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Dried Blood Spots: Applications and Techniques [Kõva köide]

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An informative and comprehensive book on the applications and techniques of dried blood spot sampling

Dried blood spot (DBS) sampling involves the collection of a small volume of blood, via a simple prick or other means, from a study subject onto a cellulose or polymer paper card, which is followed by drying and transfer to the laboratory for analysis. For many years, this method of blood sample collection has been extensively utilized in some important areas of human healthcare (for example, newborn screening for inherited metabolic disorders and HIV-related epidemiological studies). Because of its advantages over conventional blood, plasma, or serum sample collection, DBS sampling has been valued by the pharmaceutical industry in drug research and development.

Dried Blood Spots: Applications and Techniques features contributions from an international team of leading scientists in the field. Their contributions present a unique resource on the history, principles, procedures, methodologies, applications, and emerging technologies related to DBS.

Presented in three parts, the book thoroughly examines:





Applications of DBS sampling and associated procedures and methodologies in various human healthcare studies Applications and perspectives of DBS sampling in drug research and development, and therapeutic drug monitoring New technologies and emerging applications related to DBS sampling and analysis

Dried Blood Spots: Applications and Techniques is a valuable working guide for researchers, professionals, and students in healthcare, medical science, diagnostics, clinical chemistry, and pharmaceuticals, etc.
Preface viii
Contributors x
PART I HISTORY, APPLICATIONS, AND HEALTHCARE
1 Overview of the History and Applications of Dried Blood Samples
3(13)
W. Harry Hannon
Bradford L. Therrell, Jr.
2 Dried Blood Spot Cards
16(5)
Brad Davin
W. Harry Hannon
3 Dried Blood Spot Sample Collection, Storage, and Transportation
21(11)
Joanne Mei
4 Dried Blood Spot Specimens for Polymerase Chain Reaction in Molecular Diagnostics and Public Health Surveillance
32(8)
Chunfu Yang
5 Application of Enzyme Immunoassay Methods Using Dried Blood Spot Specimens
40(13)
Mireille B. Kalou
6 Applications of Dried Blood Spots in Newborn and Metabolic Screening
53(23)
Donald H. Chace
Alan R. Spitzer
Victor R. De Jesus
7 Dried Blood Spots for Use in HIV-Related Epidemiological Studies in Resource-Limited Settings
76(19)
Sridhar V. Basavaraju
John P. Pitman
8 Use of Dried Blood Spot Samples in HCV-, HBV-, and Influenza-Related Epidemiological Studies
95(19)
Harleen Gakhar
Mark Holodniy
9 Applications of Dried Blood Spots in General Human Health Studies
114(16)
Eleanor Brindle
Kathleen A. O'Connor
Dean A. Garrett
10 Applications of Dried Blood Spots in Environmental Population Studies
130(10)
Antonia M. Calafat
Kayoko Kato
11 The Use of Dried Blood Spots and Stains in Forensic Science
140(13)
Donald H. Chace
Nicholas T. Lappas
PART II PHARMACEUTICAL APPLICATIONS
12 Pharmaceutical Perspectives of Use of Dried Blood Spots
153(7)
Christopher Evans
Neil Spooner
13 Punching and Extraction Techniques for Dried Blood Spot Sample Analysis
160(8)
Philip Wong
Christopher A. James
14 Considerations in Development and Validation of LC-MS/MS Method for Quantitative Analysis of Small Molecules in Dried Blood Spot Samples
168(11)
Wenkui Li
15 Challenges and Experiences with Dried Blood Spot Technology for Method Development and Validation
179(9)
Chester L. Bowen
Christopher A. Evans
16 Clinical Implications of Dried Blood Spot Assays for Biotherapeutics
188(7)
Matthew E. Szapacs
Jonathan R. Kehler
17 Potential Role for Dried Blood Spot Sampling and Bioanalysis in Preclinical Studies
195(7)
Qin C. Ji
Laura Patrone
18 Clinical and Bioanalytical Evaluation of Dried Blood Spot Sampling for Genotyping and Phenotyping of Cytochrome p450 Enzymes in Healthy Volunteers
202(14)
Theo de Boer
Izaak den Daas
Jaap Wieling
Johan Wemer
LingSing Chen
19 Application of Dried Blood Spot Sampling in Clinical Pharmacology Trials and Therapeutic Drug Monitoring
216(13)
Kenneth Kulmatycki
Wenkui Li
Xiaoying (Lucy) Xu
Venkateswar Jarugula
20 Automation in Dried Blood Spot Sample Collection, Processing, and Analysis for Quantitative Bioanalysis in Pharmaceutical Industry
229(6)
Leimin Fan
Katty Wan
Olga Kavetskaia
Huaiqin Wu
21 Beyond Dried Blood Spots---Application of Dried Matrix Spots
235(10)
Shane R. Needham
PART III NEW TECHNOLOGIES AND EMERGING APPLICATIONS
22 Direct Analysis of Dried Blood Spot Samples
245(53)
Paul Abu-Rabie
23 Paper Spray Ionization for Direct Analysis of Dried Blood Spots
298(16)
Jiangjiang Liu
Nicholas E. Manicke
R. Graham Cooks
Zheng Ouyang
24 Direct Solvent Extraction and Analysis of Biomarkers in Dried Blood Spots Using a Flow-Through Autosampler
314(11)
David S. Millington
Haoyue Zhang
M. Arthur Moseley
J. Will Thompson
Peter Smith
25 Development of Biomarker Assays for Clinical Diagnostics Using a Digital Microfluidics Platform
325(7)
David S. Millington
Ramakrishna Sista
Deeksha Bali
Allen E. Eckhardt
Vamsee Pamula
26 Applications and Chemistry of Cellulose Papers for Dried Blood Spots
332(12)
Jacquelynn Luckwell
ke Danielsson
Barry Johnson
Sarah Clegg
Mark Green
Alan Pierce
27 Derivatization Techniques in Dried Blood Spot Analysis
344(11)
Ann-Sofie M.E. Ingels
Nele Sadones
Pieter M.M. De Kesel
Willy E. Lambert
Christophe P. Stove
Index 355
WENKUI LI currently serves as Senior Fellow in the Department of Drug Metabolism & Pharmacokinetics at Novartis Institutes for BioMedical Research, where he focuses on regulated LC-MS/MS bioanalysis for the toxicokinetic and pharmacokinetic assessment of drug candidates. Dr. Li is a member of the editorial board of Biomedical Chromatography.

MIKE S. LEE currently serves as a provider of consulting services specializing in pharmaceutical analysis, accelerated drug discovery and development strategies, and analytical technologies. He has delivered many presentations as invited speaker, plenary speaker, and workshops instructor in the areas of drug discovery and development at universities, conferences, and industrial technical centers. He has published numerous papers and books and obtained two U.S. patents.