Chlamydiosis are common and hazardous diseases, yet their clinical and morphological aspects are rarely described in the literature. Visceral and brain lesions remain virtually unknown.
This book presents the results of long-term studies conducted by the authors and their collaborators, including pathologists, infectologists, neurologists, ophthalmologists, and urologists. It compares clinical (adults, infants, placentas) and experimental materials with modern literary data. Many aspects of this problem have never been addressed in world literature. The text includes well-illustrated clinical, laboratory, and morphological issues of lesions across all locations, with examples from our own practice. It presents modern views on the taxonomy, properties, and diagnostics of Chlamydia. The possible role of the pathogen in the development of non-infectious lesions is also discussed, and directions for further studies is outlined.
This book is valuable for specialists and students in general medicine, infectious diseases, urology, obstetrics and gynecology, neurology, pediatrics, neonatology, ophthalmology, pathology, and legal medicine.
Introduction.
Chapter
1. Taxonomy of Chlamydia.- 1.1. Taxonomy of
Chlamydiales.- 1.2. Brief characteristics of the Chlamydiaceae family.-
Chapter
2. Pathogenesis of Chlamydiosis.- 2.1 Structural and functional
characteristics, virulence factors of chlamydia spp.- 2.2. Interaction of
chlamydia with host cells.- 2.3 Functional state of the immune system in
patients with various forms of chronic urogenital chlamydial infection.- 2.4
Results of correlation analysis of immunological parameters in patients with
localized and widespread forms of urogenital chlamydiosis.
Chapter
3.
Epidemiology of chlamydial infections.- 3.1. Infections due to Chlamydia
trachomatis.- 3.2. Infections caused by Chlamydia pneumonia.- 3.3 Infections
by Chlamydia psittaci.- 3.4. Diseases caused by Chlamydia felis, Chlamydia
abortus and Chlamydia caviae.
Chapter
4. Laboratory, instrumental and
morphological diagnostics of Chlamydial infections.- 4.1 Modern aspects of
diagnostics of diseases caused by C. trachomatis.- 4.2 Indications for
testing for urogenital chlamydia.- 4.3 Methodological aspects of laboratory
diagnostics of chlamydia.- 4.4 Diagnostic value of the results obtained by
various methods of diagnosing chlamydial infection.- 4.5 Molecular
¬biological methods for diagnostics of C.trachomatis.- 4.6 Cultural method.-
4.7 Rapid tests in the diagnosis of sexually transmitted infections.- 4.8
Serological tests (enzyme-linked immunosorbent assay, indirect
immunofluorescence).- 4.9 Determination of serotypes and molecular
¬biological characteristics of C. trachomatis.- 4.10 Diagnostics of
urogenital chlamydia associated with trichomonas invasion.- 4.11 Diagnosis of
widespread forms of chlamydial infection.- 4.12 Diagnosis of persistent forms
of chlamydial infection.- 4.13. Laboratory and instrumental diagnostics of
pneumochlamydiosis.- 4.14 Laboratory and instrumental diagnostics of
ornithosis.- 4.15. Morphological methods for diagnosing chlamydiosis.-
Chapter
5. Clinical and morphological characteristics of Chlamydial
infections in humans.- 5.1. Urogenital chlamydiosis.- 5.2 Chlamydial lesions
of the visual organ (Boyko E.V., Poznyak A.L., Suetov A.A.).- 5.3. Chlamydial
lesions of the nervous system (with the participation of Vainshenker Yu.I.,
Mudritsky V.M.).- 5.4 PNEUMOCHLAMYDIOSIS.- 5.5 Arthropathy associated with
chlamydial infection.- 5.6. Periodontitis (Together with A.F. Eliseeva).- 5.7
Other organ lesions.
Chapter
6. Perinatal chlamydiosis.- 6.1 Lessons of the
afterbirth in chlamydiosis.- 6.2 Intrauterine chlamydiosis.- 6.3 Remote
consequences of intrauterine chlamydiosis (in collaboration with YI
Vainshenker).
