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CMOS Capacitive Sensors for Lab-on-Chip Applications: A Multidisciplinary Approach 2010 ed. [Kõva köide]

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  • Formaat: Hardback, 146 pages, kõrgus x laius: 235x155 mm, kaal: 890 g, X, 146 p., 1 Hardback
  • Sari: Analog Circuits and Signal Processing
  • Ilmumisaeg: 22-Mar-2010
  • Kirjastus: Springer
  • ISBN-10: 9048137268
  • ISBN-13: 9789048137268
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CMOS Capacitive Sensors for Lab-on-Chip Applications: A Multidisciplinary Approach 2010 ed.Suurem pilt
  • Formaat: Hardback, 146 pages, kõrgus x laius: 235x155 mm, kaal: 890 g, X, 146 p., 1 Hardback
  • Sari: Analog Circuits and Signal Processing
  • Ilmumisaeg: 22-Mar-2010
  • Kirjastus: Springer
  • ISBN-10: 9048137268
  • ISBN-13: 9789048137268
Teised raamatud teemal:
Püsilink: https://www.kriso.ee/db/9789048137268.html
Märksõnad:
1.1 Overview of Lab-on-Chip Laboratory-on-Chip (LoC) is a multidisciplinary approach used for the miniaturization, integration and automation of biological assays or procedures in analytical chemistry [ 13]. Biology and chemistry are experimental sciences that are continuing to evolve and develop new protocols. Each protocol offers step-by-step laboratory instructions, lists of the necessary equipments and required biological and/or chemical substances [ 47]. A biological or chemical laboratory contains various pieces of equipment used for performing such protocols and, as shown in Fig. 1.1, the engineering aspect of LoC design is aiming to embed all these components in a single chip for single-purpose applications. 1.1.1 Main Objectives of LoC Systems Several clear advantages of this technology over conventional approaches, including portability, full automation, ease of operation, low sample consumption and fast assays time, make LoC suitable for many applications including. 1.1.1.1 Highly Throughput Screening To conduct an experiment, a researcher fills a well with the required biological or chemical analytes and keeps the sample in an incubator for some time to allowing the sample to react properly. Afterwards, any changes can be observed using a microscope. In order to quickly conduct millions of biochemical or pharmacolo- cal tests, the researchers will require an automated highly throughput screening (HTS) [ 8], comprised of a large array of wells, liquid handling devices (e.g., mic- channel, micropump and microvalves [ 911]), a fully controllable incubator and an integrated sensor array, along with the appropriate readout system.
Introduction
1(24)
Overview of Lab-on-Chip
1(2)
Main Objectives of LoC Systems
1(2)
From Macro to Micro Bioassays
3(6)
Micro-scale Liquid Handling
3(1)
Thermal Management in Microenvironment
4(1)
DNA Amplification
5(1)
Sample Handling
5(3)
Advantages of Performing Bioassays in Microscale
8(1)
CMOS-Based LoC
9(13)
Manipulation Methods
10(2)
Optical Techniques
12(2)
Electrochemical Sensors
14(2)
Mechanical Sensors
16(1)
Magnetic Sensor
17(1)
Temperature Control
18(3)
Capacitive Sensing LoC
21(1)
Objectives and Organization of Book
22(3)
Capacitive Sensing Electrodes
25(10)
On-Chip Microelectrode Configurations
25(4)
Passivated Electrodes
25(2)
Unpassivated Electrodes
27(1)
Sensitivity-Enhanced Passivated Electrodes
27(1)
Quasi Interdigitated Electrodes
27(1)
Gold Electrodes on CMOS Chip
28(1)
Microfluidic Channel Integrated Atop Sensing Electrodes
28(1)
Micromachining Gold Electrode on CMOS Chip
29(2)
Electrical Model of Sensing Electrodes
31(2)
Summary
33(2)
Capacitive Bio-interfaces
35(16)
Biochemical Capacitive Sensing Methods
36(9)
Hybridization Detection
36(1)
Antibody---Antigen Recognition
37(1)
Living Cells Monitoring
38(2)
Organic Solvent Sensors
40(1)
Bacteria Growth Monitoring
41(2)
Polyelectrolyte Monolayer
43(1)
Detection of Protein Conformation
44(1)
Design of Recognition Element: An Example for Continuous Glucose Monitoring
45(5)
Introduction to Glucokinase-Based Glucose Sensor
46(1)
Immobilization of Glucokinase on Gold Electrode
47(1)
Glucose Testing
48(2)
Summary
50(1)
Capacitive Interface Circuits for LoC Applications
51(40)
LBCS Versus MBCS
51(3)
Instant Measurement
51(1)
Aqueous Measurement
52(1)
On-Chip Sensing Electrodes
53(1)
Measurement Time
53(1)
