This book presents cutting-edge insights into formaldehyde, with a particular focus on endogenous formaldehyde, revealing its many key roles in the human body. It delves into the relationship between endogenous formaldehyde and cognition, as well as age-related cognitive impairment. It discusses different aspects such as formaldehyde metabolism, its function in the brain, links with epigenetics and neurophysiology, and epidemiological and clinical investigations. The author also provides suggestions on how to prevent cognitive impairment caused by excessive endogenous formaldehyde. This book appeals to all readers who are interested in cognitive science and toxicology.
This updated edition significantly expands upon the 1st edition. The author adds five new chapters to broaden and deepen the progression and knowledge of formaldehyde and cognition in recent years.
Chapter
1. Formaldehyde from Environment.
Chapter
2. Metabolism of
Formaldehyde In Vivo.
Chapter
3. Formaldehyde and Catecholamine
Neurotransmitters in Cognitive Impairment.
Chapter
4. Formaldehyde Serves as
a Key Factor in the (De)methylation for Memory Formation.
Chapter
5.
Dehydration, Formaldehyde, and Age-Related Cognitive Impairment.
Chapter
6.
The Role of Formaldehyde in Cell Proliferation and Death.
Chapter
7. Gut
Microbiota, Formaldehyde Dysmetabolism, and Cognitive Impairment.
Chapter
8.
Multi-functional Protein Tau Aggregation and Cytotoxicity.
Chapter
9. Cognitive Ability and Impairment Related to Formaldehyde.
Chapter
10.
Amyloid Deposition, Tau Phosphorylation, ApoE4 Dysfunction and
Formaldehyde.
Chapter
11. Formaldehyde Exposure Leads to Circadian Rhythm,
Anxiety, Depression, and Other Neuropsychiatric Disorders.
Chapter
12.
Formaldehyde, Neuroinflammation and Cognitive Impairment.
Chapter
13.
Formaldehyde in Stroke and Vascular Dementia.
Chapter
14. Formaldehyde in
Diabetes and Cognitive Impairment.
Chapter
15. Formaldehyde Affects Lifespan
and Stress Resistance in Drosophila.
Chapter
16. Molecular, Cellular, and
Animal Experiments in Formaldehyde Study.
Chapter
17. Methods in
Determination of Formaldehyde.
Chapter
18. Potential Drug Interventions on
Formaldehyde Induced Neuronal Toxicity.
Dr. Rongqiao He is a professor at the State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences. He currently serves as an editor-in-chief for Progress in Biochemistry and Biophysics. From 2007 to 2021, he held the role of editor-in-chief in Microbiology China and now he is the advisor of Microbiology China. In addition, Dr. He is a dedicated editorial board member for Biochimica Biophysica Acta-GS and Science China Life Sciences. Dr. Hes research focuses on the relationship between the structure and function of neuronal proteins, protein chemical modification, misfolding, and neurodegeneration.
