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Evidence-based Clinical Chinese Medicine - Volume 16: Atopic Dermatitis [Kõva köide]

Editor-in-chief (Guangdong Provincial Hospital Of Chinese Medicine, China), (Rmit Univ, Australia), (Guangdong Provincial Hospital Of Chinese Medicine, China), Editor-in-chief (Rmit Univ, Australia)
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"The authors start the book with overviews of the understanding and management of atopic dermatitis in conventional and Chinese medicine. They then review how atopic dermatitis was treated with herbal medicine and other Chinese medicine therapies in past eras, and highlight the treatments that continue to be used in contemporary clinical practice. The authors use evidence-based medicine principles and scientific techniques to review the current state of evidence from clinical studies of Chinese herbal medicine, acupuncture, and combinations of these therapies. Attention is given to studies evaluating these therapies used as an adjunct to conventional treatments. The authors summarise the results of analyses of clinical outcomes and discuss their implications for clinical practice of Chinese medicine and for future research. This book will inform clinicians and students of Chinese and integrative medicine of the current state of evidence from contemporary and traditional sources. Clinicians can refer to the herbal formulas and acupuncture treatments described in this book to make evidence-based decisions in patient care. The following features mark the importance of this book in the field: An innovative 'whole evidence' approach: This book combines multiple types of evidence from multiple sources to provide a unique and comprehensive assessment of the available evidence for Chinese medicine in atopic dermatitis. Clinically informative and relevant: This book integrates the results of meta-analyses of clinical trial data with evidence from the classical Chinese medicine literature, and contemporary clinical guidelines for the application of Chinese medicine in atopic dermatitis. Chinese medicine syndrome differentiation is described where available to provide relevance for clinical practice. The full scope of the clinical literature is synthesised to provide matrices of the available evidence. Developed by a skilled team: The authors are internationally recognized, well-respected leaders in the field of Chinese medicine and evidence-based medicine with strong track records in research."

Disclaimer v
Foreword vii
Purpose of this Book xi
Authors and Contributors xv
Members of Advisory Committee and Panel xvii
Distinguished Professor Charlie Changli Xue xix
Professor Chuanjian Lu xxi
Acknowledgements xxiii
List of Figures xxxv
List of Tables xxxvii
1 Introduction to Atopic Dermatitis 1(22)
Definition of Atopic Dermatitis
1(1)
Clinical Presentation and Subtypes of Atopic Dermatitis
2(1)
Epidemiology
3(1)
Burden
4(2)
Risk Factors
6(1)
Pathological Processes
7(3)
Diagnosis
10(1)
Management
11(5)
Pharmacological Treatments
14(1)
Topical Therapies
14(1)
Systemic Agents
15(1)
Non-pharmacological Treatments
15(1)
Prognosis
16(1)
References
17(6)
2 Atopic Dermatitis in Chinese Medicine 23(16)
Introduction
23(1)
Aetiology and Pathogenesis
23(2)
Syndrome Differentiation and Treatments
25(2)
Oral Chinese Herbal Medicine Treatment Based on Syndrome Differentiation
27(3)
Spleen Deficiency with Heart Heat
27(1)
Spleen Deficiency with Dampness Retention
28(1)
Wind-dampness Encumbering the Skin
29(1)
Blood Deficiency with Wind-Dryness
29(1)
Topical Chinese Herbal Medicine Treatment
30(1)
Rashes, Papules or Blisters, without Exudate
30(1)
Inflamed, Swollen and Cracked Skin with Exudate
31(1)
Dry, Flaked, Thick and Leathery Skin
31(1)
Acupuncture and Other Chinese Medicine Therapies
31(4)
Acupuncture
32(2)
Moxibustion
34(1)
Ear Acupuncture
34(1)
Electroacupuncture
35(1)
Plum Blossom Needle Therapy
35(1)
Tuina
35(1)
Other Management Strategies
35(1)
References
36(3)
3 Classical Chinese Medicine Literature 39(30)
Introduction
39(1)
Search Terms
40(2)
Procedures for Search, Data Coding and Data Analysis
42(2)
Search Results
44(1)
Definitions of Atopic Dermatitis
45(2)
Descriptions of the Aetiology of Atopic Dermatitis
47(1)
Symptom Location
48(1)
Chinese Herbal Medicine
49(2)
Frequency of Treatment Citations by Dynasty
50(1)
Treatment with Chinese Herbal Medicine
51(11)
Most Frequent Formulas in 'Possible' Atopic Dermatitis Citations
