The History of Blood Transfusions
Modern Blood Banking
Component Therapy and Whole Blood: Packed Red Blood Cells, Fresh Frozen Plasma, Cryoprecipitate, washed and or radiated red cells
The Coagulation System and Clot Stability
Fibrinolysis- Tranexamic Acid and Aminocaproic Acid.
Hypercoagulation and Thrombotic Disorders: TTP, Factor 5 Leiden, Phospholipid Syndrome, Anti-thrombin 3, hypereosinophils, oxidative stress, cancer.
Diseases or Conditions of Platelet Dysfunction
The Massive Transfusion Protocol
New Biologicals to Assist Clotting- Riastap, Prothrombin Concentrates. Antithrombin3, Fibrogammin and factor13, Fibrosupernatant, Fibrinogen Concentrates, Recombinant Factor 7, DDAVP, Octaplast G., Factor 10A, KCentraBiologicals that Inhibit Clot generation -The Heparins, Factor 10A inhibitors, rivaroxaban, apixaban, dabigatran,
Point of Care Testing and Goal Directed Therapy- Thromboelastography, ROTEM, Platelet function analyzer, stat-PT, thrombin generation assays, multi-electro-aggregometry, OHP (Overall hemostatic potential assay), ACT.
Complications of Blood Transfusions: TRALI, TACO, Blood type mismatch, infection
Diseases of the Coagulation System- Hemophilia, VonWillebrand Disease, Cryoglobulinemia, Inborn Errors of Factor Synthesis
Blood Conservation Strategies and Bloodless Surgery- normovolemic hemodilution, cell saver,
Bridges to Transfusion when blood is not immediately available.Artificial Blood
Preoperative correction of anemia
Blood Deployment in Natural Disasters and the Military in Combat
Commonly prescribed medications that affect clotting-anti-depressants, NSAIDS, ASA
Anesthesia for the severe trauma patient- new evidence from new trials
Old blood vs. new blood- Is storage injury a concern?
Vascular Endothelial dysfunction and inflammatory states
Liberal or restrictive blood transfusions