RC Model Sample
53(1)
LBCS Methods
54(6)
SC-Based Interface Circuit
54(1)
Time Constant Method
55(1)
Capacitive Inverter Amplifier
56(3)
CBCM Methods
59(1)
Core---CBCM Interface Circuit
60(19)
Principle of CBCM for Sensing Applications
60(1)
Two Transistors CBCM Sensor
61(3)
Opamp-Based Integrator Incorporated with CBCM Sensor
64(1)
Differential Current CBCM Techniques
65(1)
Current Mirror Integrated with CBCM Structure
66(13)
Core-CBCM ΣΔ Capacitive Sensor
79(7)
Definitions
79(1)
Charge to Digital Converter
79(3)
Discussions
82(1)
Circuit Level Simulation Results
83(1)
Decoding Technique
84(2)
Core-CBCM Capacitive Sensing System
86(4)
A System Level Realization
86(1)
Experimental Procedures
87(3)
Summary
90(1)
Microfluidic Packaging Process
91(28)
Microfluidic Packaging Methods
92(3)
On-Chip Micromachining Procedures
92(1)
Adhesive Methods
93(1)
Rapid Prototyping Techniques
94(1)
Direct-Write Microfabrication Process
95(10)
Direct-Ink Writing
95(1)
Fundamentals of DWFP
96(2)
Direct-Write Microfluidic Fabrication Process
98(7)
Direct-Write Microfluidic Packaging Procedure
105(7)
Encapsulation of Bonding Pads and Wires
106(1)
Ink Deposition
106(4)
Fitting Connections
110(1)
Fugitive Dam
110(1)
Ink Encapsulation and Filling Process
110(1)
Ink Removal and Analyte Injection
110(2)
Emerging Applications of DWFP
112(6)
Microvalve
112(2)
Direct-Write Heat Exchanger
114(1)
Optical Waveguide for Biosensing Applications
115(3)
Summary
118(1)
Current Technology and Future Works
119(8)
Conventional Impedometric and Capacitive Measurement Systems
119(3)
Handheld Impedance Measurement Systems
122(2)
Towards Fully Integrated Capacitive Sensing LoC
124(2)
Packaging
124(1)
Capacitance Characterization
124(1)
Electrical Modeling of Biological Sample
125(1)
Cleaning Procedure
126(1)
Summary
126(1)
References 127(16)
Index 143
Ebrahim Ghafar-Zadeh received the BSc and MSc degrees in Electrical Engineering from KNT and Tehran Universities, Tehran, Iran, in 1992 and 1994, respectively. In 1994 he joints the electrical engineering department at SCU University, Ahvaz, Iran as faculty memeber. During 2004-2008, he pursued a PhD degree in electrical engineering at Ecole Polytechnique de Montreal, Canada. In January 2008 and September 2008, he received two fellowship award from NSERC Canada and ReSMiQ Quebec, Canada which allowed him to continue his research for fully integrated bacteria detection. The research interests of Dr. Ghafar-zadeh include the circuit and system design, implementation and packaging technologies for lab-on-chip applications.









Mohamad Sawan received his BSc in Electrical Engineering from Université Laval (1984), and MSc (1986) and PhD (1990) both in Electrical Engineering from Université de Sherbrooke. He then completed post-doctoral training at Montréal's McGill University in 1991, and in that same year, joined École Polytechnique de Montréal, where he is currently a Professor of Microelectronics. Dr. Sawan's scientific interests focus on the design and testing of mixed-signal (analog, digital and RF) circuits and systems; digital and analog signal processing; and the modelling, design, integration, assembly and validation of advanced wirelessly powered and controlled monitoring and measurement techniques. These topics are oriented toward biomedical implantable devices and telecommunications applications. Dr. Sawan is holder of the Canada Research Chair in Smart Medical Devices. He heads the Microsystems Strategic Alliance of Québec ReSMiQ and is founder of the Eastern Canada Chapter of the IEEE-Solid State Circuits Society. He also founded the International IEEE-NEWCAS conference, co-founded the International Functional Electrical Stimulation Society, and founded the Polystim Neurotechnologies Laboratoryat Ecole Polytechnique. He is the editor of Springer mixed-signal letters, Chair of the IEEE Biomedical CAS (BioCAS) Technical Committee, and member of the Biotechnology Council representing the IEEE-CAS Society. He has been awarded seven patents. He received the Barbara Turnbull Award for spinal cord research, the Medal of Merit from the Lebanese President (2005), and the J.-A. Bombardier Award from the Association Francophone pour le savoir (ACFAS). Dr. Sawan is a Fellow of both the Canadian Academy of Engineering and the IEEE.