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Clinical and Laboratory Medicine Textbook [Pehme köide]

  • Formaat: Paperback / softback, 739 pages, kõrgus x laius: 279x210 mm, 279 Illustrations, color; 2 Illustrations, black and white; XVII, 739 p. 281 illus., 279 illus. in color., 1 Paperback / softback
  • Ilmumisaeg: 10-Mar-2025
  • Kirjastus: Springer International Publishing AG
  • ISBN-10: 3031249607
  • ISBN-13: 9783031249600
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  • Pehme köide
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  • Formaat: Paperback / softback, 739 pages, kõrgus x laius: 279x210 mm, 279 Illustrations, color; 2 Illustrations, black and white; XVII, 739 p. 281 illus., 279 illus. in color., 1 Paperback / softback
  • Ilmumisaeg: 10-Mar-2025
  • Kirjastus: Springer International Publishing AG
  • ISBN-10: 3031249607
  • ISBN-13: 9783031249600
Teised raamatud teemal:
This textbook describes several diseases and clinical conditions, from physiopathological mechanisms to main clinical pictures, highlighting the importance of laboratory medicine, with the aim to provide the necessary tools for guiding correct laboratory findings interpretation.





Indeed, it is now widely recognized that laboratory medicine has a pivotal role in clinical medicine, significantly influencing clinical decisions. Thus, it is crucial to understand and use laboratory data appropriately.





This book has the great advantage of describing each topic exhaustively in order to facilitate its understanding. Specifically, it describes both diseases with a high incidence in the population, such as Diabetes Mellitus, Cardiovascular Diseases, Dyslipidemias, and Autoimmune Diseases, as well as rare diseases, such as Hereditary Metabolic Diseases. In addition, unusual topics are treated, such as Clinical Biochemistry of the Mind, as well as hot topics, such as Biological Drugs, Biobanks, Health Technology Assessment, and Omics Sciences. Finally, the book includes a chapter on the new health emergency, the SARS-CoV-2 pandemic. Two appendices are provided at the end of the book: a table summarizing the reference range and decisional cut-off for the main laboratory parameters and instructions on performing a venous blood sample.





The book will be an invaluable tool for medical and biomedical students, as well as for practitioners.
1 The role of laboratory medicine in the clinical context.- 2 The
laboratory diagnostic process.- 3 Elements of biomedical laboratory
organization.- 4 The role of statistics in laboratory medicine.- 5 Elements
of metrology.- 6 The pre-analytical phase.- 7 The quality of the laboratory
result: SOURCES OF VARIABILITY, METHOD OF ASSESSMENT AND ESTIMATION OF THEIR
CLINICAL IMPACT.- 8 Principles of Immunochemistry.- 9 General information on
laboratory tests and biomarkers.- 10 Enzymes and their clinical use.- 11
Liver: from biochemistry to clinical biochemistry.- 12 Protein diagnostics.-
13 Biomarkers of the nutritional state.- 14 Dyslipidemia.- 15 Hematological
diagnostics.- 16 Immunohematology.- 17 Hemostasis.- 18 Kidney.- 19 Physical,
Chemical and morphological urine examination.- 20 Hydroelectrolytic
disorders.- 21 Blood gas analysis.- 22 Cardiac biomarkers.- 23 Stroke
biomarkers.- 24 Thrombophilia.- 25 Endocrine system.- 26 Diabetes mellitus:
from definition to therapy.- 27  Diabetes mellitus: the role of the
laboratory.- 28 Metabolic syndrome.- 29 Hypoglycemia.- 30 The role of
laboratory in pregnancy.- 31 Hereditary metabolic diseases.- 32
Hyperphenylalaninemia, thyrosinemia, glycogenosis, hyperammoniemia.- 33
Circulating biomarkers in oncology: areas of application, critical issues and
perspectives.- 34 Liquid biopsy.- 35 Biological fluids.- 36 Laboratory
diagnostics of autoimmune diseases.- 37 Laboratory diagnostics in allergic
diseases.- 38 Biomarkers of bone remodeling.- 39 Alzheimer's disease and
other neurodegenerative dementias.- 40  In vivo clinical biochemistry.- 41
Clinical biochemistry of the mind.- 42 Clinical molecular biology.- 43 Fever
of unknown origin.- 44 Biomarkers of inflammation.- 45 Biomarkers of sepsis.-
46 Laboratory medicine and physical exercise.- 47 Clinical biochemistry of
the physical exercise.- 48 Preoperative laboratory tests.- 49 The laboratory
in urgency/emergency.- 50 Biological drugs.- 51 Mass spectrometry in clinical
biochemistry and laboratory medicine.- 52 Toxicology and analytical
pharmacology.- 53 Pharmacotoxicology of substances of abuse.- 54 Applications
of omics sciences in the laboratory.- 55 Covid-19.- 56 From aging to
healthy longevity: from an oxymoron to an hendiadys. Innovation in Medicine
including Predictive Medicine and Laboratory Medicine approaches.- 57
Biobanks of biomedical interest.- 58 Health technology assessment in
laboratory medicine.-APPENDIX A - RECOMMENDATIONS FOR THE APPROPRIATE VENOUS
BLOOD COLLECTION.-APPENDIX B - TABLE OF REFERENCE AND DECISIONAL VALUES OF
THE MAIN BIOMARKERS.
Dr. Marcello Ciaccio is a Full Professor of Clinical Biochemistry and Laboratory Medicine and Dean of the School of Medicine at the University of Palermo. He is the Director of the Institute of Clinical Biochemistry, Clinical Molecular Medicine and Clinical Laboratory Medicine, Department of Biomedicine, Neurosciences, and Advanced Diagnostics at the University of Palermo. He is also Director of the Department of Laboratory Medicine - A.O.U.P. Palermo P. Giaccone. He was Past-President (2016-2017) and President-Elect (2024-2025) of the Italian Society of Clinical Biochemistry and Clinical Molecular Biology - Laboratory Medicine (SIBioC). He is part of the Editorial Board of several peer-reviewed Journals, and he serves as a Reviewer for many prestigious Journals. He is the author of more than 400 scientific publications in national and international Journals.