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Critical Care Management for Laboratory Mice and Rats [Pehme köide]

(University of Pennsylvania, Philadelphia, United States)
  • Formaat: Paperback / softback, 272 pages, kõrgus x laius: 234x156 mm, kaal: 500 g, 20 Tables, black and white; 69 Illustrations, color
  • Sari: Laboratory Animal Pocket Reference
  • Ilmumisaeg: 03-Oct-2013
  • Kirjastus: CRC Press Inc
  • ISBN-10: 0849324998
  • ISBN-13: 9780849324994
  • Pehme köide
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  • Formaat: Paperback / softback, 272 pages, kõrgus x laius: 234x156 mm, kaal: 500 g, 20 Tables, black and white; 69 Illustrations, color
  • Sari: Laboratory Animal Pocket Reference
  • Ilmumisaeg: 03-Oct-2013
  • Kirjastus: CRC Press Inc
  • ISBN-10: 0849324998
  • ISBN-13: 9780849324994

For critical care of laboratory rodents, there is a scarcity of sources for comprehensive, feasible, and response-oriented information on clinical interventions specific to spontaneous and induced models of disease. With the more complex cases that need critical care management, many treatment approaches to veterinary emergencies cannot be applied directly to the laboratory rodent. The first text of its kind devoted to the challenges of critical care management for laboratory rodents, Critical Care Management for Laboratory Mice and Rats provides a specialized resource for all veterinary, husbandry, technical, and research professionals who utilize rodent models for biomedical research.

The book covers the varied approaches to laboratory rodent patient care, health assessments, characteristics of specific disease models, monitoring and scoring of disease parameters, and humane interventions. Giving primary consideration to preservation of animal health and welfare, the text also considers how best to balance welfare with the achievement of proposed scientific objectives. Organized into five chapters, this full-color book covers the following topics:

  • General Approaches for Critical Care
  • Critical Care Management for Laboratory Mice
  • Critical Care Management for Laboratory Rats
  • Special Considerations for Critical Care Management in Laboratory Rodents
  • Resources and Additional Information

The author provides treatment guidelines with the expectation that they will be applied with apt professional judgment, allowing for further modification of clinical recommendations for improved patient-based care and welfare for research animals.

