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Flow Cytometry of Hematological Malignancies 2nd edition [Kõva köide]

(Ospedale dell'Angelo, Venice, Italy)
  • Formaat: Hardback, 464 pages, kõrgus x laius x paksus: 279x216x29 mm, kaal: 1474 g
  • Ilmumisaeg: 14-Apr-2021
  • Kirjastus: Wiley-Blackwell
  • ISBN-10: 1119611253
  • ISBN-13: 9781119611257
Teised raamatud teemal:
  • Formaat: Hardback, 464 pages, kõrgus x laius x paksus: 279x216x29 mm, kaal: 1474 g
  • Ilmumisaeg: 14-Apr-2021
  • Kirjastus: Wiley-Blackwell
  • ISBN-10: 1119611253
  • ISBN-13: 9781119611257
Teised raamatud teemal:
Flow Cytometry of Hematological Malignancies

Flow cytometric analysis is often integral to the swift and accurate diagnosis of leukemias and lymphomas of the blood, bone marrow, and lymph nodes. However, in the fast-moving and expanding field of clinical hematology, in can be challenging to remain up to speed with the latest biological research and technological innovations. Flow Cytometry of Hematological Malignancies has been designed to provide all those working in hematological oncology with a practical, cutting-edge handbook, featuring clear and fully illustrated guidance on all aspects of cytometry&;s role in diagnosis and analysis. This essential second edition includes:

  • Explorations of more than 70 antigens
  • Full-color illustrations throughout
  • New descriptions of recently discovered markers
  • WHO classifications of hematological neoplastic diseases
  • Helpful tips for result interpretation and analysis

Featuring all this and more, Flow Cytometry of Hematological Malignancies, Second Edition, is an invaluable resource for both trainee and experienced hematologists, hematopathologists, oncologists, and pathologists, as well as medical students and diagnostic lab technicians.

