In this thoroughly revised and updated second edition, the emphasis remains on providing a practical and up-to-date guide for the practicing pathologist when evaluating peripheral blood, bone marrow and lymph node specimens from pediatric patients. Over 400 high quality colour figures aid accuratecountries, the use of molecular diagnostics, and the role of flow cytometry in diagnosis and post-therapy monitoring of hematologic malignancies. The importance of unique diagnostic features of benign and malignant hematologic disorders in children is retained, with chapters authored by experienced pediatric hematopathologists and clinical scientists drawn from major children's hospitals across the US, Europe and Africa. The print book comes with access to the text and expandable figures online at Cambridge Core, which can be accessed via the code printed on the inside of the cover.
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A comprehensive guide to diagnostic pediatric hematopathology, emphasizing practical guidance, aided by over 400 colour figures.
Introduction; Section I. General and Non-neoplastic Hematopathology:
1.
Hematologic values in the healthy fetus, neonate, and child Maria A.
Proytcheva;
2. Normal bone marrow Maria A. Proytcheva;
3. Disorders of
erythrocyte production: nutritional deficiencies, iron deficient, and
sideroblastic anemia Angela E. Thomas and Barbara J. Bain;
4. Disorders of
hemoglobin synthesis thalassemias and structural hemoglobinopathies Archana
M. Agarwal and Anton Rets;
5. Hemolytic anemias: immune- and
non-immune-mediated hemolytic anemias, RBC membrane defects, and hereditary
disorders due to RBC enzyme defects Maria A. Proytcheva;
6. Anemias in
children in developing countries Simon Osongo and Elizabeth Kagotho;
7.
Inherited bone marrow failure syndromes Jyotinder N. Punia, M. Tarek
Elghetany and Maria A. Proytcheva;
8. Peripheral blood and bone marrow
manifestations of metabolite storage diseases Andrea N. Marcogliese;
9.
Reactive lymphadenopathies Maria A. Proytcheva;
10. Spleen: normal
architecture and non-neoplastic and neoplastic lesions Flavia G. N. Rosado,
Genevieve M. Craine, and Dennis P. O'Malley;
11. Chromosome abnormalities of
hematologic malignancies: a practical guide to cytogenetic analysis Katrin M.
Leuer and Pamela Rathbun; Section II. Neoplastic Hematopathology:
12.
Molecular diagnostics of pediatric acute leukemias in the era of high
throughput sequencing Somak Roy and Erin H. Breese;
13. Immunophenotypic
characterization of pediatric leukemia/lymphoma by flow cytometry including
minimal residual disease detection Sunita Park and Yi Zhou;
14.
Myeloproliferative neoplasms and their mimics Robert B. Lorsbach;
15.
Mastocytosis and related disorders Robert B. Lorsbach;
16. Juvenile
myelomonocytic leukemia and related disorders John Kim Choi;
17.
Myelodysplastic syndromes Robert B. Lorsbach;
18. Acute myeloid leukemia and
related precursor neoplasms Robert B. Lorsbach;
19. Hematologic abnormalities
in individuals with Down syndrome John Kim Choi;
20. Lymphoblastic neoplasms
Mihaela Onciu;
21. Advances in prognostication and treatment of pediatric
acute leukemia substantial revision Nobuko Hijiya and Jing Chen;
22. Bone
marrow findings post-chemotherapy and hematopoietic stem cell transplantation
Maria A. Proytcheva;
23. Pediatric small blue cell tumors metastatic to the
bone marrow Maria A. Proytcheva;
24. Pediatric mature B-cell non-Hodgkin
lymphomas Rodney R. Miles and Sherrie L. Perkins;
25. Pediatric mature T-cell
and NK-cell non-Hodgkin lymphomas Rodney R. Miles and Sherrie L. Perkins;
26.
Classic Hodgkin lymphoma and nodular lymphocyte predominant B-cell lymphoma
Robert B. Lorsbach and Mihaela Onciu;
27. Immunodeficiency-associated
lymphoproliferative disorders: congenital immune deficiencies, acquired
immune deficiencies, and post-transplant lymphoproliferative disorders
Michele Paessler and Brian Lockhart;
28. Histiocytic proliferations in
childhood Jennifer Picarsic, Ashish Kumar, and Rebecca Marsh;
29. Cutaneous
and subcutaneous lymphomas in children Jasmine Saleh, Woo Jin Lee, and Joan
Guitart; Index.
Maria A. Proytcheva is Professor of Pathology and Pediatrics as well as Chair for Laboratory Medicine at the Department of Pathology and Laboratory Medicine at the University of Arizona College of Medicine. Apart from authoring many journal articles, she has been chair of the Scientific Committee on Hematopathology and Clinical Laboratory Hematology of the American Society of Hematology, a member of the Editorial Board of the Frontiers in Pediatrics, a reviewer for other journals, and won numerous teaching awards. Robert B. Lorsbach is Director of Hematopathology at Cincinnati Children's Hospital Medical Center and has expertise in all facets of diagnostic and investigative pediatric hematopathology. He has published numerous original research articles, reviews, and book chapters focusing on pediatric hematopathology, including pediatric follicular lymphoma, acute megakaryoblastic leukemia, and acute leukemia.
