"The 12th edition continues in this tradition. That said, we acknowledge that prioritizing and organizing the content for a new edition of Diseases of Swine is a formidable challenge. Continuing advances in swine genetics, management, and nutrition provide new opportunities for improvements in health and productivity. But these advances are tempered by the new challenges to swine health presented by infectious and non-infectious agents and the multifactorial disease challenges they pose"-- Provided by publisher.
A comprehensively updated edition of the gold standard reference on swine health and disease
This newly revised Twelfth Edition of Diseases of Swine is designed to serve as a comprehensive and detailed reference on swine health and disease. It offers swine health specialists the information and knowledge they need to effectively respond to and treat pig diseases. It provides coverage of individual pig and herd health, making the book an effective resource for addressing diseases at the farm, local, regional, and global levels.
With contributions and updates from more than 100 international experts in swine health, this edition of Diseases of Swine provides improved organization and ease of access, allowing readers to quickly find the information they need. The new edition also includes new and updated chapters on surveillance, monitoring, and biosecurity, as well as information concerning new emerged and transboundary infectious agents.
Readers will also find:
- A thorough introduction to herd evaluation and considerations of pig behavior and welfare
- Comprehensive explorations of environment and health, including recommended air temperatures, minimum ventilation rates, and more
- Practical discussions on differential diagnosis of disease
- Complete coverage of drug pharmacology, therapy, and prophylaxis
Written for practicing swine veterinarians, academicians, and veterinary students, Diseases of Swine, Twelfth Edition will also benefit professionals working with agencies responsible for swine health, public health, or zoonotic diseases.
List of Contributors xi
Editors Note xxiii
Acknowledgments xxv
Section I Veterinary Practice 1
1 Evidence-based Practice of Swine Medicine 3
Evidence-based medicine, determining causation, impact of pig flow,
synthesizing evidence for a diagnosis, conducting a field investigation, case
management, 5 circles, client communication.
2 The Healthy Pig 29
Reference intervals, health pig parameters, reference population, swine
health, physiologic parameters.
3 Behavior and Welfare 49
Definitions of welfare, normal vs abnormal behaviors, maternal behaviors,
minimizing welfare impact of invasive procedures, feeding and drinking
behaviors, human interactions, behavior responses due to disease, recognizing
pain.
4 Effect of Genetics on Health 75
Genetic selection, heritability, resistance, phenotype, gene, trait.
5 Facilities and Environment 83
Effect of the environment on health, thermal conditions, air quality,
disease transmission via ventilation, facility design for bioexclusion,
filtration, technology for health monitoring.
6 Effect of Nutrition on Health 97
Nutrient requirements, body condition, energy requirements, vitamins,
feeding programs, weaning transition, water quality, alternative feedstuffs,
feedstuff processing, alternative feed programs.
7 Tools and Techniques of Practice 111
Common antemortem and postmortem sampling techniques including necropsy,
cerebrospinal fluid collection, joint sampling, processing fluids, urine
collection, feed sampling.
8 Overview of the Diagnostic Process, Diagnostic Tests, and Interpretation
129
How diagnostic tests are performed, advantages, and disadvantages; PCR
testing considerations including quantitative interpretation; appropriate
uses of genetic sequencing; sources of variation in test results, screening
versus confirmatory tests, test cutoff values, appropriate applications of
advanced sequencing technologies.
9 Infectious Disease Surveillance in Swine Populations 151
Designing a surveillance program, sample selection, assay selection,
sampling strategies, using data to detect changes.
10 Biosecurity, Disease Control, and Elimination 169
Principles of biosecurity, outbreak investigation, hierarchy of control
measures, specific interventions for farm exposures, disease elimination
strategies, derivation of negative populations.
11 Anesthesia and Surgical Procedures in Swine 189
Catheterization techniques, IV fluid therapy, epidural injection, anesthetic
drug combinations, and reversal agents; surgical procedures including
castration, correction of prolapses, cystostomy procedures, cesarean section,
fracture repair, tusk removal, abdominal and musculoskeletal procedures.
