Preface |
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xvii | |
Section I: Production and Derivatives of Chitosan |
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1 Chitin and Chitosan: History, Composition and Properties |
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3 | (22) |
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4 | (7) |
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4 | (1) |
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4 | (1) |
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1.1.2.1 Terrestrial Organisms |
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4 | (1) |
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1.1.2.2 Marine or Aquatic Organisms |
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5 | (1) |
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1.1.2.3 Microorganisms (e.g., Fungi or Mushroom) |
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5 | (1) |
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1.1.3 Extraction of Chitin |
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6 | (1) |
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7 | (1) |
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7 | (1) |
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8 | (1) |
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1.1.4 Structure and Composition |
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8 | (2) |
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1.1.5 Properties of Chitin |
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10 | (1) |
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1.1.5.1 Solubility, Reactivity, and Viscosity |
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10 | (1) |
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1.1.5.2 Miscellaneous Properties |
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11 | (1) |
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11 | (10) |
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11 | (1) |
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1.2.2 Sources and Extraction |
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12 | (1) |
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1.2.2.1 Deacetylation of Chitin by Chemical Method |
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12 | (1) |
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1.2.2.2 Deacetylation of Chitin by Enzymatic Method |
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13 | (1) |
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1.2.2.3 Deacetylation of Chitin by Microwave Assisted Method |
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14 | (1) |
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1.2.3 Structure and Composition |
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14 | (1) |
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15 | (1) |
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1.2.4.1 Physical Properties |
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15 | (1) |
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1.2.4.2 Chemical Properties |
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18 | (1) |
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1.2.4.3 Miscellaneous Properties |
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20 | (1) |
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21 | (1) |
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21 | (4) |
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2 Nitrogenated Polysaccharides-Chitin and Chitosan, Characterization and Application |
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25 | (46) |
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26 | (1) |
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2.2 Extraction of Nitrogenated Polysaccharides from Natural Sources |
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27 | (1) |
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2.3 Research Methods of Nitrogenated Polysaccharides |
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28 | (19) |
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29 | (7) |
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2.3.2 Nuclear Magnetic Resonance |
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36 | (1) |
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37 | (2) |
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39 | (1) |
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40 | (2) |
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2.3.6 Electron Microscopy |
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42 | (1) |
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2.3.7 Atomic Force Microscopy |
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43 | (1) |
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2.3.8 Laser Light Scattering |
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44 | (1) |
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2.3.9 Thermoanalytical Methods |
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45 | (1) |
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46 | (1) |
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2.3.11 Composition Assay Methods |
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46 | (1) |
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2.4 Characterization of Nitrogenated Polysaccharides |
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47 | (7) |
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47 | (5) |
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52 | (2) |
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2.5 Properties of Nitrogenated Polysaccharides |
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54 | (4) |
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58 | (2) |
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60 | (1) |
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61 | (10) |
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3 Enzymes for Production of Chitin, Chitosan, and Chitooligosaccharide and Determination of Activities of Enzymes Using Chitinous Substrates |
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71 | (18) |
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72 | (2) |
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3.2 Fermentation Methods for Production of Enzymes |
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74 | (1) |
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3.3 Methods for Purification of Enzymes |
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74 | (4) |
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3.4 Storage Conditions of Enzyme |
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78 | (1) |
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78 | (1) |
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3.6 Determinations of Enzyme Activities Using Chitinous Materials |
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78 | (7) |
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85 | (1) |
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85 | (1) |
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85 | (4) |
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4 Production of Chitin, Chitosan, and Chitooligosaccharide from Shrimp and Crab Shells Using Green Technology and Applications of Their Composite Materials |
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89 | (26) |
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90 | (2) |
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4.2 Microorganisms for Production of Chitin and Chitosan Using Green Technology |
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92 | (1) |
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4.3 Production of Chitin Using Microorganisms |
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93 | (1) |
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4.4 Production of Chitosan from Chitin Using Chitin Deacetylase from Microorganisms |
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94 | (4) |
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4.5 Production of Crude Chitooligosaccharide from Shrimp and Crab Shells Using Fermentation Technology |
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98 | (3) |
