| preface |
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xiii | |
| acknowledgments |
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xv | |
| About the author |
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xvii | |
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1 General approaches for critical care |
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1 | (24) |
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1 | (2) |
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Obtaining a clinical history and medical records |
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3 | (2) |
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5 | (1) |
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Relocation for physical examinations |
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6 | (1) |
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Monitoring critically ill rodents |
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6 | (5) |
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Pain recognition and assessments |
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11 | (1) |
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Supportive care for surgical procedures |
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12 | (5) |
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Supplemental heat provision |
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17 | (1) |
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18 | (3) |
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Routes of Drug and Fluid Administration |
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18 | (3) |
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21 | (4) |
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2 Critical care management for laboratory mice |
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25 | (88) |
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25 | (1) |
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25 | (1) |
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General medical approaches to physical examination and health assessments |
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26 | (7) |
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27 | (2) |
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29 | (1) |
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Clinical Assessments of Ill Health and Pain in Mice |
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29 | (2) |
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31 | (1) |
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Objective Scoring Systems |
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31 | (2) |
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33 | (11) |
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33 | (2) |
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35 | (3) |
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Body Temperature Monitoring |
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38 | (2) |
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40 | (1) |
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Injections and Oral Administration |
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41 | (1) |
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42 | (2) |
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abnormal, critical, and emergent conditions |
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44 | (41) |
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44 | (1) |
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45 | (2) |
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Cage Flooding with Subsequent Hypothermia |
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47 | (2) |
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49 | (1) |
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50 | (1) |
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Cross Fostering of Neonates/Mouse Pups |
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51 | (1) |
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52 | (4) |
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56 | (1) |
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Fractures/Orthopedic Problems |
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57 | (2) |
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59 | (1) |
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Moribund, Weak, or Paralyzed Condition |
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59 | (2) |
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61 | (1) |
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62 | (2) |
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64 | (2) |
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66 | (2) |
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68 | (1) |
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69 | (2) |
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71 | (3) |
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74 | (2) |
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76 | (8) |
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Vaginal or Uterine Prolapse |
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84 | (1) |
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research-related medical issues |
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85 | (28) |
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85 | (2) |
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Experimental Autoimmune Encephalomyelitis Mouse Models |
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87 | (1) |
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88 | (1) |
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88 | (2) |
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Opportunistic Infections in Immunodeficient Mouse Models |
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90 | (1) |
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91 | (3) |
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Streptozotocin Induction for Diabetic Models |
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94 | (1) |
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Tumor Burden in Mouse Models |
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94 | (4) |
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Urogenital Disease in Mouse Models |
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98 | (1) |
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99 | (1) |
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99 | (14) |
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3 Critical care management for laboratory rats |
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113 | (46) |
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113 | (1) |
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114 | (1) |
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General medical approaches to physical examination and health assessments |
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114 | (6) |
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114 | (3) |
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117 | (1) |
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Clinical Assessments of Ill Health and Pain in Rats |
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117 | (2) |
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119 | (1) |
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Objective Scoring Systems |
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119 | (1) |
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120 | (11) |
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120 | (2) |
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122 | (3) |
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Body Temperature Monitoring |
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125 | (1) |
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125 | (1) |
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125 | (3) |
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Injections and Oral Administration |
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128 | (1) |
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129 | (2) |
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abnormal, critical, and emergent conditions |
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131 | (11) |
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132 | (1) |
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133 | (1) |
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Malocclusion (Incisors) and Caries |
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134 | (1) |
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135 | (2) |
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Ocular Lesions Secondary to Anesthesia |
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137 | (1) |
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137 | (2) |
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139 | (1) |
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139 | (2) |
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141 | (1) |
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research-related medical issues |
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142 | (8) |
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142 | (1) |
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Cranial Implant Maintenance |
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143 | (2) |
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Incontinence Secondary to Spinal Cord Injury Models |
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145 | (1) |
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Middle Cerebral Artery Occlusion in Rat Models of Stroke |
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145 | (1) |
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Obese and Diabetic Rat Models |
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146 | (1) |
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Opportunistic Infections in Immunodeficient Rat Models |
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147 | (1) |
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147 | (1) |
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Spontaneously Hypertensive Rat Models |
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148 | (1) |
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Tumor Burden in Rat Models |
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148 | (2) |
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150 | (1) |
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151 | (8) |
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4 Special considerations for critical care management in laboratory rodents |
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159 | (40) |
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159 | (1) |
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Aging animal model considerations |
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160 | (2) |
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Blood loss considerations |
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162 | (1) |
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Chronic indwelling device considerations |
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163 | (1) |
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Depilatory cream considerations |
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163 | (1) |
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Equipment considerations for rodent surgery and emergency procedures |
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164 | (1) |
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Euthanasia considerations |
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165 | (3) |
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Experimental autoimmune encephalomyelitis and demyelinating disease model considerations |
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168 | (2) |
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168 | (1) |
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169 | (1) |
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170 | (1) |
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Fluid therapy considerations |
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171 | (2) |
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172 | (1) |
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173 | (1) |
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Food and fluid regulation procedures |
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173 | (2) |
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Humane or "clinical" endpoint considerations |
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175 | (3) |
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Nutritional therapy considerations |
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178 | (3) |
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Perioperative care considerations |
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181 | (5) |
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Regulatory considerations |
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186 | (1) |
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Restraint collar considerations |
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187 | (1) |
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Tracheostomy considerations |
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188 | (1) |
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Tumor development and monitoring considerations |
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189 | (3) |
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190 | (1) |
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191 | (1) |
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191 | (1) |
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Ascites Produced by Tumors |
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191 | (1) |
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Wound management considerations |
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192 | (1) |
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193 | (6) |
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5 Resources and additional information |
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199 | (14) |
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199 | (1) |
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199 | (2) |
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American Association for Laboratory Animal Medicine (AALAS) |
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199 | (1) |
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American College of Laboratory Animal Medicine (ACLAM) |
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200 | (1) |
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American Society of Laboratory Animal Practitioners (ASLAP) |
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200 | (1) |
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Institute for Laboratory Animal Research (ILAR) |
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201 | (1) |
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201 | (2) |
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201 | (2) |
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203 | (1) |
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203 | (7) |
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203 | (1) |
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Animal Care Training Services (ACTS) |
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204 | (1) |
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AVMA Guidelines for the Euthanasia of Animals: 2013 Edition |
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204 | (1) |
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204 | (1) |
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Drug Enforcement Agency (DEA), Office of Diversion Control |
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205 | (1) |
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205 | (1) |
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International Council for Laboratory Animal Science (ICLAS) |
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205 | (2) |
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International Mouse Strain Resource (IMSR) |
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207 | (1) |
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207 | (1) |
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National Institutes of Health Office of Research Infrastructure Programs (ORIP): Rodent Resources |
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208 | (1) |
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Office of Laboratory Animal Welfare |
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208 | (1) |
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208 | (1) |
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209 | (1) |
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209 | (1) |
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Veterinary Bioscience Institute (VBI) |
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209 | (1) |
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Veterinary Emergency and Critical Care Society (VECCS) |
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210 | (1) |
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Veterinary Information Network (VIN) |
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210 | (1) |
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210 | (3) |
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210 | (1) |
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211 | (2) |
| Appendix A Glossary of acronyms and terms |
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213 | (2) |
| Appendix B Suggested medical supplies for rodent critical care |
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215 | (2) |
| Appendix C Rodent formulary |
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217 | (18) |
| Index |
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235 | |