Lays the foundation for new methods and applications of carbohydrate click chemistry
Introduced by K. Barry Sharpless of The Scripps Research Institute in 2001, click chemistry mimics nature, giving researchers the tools needed to generate new substances quickly and reliably by joining small units together. With contributions from more than thirty pioneering researchers in the field, this text explores the many promising applications of click chemistry in glycoscience. Readers will learn both the basic concepts of carbohydrate click chemistry as well as its many biomedical applications, including synthetic antigens, analogs of cell-surface receptors, immobilized enzymes, targeted drug delivery systems, and multivalent cancer vaccines.
Click Chemistry in Glycoscience examines a broad range of methodologies and strategies that have emerged from this rapidly evolving field. Each chapter describes new approaches, ideas, consequences, and applications resulting from the introduction of click processes. Divided into four sections, the book covers:
- Click chemistry strategies and decoupling
- Thio-click chemistry of carbohydrates
- Carbohydrate click chemistry for novel synthetic targets
- Carbohydrate click chemistry in biomedical sciences
Thoroughly researched, the book reflects the most recent findings published in the literature. Diagrams and figures throughout the book enable readers to more easily grasp complex concepts and reaction processes. At the end of each chapter, references lead to the primary literature for further investigation of individual topics.
The application of click chemistry to carbohydrates has tremendous implications for research. With this book as their guide, researchers have a solid foundation from which they can develop new methods and applications of carbohydrate click chemistry, including new carbohydrate-based therapeutics.
Foreword Preface Contributors List of Abbreviations Click chemistry
strategies and decoupling
Chapter
1. Paradigm and Advantage of Carbohydrate
Click Chemistry Strategy for Future Decoupling Roman Bielski, Zbigniew J.
Witczak Thio-click chemistry of carbohydrates
Chapter
2. Thio-click
Chemistry Overviews and Perspectives Zbigniew J. Witczak
Chapter
3.
Free-Radical Photoinduced Thiol-Ene and Thiol-Yne Coupling as Click Processes
for Glycoconjugation Alessandro Dondoni, Alberto Marra. Carbohydrate
click chemistry for novel synthetic targets
Chapter
4. The Development and
Application of Clickable Lipid Analogues for Elucidating Lipid Function
Michael Best
Chapter
5. Clicking Sugars onto Sugars: Oligosaccharide
Analogues and Glycoclusters on Carbohydrate Scaffolds Maria Laura Uhrig,
Jose Kovensky
Chapter 6 Click Multivalent Glycomaterials: Glycoclusters,
Glycodendrimers, Glycopolymers, Hybrid Glycomatrials and Glycosurfaces
Carmen Ortiz Mellet, Alejandro Mendez-Ardoy, Jose Manuel Garcia Fernandez
Chapter
7. Toward Imaging Glycotools by Click Coupling Yves Chapleur,
Christine Vala, Francoise Chretien, Sandrine Lamande-Langle
Chapter 8
Bioorthogonal Reactions for Labeling Glycoconjugates Frederic Friscourt,
Geert-Jan Boons
Chapter
9. Sweet Sucrose Macrocycles via Click Chemistry
Route Mykhaylo A. Potopnyk, Slawomir Jarosz Carbohydrate click chemistry
in biomedical sciences
Chapter
10. Neoglycoprotein Synthesis using
Copper-catalyzed Azide-Alkyne Click reaction and Native Chemical Ligation
Joanna M. Wojnar, Dong Jun Lee, Clive W. Evans, Kalyaneswar Mandal, Stephen
B.H. Kent Margaret A. Brimble
Chapter
11. Click-modified Cyclodextrin for
Biomedical Application Zhenshan Jia, Rakesh K. Singh, Dong Wang
Chapter
12. Triazolyl Glycoconjugates in Medicinal Chemistry Rama Pati Tripathi,
Pratibha Dwivedi, Anindra Sharma, Divya Kushwaha Vinod Kumar Tiwari
Chapter
13. Click Chemistry Applied to Carbohydrate-based Drug Discovery Vannessa
Leiria Campo, Ivone Carvalho Index
