Comprehensive coverage of major families of viruses, including human pathogens and viruses of organisms from bacteria to plants, with updated information on antiviral drugs, vaccines, antiviral immunity, and gene therapy
Fundamentals of Molecular Virology is a textbook designed for university students learning about viruses at the undergraduate or graduate levels. Chapters contributed by prominent virologists cover many of the major virus families. Each chapter is designed to tell a story about the viruses covered, including information on discovery, diseases and pathogenesis, virus structure, steps in replication, and interaction with cellular signaling pathways. This approach portrays the “personality” of each virus, helping students to learn the material and build up their knowledge of virology starting with smaller and simpler viruses and proceeding to more complex viruses.
Major importance is given to viruses that infect humans and cause disease, but coverage is broad, including viruses of bacteria, Archaea, algae, invertebrates, and plants. Information boxes highlight applications and research directions of particular significance. Chapters conclude with sections presenting fundamental concepts, review questions, and lists of key terms, which are defined in a glossary at the end of the book.
This 3rd edition of Fundamentals of Molecular Virology includes detailed information on the recent COVID-19 pandemic and mRNA vaccine technology, additional sections on pathogenic herpesviruses, and updates on recent outbreaks of Zika virus, Ebola virus and mpox diseases. New chapters describe hepatitis C virus, rhabdoviruses, viruses of invertebrates, oncolytic viruses, and virus-mediated gene therapy. All chapters, including those on innate and adaptive immune responses to virus infections, virus vaccines, and antiviral agents, were revised and updated.
Section I: Introduction To Virology
1. Introduction to Virology 2
Nicholas H. Acheson, McGill University Christopher D. Richardson, Dalhousie
University
2. Virus Structure and Assembly 19
Stephen C. Harrison, Harvard University
3. Virus Classification: The World of Viruses 32
Nicholas H. Acheson, McGill University Christopher D. Richardson, Dalhousie
University
4. Virus Entry 47
Ari Helenius, Swiss Federal Institute of Technology, Zurich
Section II: Viruses of Bacteria And Archaea
5. Single-Stranded RNA Bacteriophages 60
Jan van Duin, University of Leiden Karthik Chamakura, Armata
Pharmaceuticals, Inc., Los Angeles Ryland Young, Texas A&M University
6. Microviruses 74
Bentley A. Fane, University of Arizona Aaron P. Roznowski, University of
Arizona
7. Bacteriophage T7 84
William C. Summers, Yale University Ian J. Molineux, University of Texas,
Austin
8. Bacteriophage T4 94
Deborah M. Hinton, National Institutes of Health, Bethesda Eric S. Miller,
North Carolina State University
9. Bacteriophage Lambda 110
Michael Feiss, University of Iowa
10. Viruses of Archaea 123
David Prangishvili, Institut Pasteur, Paris Mart Krupovic, Institut Pasteur,
Paris
Section III: Positive-Strand Rna Animal Viruses
11. Picornaviruses 140
Bert L. Semler, University of California, Irvine
12. Flaviviruses 152
Richard Kuhn, Purdue University Shelton Bradrick, Trudeau Institute, New
York
13. Hepaciviruses 164
John Lok Man Law, Memorial University of Newfoundland Michael Houghton,
University of Alberta
14. Togaviruses and Rubella Virus 178
Anil Kumar, University of Saskatchewan Milton Schlesinger, Washington
University, St. Louis Sondra Schlesinger, Washington University, St. Louis
Tom C. Hobman, University of Alberta
15. Coronaviruses 192
Marc Desforges, Ste. Justine Hospital, Université de Montréal Pierre Talbot,
Institut Armand-Frappier Mark Denison, Vanderbilt University
Section IV: Negative-Strand and Double-Stranded Rna Animal Viruses
16. Paramyxoviruses and Pneumoviruses 210
Copyrighted Material Nicholas H. Acheson, McGill University Daniel
Kolakofsky, University of Geneva Laurent Roux, University of Geneva
Christopher D. Richardson, Dalhousie University
17. Rhabdoviruses 226
Valery Grdzelishvili, University of North Carolina, Charlotte Cassandra A.