51(3)
Most Frequent Herbs in 'Possible' Atopic Dermatitis Citations
54(3)
Most Frequent Formulas in 'Most Likely' Atopic Dermatitis Citations
57(3)
Most Frequent Herbs in 'Most Likely' Atopic Dermatitis Citations
60(2)
Other Chinese Medicine Therapies
62(1)
Classical Literature in Perspective
63(4)
References
67(2)
4 Methods for Evaluating Clinical Evidence 69(18)
Introduction
69(1)
Search Strategy
70(2)
Inclusion Criteria
72(1)
Exclusion Criteria
72(1)
Outcomes
72(7)
Clinician-reported Eczema Signs
74(1)
Patient-reported Eczema Symptoms
75(1)
Long-term Control
76(1)
Health-related Quality of Life
76(1)
Effective Rate
77(2)
Adverse Events
79(1)
Risk of Bias Assessment
79(2)
Statistical Analyses
81(1)
Assessment Using GRADE
82(1)
References
83(4)
5 Clinical Evidence for Chinese Herbal Medicine 87(92)
Introduction
87(1)
Previous Systematic Reviews
87(2)
Identification of Clinical Studies
89(1)
Oral Chinese Herbal Medicine
89(33)
Randomised Controlled Trials of Oral Chinese Herbal Medicine
91(4)
Risk of Bias
95(2)
Outcomes
97(14)
Scoring Atopic Dermatitis Index
97(3)
Oral Chinese herbal medicine alone
97(2)
Oral Chinese herbal medicine as an integrative medicine
99(1)
Eczema Area and Severity Index
100(1)
Oral Chinese herbal medicine alone
100(1)
Oral Chinese herbal medicine as an integrative medicine
100(1)
Other Measures of Clinical Signs
100(2)
Oral Chinese herbal medicine alone
101(1)
Oral Chinese herbal medicine as an integrative medicine
101(1)
Pruritus
102(1)
Oral Chinese herbal medicine alone
102(1)
Oral Chinese herbal medicine as an integrative medicine
103(1)
Sleep Disturbance
103(1)
Oral Chinese herbal medicine alone
103(1)
Oral Chinese herbal medicine as an integrative medicine
103(1)
Other Patient-reported Symptoms
104(1)
Oral Chinese herbal medicine alone
104(1)
Oral Chinese herbal medicine as an integrative medicine
104(1)
Recurrence
104(3)
Oral Chinese herbal medicine alone
105(1)
Oral Chinese herbal medicine as an integrative medicine
106(1)
Health-related Quality of Life
107(1)
Oral Chinese herbal medicine alone
107(1)
Oral Chinese herbal medicine as an integrative medicine
108(1)
Effective Rate
108(1)
Oral Chinese herbal medicine alone
108(1)
Oral Chinese herbal medicine as an integrative medicine
109(1)
Assessment Using Grading of Recommendations, Assessment, Development and Evaluation
109(8)
Oral Chinese herbal medicine as an integrative medicine vs. topical corticosteroids
111(1)
Randomised Controlled Trial Evidence for Individual Oral Formulas
111(1)
Frequently Reported Orally Used Herbs in Meta-analyses Showing Favourable Effect
112(2)
Safety of Oral Chinese Herbal Medicine in Randomised Controlled Trials
114(2)
Controlled Clinical Trials of Oral Chinese Herbal Medicine
116(1)
Outcomes
117(2)
Clinical Signs
117(1)
Recurrence
118(1)
Health-related Quality of Life
119(1)
Effective Rate
119(1)
Safety of Oral Chinese Herbal Medicine in Controlled Clinical Trials
119(1)
Non-controlled Studies of Oral Chinese Herbal Medicine
119(3)
Safety of Oral Chinese Herbal Medicine in Non-controlled Studies
122(1)
Topical Chinese Herbal Medicine
122(22)
Randomised Controlled Trials of Topical Chinese Herbal Medicine
122(3)
Risk of Bias
125(1)
Outcomes
126(8)
Scoring Atopic Dermatitis Index
126(1)
Topical Chinese herbal medicine alone
126(1)
Topical Chinese herbal medicine as an integrative medicine
127(1)
Eczema Area and Severity Index
127(1)
Topical Chinese herbal medicine alone
128(1)
Topical Chinese herbal medicine as an integrative medicine
128(1)
Other Measures of Clinical Signs
128(1)
Topical Chinese herbal medicine alone
128(1)
Topical Chinese herbal medicine as an integrative medicine
129(1)
Pruritus
129(2)
Topical Chinese herbal medicine alone
129(1)
Topical Chinese herbal medicine as an integrative medicine
130(1)
Other Patient-reported Symptoms
131(1)
Recurrence
131(2)
Topical Chinese herbal medicine alone
131(1)
Topical Chinese herbal medicine as an integrative medicine
132(1)
Health-related Quality of Life
133(1)
Topical Chinese herbal medicine alone
133(1)
Topical Chinese herbal medicine as an integrative medicine
133(1)
Effective Rate
133(1)
Topical Chinese herbal medicine alone
134(1)
Topical Chinese herbal medicine as an integrative medicine
134(1)
Assessment Using Grading of Recommendations, Assessment, Development and Evaluation
134(10)
Topical Chinese Herbal Medicine vs. Topical Corticosteroids
135(1)