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4.6 Applications of Chitin, Chitosan, Chitooligosaccharides and Their Composite Materials |
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101 | (1) |
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102 | (5) |
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107 | (1) |
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107 | (8) |
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5 Chitosan and Its Derivatives: Overview of Commercial Applications in Diverse Fields |
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115 | (36) |
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115 | (1) |
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5.2 Synthesis of Chitosan |
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116 | (1) |
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117 | (1) |
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5.4 Biological Properties |
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117 | (1) |
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5.5 Physicochemical Aspects |
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118 | (1) |
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118 | (1) |
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118 | (1) |
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119 | (1) |
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5.8.1 Mild Acidic Conditions |
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119 | (1) |
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5.8.1 Other Acidic Conditions |
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120 | (1) |
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120 | (1) |
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120 | (1) |
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5.9.2 Self-Assembly Mechanism |
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121 | (1) |
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5.10 Strategies Self-Assembly |
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121 | (1) |
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5.10.1 Solution Self-Assembly |
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121 | (1) |
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5.10.1 Template Self-Assembly |
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121 | (1) |
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122 | (1) |
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122 | (1) |
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5.13 Chemical Modification |
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122 | (1) |
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5.14 Technologic Features for Medicinal Utilization |
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122 | (1) |
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5.15 Synthetic Procedure of Chitosan Nanoparticles |
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123 | (1) |
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123 | (1) |
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5.17 Carboxymethyl Chitosan (CMC) |
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123 | (1) |
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124 | (1) |
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124 | (2) |
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5.20 Antibacterial Properties |
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126 | (1) |
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5.21 Antimicrobial Activity |
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126 | (3) |
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129 | (1) |
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129 | (1) |
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5.23.1 Photo-Cross-Linkable Chitosan |
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129 | (1) |
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130 | (1) |
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130 | (1) |
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5.26 Parameter Moving Transfection Competence |
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131 | (1) |
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131 | (1) |
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5.28 Functionalization of Chitosan |
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131 | (1) |
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5.29 Schiff's Base Formation |
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131 | (3) |
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134 | (1) |
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5.31 Chitosan-Proteins Interaction |
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134 | (1) |
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135 | (1) |
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5.33 Chitosan-Starch Blends |
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135 | (1) |
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5.34 Application in Various Fields |
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135 | (11) |
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5.34.1 Administration Routes |
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135 | (1) |
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136 | (1) |
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136 | (1) |
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136 | (1) |
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137 | (1) |
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137 | (1) |
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137 | (1) |
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137 | (2) |
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139 | (1) |
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139 | (1) |
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140 | (1) |
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140 | (1) |
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5.34.13 Electrochemical Sensor |
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141 | (1) |
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5.34.14 Enzymatic Assembly |
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141 | (1) |
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5.34.15 Electrochemical Enzyme Immobilization |
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142 | (1) |
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5.34.16 Plasma Treatment in Textile |
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143 | (1) |
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144 | (1) |
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144 | (1) |
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144 | (1) |
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145 | (1) |
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145 | (1) |
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5.34.20 Wastewater Treatment |
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145 | (1) |
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146 | (1) |
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146 | (5) |
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6 Chitin and Chitosan-Complexes and Their Applications |
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151 | (16) |
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152 | (1) |
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6.2 Synthesis of Chitosan from Chitin |
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153 | (1) |
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6.3 Different Properties of Chitosan |
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154 | (2) |
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6.3.1 Chemical Properties of Chitosan |
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154 | (1) |
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6.3.2 Biological Properties of Chitosan |
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155 | (1) |
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6.4 Polyelectrolyte Complexes of Chitosan |
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156 | (1) |