Catacalos, University of North Carolina, Charlotte
18. Filoviruses 237
Heinz Feldmann, Rocky Mountain Laboratories, Montana Hans-Dieter Klenk,
University of Marburg Nicholas H. Acheson, McGill University Angela
Rasmussen, University of Saskatchewan
19. Bunyaviruses 251
Richard M. Elliott, University of Glasgow Lev Levanov, University of
Helsinki Alexander Plyusnin, University of Helsinki
20. Influenza Viruses 262
Dalius J. Briedis, McGill University Alyson Kelvin, University of Calgary
21. Reoviruses 278
Kristen M. Ogden, Vanderbilt University Terence S. Dermody, University of
Pittsburgh School of Medicine
Section V: Small Dna Animal Viruses
22. Parvoviruses 292
Peter Beard, École Polytechnique Fédérale de Lausanne Sarah Wootton,
University of Guelph
23. Polyomaviruses 302
Nicholas H. Acheson, McGill University James A. DeCaprio, Dana-Farber Cancer
Institute, Harvard University
24. Papillomaviruses 318
Greg Matlashewski, McGill University Lawrence Banks, International Centre
for Genetic Engineering and Biotechnology, Trieste Miranda Thomas,
International Centre for Genetic Engineering and Biotechnology, Trieste
Section VI: Large Dna Animal Viruses
25. Adenoviruses 330
Philip Branton, McGill University Richard C. Marcellus, McGill University
Luca D. Bertzbach, Leibniz Institute of Virology, Hamburg Thomas Dobner,
Leibniz Institute of Virology, Hamburg
26. Herpesviruses 344
Bernard Roizman, University of Chicago Gabriella Campadelli-Fiume,
University of Bologna Richard Longnecker, Northwestern University Bruce
Banfield, Queens University Craig McCormick, Dalhousie University
27. Poxviruses 366
Richard Condit, University of Florida Matthew D. Gresseth, Medical
University of South Carolina Paula Traktman, Medical University of South
Carolina
Section VII: Viruses with a Reverse Transcriptase
28. Retroviruses 382
Alan Cochrane, University of Toronto
29. Human Immunodeficiency Virus 394
Alan Cochrane, University of Toronto
30. Hepadnaviruses 406
Christopher D. Richardson, Dalhousie University William Addison, University
of Alberta D. Lorne Tyrrell, University of Alberta
Section VIII: Viroids and Prions
31. Viroids and Hepatitis Delta Virus 420
Jean-Pierre Perreault, Université de Sherbrooke Martin Pelchat, University
of Ottawa Charith Raj Adkar-Purushothama, Université de Sherbrooke
32. Prions 431
Dalius J. Briedis, McGill University David Westaway, University of
California, San Francisco
Section IX: Viruses of Plants, Algae, And Invertebrates
33. Cucumber Mosaic Virus 444
Marilyn J. Roossinck, Pennsylvania State College of Agricultural Sciences
34. Viruses of Algae and Mimivirus, a Giant Virus 457
Michael J. Allen, University of Exeter William H. Wilson, Marine Biological
Association, Plymouth John A. Duffy, University of Exeter
35. Baculoviruses 478
Eric Carstens, Queens University Robert L. Harrison, U.S. Department of
Agriculture, Beltsville, Maryland
36. Viruses of Invertebrates 489
Peter Krell, University of Guelph
Section X: Host Defenses Against Virus Infection
37. Innate Immune Responses Against Virus Infection 506
Karen Mossman, McMaster University John Hiscott, Istituto Pasteur-Fondazione
Cenci Bolognetti, Rome Alessandra Zevini, Istituto Pasteur-Fondazione Cenci
Bolognetti, Rome
38. Adaptive Immune Responses to Virus Infection 527
Malcolm G. Baines, McGill University Karen Mossman, McMaster University
Naglaa Shoukry, University of Montreal
Section XI: Medical Applications of Virology
39. Antiviral Vaccines 542
Brian Ward, McGill University Hilary E. Hendin, McGill University
40. Antiviral Chemotherapy 562
Donald M. Coen, Harvard Medical School
41. Oncolytic Viruses 578
Vishnupriyan Kumar, Dalhousie University Liang-Tzung Lin, Taipei Medical
University Shashi Gujar, Dalhousie University
42. Virus-Mediated Gene Therapy 586
Richard Peluso, Renovacor, Philadelphia Christopher D. Richardson, Dalhousie
University
Christopher D. Richardson is Professor, Department of Microbiology & Immunology, Department of Pediatrics, Dalhousie University, Canada. Dr. Chris Richardson is a molecular virologist with 35 years of experience working with a variety of viruses. He earned his PhD at the University of British Columbia and did postdoctoral work at The Rockefeller University and the National Institutes of Health (Bethesda, USA). He previously held faculty positions at the National Research Council of Canada, McGill University, and the University of Toronto.
Nicholas H. Acheson is Emeritus Professor of Microbiology & Immunology at McGill University, Quebec, Canada. He earned his PhD from The Rockefeller University and was a postdoctoral fellow at the Swiss Institute for Experimental Cancer Research (Lausanne) and Institut Pasteur (Paris). He carried out research on Semliki Forest virus and mouse polyomavirus, and taught a virology course for advanced undergraduate students at McGill University.