Foreword to the Second Edition xi
Michael J. Borowitz
Foreword to the First Edition xii
Maryalice Stetler-Stevenson
Foreword to the First Edition xiii
Bruno Brando
Preface to the Second Edition xv
Preface to the First Edition xvi
Abbreviations xvii
1 Antigens 1(154)
Clustered (CD) Antigens
CD1
3(2)
CD2
5(3)
CD3
8(9)
CD4
17(4)
CD5
21(3)
CD7
24(2)
CD8
26(4)
CD10
30(5)
CD1lb
35(3)
CD11c
38(2)
CD13
40(4)
CD14
44(2)
CD15
46(3)
CD16
49(3)
CD19
52(3)
CD20
55(4)
CD22
59(2)
CD23
61(3)
CD24
64(2)
CD25
66(1)
CD26
67(2)
CD27
69(1)
CD28
70(1)
CD30
71(2)
CD33
73(4)
CD34
77(2)
CD38
79(2)
CD43
81(1)
CD45
82(5)
CD45 Isoforms
87(3)
CD49
90(3)
CD56
93(3)
CD57
96(1)
CD61
97(1)
CD62L
98(1)
CD64
99(2)
CD65
101(1)
CD66c
102(1)
CD71
103(1)
CD79
104(3)
CD81
107(1)
CD103
108(2)
CD117
110(2)
CD123
112(1)
CD138
113(1)
CD200
114(2)
CD305
116(1)
CD307 (IRTA) Antigen Family
117(1)
CD371
118(1)
Non clustered (or primarily known with other names) antigens
Bcl-2 Protein
119(2)
Chemokines and Chemokine Receptors
121(7)
CRLF2
128(1)
Cytotoxic Proteins
129(1)
HLA-DR
130(2)
Immunoglobulins
132(4)
KIR, CD158 isoforms
136(3)
Myeloperoxidase (MPO)
139(1)
NG2
140(1)
PCA-1
141(1)
ROR1
141(1)
SLAM Molecules and SLAM-associated Protein (SAP)
142(2)
SOX11
144(1)
T-cell Receptor (TCR)
145(3)
Terminal Deoxy-nucleotidyl-transferase (TdT)
148(2)
Toll-like Receptors (TLR)
150(1)
VS38
151(1)
ZAP-70
152(3)
2 Diseases 155(138)
Myeloproliferative neoplasms
157(5)
Chronic myeloid leukemia (CML)
157(3)
Myeloproliferative neoplasms other than CML
160(2)
Chronic neutrophilic leukemia (CNL)
160(1)
Polycythemia vera (PV)
160(1)
Primary myelofibrosis (PMF)
160(1)
Essential thrombocythemia (ET)
160(1)
Chronic eosinophilic leukemia (CEL)
161(1)
Mastocytosis
162(2)
Acute mast-cell leukemia (AMCL)
162(1)
Chronic mast-cell leukemia (CMCL)
163(1)
Myelomastocytic leukemia (MML)
163(1)
Myelodysplastic/myeloproliferative neoplasms
164(4)
Chronic myelomonocytic leukemia (CMML)
164(3)
Other myelodysplastic/myeloproliferative neoplasms and related conditions
167(5)
Juvenile myelomonocytic leukemia (JMML)
167(1)
Atypical CML bcr/abl negative (ACML)
167(1)
RAS-associated autoimmune leukoproliferative disorder (RALD)
167(1)
Myelodysplastic syndromes
168(3)
Myeloid neoplasms with germline predisposition
171(1)
Acute myeloid leukemias
172(17)
AMLs with recurrent genetic anomalies
173(9)
AMLs with chromosomal anomalies
173(7)
AMLs with gene mutations
180(1)
Relationships between genotype and phenotype in cases of AML not recognized as separate entities in WHO 2017
181(1)
AMLs with myelodysplasia-related changes (AML-MRC)
182(1)
AMLs not otherwise specified
182(6)
AML with minimal differentiation
182(1)
AML without maturation
183(1)
AML with maturation
183(1)
Acute myelomonocytic leukemia (AMMoL)
183(1)
Acute monoblastic and monocytic leukemia (AMoL)
184(1)
Pure erythroid leukemia (PEL)
185(1)
Acute megakaryoblastic leukemia (AMKL)
186(2)
Acute basophilic leukemia (ABL)
188(1)
Myeloid proliferations associated with Down syndrome
188(4)
Transient abnormal myelopoiesis (TAM)
189(1)
AMLs in patients with Down syndrome
189(1)
Blastic plasmacytoid dendritic cell neoplasm (BPDCN/PDCL)
189(3)
Acute leukemias with ambiguous lineage attribution (ALAL)
192(2)
Acute undifferentiated leukemias (AUL)
192(1)
Mixed phenotype acute leukemias (MPAL)
192(2)
Neoplastic diseases of B and T lymphatic precursors
194(12)
B lymphoblastic leukemia/lymphoma, not otherwise specified (B-ALL/LBLnos)
195(2)
B lymphoblastic leukemia/lymphoma with recurrent genetic anomalies
197(5)
Relationships between genotype and phenotype in cases of B-ALL not recognized as separate entities in WHO 2017
201(1)
T lymphoblastic leukemia/lymphoma (T-ALL/LBL)
202(3)
Early T-cell precursor lymphoblastic leukemia (ETP-ALL)
205(1)
NK lymphoblastic leukemia/lymphoma (NK-ALL/LBL)
205(1)
Neoplastic diseases of mature B cells
206(52)
Chronic lymphocytic leukemia/small lymphocytic lymphoma (B-CLL/SLL)
206(10)
Familial B-CLL
215(1)
Richter syndrome
215(1)
Monoclonal B-cell lymphocytosis (MBL)
216(1)
CLL-like monoclonal B lymphocytosis
216(1)
Non-CLL-like monoclonal B lymphocytosis
216(1)
B-cell prolymphocytic leukemia (B-PLL)
216(2)
Lymphoplasmacytic lymphoma (LPL)
218(3)
Heavy chain disease (HCD)
221(1)
γ heavy chain disease
222(1)
µ heavy chain disease
222(1)
α heavy chain disease
222(1)
Hairy cell leukemia (HCL)
222(4)
Hairy cell leukemia, variant (HCL-v)
226(1)
Hairy cell leukemia, Japanese variant (HCL-J)
227(1)
Splenic diffuse red pulp lymphoma (SDRPL)
227(1)
Marginal zone lymphomas (MZL)
228(6)
Nodal marginal zone lymphoma (NMZL)
229(1)
Splenic marginal zone lymphoma (SMZL)
230(2)
Extranodal marginal zone lymphoma (EMZL/MALToma)
232(1)
Clonal B-cell lymphocytosis with MZL-like phenotype (CBL-MZ)
233(1)
Follicular lymphoma (FCL)
234(3)
Testicular follicular lymphoma
237(1)