Chapter
7. Problems of mixed chlamydial infections.- 7.1
Chlamydiosis and influenza.- 7.2 Chlamydiosis and Covid.- 7.3 Combined brain
lesions in severe non-infectious lesions (jointly with Yu.I. Vainshenker).-
7.4. Chlamydiosis and other urogenital infections.
Chapter
8. Chlamydia and
non-infectious diseases.- 8.1 Chlamydia Pneumonia and atherosclerosis
(jointly with Yu.I. Vainshenker).- 8.2 Role of Chlamydia pneumoniae in the
pathogenesis of multiple sclerosis.- 8.3. Chlamydia and neurodegenerative
diseases.- 8.4 Brain lesions in HIV infected patients associated with C.
pneumoniae (in collaboration with Y.I. Vainshenker.- 8.5 Different
neurological pathology associated with chlamydia (in collaboration with Y.I.
Vainshenker).- 8.6 Other diseases probably associated with chlamydiosis.-
Chapter
9. Chlamydiosis in animals.- 9.1. Chlamydiosis in cattle.- 9.2.
Chlamydiosis in sheep.- 9.3. Chlamydiosis in pigs.- 9.4 Conclusion.
Chapter
10. Experimental chlamydiosis.- 10.1 Review of existing models of chlamydial
infections.- 10.2 Review of existing experimental models of chlamydial
infection of the nervous system.- 10.2 Ultrastructural changes in
experimental chlamydial meningoencephalitis (L.S. Onischenko, partly in
collaboration with M.M. Odinak, M.M. Mikhailenko, I.V. Nuralova).- Conclusion.
Prof. Vsevolod A. Zinserling (Tsinzerling) graduated from Leningrad Paediatric Medical Institute in 1977, worked as research scientist, practicing as pathologist in Leningrad Research Institute of Childrens Infections (1977-1988). In 1978-80 had postgraduate training at the chair of pathology (chief. Prof. O.K. Khmelnitsky) of Leningrad Institute for Postgraduate Medical Training. 1981 defended his cand. med. sc. (Dr. med.) thesis Brain changes in mycoplasmosis. In 1988-92 chief of the Central Research Laboratory of Leningrad Paediatric Medical Institute. In 1988 defended the doct. med. sci. thesis Brain lesions due to respiratory viruses. Since 1992-2007 chief of the Institute of Pathology St. Petersburg Paediatric Medical Academy. Since 2017 V. Zinserling is organizing and providing the postgraduate medical training in pediatric pathology in Russia. He is also providing consultations in the citys Consulting Centre for the Infectious Pathology and. Since 2017 professor of pathology at the V.A. Almazov National Research Center. Author of more than 400 scientific publications devoted to different topics of infectious, perinatal and brain pathology, including manuals (in Russian) Modern Infections (2002), Perinatal infections (2002), Infections of the Nervous System (2005). Author of two books Infectious Lesions of Respiratory tract (2021) and Infectious Lesions of the central Nervous System (2022), by Springer. Participant of many international congresses, being invited lecturer at European Congresses of ESP (2010-2022).
Prof. Alexey L. Poznyak works at the Department of Infectology of I.I. Mechnikov North-West Medical University (Saint-Petersburg, Russia). Author of 257 publications, including 3 monographs, chapters in 3 manuals, many of which were devoted to Chlamydiosis.
Dr. Sergey N Sidorchuk is an Assistant Professor at the Department of Infectology since 2021. Author of 144 publications, including chapter Chlamydiosis in the manuals Infectious diseases, Chlamydial infections.
Dr Katharina Wassilew graduated from the Charite'- Humboldt University in Berlin/Germany (MD). She trained in histopathology at well-known University hospitals in Israel, Bulgaria and Switzerland and subspecialised initially in soft tissue and bone pathology and further in cardiothoracic pathology in subspecialised departments in Italy (Rizzoli Institute) and in the UK (Royal National Orthopedic Hospital, Royal Brompton Hospital). During her career, she led and developed subspecialised units and research groups in cardiovascular and heart/lung transplant pathology, as at the Deutsches Herzzentrum Berlin/Germany and was appointed as Associate Professor at Copenhagen University in Denmark, balancing responsibilities of combined diagnostic service / leadership positions and teaching.
