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Essential Human Virology 2nd edition [Pehme köide]

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(Professor of Biology; Director, Scholars in STEM Program; Director, Advanced Majors Program, Kennesaw State University, Kennesaw, GA, USA)
  • Formaat: Paperback / softback, 416 pages, kõrgus x laius: 276x216 mm, kaal: 1090 g, Approx. 300 illustrations (300 in full color); Illustrations
  • Ilmumisaeg: 17-Aug-2022
  • Kirjastus: Academic Press Inc
  • ISBN-10: 032390565X
  • ISBN-13: 9780323905657
Teised raamatud teemal:
Essential Human Virology 2nd editionSuurem pilt
  • Formaat: Paperback / softback, 416 pages, kõrgus x laius: 276x216 mm, kaal: 1090 g, Approx. 300 illustrations (300 in full color); Illustrations
  • Ilmumisaeg: 17-Aug-2022
  • Kirjastus: Academic Press Inc
  • ISBN-10: 032390565X
  • ISBN-13: 9780323905657
Teised raamatud teemal:
Püsilink: https://www.kriso.ee/db/9780323905657.html
Märksõnad:

Essential Human Virology, Second Edition focuses on the structure and classification of viruses, virus transmission and virus replication strategies based upon type of viral nucleic acid. Several chapters focus on notable and recognizable viruses and the diseases caused by them, including influenza, HIV, hepatitis viruses, poliovirus, herpesviruses and emerging and dangerous viruses. Additionally, how viruses cause disease (pathogenesis) is highlighted, along with discussions on immune response to viruses, vaccines, anti-viral drugs, gene therapy, the beneficial uses of viruses, research laboratory assays and viral diagnosis assays.

Fully revised and updated with new chapters on coronaviruses, nonliving infectious agents, and notable non-human viruses, the book provides students with a solid foundation in virology.

  • Focuses on human diseases and the cellular pathology that viruses cause
  • Highlights current and cutting-edge technology and associated issues
  • Presents real case studies and current news highlights in each chapter
  • Features dynamic illustrations, chapter assessment questions, key terms, and a summary of concepts, as well as an instructor website with lecture slides, a test bank and recommended activities
  • Updated and revised, with new chapters on coronaviruses, nonliving infectious agents, and notable non-human viruses
Preface ix
About the Author xi
Companion Site xiii
1 The world of viruses
1(18)
1.1 The importance of studying viruses
2(4)
1.2 Viruses are not alive
6(1)
1.3 The origin of viruses
7(3)
1.4 The discovery of viruses
10(5)
1.5 How viruses are discovered today
15(4)
Flash card vocabulary
16(1)
Chapter review questions
16(2)
Summary of key concepts
18(1)
2 Vims structure and classification
19(14)
2.1 Common characteristics of viruses
19(1)
2.2 Structure of viruses
20(6)
2.2.1 Helical capsid structure
21(1)
2.2.2 Icosahedral capsid structure
22(2)
2.2.3 Complex viral structures
24(2)
2.3 Virus classification and taxonomy
26(7)
Flash card vocabulary
30(1)
Chapter review questions
30(1)
Summary of key concepts
31(2)
3 Features of host cells: Molecular and cellular biology review
33(20)
3.1 The basic organization of the cell
33(2)
3.2 The plasma membrane, exocytosis, and endocytosis
35(2)
3.3 The cell cycle
37(1)
3.4 The central dogma of molecular biology: DNA replication
38(3)