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6.5 Complexes of Polyelectrolyte between Chitosan and Naturally Occurring Polymers |
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157 | (2) |
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6.5.1 Chitosan-Alginate Polyelectrolyte Complex |
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157 | (1) |
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6.5.2 Chitosan-Carrageenan Polyelectrolyte Complex |
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158 | (1) |
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6.5.3 Chitosan-Pectin Polyelectrolyte Complex |
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158 | (1) |
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6.5.4 Chitosan-Xanthan Gum Polyelectrolyte Complex |
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159 | (1) |
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6.5.5 Chitosan-Hyaluronic Acid Polyelectrolyte Complex |
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159 | (1) |
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6.6 Various Useful and Important Applications of Chitosan |
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159 | (3) |
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6.6.1 Chitosan Application in Agriculture |
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160 | (1) |
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6.6.2 Application of Chitosan in Wastewater and Contaminated Water Treatment |
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160 | (1) |
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6.6.3 Chitosan Use in Food Industries |
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161 | (1) |
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6.6.4 Chitosan and Biomedical Applications |
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161 | (1) |
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162 | (1) |
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162 | (1) |
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162 | (5) |
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7 Enzymes from Genetically Modified Microorganisms for Production of Chitin, Chitosan, and Chitooligosaccharide |
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167 | (18) |
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168 | (1) |
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7.2 Enzymes for Production of Chitin/Chitosan, and Chitooligosaccharide |
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169 | (1) |
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7.3 Enzyme and DNA Technology for Production of Chitin, Chitosan, and CTO |
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169 | (3) |
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7.4 Determinations of Enzyme Activities Using Chitinous Materials |
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172 | (4) |
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176 | (3) |
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179 | (6) |
Section II: Chitosan in Textile and Food Industry |
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8 Chitosan Applications for the Food Industry |
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185 | (48) |
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185 | (2) |
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8.2 Biological Activities of Chitosan and Its Derivatives |
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187 | (6) |
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8.2.1 Antioxidant Properties |
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187 | (3) |
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8.2.2 Antioxidant Properties of Native Chitosan and Its Oligomers |
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190 | (1) |
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8.2.3 Antioxidant Properties of Modified Chitosan |
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190 | (1) |
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8.2.4 In Vivo Studies of the Antioxidant Properties of Chitosan |
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191 | (1) |
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8.2.5 Lipid-Lowering Effects |
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192 | (1) |
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8.2.6 Other Biological Activities |
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193 | (1) |
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8.3 Chitosan and Its Derivatives for Food Applications |
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193 | (20) |
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8.3.1 Antimicrobial Applications |
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193 | (1) |
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8.3.1.1 Antimicrobial Activity of Modified Chitosan |
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196 | (4) |
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8.3.2 Chitosan-Based Emulsions for Food Quality Preservation |
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200 | (1) |
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8.3.3 Edible Film/Coating and Food Packaging Applications |
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201 | (2) |
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8.3.4 Encapsulation and Nutrient Delivery Applications |
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203 | (1) |
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8.3.4.1 Chitosan-Based Delivery Systems for Food Applications |
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203 | (1) |
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8.3.4.2 Nano/Micro-Particles |
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204 | (1) |
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208 | (1) |
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8.3.4.4 The Encapsulation and Delivery of Nutrients |
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209 | (1) |
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8.3.4.5 The Encapsulation and Delivery of Probiotics |
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210 | (1) |
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8.3.5 The Immobilization of Enzymes by Chitin and Chitosan |
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211 | (1) |
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8.3.6 Other Applications of Chitosan in the Food Sciences |
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212 | (1) |
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8.4 Nutritional Aspects of Chitin and Chitosan |
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213 | (2) |
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8.5 Preparation of Chitin and Chitosan Oligomers and Their Applications in the Food Industry as Health Supplements |
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215 | (2) |
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8.6 Future Trends: Chitosan-Based Nanotechnology for Food Applications |
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217 | (1) |
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217 | (1) |
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218 | (1) |
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218 | (15) |
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9 Chitosan: Sustainable and Environmental-Friendly Resource for Textile Industry |
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233 | (22) |
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233 | (1) |
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9.2 Chitosan and Chitosan Resources |
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234 | (2) |
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9.3 Chitosan Treatment of Textiles |
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236 | (4) |
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237 | (1) |
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238 | (1) |
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238 | (1) |
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9.3.4 Others (Synthetic or Semisynthetic Fibers) |