12 Drug Pharmacology and Treatment Management 215
Considerations for treatment, swine specific pharmacokinetics, residue
avoidance, withdrawal management, establishing treatment regimens, impact of
drug treatment on immunity, anti-inflammatory drugs, antimicrobial
stewardship, drug toxicities, interpreting in vitro SIR interpretations,
clinical parameters suggesting efficacy, pig treatment implications of
antibiotic resistance.
13 Veterinarian, Consumer, and Public Health 239
Safety, foodborne illness, physical hazards, antimicrobial resistance,
chemical hazards, agrotourism.
Section II Body Systems 253
14 Cardiovascular and Hematopoietic Systems 255
Anatomy, pathophysiology, mulberry heart disease, anemia, shock, clinical
pathology.
15 Digestive System 273
Interactions of microbiota, nutrition, immune system; anatomy,
pathophysiology, gastric ulcers, hemorrhagic bowel syndrome, prolapses,
hernias.
16 Immune System 303
Innate and adaptive immunity; cellular, humoral, mucosal and passive immune
mechanisms, stress, nutrition, immunosuppression, vaccination; lactogenic
immunity (humoral and CMI).
17 Integumentary SystemSkin, Hoof, and Claw 329
Pathophysiology of skin, infectious conditions and non-infectious
conditions; ear necrosis, porcine dermatopathy and nephropathy syndrome;
pathophysiology of coronary band, foot and claw; traumatic and nutritional
contributors to foot and claw lesions.
18 Mammary System 351
Structure and development, physiology of lactation, physiology of maternal
immunity, pathophysiology of lactation dysfunction, mastitis, dysgalactia,
risk factors.
19 Nervous and Locomotor System 375
Pathophysiology of nervous and musculoskeletal systems, muscle, bone, joint
and eye; congenital abnormalities, splayleg, congenital tremor, myopathy,
porcine stress syndrome, arthritis, metabolic bone disease, rickets,
osteochondrosis.
20 Reproductive System 417
Control of estrus, pregnancy, and parturition; pregnancy diagnosis,
dystocia, prolapse, discharge, male reproductive function and semen quality;
laboratory investigation of abortion and reproductive failure.
21 Respiratory System 439
Anatomy, structure, function; nasopharynx (including tonsil) and commonly
found common microbiota, pathophysiology.
22 Urinary System 457
Anatomy, structure, function; pathophysiology of infectious and
noninfectious conditions.
Section III Viral Diseases 479
23 Overview of Viruses 481
General characteristics of viruses, virus taxonomy, detection and
characterization of viruses.
24 African Swine Fever Virus 499
African swine fever, African swine fever virus, viral hemorrhagic fever,
domestic pigs, wild suids, pandemic, vaccine.
25 Astroviruses 513
Porcine astrovirus, mamastrovirus, swine, diarrhea,
meningoencephalomyelitis, paralysis.
26 Caliciviruses 517
Vesicular exanthema of swine virus, porcine noroviruses, porcine
sapoviruses, St-Valérien virus.
27 Circoviruses 527
Porcine circoviruses, PCV1, PCV2, PCV3, PCV4, postweaning, reproductive,
porcine dermatitis and nephropathy syndrome, PCV2 vaccines.
28 Coronaviruses 547
Transmissible gastroenteritis virus, porcine respiratory coronavirus,
porcine hemagglutinating encephalomyelitis virus, porcine epidemic diarrhea
virus, porcine deltacoronavirus, swine acute diarrhea syndrome coronavirus.
29 Filoviruses 589
Orthoebolavirus, Reston virus (RESTV), Ebola virus (EBOV).
30 Japanese Encephalitis Virus and Other Orthoflaviviruses 597
Japanese encephalitis virus, Murray Valley encephalitis virus, West Nile
virus, others.
31 Herpesviruses 615
Pseudorabies virus (suid alphaherpesvirus 1, Aujeszkys disease virus),
porcine cytomegalovirus (suid betaherpesvirus 2), porcine lymphotropic
herpesviruses 1-3 (suid gammaherpesviruses 3-5), malignant catarrhal fever
virus (ovine gammaherpesvirus 2).
