Victor McKusick, pre-eminent in the field, has contributed the first chapter outlining the origin of the concept of heritable disorders of connective tissue, its evolution, and its validation by the definition of molecular defects. The concept is undergoing continuing expansion as susceptibility to common disorders of connective tissue is being related to genetic differences. Coverage here encompasses the biology of the extracellular matrix and consideration of conditions classically regarded as inherited disorders of connective tissue, as well as a number of others. Annotation copyright Book News, Inc. Portland, Or.
Synthesizes a wealth of new information in the areas of biochemistry, genetics and molecular biology. Contains clear,well-organized material regarding advances in the study of heritable disorders of connective tissue, describing breakthroughs in the last ten years which, until now, have not been published.