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239 | (1) |
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9.4 Textile Functionalities Achieved |
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240 | (5) |
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9.4.1 Antimicrobial Finishing and Enhanced Dyeing Effects |
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241 | (2) |
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9.4.2 Wrinkle Proof Resistance |
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243 | (1) |
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9.4.3 Biomedical Applications |
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244 | (1) |
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9.5 Effluent Treatment Applications |
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245 | (1) |
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9.6 Future Perspectives and Conclusion |
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246 | (1) |
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247 | (8) |
Section III: Chitosan in Biomedical Applications |
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10 Perspectives of Chitin-and Chitosan-Based Scaffolds Dressing in Regenerative Medicine |
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255 | (16) |
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Parappurath Narayanan Sudha |
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256 | (2) |
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10.2 Scaffold Characteristics |
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258 | (2) |
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258 | (1) |
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259 | (1) |
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10.2.3 Manufacturing Technology |
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259 | (1) |
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10.2.4 Mechanical Properties |
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259 | (1) |
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10.2.5 Scaffold Properties |
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260 | (1) |
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10.3 Fabrication Techniques |
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260 | (1) |
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10.4 Applications of Chitin and Chitosan as Regenerative Medicine |
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261 | (3) |
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264 | (1) |
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265 | (6) |
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11 Chitin-and Chitosan-Based Scaffolds |
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271 | (40) |
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272 | (2) |
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274 | (1) |
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11.3 Scaffold Requirements |
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275 | (2) |
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11.3.1 Pore Size and Porosity |
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276 | (1) |
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276 | (1) |
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276 | (1) |
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277 | (1) |
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11.3.5 Mechanical Strength |
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277 | (1) |
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11.4 Chitin-and Chitosan-Based Scaffolds Fabrication Techniques |
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277 | (5) |
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11.4.1 Non-Designed Manufacturing Techniques |
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278 | (1) |
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11.4.1.1 Phase Separation |
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278 | (1) |
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278 | (1) |
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11.4.1.3 Solvent Casting and Particulate Leaching |
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279 | (1) |
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11.4.1.4 Freeze Drying or Emulsion Freezing |
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280 | (1) |
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11.4.1.5 Gas Foaming or High Pressure Processing |
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280 | (1) |
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281 | (1) |
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11.4.2 Designed Fabrication Technique |
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281 | (1) |
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11.4.2.1 Rapid Prototyping (RP) |
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281 | (1) |
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11.5 Applications of Chitin and Chitosan for Regeneration of Various Tissues |
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282 | (13) |
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282 | (3) |
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285 | (1) |
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286 | (3) |
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289 | (1) |
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290 | (1) |
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291 | (2) |
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293 | (1) |
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293 | (1) |
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294 | (1) |
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11.6 Chitin-and CS-Based Scaffolds for Drug and Growth Factors Delivery |
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295 | (1) |
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11.7 Chitin-and CS-Based Scaffolds/Dressings in Market |
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295 | (1) |
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295 | (4) |
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299 | (1) |
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299 | (1) |
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300 | (11) |
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12 Nanopolymer Chitosan in Cancer and Alzheimer Biomedical Application |
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311 | (50) |
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311 | (6) |
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12.1.1 Chemistry of Chitosan |
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312 | (2) |
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12.1.2 Brief Overview on Cancer |
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314 | (2) |
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12.1.3 Brief Overview on Alzheimer's Disease |
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316 | (1) |
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12.2 Chitosan Applications in Cancer |
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317 | (18) |
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12.2.1 Drug Delivery System |
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317 | (7) |
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12.2.2 Treatment and Therapy |
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324 | (4) |
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12.2.3 Diagnostic Strategy |
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328 | (7) |
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12.3 Chitosan Applications in Alzheimer's |
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335 | (12) |
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12.3.1 Pharmaceutical Formulation and Drug Delivery Application (Nanocarrier) |
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335 | (1) |
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12.3.1.1 Amyloid-P-Targeted Nanocarier |
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335 | (1) |