Topical Chinese Herbal Medicine as an Integrative Medicine vs. Topical Corticosteroids
135(2)
Topical Chinese Herbal Medicine as an Integrative Medicine vs. Topical Calcineurin Inhibitors
137(2)
Frequently Reported Topically Used Herbs in Meta-analyses Showing Favourable Effect
139(1)
Safety of Topical Chinese Herbal Medicine in Randomised Controlled Trials
139(2)
Controlled Clinical Trials of Topical Chinese Herbal Medicine
141(1)
Outcomes
141(1)
Clinical Signs
142(1)
Patient-reported Symptoms
142(1)
Effective Rate
142(1)
Safety of Topical Chinese Herbal Medicine in Controlled Clinical Trials
142(1)
Non-controlled Studies of Topical Chinese Herbal Medicine
143(1)
Safety of Topical Chinese Herbal Medicine in Non-controlled Studies
143(1)
Oral Plus Topical Chinese Herbal Medicine
144(15)
Randomised Controlled Trials of Oral Plus Topical Chinese Herbal Medicine
144(3)
Risk of Bias
147(2)
Outcomes
149(5)
Scoring Atopic Dermatitis Index
149(1)
Eczema Area and Severity Index
150(1)
Other Measures of Clinical Signs
150(1)
Pruritus
150(1)
Other Patient-reported Symptoms
151(1)
Recurrence
152(1)
Health-related Quality of Life
152(1)
Effective Rate
153(1)
Oral Chinese herbal medicine alone
153(1)
Oral Chinese herbal medicine as an integrative medicine
154(1)
Assessment Using Grading of Recommendations, Assessment, Development and Evaluation
154(52)
Oral Plus Topical Chinese Herbal Medicine vs. Topical Corticosteroids
154(1)
Frequently Reported Orally and Topically Used Herbs in Meta-analyses Showing Favourable Effect
154(2)
Safety of Oral Plus Topical Chinese Herbal Medicine in Randomised Controlled Trials
156(1)
Controlled Clinical Trials of Oral Plus Topical Chinese Herbal Medicine
156(1)
Non-controlled Studies of Oral Plus Topical Chinese Herbal Medicine
157(2)
Safety of Oral Plus Topical Chinese Herbal Medicine in Non-controlled Studies
159(1)
Clinical Evidence for Commonly Used Chinese Herbal Medicine Treatments
159(2)
Summary of Chinese Herbal Medicine Clinical Evidence
161(5)
References
166(2)
References for Included Chinese Herbal Medicine Clinical Studies
168(11)
6 Pharmacological Actions of Frequently Used Herbs 179(26)
Introduction
179(1)
Methods
180(1)
Experimental Studies on bai xian pi
181(2)
Experimental Studies on bai zhu
183(1)
Experimental Studies on dang gui
184(1)
Experimental Studies on fang feng
185(1)
Experimental Studies on fu ling
186(2)
Experimental Studies on gan cao
188(2)
Experimental Studies on jin yin hua
190(1)
Experimental Studies on long gu
191(1)
Experimental Studies on mu Ii
192(1)
Experimental Studies on sheng di
193(2)
Experimental Studies on yi yi ren
195(2)
Summary of Pharmacological Actions of the Common Herbs
197(1)
References
198(7)
7 Clinical Evidence for Acupuncture and Other Chinese Medicine Therapies 205(10)
Introduction
205(1)
Previous Systematic Reviews
206(1)
Identification of Clinical Studies
206(1)
Acupuncture
206(4)
Randomised Controlled Trials of Acupuncture
208(1)
Assessment Using Grading of Recommendations, Assessment, Development and Evaluation
208(1)
Non-controlled Studies of Acupuncture
209(1)
Safety of Acupuncture
209(1)
Acupressure
210(1)
Transcutaneous Electrical Nerve Stimulation
211(1)
Cupping
211(1)
Clinical Evidence for Commonly Used Acupuncture and Related Therapies
212(1)
Summary of Clinical Evidence for Acupuncture and Related Therapies
212(1)
References
213(1)
References for Clinical Studies of Included Acupuncture Therapies
214(1)
8 Clinical Evidence for Combination Therapies 215(8)
Introduction
215(2)
Randomised Controlled Trials of Combination Therapies
217(1)
Non-Controlled Studies of Combination Therapies
218(1)
Clinical Evidence for Commonly Used Combination Therapies
219(1)
Safety of Combination Therapies
220(1)
Summary of Combination Therapies Evidence
220(1)
References
220(1)
References for Clinical Studies of Included Combination Therapies
221(2)
9 Summary and Conclusions 223(26)
Introduction
223(1)
Chinese Medicine Syndrome Differentiation
224(2)
Chinese Herbal Medicine
226(8)
Chinese Herbal Medicine Formulas in Key Clinical Guidelines and Textbooks, Classical Literature and Clinical Studies
229(5)
Acupuncture and Other Chinese Medicine Therapies
234(4)
Acupuncture Therapies in Key Clinical Guidelines and Textbooks, Classical Literature and Clinical Studies
235(3)
Limitations of Evidence
238(3)
Implications for Practice
241(2)
Implications for Research
243(2)
References
245(4)
Glossary 249(10)
Index 259