This book is an inquiry into the application of the principles and the methodologies of pharmacokinetics and pharmacodynamics for the endogenous compounds creatine and creatinine, and assesses presence of nonlinear in vivo kinetics for creatine while providing new pathways for studies and bench research.
The conceptual basis to summarize and predict the in vivo behavior and the related mathematical descriptions and models of creatine and creatinine are currently based on the principles and methodologies of pharmacokinetics and pharmacodynamics. Most in vivo kinetic analyses and models of creatine and creatinine are assumed to be linear. The presence of nonlinear in vivo kinetics for creatine is assessed by the author due to the affinity and preferential uptake of the molecule in the muscle. This book is an inquiry into the application of these principles and methodologies for the endogenous compounds creatine and creatinine, and provides new pathways for studies and bench research.
Key Features
- Discusses the term 'in vivo kinetics' and related rates for defining the production, distribution, metabolism and excretion (PDME) of creatine and creatinine.
- Evaluates the current kinetic models of creatine and creatinine, and other applied modeling approaches.
- Uses an integrated interdisciplinary approach in addressing the kinetics and dynamics of creatine and creatinine.
- Establishes new pathways in creatine and creatinine studies and bench research.
Preface. Historical Prologue. About the Author.
Chapter 1: Production of
Creatine (CR) and Creatinine (Cr).
Chapter 2: "In Vivo Distribution of
Endogenous Creatine (CR) and Creatinine (Cr)".
Chapter 3: Elimination
(Metabolism and Excretion) of Creatine (CR) and Creatinine (Cr).
Chapter 4:
Mathematical Models of Creatine (CR) and Creatinine (Cr)
Chapter 5: Creatine
(CR) and Creatinine (Cr) as Biological Markers.
Chapter 6 Creatine (CR) and
Creatinine (Cr) Analytical Methodologies.
Chapter 7: Creatine Supplement and
Co-Supplements: Dosing Regimen, Bioavailability, Influence of Gender, and
Effect of Diet.
Chapter 8: Potential Therapeutic Values of Creatine
Supplements in Selected Disease States.
Chapter 9: Side Effects of Orally
Administered Exogenous Creatine.
Chapter 10: Exogenous Creatinine Supplement:
Clinical Application of Creatinine Clearance. Addendum: General Equations of
Linear Two-Compartment Models: Extension of
Chapter 4 and Figure 4.1. Index
Mehdi Boroujerdi received his Ph.D. in pharmaceutics and pharmacokinetics with minor in Biochemistry from the University of North Carolina at Chapel Hill in 1978. He completed his postdoctoral training at the National Institute of Health, National Institute of Environmental Health Sciences at Research Triangle Park. He served as the professor of pharmaceutics/pharmacokinetics with tenure at Northeastern University, Boston, MA (19822002); professor of pharmaceutics and pharmacokinetics at the MCPHS University, School of Pharmacy, Boston, MA (20022005); professor of pharmaceutical sciences with tenure at the Albany College of Pharmacy and Health Sciences, Albany, New York (20052015); and professor of pharmaceutical sciences with tenure at the College of Health Sciences, University of Massachusetts, Lowell, MA (20152017).
Boroujerdi has also served as Dean of School of Pharmacy at Bouvé College of Health Sciences at Northeastern University (19881999); as Dean of School of Pharmacy-Boston at MCPHS University (20022005); as Dean of Pharmacy and Vice President for Academic Affairs, Provost, at the Albany College of Pharmacy and Health Sciences (20062012); and Founding Dean of School of Pharmacy and Pharmaceutical Sciences at the College of Health Sciences, University of Massachusetts at Lowell (20152017). He also served as the Dean of Research and Graduate Studies at MCPHS (20032005), and Director of Graduate Programs in Biomedical Sciences at Northeastern University (19881999).
Boroujerdi has to his credit 112 peer-reviewed publications, and he is the sole author of three books: Pharmacokinetics, Principles and Applications (McGraw Hill, 2002), Pharmacokinetics and Toxicokinetics (CRC Publications, 2015), and Handbook of Pharmacokinetics and Toxicokinetics (CRC Publications, 2023). He has trained many graduate and undergraduate students through his research programs focused on pharmacokinetics and toxicodynamics of anticancer drugs, carcinogenesis, and efflux proteins.
He also served as a consultant to five pharmaceutical industries.
As a professor, he taught graduate courses in advanced pharmacokinetics and biopharmaceutics, drug metabolism, advanced pharmaceutics, and drug delivery systems; his teaching of undergraduate courses included drug discovery and development, biopharmaceutics and pharmacokinetics, physical pharmacy and pharmaceutics, and pharmacokinetics in disease states.