Word Origin: DNA and RNA
41(1)
3.5 The central dogma of molecular biology: RNA transcription and processing
41(2)
3.6 The genetic code
43(1)
3.7 The central dogma of molecular biology: Protein translation
44(3)
3.8 Promotion of viral transcription and translation processes
47(6)
Flash card vocabulary
49(1)
Chapter review questions
49(2)
Summary of key concepts
51(2)
4 Virus replication
53(24)
4.1 Attachment
53(2)
4.2 Penetration
55(2)
4.3 Uncoating
57(1)
4.4 Replication
58(11)
4.4.1 Class I: dsDNA viruses
59(2)
4.4.2 Class II: ssDNA viruses
61(1)
4.4.3 Class III: dsRNA viruses
62(1)
4.4.4 Class IV +ssRNA viruses
62(2)
4.4.5 Class V-ssRNA viruses
64(1)
4.4.6 Class VI: RNA viruses that reverse transcribe
65(3)
4.4.7 Class VII: DNA viruses that reverse transcribe
68(1)
4.5 Assembly
69(1)
4.6 Maturation
70(1)
4.7 Release
71(1)
4.8 Virus growth curves
71(6)
Flash card vocabulary
72(1)
Chapter review questions
72(2)
Summary of key concepts
74(3)
5 Virus transmission and epidemiology
77(24)
5.1 Portals of virus entry
77(8)
5.1.1 Respiratory tract
77(2)
5.1.2 Gastrointestinal tract
79(2)
5.1.3 Genital tract
81(1)
5.1.4 Skin
81(1)
5.1.5 Eyes
82(1)
5.1.6 Placenta
82(1)
5.1.7 Transplants
83(2)
5.2 Dissemination within a host
85(1)
5.3 Portals of virus exit
86(1)
5.4 Patterns of infection
87(2)
5.5 Epidemiology
89(4)
5.5.1 Causation of disease
90(1)
5.5.2 Chain of infection
90(3)
5.6 Epidemiological studies
93(8)
Flash card vocabulary
97(1)
Chapter review questions
98(1)
Summary of key concepts
99(2)
6 The immune response to viruses
101(18)
6.1 The innate immune system
101(5)
6.1.1 Pattern recognition receptors
101(2)
6.1.2 Cytokines
103(2)
6.1.3 Macrophages and dendritic cells
105(1)
6.1.4 Natural killer cells
106(1)
6.2 The adaptive immune system
106(6)
6.2.1 Cytotoxic T lymphocytes
107(3)
6.2.2 Helper T lymphocytes
110(1)
6.2.3 B Lymphocytes and antibody
110(1)
6.2.4 Immunological memory
111(1)
6.3 Viral evasion of the immune response
112(7)
6.3.1 Antigenic variation
112(2)
6.3.2 Latency
114(1)
6.3.3 Virus-encoded evasion mechanisms
115(1)
Flash card vocabulary
116(1)
Chapter review questions
116(1)
Summary of key concepts
117(2)
7 Virology research and diagnosis of viral infections
119(26)
7.1 Collection and transport of clinical specimens
119(3)
7.2 Virus culture and cell/tissue specimens
122(5)
7.3 Detection of viral antigens or antiviral antibodies
127(6)
7.4 Detection of viral nucleic acids
133(12)
Flash card vocabulary
141(1)
Chapter review questions
141(2)
Summary of key concepts
143(2)
8 Vaccines, antivirals, and the beneficial uses of viruses
145(24)
8.1 Vaccine development
145(12)
8.1.1 A Brief history of vaccination
146(1)
8.1.2 Current vaccines
147(5)
8.1.3 Vaccines in development
152(4)
8.1.4 Passive immunity
156(1)
8.2 Antivirals
157(3)
8.2.1 Inhibition of entry, penetration, and uncoating
157(1)
8.2.2 Inhibition of genome replication
158(1)
8.2.3 Inhibition of assembly, maturation, and release
159(1)
8.2.4 Boosting the immune response
160(1)
8.3 The Beneficial uses of viruses
160(9)
8.3.1 Gene therapy
161(2)
8.3.2 The Use of viruses in anticancer therapies
163(3)
Flash card vocabulary
166(1)
Chapter review questions
167(1)
Summary of key concepts
167(2)
9 Viruses and cancer
169(16)
9.1 Properties of cancerous cells
169(1)
9.2 Control of the cell cycle
170(2)
9.3 Important genes involved in the development of cancer
