From the drawing board to the Digital Twin: the last 40 years of aerospace engineering.- Structural Optimization of a Wing for Wind Tunnel Testing Through Mesh Morphing.- A mixed intrusive and non-intrusive approximation technique for efficient robust aerodynamic shape design.- Induced Drag and Vorticity in Viscous and Inviscid Flows.- An interactive design tool for NACA intakes based on high fidelity CFD simulations and Reduced Order Models.- The role of high-fidelity Computer-Aided Engineering (CAE) multi-physics design within the research institutes of the National Institute for Astrophysics (INAF).