Muutke küpsiste eelistusi

Evaluating Evidence of Mechanisms in Medicine: Principles and Procedures 2018 ed. [Pehme köide]

4.00/5 (1 hinnangut Goodreads-ist)
, , , , , , , , ,
  • Formaat: Paperback / softback, 125 pages, kõrgus x laius: 235x155 mm, kaal: 2292 g, 14 Illustrations, black and white; XVIII, 125 p. 14 illus., 1 Paperback / softback
  • Sari: SpringerBriefs in Philosophy
  • Ilmumisaeg: 24-Jul-2018
  • Kirjastus: Springer International Publishing AG
  • ISBN-10: 3319946099
  • ISBN-13: 9783319946092
Teised raamatud teemal:
  • Pehme köide
  • Hind: 20,90 €*
  • * hind on lõplik, st. muud allahindlused enam ei rakendu
  • Tavahind: 24,59 €
  • Säästad 15%
  • Raamatu kohalejõudmiseks kirjastusest kulub orienteeruvalt 2-4 nädalat
  • Kogus:
  • Lisa ostukorvi
  • Tasuta tarne
  • Tellimisaeg 2-4 nädalat
  • Lisa soovinimekirja
Evaluating Evidence of Mechanisms in Medicine: Principles and Procedures 2018 ed.Suurem pilt
  • Formaat: Paperback / softback, 125 pages, kõrgus x laius: 235x155 mm, kaal: 2292 g, 14 Illustrations, black and white; XVIII, 125 p. 14 illus., 1 Paperback / softback
  • Sari: SpringerBriefs in Philosophy
  • Ilmumisaeg: 24-Jul-2018
  • Kirjastus: Springer International Publishing AG
  • ISBN-10: 3319946099
  • ISBN-13: 9783319946092
Teised raamatud teemal:
Püsilink: https://www.kriso.ee/db/9783319946092.html
This book is open access under a CC BY license. 

This book is the first to develop explicit methods for evaluating evidence of mechanisms in the field of medicine. It explains why it can be important to make this evidence explicit, and describes how to take such evidence into account in the evidence appraisal process. In addition, it develops procedures for seeking evidence of mechanisms, for evaluating evidence of mechanisms, and for combining this evaluation with evidence of association in order to yield an overall assessment of effectiveness. 

Evidence-based medicine seeks to achieve improved health outcomes by making evidence explicit and by developing explicit methods for evaluating it. To date, evidence-based medicine has largely focused on evidence of association produced by clinical studies. As such, it has tended to overlook evidence of pathophysiological mechanisms and evidence of the mechanisms of action of interventions. 





The bookoffers a useful guide for all those whose work involves evaluating evidence in the health sciences, including those who need to determine the effectiveness of health interventions and those who need to ascertain the effects of environmental exposures.
Part I Why Consider Mechanisms?
1 Introduction
3(8)
1.1 What is the Key Evidence?
4(2)
1.2 The Process of Evaluating Evidence
6(2)
1.3 Our Approach to Evaluating Evidence
8(1)
References
8(3)
2 An Introduction to Mechanisms
11(12)
2.1 Mechanisms at a Glance
11(2)
2.2 What is a Mechanism?
13(2)
2.3 Why Consider Evidence of Mechanisms?
15(5)
References
20(3)
3 How to Consider Evidence of Mechanisms: An Overview
23(14)
3.1 Questions to Address
23(2)
3.2 Quality of Evidence and Status of Claim
25(2)
3.3 Overall Approach
27(6)
References
33(4)
Part II Tools for Working with Mechanisms
4 Tools
37(26)
4.1 Introduction
37(2)
4.2 Is Your Policy Really Evidence-Based?
39(3)
4.3 Mechanisms in Clinical Research Appraisal Tool
42(5)
4.4 Mechanisms in Basic Science Research Appraisal Tool
47(3)
4.5 Critical Appraisal Tool for Evidence of Mechanisms
50(1)
4.6 GRADE-Style Tables for Mechanism Assessment
50(6)
4.7 Public Health and Social Care Tool
56(2)
References
58(5)
Part III Core Principles
5 Gathering Evidence of Mechanisms
63(14)
5.1 Identify Specific Mechanism Hypotheses
64(4)
5.2 Formulate the Review Questions
68(1)
5.3 Search the Literature
69(1)
5.4 Refine Results of the Search
70(1)
5.5 Presenting the Evidence of Mechanisms
71(2)
5.6 Worked Example on Probiotics and Dental Caries
73(1)
References
74(3)
6 Evaluating Evidence of Mechanisms
77(14)
6.1 Overview
77(3)
6.2 Evaluating Mechanistic Studies
80(2)
6.3 Determining the Status of the General Mechanistic Claim
82(3)
6.4 Presenting the Quality of Evidence of Mechanisms
85(4)
References
89(2)
7 Using Evidence of Mechanisms to Evaluate Efficacy and External Validity
91(10)
7.1 Efficacy
91(3)
7.2 External Validity
94(3)
7.3 Presenting the Status of a Causal Claim
97(1)
References
98(3)
Part IV Particular Applications
8 Assessing Exposures
101(10)
8.1 Comparison to IARC
102(5)
8.2 Comparison to SYRINA
107(2)
References
109(2)
9 Assessing Mechanisms in Public Health
111(10)
9.1 Introduction
111(1)
9.2 Public Health and Evidence-Based Medicine in the UK
112(1)
9.3 Statistical Associations and Correlations in Public Health
112(1)
9.4 Recurrent Public Health Problems--Non-communicable Disease in the Present
113(1)
9.5 The Individual Level and the Population Level
114(2)
9.6 The Biological Level and the Social Level
116(1)
9.7 Mechanisms of Disease and Mechanisms of Prevention
116(3)
References
119(2)
10 Particularisation to an Individual
121
References
125
The authors of this book are members of EBM+ (ebmplus.org), a network of researchers investigating the role of evidence of mechanisms in the health sciences. During the writing of this book, Parkkinen, Wallmann, Wilde and Williamson were based at the Centre for Reasoning, University of Kent; Clarke, Illari and Norell at the Department of Science and Technology Studies, UCL; Kelly at the Department of Public Health and Primary Care, University of Cambridge; Russo at the Department of Philosophy, University of Amsterdam; and Shaw at the National Institute of Health and Care Excellence, UK. This research way supported by the UK Arts and Humanities Research Council and the Leverhulme Trust.