172(1)
9.4 Oncogenic viruses
173(12)
9.4.1 Oncogenic retroviruses
173(3)
9.4.2 PvNA tumor viruses
176(1)
9.4.3 Small DNA tumor viruses
177(2)
9.4.4 Large DNA tumor viruses
179(3)
Flash card vocabulary
182(1)
Chapter review questions
183(1)
Summary of key concepts
184(1)
10 Influenza viruses
185(24)
10.1 Influenza taxonomy and types
185(1)
10.2 Clinical course of infection
186(2)
10.3 Molecular virology
188(7)
10.3.1 Attachment, fusion, and uncoating
191(1)
10.3.2 Replication
192(2)
10.3.3 Assembly, maturation, and release
194(1)
10.4 Genetic changes in the influenza genome
195(1)
10.5 Historic influenza antigenic shifts
196(3)
10.6 Highly pathogenic avian influenza viruses
199(10)
Flash card vocabulary
204(1)
Chapter review questions
204(2)
Summary of key concepts
206(3)
11 Human immunodeficiency Viruses
209(22)
11.1 History of HIV infection
209(1)
11.2 Taxonomy and origins of HIV
210(4)
11.3 Epidemiology of HIV/AIDS
214(2)
11.4 Clinical progression of HIV/AIDS
216(3)
11.5 Molecular virology and replication of HIV-1
219(12)
11.5.1 HIV attachment, penetration, uncoating, and reverse transcription
219(3)
11.5.2 Integration and replication
222(2)
11.5.3 Assembly, maturation, and release
224(2)
Flash card vocabulary
226(1)
Chapter review questions
227(2)
Summary of key concepts
229(2)
12 Hepatitis Viruses
231(24)
12.1 Clinical course of hepatitis virus infections
231(1)
12.2 Transmission and epidemiology of hepatitis viruses
232(6)
12.2.1 Hepatitis A virus
232(2)
12.2.2 Hepatitis B virus
234(1)
12.2.3 Hepatitis C virus
235(2)
12.2.4 Hepatitis D virus
237(1)
12.2.5 Hepatitis E virus
237(1)
12.3 Molecular virology of the hepatitis viruses
238(17)
12.3.1 Hepatitis A virus
238(2)
12.3.2 Hepatitis B virus
240(3)
12.3.3 Hepatitis C virus
243(3)
12.3.4 Hepatitis D virus
246(1)
12.3.5 Hepatitis E virus
247(2)
Flash card vocabulary
249(1)
Chapter review questions
250(2)
Summary of Key Concepts
252(3)
13 Herpesviruses
255(22)
13.1 Herpesvirus classification
255(2)
13.2 Clinical conditions caused by herpesviruses
257(10)
13.2.1 Herpes simplex virus type 1 and type 2 (HSV-1/HHV-1 and HSV-2/HHV-2)
257(4)
13.2.2 Varicella zoster virus (VZV/HHV-3)
261(3)
13.2.3 Epstein-barr virus (EBV/HHV4)
264(1)
13.2.4 Human cytomegalovirus (CMV/HHV-5)
264(2)
13.2.5 HHV-6A, HHV-6B, and HHV-7
266(1)
13.2.6 Kaposi sarcoma-Associated herpesvirus (KSHV/HHV-8)
267(1)
13.3 Molecular virology
267(6)
13.3.1 Attachment, penetration, and uncoating
269(2)
13.3.2 Expression of proteins and replication of nucleic acid
271(1)
13.3.3 Assembly, maturation, and release
271(2)
13.4 Latency
273(4)
Flash card vocabulary
274(1)
Chapter review questions
274(2)
Summary of key concepts
276(1)
14 Coronaviruses
277(30)
14.1 Coronavirus taxonomy
277(1)
14.2 Coronavirus outbreaks and their origins
278(4)
14.2.1 Sars-cov-1
278(1)
14.2.2 Mers-cov
279(1)
14.2.3 Sars-cov-2
280(2)
14.3 Epidemiology and the clinical course of coronavirus infections
282(2)
14.3.1 Endemic (seasonal) coronaviruses
282(2)
14.3.2 Clinical presentation and epidemiology of COVID-19
284(1)
14.4 Replication cycle of SARS-CoV-2
284(8)
14.4.1 Attachment, penetration, and uncoating
287(1)
14.4.2 Replication
288(1)
14.4.3 Assembly, maturation, and release
288(2)
14.4.4 SARS-CoV-2 mutations
290(2)
14.5 Coronavirus vaccine and treatment efforts
292(15)
