This book is a comprehensive volume dedicated to dermal absorption and decontamination. Given risks including chemical warfare and accidents with toxic industrial chemicals, studies involving dermal absorption and decontamination are of the utmost importance. Each chapter consists of a systematic review on an important dermal absorption and/or decontamination topic. Chapters address key issues such as the general acceptance of water/ soap and water as the gold standard of dermal decontamination despite the fact that it commonly provides incomplete decontamination and may even result in a “wash-in effect” (an increased penetration of contaminant). Decontamination with other substances (e.g. RSDL) is explored, and factors that affect dermal penetration (e.g. anatomical variation) are summarized. All systematic reviews are comprehensive and up-to-date.
Dermal Absorption and Decontamination will be useful for many fields and disciplines. Firstly, information on dermal decontamination may be used by governments for military and national defense purposes in the event of chemical warfare. Additionally, this information would be of use to many production companies, whose employees are at risk of an accident with toxic industrial chemicals. Topics covered in the book will also be of use to pharmaceutical companies, especially those exploring transdermal delivery of drugs and is of great relevance to those in the medical field, particularly dermatologists.
Skin Decontamination with Water: Evidence from In Vivo Human Studies.-
Towards a harmonized protocol for in vitro human skin decontamination
efficacy.- In Vitro Human Skin Decontamination with Water: Chemical Warfare
Agents or Simulants.- In Vitro Human Skin Decontamination with Water:
Occupational Contaminants.- Skin Decontamination with Water: Evidence from In
Vivo Animal Models.- Skin Decontamination with Water: Evidence from In Vitro
Animal Models.- Dry Decontamination with Readily Available Products.- A
Review of Reactive Skin Decontamination Lotion Efficacy.- Aqueous suspensions
of Fullers earth potentiate the adsorption capacities of Paraoxon and
improve skin decontamination properties.- Development of a next generation
military skin decontaminant: Initial efficacy studies of Zirconium
Hydroxide.- Findings from the PHOENIX project: Protocols for Hair and the
Optimisation of Existing and Novel decontamination Interventions through
experimentation.- Twenty clinically pertinent factors/ observations for
percutaneous absorption in humans.- Lateral Spread and Percutaneous
Penetration: An Overview.- Regional Variation in Percutaneous Absorption:
Evidence from In Vitro Human Models.- Experimental Variability in TEWL Data.-
Relationships Between Skin of Color and the TEWL Barrier.
Aileen M Feschuk Faculty of Medicine, Memorial University of Newfoundland, St. Johns, NL, Canada Rebecca M Law, PharmDSchool of Pharmacy, Memorial University of NewfoundlandFaculty of Medicine, Memorial University of NewfoundlandSt. Johns, NL, Canada Howard I Maibach, MDDepartment of Dermatology, University of California San Francisco, San Francisco, CA, USA