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12.3.1.2 Cholinesterase-Targeted Nanocarrier |
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339 | (1) |
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12.3.1.3 Other Functional Drug Carrier |
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343 | (1) |
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12.3.2 Treatment and Therapy |
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344 | (2) |
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12.3.3 Sensing and Diagnosis |
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346 | (1) |
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347 | (1) |
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348 | (13) |
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13 Biomedical Significance of Chitin-and Chitosan-Based Nanocomposites |
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361 | (24) |
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362 | (1) |
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13.2 Biomedical Applications |
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363 | (14) |
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364 | (3) |
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367 | (3) |
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13.2.3 Tissue Engineering |
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370 | (5) |
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13.2.4 Dental Application |
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375 | (1) |
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13.2.5 Antimicrobial Applications |
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376 | (1) |
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377 | (1) |
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378 | (7) |
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14 Potential Biomedical Applications of Chitosan-and Chitosan-Based Nanomaterials |
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385 | (26) |
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386 | (1) |
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14.2 Production of Chitin and Chitosan |
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387 | (1) |
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14.3 Bioactivities of Chitin and Chitosan |
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388 | (6) |
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14.3.1 Antitumor Activity |
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388 | (2) |
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14.3.2 Antibacterial Activity |
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390 | (2) |
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392 | (1) |
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392 | (1) |
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393 | (1) |
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14.4 Biomedical Application of Chitin-and Chitosan-Based Nanomaterials |
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394 | (6) |
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14.4.1 Wound Healing and Burns |
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394 | (1) |
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14.4.2 Tissue Engineering |
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395 | (1) |
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396 | (1) |
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397 | (3) |
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14.5 Conclusions and Future Perspective |
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400 | (1) |
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401 | (1) |
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401 | (10) |
Section IV: Chitosan in Agriculture and Water Treatment |
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15 Practical and Plausible Implications of Chitin-and Chitosan-Based Nanocomposites in Agriculture |
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411 | (20) |
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412 | (1) |
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15.2 Applications of Chitin and Chitosan Nanocomposite in Agriculture |
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413 | (10) |
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15.2.1 Controlled Pesticide, Insecticide, and Herbicide Delivery |
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413 | (4) |
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15.2.2 Efficient Fertilizer and Micronutrient Delivery |
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417 | (2) |
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419 | (1) |
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15.2.4 Genetic Engineering in Crop Plants |
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420 | (1) |
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421 | (2) |
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423 | (1) |
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423 | (1) |
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423 | (8) |
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16 Scope of Electrospun Chitosan Nanofibrous Web for its Potential Application in Water Filtration |
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431 | (22) |
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431 | (2) |
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16.2 Chitosan as an Efficient Material for Water Purification/ Disinfection |
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433 | (5) |
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16.2.1 Structure of Chitosan |
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433 | (1) |
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16.2.2 Physical, Chemical, and Biological Properties of Chitosan |
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434 | (1) |
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16.2.3 Chitosan for Water Purification/Disinfection |
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435 | (1) |
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16.2.3.1 Chitosan as a Coagulant/Flocculant |
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435 | (1) |
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16.2.3.2 Removal of Heavy Metals |
|
|
436 | (1) |
|
16.2.3.3 Removal of Organic Compounds |
|
|
437 | (1) |
|
16.2.3.4 Removal of Bacteria |
|
|
437 | (1) |
|
16.3 Electrospinning Process |
|
|
438 | (4) |
|
16.3.1 Electrospinning of Chitosan to obtain Nanofibres |
|
|
439 | (3) |
|
16.4 Electrospun Chitosan Nanofibers Embedded with Silver Nanoparticles for Filtration of Water Contaminated with Bacteria |
|
|
442 | (4) |
|
16.5 Chitosan-Based Nanocomposites for Water Filtration |
|
|
446 | (2) |
|
16.6 Current Challenges and Future Perspectives |
|
|
448 | (1) |
|
|
449 | (4) |
|
17 Application of Chitin/Chitosan and Its Derivatives as Adsorbents, Coagulants, and Flocculants |
|
|
453 | (36) |
|
Parappurath Narayanan Sudha |
|
|
|
|
|
|
|
|
|
|
454 | (1) |
|
|
455 | (1) |
|
17.3 Properties of Chitin and Chitosan |
|
|
455 | (1) |
|
17.3.1 Color and Appearance |
|
|
455 | (1) |
|
|
456 | (1) |
|
17.3.3 Molecular Weight and Degree of Polymerization |
|
|
456 | (1) |
|
17.4 Modification of Chitin and Chitosan |
|
|
456 | (5) |
|
17.4.1 Physical Modification |
|
|
457 | (1) |
|
17.4.2 Chemical Modification |
|
|
458 | (1) |
|
17.4.3 Multiple Modifications |
|
|
459 | (1) |
|
17.4.3.1 Blends of Chitosan |
|
|
459 | (1) |
|
17.4.3.2 Composites of Chitosan |
|
|
460 | (1) |
|
17.4.3.3 Grafted Chitosan |
|
|
460 | (1) |
|
17.5 Application of Natural Polymers in Wastewater Treatment as Promising Adsorbents |
|
|
461 | (4) |
|
17.5.1 For Heavy Metal Removal |
|
|
461 | (2) |
|
|
463 | (1) |
|
17.5.3 For General Wastewater Treatment |
|
|
464 | (1) |
|
17.6 Chitin and Chitosan as a New Type of Polymer Coagulant/Flocculants |
|
|
465 | (9) |
|
17.6.1 For Heavy Metal Removal |
|
|
469 | (1) |
|
|
470 | (2) |
|
17.6.3 For General Wastewater Treatment |
|
|
472 | (2) |
|
17.7 Future Directions for Research |
|
|
474 | (1) |
|
|
475 | (1) |
|
|
475 | (1) |
|
|
475 | (14) |
Index |
|
489 | |