14.5.1 Prior scientific advances important for the creation of a covid-19 vaccine
292(3)
14.5.2 COVID-19 vaccine design, development, and administration
295(1)
14.5.3 Efficacy and Safety of COVID-19 Vaccines in Real-World Conditions
296(1)
14.5.4 Antiviral medications against SARS-CoV-2
297(3)
Flash card vocabulary
300(1)
Chapter review questions
300(5)
Summary of key concepts
305(2)
15 Poliovirus
307(16)
15.1 The early years of poliovirus
307(4)
15.2 Clinical course of infection
311(3)
15.3 Poliovirus replication
314(2)
15.3.1 Attachment, penetration, and uncoating
314(1)
15.3.2 Translation and replication
314(2)
15.3.3 Assembly, maturation, and release
316(1)
15.4 Epidemiology and worldwide eradication efforts
316(7)
Flash card vocabulary
320(1)
Chapter review questions
320(1)
Summary of key concepts
321(2)
16 Poxviruses
323(18)
16.1 Taxonomy
323(1)
16.2 Clinical course of variola infection
323(4)
16.3 Poxvirus replication cycle
327(5)
16.3.1 Poxvirus attachment, penetration, and uncoating
328(1)
16.3.2 Viral protein expression and genome replication
329(2)
16.3.3 Assembly, maturation, and release
331(1)
16.4 Eradication of smallpox
332(9)
16.4.1 Origin of smallpox vaccination
333
16.4.2 Modern attempts at smallpox eradication
329(6)
16.4.3 Cessation of smallpox vaccination
335(3)
Flash card vocabulary
338(1)
Chapter review questions
338(1)
Summary of key concepts
339(2)
17 Emerging and Reemerging Viral Diseases
341(20)
17.1 Factors Involved in the Emergence of Viral Infectious Diseases
341(5)
17.1.1 Human Factors
341(3)
17.1.2 Environmental and Ecological Factors
344(1)
17.1.3 Viral Factors
345(1)
17.2 Notable Emerging Viral Diseases
346(15)
17.2.1 Arboviruses
346(5)
17.2.2 Vertebrate Zoonoses
351(5)
Flash Card Vocabulary
356(1)
Chapter Review Questions
357(2)
Summary of Key Concepts
359(2)
18 Prokaryotic viruses and other nonliving infectious agents
361(16)
18.1 Prokaryotic viruses
361(2)
18.1.1 Structures of bacterial and archaeal viruses
361(2)
18.2 Life cycles of prokaryotic viruses
363(7)
18.2.1 Attachment and genome delivery
364(2)
18.2.2 Replication cycles
366(1)
18.2.3 Protein translation and genome replication
367(1)
18.2.4 Bacteriophage assembly and maturation
368(1)
18.2.5 Bacteriophage release
369(1)
18.3 Ecological impacts of viruses
370
18.4 Other nonliving infectious agents
365(12)
Flash card vocabulary
371(2)
Chapter review questions
373(2)
Summary of key concepts
375(2)
Appendix 1 Abbreviations 377(4)
Appendix 2 Glossary 381(8)
Index 389
Jennifer Louten is currently a Professor of Biology at Kennesaw State University in Georgia, USA. She has served as a Teaching Fellow and has developed courses in virology, biotechnology, immunology, and cell culture techniques. She is the recipient of an Outstanding Teaching Award, Outstanding Early Career Faculty Award, and the Student Government Associations Faculty of the Year Award. She received her Ph.D. from Brown University Medical School, where she investigated the cellular targets of infection and the induction of type 1 interferons following infection with lymphocytic choriomeningitis virus. Before joining academia, Dr. Louten performed research in drug discovery at Schering-Plough Biopharma (currently Merck Research Laboratories). She received her Bachelor of Science in biotechnology from the Rochester Institute of Technology.