32 Influenza Viruses 645
Influenza A virus, swine, epidemiology, pathogenesis, diagnosis, vaccines.
33 Paramyxoviruses 665
La Piedad-Michoacan virus (blue eye paramyxovirus), Menangle virus, Nipah
virus, porcine parainfluenza virus
1.
34 Parvoviruses 685
Porcine parvoviruses, porcine bocaviruses, canine parvovirus
2.
35 Pestiviruses 699
Classical swine fever virus, Bungowannah virus, bovine viral diarrhea virus,
Border disease virus, atypical porcine pestivirus.
36 Picornaviruses 723
Foot-and-mouth disease virus, swine vesicular disease virus,
encephalomyocarditis virus, porcine teschovirus, Seneca Valley virus, porcine
kobuvirus, porcine sapelovirus, porcine enterovirus G, swine pasiviruses,
porcine tottorivirus, parechovirus A.
37 Porcine Reproductive and Respiratory Syndrome Virus (Porcine
Arteriviruses) 769
Betaarterivirus, PRRS, PRRSV, acute infection, persistent infection,
reproductive disorder, respiratory disease, immune suppression, vaccination,
CD163, genetic resistance and resilience.
38 Rotaviruses and Reoviruses 797
Porcine rotaviruses, rotavirus A, rotavirus B, rotavirus C, rotavirus H,
porcine reoviruses, mammalian reoviruses.
39 Rhabdoviruses 813
Rabies virus, vesicular stomatitis viruses.
40 Swinepox Virus 823
Swinepox, swinepox virus, SWPV.
41 Miscellaneous Viral Infections 831
Porcine adenoviruses, anelloviruses, torque teno sus viruses, bunyaviruses,
hepatitis E virus, porcine endogenous retroviruses, togaviruses, eastern
equine encephalitis virus, getah virus, Sagiyama virus, Ross River virus,
porcine
torovirus.
Section IV Bacterial Diseases 849
42 Overview of Bacteria and Microbiota 851
Characteristics of genera, disease mechanisms, table of bacterial diseases,
issues in the development of bacterial disease (normal microbiota, biofilms,
dysbacteriosis), and understanding microbial census data.
43 Actinobacillus spp. 857
Actinobacillus pleuropneumoniae pleuropneumonia; Actinobacillus suis
septicemia, pleuropneumonia;
Actinobacillus equuli septicemia.
44 Bordetella 879
Bordetella bronchiseptica non-progressive atrophic rhinitis,
bronchopneumonia.
45 Brachyspira spp. 891
Brachyspira hyodysenteriae, hampsonii, suanatina swine dysentery,
Brachyspira pilosicoli intestinal (colonic) spirochetosis, Brachyspira
intermedia, murdochii occasional colitis.
46 Brucella 913
Brucella suis infertility, abortion, perinatal mortality.
47 Clostridia 929
Clostridium perfringens type C necrohemorrhagic enteritis, Clostridium
perfringens type A enteritis, Clostridioides difficile necrotizing
colitis, Clostridium septicum, perfringens type A, novyi, chauvoei
cellulitis and gas gangrene, Clostridiium tetani tetanus, Clostridiium
botulinum botulism.
48 Erysipelothrix spp. 947
Erysipelothrix rhusiopathiae, tonsillarum septicemia, arthritis,
endocarditis.
49 Escherichia 957
Neonatal E. coli diarrhea, postweaning E. coli diarrhea infections and edema
disease, E. coli causing fatal shock,
systemic E. coli infections, coliform mastitis, nonspecific urinary tract
infections.
50 Glaesserella 997
Glaesserella parasuis fibrinous polyserositis and arthritis.
51 Lawsonia 1009
Lawsonia intracellularis porcine proliferative enteropathy, proliferative
hemorrhagic enteropathy.
52 Leptospira 1023
Leptospira spp. serovars Pomona, Kennewicki, Bratislava, Muenchen,
Tarassovi, Canicola, Grippotyphosa, Hardjo,
others abortion and stillbirths.
