This book presents the latest developments in glycoscience and outlines a roadmap for the next decade, reflecting Japans leadership in this rapidly evolving field. Building on the previous edition, Glycoscience: Basic Science to Applications (2019), the Japan Consortium for Glycobiology and Glycotechnology (JCGG) has compiled this revised edition to foster global collaboration and accelerate innovation across the life sciences.
This edition contains 167 entries contributed by 170 experts and is organized into six thematic parts: emerging glycan technologies; medicine, healthcare, and diseases involving glycans; glycan-related pharmaceuticals; glycan-related foods and their functions; glycan-based functional materials; and glycoinformatics. Each entry offers a structured overview of the topics current status, scientific and societal impact, industrial applicability, and future challenges.
The book is a distinctive and valuable resource for researchers, students, clinicians, industry professionals, and policymakers. It promotes interdisciplinary integration, supports education and outreach, and serves as a strategic guide for advancing glycoscience globally.
Chapter 1.Introduction.
Chapter
2. Liquid Chromatography-Mass
Spectrometry (LC-MS).
Chapter
3. Ion Mobility Mass Spectrometry (IM-MS).-
Chapter
4. Current Status and Future of the Automated Glycan Analysis
Technologies.
Chapter
5. Glycoproteomics.
Chapter
6. O-Glycomics of
Glycoproteins.
Chapter
7. Glycolipidomics.
Chapter
8. Measurement of Sugar
Metabolites.
Chapter
9. Single Cell Glycomics.
Chapter
10. Glycan Array.-
Chapter
11. Lectin Blotting.
Chapter
12. Lectin Engineering.
Chapter
13.
Antibodies Recognizing Glycans Created as Antigens from Human iPS Cells.-
Chapter
14. EMARS Method.
Chapter
15. Structural Biology by H-D Exchange
Method.
Chapter
16. Structural analysis of glycoproteins and related
biological molecules by cryo-electron microscopy.
Chapter
17. Conformational
Analysis of Glycans.
Chapter
18. Conformation Analysis of Glycans (2).-
Chapter
19. Structural Analysis of Glycan-Related Proteins (1).
Chapter
20.
Structural Analysis of Glycan-Related Proteins (2).
Chapter
21. Glycoside
hydrolases.
Chapter
22. Protein Structure Prediction (AlphaFold).
Chapter
23. Membrane Simulation and Imaging (1).
Chapter
24. Simulation and Imaging
of Membranes (2).
Chapter
25. Imaging Using Labeled Glycans (1).
Chapter
26. Imaging with Labeled Glycans (2).
Chapter
27. Glycoside
hydrolases-resistant glycans: Biological activity and application to
molecular imaging.
Chapter
28. Mass Spectrometry Imaging (MSI).
Chapter
29.
Visualization of Golgi apparatus glycosyltransferase.
Chapter
30. Synthetic
Glycans.
Chapter
31. Glycan Synthesis by Microflow.
Chapter
32. Automation
of Glycan Synthesis.
Chapter
33. New synthesis method for the production of
N-glycans: Glycoproteins (1).
Chapter
34. Novel synthesis method for the
production of standard glycan compounds: Glycoproteins (2).
Chapter
35.
Novel synthesis method for the production of standard glycan compounds:
Glycolipids.
Chapter
36. Novel synthesis method for the production of
standard glycosides: Sialic acid containing glycans.
Chapter
37. Novel
synthesis method for the production of standard glycan compounds:
Glycosylphosphatidylinositol (GPI).
Chapter
38. Synthetic Glycosaminoglycan
(GAG).
Chapter
39. Genetically Modified Mice: Glycolipids.
Chapter
40.
Genetically Modified Mice: Glycoproteins.
Chapter
41. Genetically modified
mice: Glycosaminoglycan (GAG).
Chapter
42. Genetic modification: Small
fish.
Chapter
43. Genetic modification: Yeast.
Chapter
44. Drosophila
melanogaster.
Chapter
45. Caenorhabditis elegans.
Chapter
46. Plants and
glycans.
Chapter
47. Chemical Biology.
Chapter
48. Role of glycans in
evolution, development, and stem cells.
Chapter
49. Glycosylation in stem
cells.
Chapter
50. Epigenetic regulation of glyco-genes.
Chapter
51.
Involvement of glycans in the acquisition of drug resistance in cancer.-
Chapter
52. Extracellular vesicles.
Chapter
53. Carbohydrate metabolism.-
Chapter
54. Glycation reaction (Maillard reaction) and medicine.- chapter
55.
Schizophrenia (Polysialic acid).
Chapter
56. Schizophrenia (Core fucose and
polysialic acid).
Chapter
57. Spinal cord injury and glycosaminoglycan.-
Chapter
58. Alzheimer's disease (AD)(1).
Chapter
59. Alzheimer's disease
(AD)(2).- chapter
60. Parkinson's disease.
Shoko Nishihara, Ph.D. Distinguished Professor and Director, Glycan and Life System Integration Center, Soka University President, Japan Consortium for Glycobiology and Glycotechnology (JCGG)
Dr. Nishihara received her Ph.D. in Chemistry from the University of Tokyo, specializing in protein structural analysis. She began her research career at the Jikei University School of Medicine, where she investigated the pathogenic mechanisms of Staphylococcus aureus. She subsequently pursued postdoctoral research in Drosophila development at the University of North Carolina and the Mitsubishi Kasei Institute of Life Sciences. After joining Soka University as a Lecturer (equivalent to Assistant Professor), she transitioned into glycobiology and established an interdisciplinary research program integrating developmental biology, glycoscience, and stem cell biology. Her current research focuses on glycan functions in stem cells and development, as well as the molecular basis of glycosylation-related disorders. Dr. Nishihara also serves on the Editorial Board of Glycoconjugate Journal.
Jun Hirabayashi, PhD. Designated Professor, Institute for Glyco-core Research, Nagoya University Vice-President, Japan Consortium for Glycobiology and Glycotechnology (JCGG)
Dr. Hirabayashi graduated from Tohoku University and began his academic career at Teikyo University, where he initiated foundational studies on animal lectins, now known as galectins. He later joined the National Institute of Advanced Industrial Science and Technology (AIST) in Tsukuba, focusing on the industrial application of glycoscience technologies such as frontal affinity chromatography and lectin microarrays. He is also a visiting professor at Kagawa University and a member of the Kagawa Rare Sugar Project. His research interests include biochemistry, glycoscience, glycotechnology, and lectin engineering.
