Shan Ye, and Xingdi WangChapter 5
Thiodisaccharides by Photoinduced Hydrothiolation of 2-Acetoxy GlycalsDániel
Eszenyi, László Lázár, Anikó Borbás, andRuairi O. McCourtChapter 6 One-Step
Preparation of Protected N-tert-Butanesulfinyl d-ribo and d-xylo
Furanosylamines from Related Sugar HemiacetalsChloé Cocaud, Cyril Nicolas,
Olivier R. Martin, and Jérôme DésiréChapter 7 An Alternative Preparation of
Azides from Amines via Diazotransfer with Triflyl AzideYuqian Ye, Xin-Shan
Ye, and Xingdi WangChapter 8 Simple Preparation of Dimethyldioxirane and Its
Use as an Epoxidation Agent for the Transformation of Glycals to Glycosyl
PhosphatesKatharina Kettelhoit, Daniel B. Werz, Aniruddha Sasmal, Xinyu Liu,
and Philipp GritschChapter 9 Preparation of Glycosyl Bromides of
?-d-Gluco-hept-2-ulopyranosonic Acid DerivativesVeronika Nagy, Katalin
Czifrák, László Juhász, László Somsák, and Olena ApeltChapter 10 Preparation
of 2,6-Anhydro-hept-2-enonic Acid Derivatives and Their 3-Deoxy Count
Christian Vogel earned a PhD in organic chemistryheterocyclic chemistry under the supervision of Professor Klaus Peseke at the University of Rostock in 1980. Since 1992, he has served as a professor in the Department of Organic Chemistry, University of Rostock. In addition to fucose chemistry, Dr. Vogels main interests are pectin fragment synthesis using the modular design principle, the synthesis of rare sugars for structural investigations, and C-nucleosides.
Paul V. Murphy was appointed to the position of Established Professor of Chemistry at National University of Ireland Galway (NUI Galway) in 2008. He is from the West of Ireland (Turloughmore, Co. Galway). His group is engaged in the design and synthesis of bioactive compounds, with a focus on carbohydrates, maintaining a long tradition in carbohydrate research in Galways School of Chemistry.
