"This volume, The Glycome: Understanding the Diversity and Complexity of Glycobiology, provides a comprehensive understanding of the enigmatic identity of the glycome, a complex but important area of research, one largely ignored because of its complexity. In this volume, the authors thoroughly deal with almost all aspects of the glycome, i.e., elucidation of the glycan identity enigma and its role in regulation of the cellular process and in disease etiology. It bridges the knowledge gap in understanding the glycome, from being a cell signature to its applications in disease etiology. In addition, it details many of the major insights regarding the possible role of the glycome in various diseases as a therapeutic marker. The book systematically covers the major aspects of the glycome, including the significance of substituting the diverse monosaccharide units to glycoproteins, the role of glycans in disease pathologies, and the challenges and advances in glycobiology. The authors stress the significanceand huge encoding power of carbohydrates as well as provide helpful insights in framing the bigger picture. The authors begin with an introduction to the trends and developments in glycobiology and then proceed to discussing its role in disease pathologies, followed by its roles in other organisms, including bacteria, plants, and as stress busters. Chapters cover the involvement of the glycome in congenital and noncongenital disorders, the role of glycans in immunological processes, the role of glycans in neurodegeneration and metastasis, the involvement of glycans in host-pathogen interaction, and their role in microbial infection and the immune evasion. The book also provides insights into the therapeutic aspects of acylation as a vital glycosylationalmodification of proteins. A chapter highlights the scenario of glycans in plants while another discusses glycans as stress coping agents. The Glycome: Understanding the Diversity and Complexity of Glycobiology details state-of-the-art developments and emerging challenges of glycome biology, which are going to be key areas of future research, not only in the glycobiology field but also in pharmaceutics"--
This book details state-of-the-art developments and emerging challenges of glycome biology, which are going to be key areas of future research, not only in the glycobiology field but also in pharmaceutics.
This volume provides a comprehensive understanding of the enigmatic identity of the glycome, a complex but important area of research that has been largely ignored due to its complexity. The authors thoroughly deal with almost all aspects of the glycome, i.e., elucidation of the glycan identity enigma and its role in regulation of the cellular process, and in disease etiology. The book bridges the knowledge gap in understanding the glycome, from being a cell signature to its applications in disease etiology. In addition, it details many of the major insights regarding the possible role of the glycome in various diseases as a therapeutic marker.
The book systematically covers the major aspects of the glycome, including the significance of substituting the diverse monosaccharide units to glycoproteins, the role of glycans in disease pathologies, and the challenges and advances in glycobiology. The authors stress the significance and huge encoding power of carbohydrates as well as provide helpful insights in framing the bigger picture.
The Glycome: Understanding the Diversity and Complexity of Glycobiology
details state-of-the-art developments and emerging challenges of glycome biology, which are going to be key areas of future research, not only in the glycobiology field but also in pharmaceutics.
| Contributors |
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ix | |
| Abbreviations |
|
xiii | |
| Preface |
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xix | |
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1 Trends and Advancements in Glycobiology: Towards Development of Glycan-Based Therapeutics |
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1 | (34) |
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2 Defects in the Human Glycome: Congenital and Non-Congenital Disorders |
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35 | (36) |
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3 Glycome in Immunological Processes: Current Scenario and Future Prospects |
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71 | (40) |
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4 Role of Glycans in Neurodegeneration |
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111 | (16) |
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5 Glycome in Metastasis: Glycan Remodeling and Tumor Progression |
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127 | (30) |
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6 Glycans in the Host-Pathogen Interaction |
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157 | (42) |
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7 Glycome in Microbial Infections and Immune Evasion |
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199 | (18) |
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8 Acylation as a Vital Post-Glycosylation Modification of Proteins: Insights and Therapeutics Prospects |
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217 | (18) |
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9 Glycome Profiling in Plants: Towards Understanding the Scenario of Carbohydrates |
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235 | (40) |
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10 Sugars: Coping the Stress in Plants |
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275 | (22) |
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| Index |
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297 | |
Adeel Malik, PhD, is a Research Professor at the Institute of Intelligence Informatics Technology, Sangmyung University, Seoul, South Korea. He obtained his PhD from the Department of Biosciences, Jamia Millia Islamia (JMI), New Delhi, India. During his PhD, he developed computational methods for the prediction of carbohydrate binding sites in proteins using sequence and evolutionary information. This was the first sequence-based method to predict the carbohydrate binding sites in proteins. Later he joined School of Computational Sciences, Korea Institute for Advanced Study (KIAS), Seoul, South Korea, to pursue his postdoctoral fellowship. As a part of his research, he investigated plant lectin-carbohydrate interactions via community-based network analysis by using glycan array data. He also worked as an Assistant Professor at Perdana University Center for Bioinformatics (PU-CBi), Malaysia from 20142016. Dr. Adeel has broad research interests in the area of bioinformatics that include protein-carbohydrate interactions, machine learning, NGS, etc. He has also to his credit several research publications in peer-reviewed international journals, book chapters, and edited books with international publishers.
Tanveer A. Dar, PhD, is Assistant Professor in the Department of Clinical Biochemistry, University of Kashmir, India. Dr. Dar received his masters degree in Biochemistry from Hamdard University, New Delhi, India, and a PhD in Protein Biophysics from Jamia Millia Islamia, New Delhi, India. After completing his doctorate, Dr. Dar joined as a postdoctorate at the University of Montana, Missoula, USA, where his main research area involved characterization of protein denatured states. Dr. Dars research interests mainly include i) structural and functional characterization of glycosylated therapeutic proteins from medicinal plants and ii) role of chemical chaperones/osmolytes in modulating fibrillation/aggregation of proteins. He has authored more than 40 publications in both national and international journals of repute in the field of protein biophysics and proteomics and is also a recipient of an INSA visiting fellowship from the Indian National Science Academy (INSA), India. In addition to this, Dr. Dar has co-authored a number of edited volume books published by internationally reputed publishers, including Springer and Elsevier.