Duodenal type follicular lymphoma
237(1)
Pediatric type follicular lymphoma
237(1)
Primitive cutaneous follicular lymphoma (PCFL)
237(1)
Large B-cell lymphoma with IRF4 rearrangement
237(1)
Mantle-cell lymphoma (MCL)
237(3)
Blastic mantle-cell lymphoma (BMCL)
240(1)
Leukemic non nodal mantle-cell lymphoma
240(1)
DLBCL not otherwise specified (DLBCLnos)
240(3)
CD5(+) diffuse large cell lymphoma (CD5(+) DLBCL)
243(1)
T-cell/histiocyte-rich B-cell lymphoma (THRLBCL)
243(1)
Primary DLBCL of the CNS (PCNSL)
244(1)
Primary cutaneous DLBCL, "leg type"
244(1)
EBV(+) DLBCLnos
244(1)
DLBCL associated with chronic inflammation (PAL)
245(1)
Fibrin associated DLBCL
245(1)
Lymphomatoid granulomatosis (LYG)
245(1)
Primary mediastinal B-cell lymphoma (PMBCL)
245(1)
Intravascular large B-cell lymphoma (IVBCL)
246(1)
ALK-positive large cell lymphoma (ALK(+) LBCL)
246(1)
Plasmablastic lymphoma (PBL)
247(1)
Primary effusion lymphoma (PEL)
247(1)
HHV8-associated lymphoproliferative disorders
247(1)
HHV8-positive DLBCL
248(1)
HHV8-positive germinotropic lymphoproliferative disorder
248(1)
Burkitt lymphoma (BL)
248(3)
Burkitt leukemia with immature phenotype
250(1)
Burkitt-like lymphoma with 11q aberrations
251(1)
High-grade B-cell lymphoma (HGBL)
251(1)
Plasma cell neoplasms
251(7)
Monoclonal gammopathies of undetermined significance (MGUS)
253(1)
Multiple myeloma (MM)
253(4)
Plasma cell leukemia (PCL)
257(1)
Neoplastic diseases of mature T and NK cells
258(31)
T-cell prolymphocytic leukemia (T-PLL)
258(3)
T-cell large granular lymphocytic leukemia (T-LGL)
261(2)
Chronic lymphoproliferative disorders of NK cells (CLPD-NK/CNKL)
263(3)
Aggressive NK-cell leukemia (ANKL)
266(1)
Adult T-cell leukemia/lymphoma (ATLL)
266(3)
Extranodal NK/T-cell lymphoma, "nasal type" (ENKTL)
269(1)
Intestinal T-cell lymphomas (ITCL)
270(3)
Enteropathy-associated T-cell lymphoma (EATCL)
270(2)
Monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL)
272(1)
Indolent gastrointestinal T lymphoproliferative disorder (indolent GI T-LPD)
273(1)
Hepatosplenic 1-cell lymphoma (HSTCL)
273(2)
Subcutaneous panniculitis-like T-cell lymphoma (SPTCL)
275(1)
Mycosis fungoides (MF)
275(2)
Sezary syndrome (SS)
277(2)
Primary cutaneous CD30(+) lymphoproliferative disorders
279(1)
Lymphomatoid papulosis (LyP)
279(1)
Primary cutaneous anaplastic T-cell lymphoma (pcALCL)
279(1)
Primary cutaneous peripheral T-cell lymphoma (PTCL)
280(1)
Primary cutaneous TCR&gama;δ(+) T-cell lymphoma (PCGD-TCL)
280(1)
Primary cutaneous CD8(+) aggressive epidermotropic cytotoxic T-cell lymphoma (PCAETL)
280(1)
Primary cutaneous acral CD8(+) T-cell lymphoma (PCATCL)
280(1)
Primary cutaneous lymphoma of the medium/small CD4(+) T cells (PCSM-TCL)
281(1)
Peripheral T-cell lymphoma, not otherwise specified (PTCLnos)
281(2)
Nodal lymphomas of follicular T-helper derivation
283(2)
Angioimmunoblastic T-cell lymphoma (A1TL)
283(2)
Follicular T-cell lymphoma (FTCL)
285(1)
Nodal PTCL with follicular T-helper phenotype
285(1)
Anaplastic large cell lymphoma ALK(+) (ALCL ALK(+))
285(3)
Anaplastic large cell lymphoma ALK(-) (ALCL ALK(-))
288(1)
Breast implant-associated anaplastic large cell lymphoma (biaALCL)
288(1)
Hodgkin lymphomas
289(2)
Classic Hodgkin lymphoma (CHL)
289(1)
Nodular lymphocyte predominant Hodgkin lymphoma (NLPHL)
290(1)
Neoplastic diseases of histiocytic and dendritic cells
291(2)
Histiocytic sarcoma (HS)
292(1)
Langerhans cell histiocytosis (LCH)
292(1)
Indeterminate dendritic cell tumor (IDCT)
292(1)
Interdigitating dendritic cell sarcoma (IDCS)
292(1)
Follicular dendritic cell sarcoma (FDCS)
292(1)
Erdheim-Chester disease (EDC)
292(1)
3 Appendix 293(8)
Acute leukemias not recognized by the 2017 WHO classification
294(1)
Acute leukemia of myeloid/NK precursors (MINK-AL)
294(1)
Acute leukemia of myeloid dendritic cells (MDCL)
294(1)
Acute leukemia of Langerhans cells
294(1)
Composite lymphomas
294(1)
Hypereosinophilic syndrome (HES), lymphocyte variant
295(1)
Indolent T lymphoblastic proliferations (iT-LBP)
295(3)
Polyclonal lymphocytoses of B lymphocytes
298(2)
Persistent polyclonal B-cell lymphocytosis (PPBL)
298(1)
Persistent polyclonal CD5(+) B-cell lymphocytosis
298(1)
Persistent polyclonal B-cell lymphocytosis, Japanese (hairy) variant
298(1)
Polyclonal plasmacytoses
299(1)
Small round (blue) cell tumors (SR(B)CT)
300(1)
References 301
Index 42
About the author

Claudio Ortolani is an expert in the area of diagnosis of hematological malig­­nancies. Now retired, Dr Ortolani was Consultant in the Department of Clinical Pathology at Venice General Hospital, Venice, Italy. He is one of the founding members of the Italian Society for Cytometric Cell Analysis (ISCCA), of whose board he is currently a member. He has taught and lectured internationally on how to use flow cytometry to aid in diagnosing hematological diseases.