This book addresses the issues relating to a wide variety of ocular diseases from which millions of people suffer. Long-term challenges include visual impairment and ocular blindness. Certain ocular diseases are quite rare, whereas others, such as cataracts, age-related macular degeneration (AMD), and glaucoma, are very common, especially in the aging population. A rapid expansion of new technologies in ocular drug delivery and new drug candidates, including biologics, to treat these challenging diseases in the retina and posterior segments of the eye have recently emerged. These approaches are necessary because the eye has many unique barriers to drug delivery. Thus, this timely reference Drug Delivery for the Retina and Posterior Segment Disease compiles and analyzes recent advances in the research and development of drug delivery systems for retina and posterior segment diseases of the eye, with an emphasis on the use of implantable devices, iontophoresis as well as micro- and nanoparticles.
Part I-Introduction and basic concept of drug delivery for retina and
posterior segment disease.- Anatomy and physiology of retina and posterior
segment of the eye .- Pharmacotherapy of diabetic macular edema and
retinopathy.- Drug delivery to posterior segment of eye: Conventional
delivery strategies, their barriers and restrictions.- Penetration routes to
retina and posterior segment.- Diabetic Retinopathy: Pathogenesis,
Treatment, and Complications.- PART II-Nanotechnology based formulations for
retina and posterior segment disease.- Liposomes for retina and posterior
segment disease.- Nano/microparticles for retina and posterior segment
disease.- Non-viral delivery systems for gene therapy for retina and
posterior segment disease.- Oxidative stress in ocular disorders: Exploring
the link to pesticide exposure and potential for using nanotechnology for
antioxidant delivery.- Advances in the microbial infection in cornea and role
of nanotechnology to cure ocular surface .- Nanomedicine based delivery to
the posterior segment of eye: Brighter tomorrow.- Part III-Transscleral
iontophoresis for retina and posterior segment disease.- Transscleral drug
delivery to retina and posterior segment disease.- Colloidal carrier systems
transscleral drug delivery.- Transscleral Iontophoretic Drug Delivery for
Treating Retinal Diseases.- Part IV-Implant formulation for posterior eye
segment.- Biodegradable polymeric implants for retina and posterior segment
disease.- Nanomedicine based gene delivery for the retina and posterior
segment diseases.- Part V-Prodrug strategies for retina and posterior segment
disease.- Transporter targeted Pro-drug approach for retina and posterior
segment disease.- Lipid Prodrug based delivery for retina and posterior
segment disease.- Injectable Pro-drugs approach for retina and posterior
segment disease .- Stereoisomeric dipeptide Pro-drug approach for retina and
posterior segment disease.- Part VI-Other advances for retina and posterior
segment diseases.- Receptor targeted Pro-drug approach for retina and
posterior segment disease.- Intravitreal injection drug delivery for retina
and posterior segment disease: Challenges and Future ahead.- Thermoresponsive
gels drug delivery for retina and posterior segment disease.- Peptide
synthesis and delivery for retina and posterior segment disease.- Corneal
haze, refractive surgery and its implications on choroidal
neovascularisation.
Dr. Jayvadan K. Patel is a Professor of Pharmaceutics and Principal, Nootan Pharmacy College, Visnagar-384315, Gujarat, India. He has more than 20 years of academic and research experience, has published more than 180 research and review papers in international and national Journals. He is recipients of Very prestigious APTI Young Pharmacy Teacher Award-2014 by Association of Pharmaceutical Teachers of India. He has completed 12 industry and government sponsored research projects.