53 Mycoplasmataceae 1035
Mycoplasma hyopneumoniae pneumonia; Mycoplasma hyorhinis polyserositis,
arthritis; Mycoplasma hyosynoviae
arthritis; Mycoplasma (Eperythrozoon) suis anemia; other mycoplasmas
mostly non-pathogenic.
54 Pasteurella 1057
Pasteurella multocida progressive atrophic rhinitis, pneumonia,
septicemia.
55 Salmonella 1073
Salmonella Choleraesuis var. kunzendorf septicemia, enterocolitis;
Salmonella Typhimurium, Heidelberg, Typhisuis
enterocolitis; Salmonella Dublin, Enteriditis meningitis.
56 Staphylococcus spp. 1089
Staphylococcus hyicus exudative epidermitis; Staphyloccocus aureus skin
infections, mastitis, others.
57 Streptococcus spp. 1097
Streptococcus suis septicemia, meningitis, others; Streptococcus porcinus
cervical lymphadenitis; Streptococcus
dysgalactiae subsp. equisimilis arthritis; Other streptococci various
conditions.
58 Miscellaneous Bacterial Infections 1119
Actinobaculum (Eubacterium) suis cystitis, pyelonephritis; Bacillus
anthracis anthrax; Burkholderia pseudomallei
melioidosis; Campylobacter spp. subclinical shedding; Chlamydia spp.
enteritis, conjunctivitis, pneumonia, abortion, etc.; Enterococcus durans and
hirae diarrhea; Klebsiella pneumoniae septicemia; Listeria monocytogenes
septicemia, encephalitis, abortion; Mycobacterium spp. tuberculosis;
Rhodococcus equi granulomatous lymphadenitis; Treponema
pedis ear necrosis, other skin lesions; Trueperella spp. abortion,
abscesses, pyogenic sepsis; Yersinia spp.
enterocolitis.
Section V Parasitic Diseases 1149
59 External Parasites 1151
Mange (Sarcoptes, Demodex), lice, fleas, mosquitoes, flies (myiasis),
ticks.
60 Coccidia and Other Protozoa 1161
Coccidia (Cystoisospora, Eimeria), Toxoplasma, Sarcocystis, Cryptosporidium,
Giardia, Balantidium coli, Entamoeba.
61 Internal Parasites: Helminths 1179
Nematodes Gongylonema, Hyostrongylus, Strongyloides, Ascaris, Trichinella,
Trichuris, Oesophagostomum, Metastrongylus,
Paragonimus, Stephanurus and others; Cestodes Echinococcus, Taenia, and
others; parasiticides.
Section VI Non-Infectious Diseases 1193
62 Nutrient Deficiencies and Excesses 1195
Factors contributing to nutritional diseases; nutrient deficiencies and
excesses; clinical signs and diagnostic investigation
process.
63 Mycotoxins in Grains and Feeds 1215
Aflatoxin, ochratoxin, citrinin, trichothecenes (T2 toxin, DON),
zearalenone, and fumonisins.
64 Toxic Minerals, Chemicals, Plants, and Gases 1235
Minerals, feed additives, pesticides, toxic plants, gases; effects of water
quality; toxic gases and ventilation failure.
Index 1257
The editors
Jeffrey J. Zimmerman, PhD, DVM, DACVPM is Professor of Disease Ecology in the Department of Veterinary Diagnostic and Production Animal Medicine at Iowa State University.
Eric R. Burrough, PhD, DVM, is Professor and Diagnostic Pathologist in the Department of Veterinary Diagnostic and Production Animal Medicine at Iowa State University.
Locke A. Karriker, DVM, MS, DACVPM is Morrill Professor of Veterinary Diagnostic and Production Animal Medicine and Director of the Swine Medicine Education Center at Iowa State University.
Kent J. Schwartz, DVM, MS is Clinical Professor and Diagnostician in the Veterinary Diagnostic Laboratory at Iowa State University.
Jianqiang Zhang, MD, PhD, is Professor and Virologist in the Department of Veterinary Diagnostic and Production Animal Medicine at Iowa State University.
