This book aims to provide the reader with an in-depth overview of the diagnostic and therapeutic options currently available in epilepsy surgery. It juxtaposes diagnostic methods and surgical techniques that have existed for a long time and others that have recently been developed or have gained importance. The nuanced comparison shows that several methods may be applicable for the same indication but, depending on the specific circumstances, one of them may be the best choice.
The book is divided into four main parts, focusing on anatomy, pre-surgical diagnostic evaluation of epilepsy, curative surgical treatment of epilepsy and symptomatic surgical treatment of epilepsy. The chapters are designed to describe not only a method or technique but also their specific risks or the limits where the competing option may become preferable.
The book thus guides the readers through the current controversies and helps them make a rational decision for their patients. It will be a valuable resource for neurosurgeons, neurologists,neurophysiologists, neuroradiologists and neuropsychologists dedicated to the treatment of drug-resistant epilepsy and for the multidisciplinary epilepsy surgery conferences.
Preface.- Part 1.- The Temporal Lobe and the Limbic System.- Anatomy of
the Insula.- Anatomy of the Thalamus.- Part 2.- 3-Tesla MR Imaging for the
Detection of Structural Lesions.- Clinical Applications of 7 Tesla Magnetic
Resonance Imaging for Epilepsy.- Automated Detection of Structural Brain
Lesions from MRI.- Ictal SPECT and its Value in the Localization of the
Seizure-Onset Zone.- Interictal PET and its Value in the Localization of the
Seizure-Onset Zone.- Neuropsychological Assessment of Cognition and
Functional Reserve.- Functional Magnetic Resonance Imaging (fMRI) for the
Evaluation of Cognition and Functional Reserve.- The Wada Test for the
Evaluation of Cognition and Functional Reserve.- Electrical Source Imaging in
the Presurgical Evaluation.- Magnetic Source Localization.- Indication and
interpretation of SEEG.- Indication and Interpretation of
Electrocorticography by Subdural and Spencer-Type Electrodes.- Frame-Based
Implantation of Stereo EEG Electrodes.- Robot-Assisted Implantation of Stereo
EEG Electrodes.- Frameless Implantation of Stereo EEG Electrodes.- Spatial
Bayesian Approach to sEEG Electrode Placement.- Electrical Source Imaging
Guidance of Depth Electrode Placement.- Intraoperative Electrocorticography.-
Extraoperative Electrocorticography. Part 3.- Anterior Temporal Lobectomy for
Temporal Lobe Epilepsy.- Selective Amygdalohippocampectomy.- Transsylvian
approach to selective Amygdalohippocampectomy.- Subtemporal Approach for
Amygdalohippocampectomy.- Selective Amygdalohippocampotomy using LITT.-
Radiosurgery for mesial temporal lobe epilepsy.- Multiple Hippocampal
Transection for Preservation of Verbal Memory.- Microsurgery and Endoscopic
Surgery for Hypothalamic Hamartoma.- Radiosurgery for Hypothalamic
Hamartoma.- LiTT Ablation for Hypothalamic Hamartoma.- Radiofrequency
Ablation for Hypothalamic Hamartoma.- Stereo-electroencephalography guided
RadioFrequency ThermoCoagulation for (sub)cortical epileptogenic lesions.-
LiTT Ablation for Subcortical Epileptogenic Lesions.- Focused Ultrasound for
Subcortical Epileptogenic Lesions.- Hemispherotomy through Vertical
Approach.- Lateral Approach for Hemispherotomy.- Part 4.- The Evolution of
Corpus Callosotomy: Theory and Practice.- Vagus Nerve Stimulation for the
Management of Epilepsy and Epileptic Drop Attacks.- Radiofrequency ablation
of the thalamic centrum medianum for catastrophic epilepsy.- Selective
posterior callosotomy: An innovative approach targeted to disconnect fibers
relevant to epileptic drop attacks.- Callosotomy by means of
radiosurgery.- Subthalamic Nucleus as Deep Brain Stimulation Target in the
Management of Epilepsy.- The Centromedian Thalamic Nucleus as a Deep Brain
Stimulation Target in the Management of Epilepsy.- The Anterior Nucleus of
Thalamus as a Deep Brain Stimulation Target in the Management of Epilepsy.-
Open vs. Closed-Loop Stimulation in the Management of Drug-Resistant
Epilepsy.- Extraventricular Approach for Deep Brain Stimulation of the
Anterior Nucleus of Thalamus.- Transventricular Approach to Anterior Nucleus
of Thalamus.- The Psychological Impact of Epilepsy Surgery.
Dirk Van Roost graduated in medicine from KU Leuven University (Belgium) in 1977 and completed a training programme in neurosurgery at the University Hospitals of Leuven and Tübingen (Germany). From 1985 to 2003, he worked at the neurosurgery department of the University Hospital of Bonn (Germany) in various areas, including neuroradiology and neurosurgical intensive care. His habilitation (PhD) thesis at the University of Bonn addressed cerebral perfusion in brain tumours measured by xenon CT. In 2003, Dr. Van Roost was appointed professor at the University Hospital of Ghent (Belgium), where he served as Chairman of the Department of Neurosurgery from 2008 until his retirement in 2018. Since then, he has continued his neurosurgical work part-time in the same department. His surgical spectrum includes brain tumours, aneurysms and vascular malformations, skull base and spine surgery, brain endoscopy and pain management, but his areas of special interest are functional stereotaxis and epilepsy surgery.
Dr. Van Roost is former president and currently an honorary member of the Belgian Society of Neurosurgery (BSN), former president of the Belgian Society of Stereotactic and Functional Neurosurgery (BSSFN), former president and current board member of the Belgian Brain Council (BBC), panel member of the EANS Functional Section and member of the executive committee of the European Society of Stereotactic and Functional Neurosurgery (ESSFN). Under the latter´s auspices, he organised three hands-on dissection courses on epilepsy surgery in Ghent. He has also been a regular lecturer at EANS training courses. He is a member of three other international scientific societies, and a former member of the international advisory board of the journal Neurosurgery.
Olaf Schijns graduated in medicine from the University of Leiden (The Netherlands) in 1997. He is a neurosurgeon from Maastricht, The Netherlands, trained at the Maastricht University Medical Center (MUMC+) in general neurosurgery under Emile Beuls and at the Bonn University Hospital, Germany, in epilepsy surgery under Johannes Schramm. After returning from Bonn, he further developed the epilepsy surgery programme at the MUMC+ / Academic Center for Epileptology (ACE), in close collaboration with colleagues at the Kempenhaeghe Academic Center for Epileptology. In 2008, together with Albert Colon, neurologist at the Kempenhaeghe Academic Center for Epileptology, he introduced stereo-EEG in The Netherlands.He has been mainly involved in patient care and epilepsy research, with a special interest in ultra-high field imaging for epilepsy surgery and in minimally invasive diagnostic and therapeutic techniques (radiofrequency thermocoagulation with sEEG and stereotactic radiosurgery). He was elected Chair of the Functional Neurosurgery Section of the European Association of Neurosurgical Societies (EANS) in October 2021 and Chair of the Section of Functional Neurosurgery of the Dutch Neurosurgical Association (NVVN) in January 2022.Dr. Schijns is a regular lecturer at the EANS training courses and initiated the annual EANS Epilepsy Surgery Hands-on Dissection Course for senior neurosurgical trainees and young neurosurgeons in 2024.
