G-protein-coupled receptors (GPCRs) are believed to be the largest family of membrane proteins involved in signal transduction and cellular responses. They dimerize (form a pair of macromolecules) with a wide variety of other receptors. The proposed book will provide a comprehensive overview of GPCR dimers, starting with a historical perspective and including, basic information about the different dimers, how they synthesize, their signaling properties, and the many diverse physiological processes in which they are involved. In addition to presenting information about healthy GPCR dimer activity, the book will also include a section on their pathology and therapeutic potentials.
Part I. Introduction.- 1. From Monomers to Dimers and Beyond: An
Exciting Journey in the World of the G protein-coupled Receptor Family.- 2.
The use of Spatial Intensity Distribution Analysis to Examine G
protein-coupled Receptor Oligomerization.- 3. Advanced Microscopy Techniques
for Studying G protein-coupled Receptors.- Part II. Receptors.- 4. Light
Sensing G protein-coupled Receptor Rhodopsin Dimer.- 5. Extreme Vetting of
Dopamine Receptor Oligomerization.- 6. Serotonin receptors.- 7. Cannabinoid
and Opioid Receptor Heteromers.- 8. Di/oligomerization of Glycoprotein
Hormone Receptors.- 9. Chemokine Receptor Oligomerization to Tweak
Chemotactic Responses.- 10. Secretin Receptor Dimerization. Prototypic of
Class B GPCR Behavior.- 11. Receptors and RAMPs.- 12. Obligatory
Heterodimerization of GABAB Receptor.- 13. Metabotropic Glutamate
Receptors. Part III. Assembly and Trafficking.- 14. The monomer/homodimer
Equilibrium of G protein-coupled Receptors: Formation in the Secretory
Pathway and Potential Functional Significance.- 15. Probing Self-assembly of
G protein-coupled Receptor Oligomers in Membranes using Molecular Dynamics
Modeling and Experimental Approaches.- 16. Interaction of Membrane
Cholesterol with GPCRs: Implications in Receptor Oligomerization.- Part IV.
Physiology and Therapeutic Potential.- 17. Allosterism within GPCR Oligomers:
Back to Symmetry.- 18. Understanding the Physiological Significance of GPCR
Dimers and Oligomers.- 19. Heteromers form Novel Signaling Complexes.-
20. Heteroreceptor Complexes Implicated in Parkinsons Disease.
Katharine Herrick-Davis is Professor of Neuroscience and Experimental Therapeutics at Albany Medical College, Albany, USA. Her research has focused on investigating receptor dimerization and how it affects receptor function using the 5-HT2C receptor as a model system. Graeme Milligan is Professor of Molecular Pharmacology, University of Glasgow, U.K. he is the Dean of Research, College of Medical, Veterinary and Life Sciences, University of Glasgow. His main research group centres on the function, structure and regulation of GPCRs and their interacting proteins. Giuseppe Di Giovanni is Professor of Human Physiology, University of Malta, Malta. He is the President of the Malta Neuroscience Network and Treasurer of the Mediterranean Neuroscience Society. His research has focused on the pathophysiology of the monoaminergic systems in different neuropsychiatric disorders, such as Parkinson's disease, depression, drug of abuse and epilepsy.
