This book comprehensively covers the latest development in developing and deploying the genetically modified vectors, particularly Anopheles and Aedes mosquitoes responsible for transmitting malaria parasites and dengue viruses, the most deadly and/or debilitating among all the vector-borne diseases. It is considered timely and commensurate to bring about a book dealing with the various ecological, biological and social as well as regulatory aspects for the deployment of genetically modified vectors in special context with the biosafety of humans, his associates, and the environment. Written by an array of specialists and experts in various subjects of genetically modified organisms, this book centrally addresses the (i) basic principles of the genetic manipulation of vectors and they are potential impact on human and the environment, (ii) ecological, biological, ethical, legal and social implications of the use of genetically modified vectors, (iii) identification of potential hazards; assessment and management of risks for human and environment; risk/benefit analysis, (iv) principles and practices for the assessment and management of biosecurity and biosafety in laboratories (and in the field), (v) guiding principles for creation and management of institutional or national biosafety review boards and ethics review committees, and (vi) development and application of a biosafety regulatory framework and its related legal principles at national levels for securing the development and use of vector control methods based on genetic modification strategies.
This publication will be useful to researchers, scientists, and professionals engaged in academic and research institutions, government or non-government, as well as students in universities and medical colleges.
Chapter 1. Arthropod disease vectors: Genetic manipulations and other
innovative technologies for mosquito control, with emphasis on eco-bio-social
considerations.
Chapter 2. Field trials of gene drive mosquitoes: Lessons
from releases of genetically sterile males and Wolbachia-infected
mosquitoes.
Chapter 3. Genetic improvements to the Sterile Insect Technique
(SIT) for the control of mosquito population.
Chapter 4. Advances in Aedes
mosquito vector control strategies using CRISPR/Cas9.
Chapter 5. Evaluation
of transgenic Aedes aegypti L. strain in India A friendly mosquito.-
Chapter 6. Three decades of malaria vector control in Sudan: The plausible
role of Sterile Insect Technique (SIT).
Chapter 7. Perspectives into genetic
manipulations for control of dengue vector (Aedes aegypti Linnaeus, 1762)
with reference to progress in Indian experiments.
Chapter 8. Overcoming the
dengue challenges using Innovative Strategy: The Malaysian experience.-
Chapter 9. Malaria control in Africa using vector genetic manipulation.-
Chapter 10. RNA interference based technologies to control dengue vector
mosquitoes.
Chapter 11. Wolbachia: Biological control strategy against
arboviral diseases.
Chapter 12. Wolbachia endosymbiont and mosquito vectors,
with emphasis on lymphatic filariasis elimination.
Chapter 13. Laboratory
biosafety in handling genetically modified mosquitoes.
Chapter 14. Novel
diagnosis and control of arboviruses.
Chapter 15. Long lasting insecticidal
nets: an evidence-based technology for malaria vector control and future
perspectives.
Chapter 16. Novel development of an indigenous Long Lasting
Insecticide Bednet (LLIN) to defend against the hematophagous arthropods.-
Chapter 17. Nanotechnology and Polymer Science: A novel approach in vector
control.
Chapter 18. Nano-sized emulsion system: A comprehensive tool
towards controlling vectormosquito Populations.
Chapter 19. DEPA (- N,
N-Diethyl Phenyl Acetamide) Commercial journey of Indias first
indigenous mosquito repellent with novel properties.
Chapter 20. Remote
Sensing and Geographic Information Technology in novel vector control.-
Chapter 21. Social and ecological factors responsible for changing habitat of
Kala-azar vector (Phlebotomus argentines) and its control through locally
innovated environment-friendly technology.
Chapter 22. Safety assessment of
novel genetic technologies for vector control: National and international
perspectives.
Chapter 23. Measuring public attitudes to releases of
transgenic mosquitoes for disease control, with special reference to dengue
and malaria.
Chapter 24. Safe application of genetically modified mosquito
(GMM) to combat dengue and chikungunya depends on socio-economic status and
social acceptance in the developing countries: A comprehensive analysis.-
Chapter 25. Experiences and outcomes from a worldwide training programme on
genetically modified vectors (GMVs) related biosafety for human health and
the environment.-
Brij Kishore Tyagi Born 23rd July 1951, Dr. Brij Kishore Tyagi (PhD 1979) has become emeritus in 2013, with two years extension till 2015, as Scientist G & Director-in-Charge from the ICMR-Centre for Research in Medical Entomology, Madurai, after distinguished service in medical entomology and vectorborne diseases in most of States and UTs in the country. He has since continued as the Visiting Professor in various universities (20162019) and currently is the Advisor, VIT Univ., Vellore (TN) as well as the International Consultant for a BCIL-FAO Sri Lanka Project on GMO Biosafety (20192021). He has to his credit >640 scientific titles, besides 37 books, incl. a WHO Training Manual on GM vectors (2015). Recipient of the prestigious WHO-TDR First Prize in worldwide competition (1995) and the ICMRs Dr. MOT Iyengar Memorial Award (2008), he is the Founding President of the Society of Medical Arthropodology (www.soma16.org). He has participated in preparing OECDs Consensus Document on Aedes aegypti (2018), is Chairman, RCGM-DBTs Subcommittee for the formulation of biosafety guidelines to conduct and monitor research trials (CRTs) on genetically engineered mosquitoes, and an Expert Member of the DBT-RCGM Committee on GM insects.