preface xiii
acknowledgments xv
About the author xvii
1 General approaches for critical care
1(24)
overview
1(2)
Obtaining a clinical history and medical records
3(2)
Body condition scoring
5(1)
Relocation for physical examinations
6(1)
Monitoring critically ill rodents
6(5)
Pain recognition and assessments
11(1)
Supportive care for surgical procedures
12(5)
Supplemental heat provision
17(1)
Drug Therapy
18(3)
Routes of Drug and Fluid Administration
18(3)
references
21(4)
2 Critical care management for laboratory mice
25(88)
introduction
25(1)
Overall assessments
25(1)
General medical approaches to physical examination and health assessments
26(7)
Physical Examination
27(2)
Body Condition Scoring
29(1)
Clinical Assessments of Ill Health and Pain in Mice
29(2)
Monitoring Frequency
31(1)
Objective Scoring Systems
31(2)
Veterinary care measures
33(11)
Administration of Fluids
33(2)
Blood Sampling
35(3)
Body Temperature Monitoring
38(2)
Endotracheal Intubation
40(1)
Injections and Oral Administration
41(1)
Urine Sampling
42(2)
abnormal, critical, and emergent conditions
44(41)
Abdominal Swelling
44(1)
Abscessation
45(2)
Cage Flooding with Subsequent Hypothermia
47(2)
Cannibalization
49(1)
Conjunctivitis
50(1)
Cross Fostering of Neonates/Mouse Pups
51(1)
Dystocia
52(4)
Fight Wounds
56(1)
Fractures/Orthopedic Problems
57(2)
Hemorrhage
59(1)
Moribund, Weak, or Paralyzed Condition
59(2)
Mortality (Sudden Death)
61(1)
Ocular Lesions
62(2)
Perineal Swelling
64(2)
Poor Body Condition
66(2)
Rectal Prolapse
68(1)
Respiratory Distress
69(2)
Seizures
71(3)
Trauma
74(2)
Ulcerative Dermatitis
76(8)
Vaginal or Uterine Prolapse
84(1)
research-related medical issues
85(28)
Ascites Production
85(2)
Experimental Autoimmune Encephalomyelitis Mouse Models
87(1)
Hemophilic Mouse Models
88(1)
Obese Mouse Models
88(2)
Opportunistic Infections in Immunodeficient Mouse Models
90(1)
Radiation Exposure
91(3)
Streptozotocin Induction for Diabetic Models
94(1)
Tumor Burden in Mouse Models
94(4)
Urogenital Disease in Mouse Models
98(1)
euthanasia
99(1)
references
99(14)
3 Critical care management for laboratory rats
113(46)
introduction
113(1)
Overall Assessments
114(1)
General medical approaches to physical examination and health assessments
114(6)
Physical Examination
114(3)
Body Condition Scoring
117(1)
Clinical Assessments of Ill Health and Pain in Rats
117(2)
Monitoring Frequency
119(1)
Objective Scoring Systems
119(1)
Veterinary care measures
120(11)
Administration of Fluids
120(2)
Blood Sampling
122(3)
Body Temperature Monitoring
125(1)
Bone Marrow Access
125(1)
Endotracheal Intubation
125(3)
Injections and Oral Administration
128(1)
Urine Sampling
129(2)
abnormal, critical, and emergent conditions
131(11)
Burns
132(1)
Catheter Infections
133(1)
Malocclusion (Incisors) and Caries
134(1)
Moribund/Weak/Paralyzed
135(2)
Ocular Lesions Secondary to Anesthesia
137(1)
Poor Body Condition
137(2)
Ringtail
139(1)
Ulcerative Dermatitis
139(2)
Urolithiasis
141(1)
research-related medical issues
142(8)
Arthritis Models
142(1)
Cranial Implant Maintenance
143(2)
Incontinence Secondary to Spinal Cord Injury Models
145(1)
Middle Cerebral Artery Occlusion in Rat Models of Stroke
145(1)
Obese and Diabetic Rat Models
146(1)
Opportunistic Infections in Immunodeficient Rat Models
147(1)
Pododermatitis
147(1)
Spontaneously Hypertensive Rat Models
148(1)
Tumor Burden in Rat Models
148(2)
euthanasia
150(1)
references
151(8)
4 Special considerations for critical care management in laboratory rodents
159(40)
introduction
159(1)
Aging animal model considerations
160(2)
Blood loss considerations
162(1)
Chronic indwelling device considerations
163(1)
Depilatory cream considerations
163(1)
Equipment considerations for rodent surgery and emergency procedures
164(1)
Euthanasia considerations
165(3)
Experimental autoimmune encephalomyelitis and demyelinating disease model considerations
168(2)
EAE Scoring
168(1)
Animal Care
169(1)
Fasting considerations
170(1)
Fluid therapy considerations
171(2)
Crystalloids
172(1)
Colloids
173(1)
Food and fluid regulation procedures
173(2)
Humane or "clinical" endpoint considerations
175(3)
Nutritional therapy considerations
178(3)
Perioperative care considerations
181(5)
Regulatory considerations
186(1)
Restraint collar considerations
187(1)
Tracheostomy considerations
188(1)
Tumor development and monitoring considerations
189(3)
Evaluating Tumor Growth
190(1)
Tumor Ulceration
191(1)
Multiple Tumors
191(1)
Ascites Produced by Tumors
191(1)
Wound management considerations
192(1)
references
193(6)
5 Resources and additional information
199(14)
introduction
199(1)
organizations
199(2)
American Association for Laboratory Animal Medicine (AALAS)
199(1)
American College of Laboratory Animal Medicine (ACLAM)
200(1)
American Society of Laboratory Animal Practitioners (ASLAP)
200(1)
Institute for Laboratory Animal Research (ILAR)
201(1)
publications
201(2)
Books
201(2)
Periodicals
203(1)
Electronic resources
203(7)
AALAS Learning Library
203(1)
Animal Care Training Services (ACTS)
204(1)
AVMA Guidelines for the Euthanasia of Animals: 2013 Edition
204(1)
CompMed™ listserv
204(1)
Drug Enforcement Agency (DEA), Office of Diversion Control
205(1)
IACUC-Forum listserv
205(1)
International Council for Laboratory Animal Science (ICLAS)
205(2)
International Mouse Strain Resource (IMSR)
207(1)
Mouse Genome Database
207(1)
National Institutes of Health Office of Research Infrastructure Programs (ORIP): Rodent Resources
208(1)
Office of Laboratory Animal Welfare
208(1)
Pubmed
208(1)
Rat Genome Database
209(1)
TechLink listserv
209(1)
Veterinary Bioscience Institute (VBI)
209(1)
Veterinary Emergency and Critical Care Society (VECCS)
210(1)
Veterinary Information Network (VIN)
210(1)
Commercial resources
210(3)
ALN Buyer's Guide
210(1)
Lab Animal Buyer's Guide
211(2)
Appendix A Glossary of acronyms and terms 213(2)
Appendix B Suggested medical supplies for rodent critical care 215(2)
Appendix C Rodent formulary 217(18)
Index 235
F. Claire Hankenson, DVM, MS, is the senior associate director in University Laboratory Animal Resources, University of Pennsylvania, Philadelphia, and is an associate professor of laboratory animal medicine in the Department of Pathobiology at the School of Veterinary Medicine. Dr. Hankenson obtained her veterinary degree from Purdue University. Following veterinary school, she completed her laboratory animal medicine residency and graduate work (MS, microbiology) at the University of Washington, Seattle. She became a Diplomate of the American College of Laboratory Animal Medicine (ACLAM) in 2002. Her own research studies involve investigations of refinements in the care and use of laboratory rodents, particularly blood sampling, tail biopsy evaluations, and humane endpoints.